NO20054397L - Cycloalkyl derivatives with bioisosteric carboxylic acid groups, processes for their preparation and their use as a drug - Google Patents
Cycloalkyl derivatives with bioisosteric carboxylic acid groups, processes for their preparation and their use as a drugInfo
- Publication number
- NO20054397L NO20054397L NO20054397A NO20054397A NO20054397L NO 20054397 L NO20054397 L NO 20054397L NO 20054397 A NO20054397 A NO 20054397A NO 20054397 A NO20054397 A NO 20054397A NO 20054397 L NO20054397 L NO 20054397L
- Authority
- NO
- Norway
- Prior art keywords
- processes
- preparation
- carboxylic acid
- acid groups
- drug
- Prior art date
Links
- 125000002843 carboxylic acid group Chemical group 0.000 title abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 206010022489 Insulin Resistance Diseases 0.000 abstract 1
- 230000004129 fatty acid metabolism Effects 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Reproductive Health (AREA)
- Psychology (AREA)
Abstract
Oppfinnelsen beskriver sykloalkylderivater med bioisostere karboksylsyregrupper, samt deres fysiologisk godtagbare salter og fysiologisk funksjonelle derivater. Oppfinnelsen angår forbindelser med formel I der gruppene er definert som angitt i beskrivelsen, samt til deres fysiologisk godtagbare salter og fremgangsmåter til deres fremstilling. Forbindelsene er egnede for terapi og/eller prevensjon av forstyrrelser av fettsyrestoffskiftet og glukoseutnyttelses-forstyrrelser, samt forstyrrelser der insulinresistens spiller en rolle.The invention describes cycloalkyl derivatives with bioisostere carboxylic acid groups, as well as their physiologically acceptable salts and physiologically functional derivatives. The invention relates to compounds of formula I wherein the groups are defined as described in the specification, as well as to their physiologically acceptable salts and processes for their preparation. The compounds are suitable for the therapy and / or prevention of fatty acid metabolism and glucose utilization disorders, as well as disorders in which insulin resistance plays a role.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10308354A DE10308354A1 (en) | 2003-02-27 | 2003-02-27 | Cycloalkyl derivatives with biostear carboxylic acid groups, process for their preparation and their use as medicaments |
| PCT/EP2004/001585 WO2004076447A1 (en) | 2003-02-27 | 2004-02-19 | Cycloalkyl derivatives comprising bioisosteric carboxylic acid groups, method for the production thereof, and use thereof as a medicament |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20054397D0 NO20054397D0 (en) | 2005-09-22 |
| NO20054397L true NO20054397L (en) | 2005-11-23 |
Family
ID=32920628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20054397A NO20054397L (en) | 2003-02-27 | 2005-09-22 | Cycloalkyl derivatives with bioisosteric carboxylic acid groups, processes for their preparation and their use as a drug |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1601671B1 (en) |
| JP (1) | JP2006519198A (en) |
| KR (1) | KR20050106464A (en) |
| CN (1) | CN100398537C (en) |
| AR (1) | AR043426A1 (en) |
| AT (1) | ATE437874T1 (en) |
| AU (1) | AU2004215676B2 (en) |
| BR (1) | BRPI0407867A (en) |
| CA (1) | CA2516657A1 (en) |
| CL (1) | CL2004000399A1 (en) |
| CO (1) | CO5690552A2 (en) |
| DE (2) | DE10308354A1 (en) |
| DK (1) | DK1601671T3 (en) |
| EC (1) | ECSP055984A (en) |
| ES (1) | ES2330848T3 (en) |
| HR (1) | HRP20050738A2 (en) |
| MA (1) | MA27739A1 (en) |
| MX (1) | MXPA05008989A (en) |
| NO (1) | NO20054397L (en) |
| OA (1) | OA13036A (en) |
| PA (1) | PA8596601A1 (en) |
| PE (1) | PE20050294A1 (en) |
| PL (1) | PL377754A1 (en) |
| PT (1) | PT1601671E (en) |
| RU (1) | RU2005129996A (en) |
| TN (1) | TNSN05205A1 (en) |
| TW (1) | TW200508229A (en) |
| UY (1) | UY28208A1 (en) |
| WO (1) | WO2004076447A1 (en) |
| ZA (1) | ZA200505764B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ552501A (en) | 2004-08-11 | 2010-03-26 | Kyorin Seiyaku Kk | Novel cyclic aminobenzoic acid derivative |
| AU2006299091A1 (en) | 2005-09-29 | 2007-04-12 | Sanofi-Aventis | Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPO713297A0 (en) * | 1997-06-02 | 1997-06-26 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compound |
| US6506757B1 (en) * | 1998-03-10 | 2003-01-14 | Ono Pharmaceutical Co., Ltd. | Carboxylic acid derivatives and drugs containing the same as the active ingredient |
