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NO20060466L - Variable antibodies - Google Patents

Variable antibodies

Info

Publication number
NO20060466L
NO20060466L NO20060466A NO20060466A NO20060466L NO 20060466 L NO20060466 L NO 20060466L NO 20060466 A NO20060466 A NO 20060466A NO 20060466 A NO20060466 A NO 20060466A NO 20060466 L NO20060466 L NO 20060466L
Authority
NO
Norway
Prior art keywords
antibodies
factor viii
modified glycosylation
inhibitory
present
Prior art date
Application number
NO20060466A
Other languages
English (en)
Inventor
Jean-Marie Saint-Remy
Marc Jacquemin
Original Assignee
D Collen Res Foundation Vzw
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0319118A external-priority patent/GB0319118D0/en
Priority claimed from GB0319345A external-priority patent/GB0319345D0/en
Application filed by D Collen Res Foundation Vzw filed Critical D Collen Res Foundation Vzw
Publication of NO20060466L publication Critical patent/NO20060466L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Foreliggende oppfinnelse angår inhibitoriske antistoffer mot faktor VIII med modifisert glykosylering, enten ved enzymatisk deglykosylering eller ved seterettet mutagenese. Nevnte antistoffer med modifisert glykosylering har lik affinitet for FVIII, men viser forskjellige inhiberingsegenskaper. Anvendelsen av en eller en blanding av nevnte antistoffer tillater modulering av inhiberingen av faktor VIII til nivåer mellom 40 og 95 %. Foreliggende oppfinnelse angår videre farmasøytiske preparater omfattende inhibitoriske antistoffer mot faktor VIII med modifisert glykosylering, kombinasjon av disse antistoffer og metoder for behandling av hemostatiske sykdommer ved anvendelse av nevnte antistoffer og antistoffblandinger.
NO20060466A 2003-08-14 2006-01-30 Variable antibodies NO20060466L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0319118A GB0319118D0 (en) 2003-08-14 2003-08-14 Variable antibodies
GB0319345A GB0319345D0 (en) 2003-08-18 2003-08-18 Variable antibodies
PCT/BE2004/000118 WO2005016455A2 (en) 2003-08-14 2004-08-16 Antibodies against factor viii with modified glycosylation in the variable region

Publications (1)

Publication Number Publication Date
NO20060466L true NO20060466L (no) 2006-04-24

Family

ID=34196257

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060466A NO20060466L (no) 2003-08-14 2006-01-30 Variable antibodies

Country Status (9)

Country Link
US (4) US7785594B2 (no)
EP (1) EP1706079B1 (no)
JP (1) JP4934796B2 (no)
AU (1) AU2004264265C1 (no)
CA (1) CA2535489C (no)
ES (1) ES2412489T3 (no)
IL (1) IL173557A (no)
NO (1) NO20060466L (no)
WO (1) WO2005016455A2 (no)

Families Citing this family (28)

