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NO20060706L - Inhibitorer av serinproteaser, spesielt HCV NS3-NS4A-protease - Google Patents

Inhibitorer av serinproteaser, spesielt HCV NS3-NS4A-protease

Info

Publication number
NO20060706L
NO20060706L NO20060706A NO20060706A NO20060706L NO 20060706 L NO20060706 L NO 20060706L NO 20060706 A NO20060706 A NO 20060706A NO 20060706 A NO20060706 A NO 20060706A NO 20060706 L NO20060706 L NO 20060706L
Authority
NO
Norway
Prior art keywords
compounds
disclosed
inhibitors
serine proteases
ns4a protease
Prior art date
Application number
NO20060706A
Other languages
English (en)
Inventor
Janos Pitlik
Robert Perni
Shawn D Britt
Kevin M Cottrell
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34079432&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20060706(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of NO20060706L publication Critical patent/NO20060706L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Det beskrives forbindelser med formel I eUer formel la eUer farmasøytisk akseptable salter derav, som inhiberer serinproteaseaktivitet, spesielt aktiviteten av hepatitt C-virus-NS3-NS4A-protease. Som sådanne virker de ved å forstyrre livssyklusen for hepatitt C-virus og er nyttige som antivirale midler. Dessuten beskrives farmasøytisk akseptable sammensetninger omfattende forbindelsene enten for bruk ex vivo eller for administiasjon til en pasient som lider av HCV-infeksjon, og fremgangsmåter for frem- stUling av forbindelsene. Det beskrives også fremgangsmåter for å behandle en HCV-infeksjon i en pasient ved å administiere en farmasøytisk sammensetning som omfatter en forbindelse ifølge oppfmnelsen.
NO20060706A 2003-07-18 2006-02-14 Inhibitorer av serinproteaser, spesielt HCV NS3-NS4A-protease NO20060706L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48853503P 2003-07-18 2003-07-18
PCT/US2004/023054 WO2005007681A2 (en) 2003-07-18 2004-07-16 Inhibitors of serine proteases, particularly hcv ns3-ns4a protease

Publications (1)

Publication Number Publication Date
NO20060706L true NO20060706L (no) 2006-02-14

Family

ID=34079432

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060706A NO20060706L (no) 2003-07-18 2006-02-14 Inhibitorer av serinproteaser, spesielt HCV NS3-NS4A-protease

Country Status (18)

Country Link
US (2) US7109172B2 (no)
EP (3) EP2341065A3 (no)
JP (2) JP4745230B2 (no)
KR (2) KR20060052836A (no)
CN (3) CN102020700A (no)
AR (1) AR045916A1 (no)
AU (2) AU2004257288A1 (no)
BR (1) BRPI0412761A (no)
CA (1) CA2532664A1 (no)
IL (2) IL173180A0 (no)
NO (1) NO20060706L (no)
NZ (1) NZ544789A (no)
PE (1) PE20050251A1 (no)
RU (1) RU2412198C2 (no)
TW (1) TW200523270A (no)
UY (1) UY28423A1 (no)
WO (1) WO2005007681A2 (no)
ZA (1) ZA200601420B (no)

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Also Published As

Publication number Publication date
RU2412198C2 (ru) 2011-02-20
AU2010257200A1 (en) 2011-01-13
AU2010257200B2 (en) 2011-10-20
EP2341065A2 (en) 2011-07-06
IL173180A0 (en) 2006-06-11
AU2004257288A2 (en) 2008-06-26
US20060211629A1 (en) 2006-09-21
HK1098164A1 (en) 2007-07-13
BRPI0412761A (pt) 2006-09-26
WO2005007681A2 (en) 2005-01-27
EP2368900A3 (en) 2012-07-04
JP2011116784A (ja) 2011-06-16
UY28423A1 (es) 2005-02-28
JP4745230B2 (ja) 2011-08-10
WO2005007681A3 (en) 2005-06-02
TW200523270A (en) 2005-07-16
CN101724022A (zh) 2010-06-09
CA2532664A1 (en) 2005-01-27
CN1852920A (zh) 2006-10-25
ZA200601420B (en) 2007-06-27
US7109172B2 (en) 2006-09-19
PE20050251A1 (es) 2005-04-13
CN1852920B (zh) 2010-12-15
JP2008500265A (ja) 2008-01-10
EP2368900A2 (en) 2011-09-28
US8691758B2 (en) 2014-04-08
KR20060052836A (ko) 2006-05-19
AU2004257288A1 (en) 2005-01-27
EP2341065A3 (en) 2012-06-20
CN102020700A (zh) 2011-04-20
IL218698A0 (en) 2012-05-31
AR045916A1 (es) 2005-11-16
EP1646642A2 (en) 2006-04-19
US20050107304A1 (en) 2005-05-19
KR20120013450A (ko) 2012-02-14
RU2006105002A (ru) 2006-08-27
NZ544789A (en) 2010-01-29

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