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NO20063027L - Fremgangsmaten for syntesen av derivater av (2S,3aS,7aS)-1-[(S)-alkanyl]-oktahydro-lH-indol-2-karboksylsyre og anvendelse derav i syntesen av perindopril - Google Patents

Fremgangsmaten for syntesen av derivater av (2S,3aS,7aS)-1-[(S)-alkanyl]-oktahydro-lH-indol-2-karboksylsyre og anvendelse derav i syntesen av perindopril

Info

Publication number
NO20063027L
NO20063027L NO20063027A NO20063027A NO20063027L NO 20063027 L NO20063027 L NO 20063027L NO 20063027 A NO20063027 A NO 20063027A NO 20063027 A NO20063027 A NO 20063027A NO 20063027 L NO20063027 L NO 20063027L
Authority
NO
Norway
Prior art keywords
synthesis
perindopril
alkanyl
octahydro
indole
Prior art date
Application number
NO20063027A
Other languages
English (en)
Inventor
Jean-Pierre Lecouve
Thierry Dubuffet
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of NO20063027L publication Critical patent/NO20063027L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Oppfinnelsen vedrører en fremgangsmåte for syntesen av forbindelse med formel (1) hvori R representerer et hydrogenatom eUer en beskyttelsesgruppe for aminofimksjonen. Oppfirmelsen vedrører også anvendelsen derav for syntesen av perindopril og farmasøytisk akseptable salter derav.
NO20063027A 2003-12-10 2006-06-28 Fremgangsmaten for syntesen av derivater av (2S,3aS,7aS)-1-[(S)-alkanyl]-oktahydro-lH-indol-2-karboksylsyre og anvendelse derav i syntesen av perindopril NO20063027L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03293085A EP1420030A3 (fr) 2003-12-10 2003-12-10 Procédé de synthèse de dérivés de l'acide (2S, 3aS, 7aS) - 1 - [(S)-alanyl]-octahydro-1H-indole-2-carboxylique et application à la synthèse du perindopril
PCT/FR2004/003167 WO2005066199A1 (fr) 2003-12-10 2004-12-09 Procede de synthese de derives de l’acide (2s,3as,7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxylique et application a la synthese du perindopril

Publications (1)

Publication Number Publication Date
NO20063027L true NO20063027L (no) 2006-06-28

Family

ID=32116382

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20063027A NO20063027L (no) 2003-12-10 2006-06-28 Fremgangsmaten for syntesen av derivater av (2S,3aS,7aS)-1-[(S)-alkanyl]-oktahydro-lH-indol-2-karboksylsyre og anvendelse derav i syntesen av perindopril

Country Status (19)

Country Link
US (1) US7288661B2 (no)
EP (1) EP1420030A3 (no)
JP (1) JP2007537996A (no)
KR (1) KR20060096521A (no)
CN (1) CN100469787C (no)
AR (1) AR047328A1 (no)
AU (1) AU2004312186A1 (no)
BR (1) BRPI0417540A (no)
CA (1) CA2548406A1 (no)
EA (1) EA010318B1 (no)
GE (1) GEP20084408B (no)
MA (1) MA28223A1 (no)
MY (1) MY136937A (no)
NO (1) NO20063027L (no)
NZ (1) NZ547555A (no)
PL (1) PL380411A1 (no)
UA (1) UA84897C2 (no)
WO (1) WO2005066199A1 (no)
ZA (1) ZA200604368B (no)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
CN1257508C (zh) * 1999-12-28 2006-05-24 松下电器产业株式会社 记录装置
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril

Also Published As

Publication number Publication date
CA2548406A1 (fr) 2005-07-21
UA84897C2 (en) 2008-12-10
AU2004312186A1 (en) 2005-07-21
EP1420030A2 (fr) 2004-05-19
EA010318B1 (ru) 2008-08-29
HK1095840A1 (en) 2007-05-18
US20070123581A1 (en) 2007-05-31
BRPI0417540A (pt) 2007-03-27
US7288661B2 (en) 2007-10-30
EP1420030A3 (fr) 2004-05-26
MY136937A (en) 2008-11-28
CN1890259A (zh) 2007-01-03
KR20060096521A (ko) 2006-09-12
CN100469787C (zh) 2009-03-18
MA28223A1 (fr) 2006-10-02
ZA200604368B (en) 2007-10-31
GEP20084408B (en) 2008-06-25
JP2007537996A (ja) 2007-12-27
NZ547555A (en) 2009-11-27
AR047328A1 (es) 2006-01-18
PL380411A1 (pl) 2007-01-22
EA200601088A1 (ru) 2006-12-29
WO2005066199A1 (fr) 2005-07-21

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application