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US7829085B2 (en) * 1999-07-14 2010-11-09 Life Sciences Research Partners Vzw Methods of treating hemostasis disorders using antibodies binding the C1 domain of factor VIII
CN1942588B (zh) 2003-03-05 2013-06-12 海洋酶公司 可溶性透明质酸酶糖蛋白(sHASEGP)、制备它们的方法、它们的用途和包含它们的药物组合物
JP4934796B2 (ja) 2003-08-14 2012-05-16 トロンボジェニクス・ナムローゼ・フエンノートシャップ 可変抗体
FR2897868B1 (fr) * 2006-02-24 2012-08-31 Lab Francais Du Fractionnement Anticorps anti-idiotypiques neutralisant l'activite inhibitrice d'un anticorps inhibiteur dirige contre le domaine c1 du facteur viii.
CN101646775B (zh) * 2006-12-28 2016-08-24 森托科尔奥索生物科技公司 用于产生脱唾液酸化免疫球蛋白的方法和载体
WO2009024653A1 (fr) * 2007-08-23 2009-02-26 Lfb Biotechnologies Anticorps anti-idiotypigues neutralisant l'activite inhibitrice d'un anticorps inhibiteur dirige contre le domaine c1 du facteur viii
SG187411A1 (en) * 2007-12-28 2013-02-28 Baxter Int Counter-pressure filtration of proteins
WO2009129814A1 (en) * 2008-04-23 2009-10-29 Symphogen A/S Methods for manufacturing a polyclonal protein
HRP20181727T1 (hr) * 2008-06-19 2019-02-08 Prothix Bv Upotreba protutijela protiv čimbenika xi, namijenjena sprečavanju ili liječenju stvaranja krvnog ugruška
EP2233499A1 (en) * 2009-03-26 2010-09-29 CSL Behring AG Antibody composition with altered Fab sialylation
EP2451835A1 (en) 2009-07-10 2012-05-16 ThromboGenics N.V. Variants of plasminogen and plasmin
JP2013502458A (ja) 2009-08-24 2013-01-24 アムニクス オペレーティング インコーポレイテッド 凝固第ｖｉｉ因子組成物ならびにそれを製造および使用する方法
EP2480249B1 (en) 2009-08-28 2015-01-28 ThromboGenics N.V. Plasmin for the treatment of filtration failure after trabeculectomy
AU2011288464B2 (en) * 2010-08-10 2015-10-29 Glycotope Gmbh Fab-glycosylated antibodies
BR112013017172A2 (pt) 2011-01-05 2016-10-11 Thrombogenics Nv variantes de plasminogênio e plasmina
CN102172359A (zh) * 2011-03-02 2011-09-07 张始状 腺苷与核苷组合在制备治疗肿瘤药物中的应用
JP6000353B2 (ja) 2011-08-12 2016-09-28 スロンボジェニックス・ナムローゼ・フェンノートシャップＴｈｒｏｍｂｏＧｅｎｉｃｓ ＮＶ プラスミノーゲンおよびプラスミンの変異体
PL2785739T3 (pl) 2011-12-01 2017-10-31 Thrombogenics Nv Poprawa wyniku trabekulektomii
PT3564260T (pt) 2012-02-15 2023-01-18 Bioverativ Therapeutics Inc Composições de fator viii e métodos de produção e utilização das mesmas
CA2864126A1 (en) 2012-02-15 2013-08-22 Biogen Idec Ma Inc. Recombinant factor viii proteins
US9803005B2 (en) 2012-05-24 2017-10-31 Alexion Pharmaceuticals, Inc. Humaneered anti-factor B antibody
TWI667255B (zh) 2013-08-14 2019-08-01 美商生物化學醫療公司 因子ｖｉｉｉ－ｘｔｅｎ融合物及其用途
EA201890423A1 (ru) 2015-08-03 2018-07-31 Биовератив Терапьютикс Инк. Слитые белки фактора ix, способы их получения и применения
CN108779173A (zh) 2016-03-10 2018-11-09 思罗姆博基因股份有限公司 通过拮抗胎盘生长因子抑制眼后部纤维化
JP7748175B2 (ja) 2016-12-02 2025-10-02 バイオベラティブ セラピューティクス インコーポレイテッド キメラ凝固因子を使用して血友病性関節症を処置する方法
US11891451B2 (en) * 2017-05-11 2024-02-06 Vib Vzw Glycosylation of variable immunoglobulin domains
CN112512555A (zh) 2018-05-18 2021-03-16 比奥维拉迪维治疗股份有限公司 治疗血友病a的方法
MY205343A (en) 2018-05-18 2024-10-16 Glycotope Gmbh Anti-muc1 antibody

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US4451454A (en) * 1981-06-16 1984-05-29 Wong Dennis W Prophylaxis and treatment of thromboembolic disorders in man and in warm-blooded animals with bicarbonate salts of alkali metals
IL82935A0 (en) 1986-08-12 1987-12-20 Phillips Petroleum Co Secretion of heterologous proteins from yeast
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US5602015A (en) * 1989-04-25 1997-02-11 Igen, Inc. Autoantibodies which enhance the rate of a chemical reaction
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US5714350A (en) * 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
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CA2381125C (en) * 1999-07-14 2013-04-23 D. Collen Research Foundation Vzw Ligands for use in therapeutic compositions for the treatment of hemostasis disorders
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JP4934796B2 (ja) * 2003-08-14 2012-05-16 トロンボジェニクス・ナムローゼ・フエンノートシャップ 可変抗体
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EP1910420B1 (en) 2005-07-29 2011-05-18 Life Sciences Research Partners VZW Human inhibitory anti-factor viii antibodies binding to the a2 domain

Also Published As

Publication number Publication date
IL173557A0 (en) 2006-07-05
US8293234B2 (en) 2012-10-23
US8282923B2 (en) 2012-10-09
EP1706079B1 (en) 2013-02-20
US20060292149A1 (en) 2006-12-28
ES2412489T3 (es) 2013-07-11
JP2007502250A (ja) 2007-02-08
JP4934796B2 (ja) 2012-05-16
US7785594B2 (en) 2010-08-31
US20110070226A1 (en) 2011-03-24
CA2535489C (en) 2014-09-30
WO2005016455A3 (en) 2005-03-17
CA2535489A1 (en) 2005-02-24
EP1706079A2 (en) 2006-10-04
WO2005016455A2 (en) 2005-02-24
IL173557A (en) 2012-09-24
AU2004264265C1 (en) 2012-06-28
AU2004264265A1 (en) 2005-02-24
US20100266586A1 (en) 2010-10-21
US20100272715A1 (en) 2010-10-28
AU2004264265B2 (en) 2009-09-17
US8277805B2 (en) 2012-10-02

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