| KR100693771B1 (en) * | 1999-04-28 | 2007-03-12 | 사노피-아벤티스 도이칠란트 게엠베하 | Tri-aryl acid derivatives as PPAR receptor ligands and pharmaceutical compositions containing the same |
| GB9914977D0 (en) * | 1999-06-25 | 1999-08-25 | Glaxo Group Ltd | Chemical compounds |
| EP1182251A1 (en) * | 2000-08-11 | 2002-02-27 | Yissum Research Development Company of the Hebrew University of Jerusalem | Methods for identifying compounds that inhibit ubiquitin-mediated proteolysis of IkB |
| CN100357280C (en) * | 2000-12-25 | 2007-12-26 | 小野药品工业株式会社 | Dihydronaphthalene devivatives and drugs contanining these compounds as active ingrdeient |
-
2003
- 2003-02-27 DE DE10308354A patent/DE10308354A1/en not_active Withdrawn
-
2004
- 2004-02-19 CN CNB2004800054491A patent/CN100398537C/en not_active Expired - Fee Related
- 2004-02-19 RU RU2005129996/04A patent/RU2005129996A/en not_active Application Discontinuation
- 2004-02-19 MX MXPA05008989A patent/MXPA05008989A/en active IP Right Grant
- 2004-02-19 DE DE502004009823T patent/DE502004009823D1/en not_active Expired - Lifetime
- 2004-02-19 WO PCT/EP2004/001585 patent/WO2004076447A1/en not_active Ceased
- 2004-02-19 EP EP04712484A patent/EP1601671B1/en not_active Expired - Lifetime
- 2004-02-19 BR BRPI0407867-5A patent/BRPI0407867A/en not_active IP Right Cessation
- 2004-02-19 ES ES04712484T patent/ES2330848T3/en not_active Expired - Lifetime
- 2004-02-19 OA OA1200500249A patent/OA13036A/en unknown
- 2004-02-19 CA CA002516657A patent/CA2516657A1/en not_active Abandoned
- 2004-02-19 PT PT04712484T patent/PT1601671E/en unknown
- 2004-02-19 PL PL377754A patent/PL377754A1/en not_active Application Discontinuation
- 2004-02-19 DK DK04712484T patent/DK1601671T3/en active
- 2004-02-19 JP JP2006501891A patent/JP2006519198A/en active Pending
- 2004-02-19 HR HR20050738A patent/HRP20050738A2/en not_active Application Discontinuation
- 2004-02-19 AU AU2004215676A patent/AU2004215676B2/en not_active Ceased
- 2004-02-19 KR KR1020057016054A patent/KR20050106464A/en not_active Ceased
- 2004-02-19 AT AT04712484T patent/ATE437874T1/en not_active IP Right Cessation
- 2004-02-25 TW TW093104696A patent/TW200508229A/en unknown
- 2004-02-27 AR ARP040100628A patent/AR043426A1/en not_active Application Discontinuation
- 2004-02-27 UY UY28208A patent/UY28208A1/en unknown
- 2004-02-27 PE PE2004000207A patent/PE20050294A1/en not_active Application Discontinuation
- 2004-02-27 PA PA20048596601A patent/PA8596601A1/en unknown
- 2004-02-27 CL CL200400399A patent/CL2004000399A1/en unknown
-
2005
- 2005-07-19 ZA ZA200505764A patent/ZA200505764B/en unknown
- 2005-08-26 MA MA28462A patent/MA27739A1/en unknown
- 2005-08-26 CO CO05085513A patent/CO5690552A2/en not_active Application Discontinuation
- 2005-08-26 TN TNP2005000205A patent/TNSN05205A1/en unknown
- 2005-08-26 EC EC2005005984A patent/ECSP055984A/en unknown
- 2005-09-22 NO NO20054397A patent/NO20054397L/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20081367L (en) | Phenyl and pyridyl-1,2,4-oxadiazolone derivatives with phenyl group, processes for their preparation and their use as pharmaceuticals | |
| NO20054382L (en) | Diarylcycloalkyl derivatives, their preparation and their use as a drug | |
| NO20085064L (en) | 4,5-diphenyl-pyrimidinyl-oxy or mercapto-substituted carboxylic acids, processes for their preparation and use thereof as medicaments | |
| NO20081682L (en) | 4-Oxy-N- [1,3,4] -thiadiazol-2-yl-benzenesulfonamides, process for their preparation and their use as pharmaceuticals | |
| NO20085066L (en) | 4,5-diphenyl-pyrimidinyl-amino-substituted carboxylic acids, process for their preparation and use thereof as medicaments | |
| NO20081369L (en) | Phenyl and pyridinyl-1,2,4-oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals | |
| NO20090590L (en) | Metabolism modulators as well as the treatment of related disorders | |
| NO20091893L (en) | New 1,4-benzothiepine-1,1-dioxide derivatives substituted with benzyl groups, processes for the preparation of medicaments containing the compounds and their use. | |
| NO20083863L (en) | Pyrazoles such as 11-beta-hsd-1 | |
| WO2009055331A3 (en) | Bicyclic heterocycle derivatives and their use as modulators of the activity of gpr119 | |
| NO20054408L (en) | 3 (2-Phenyl-oxazol-4-yl-methoxy) -cyclohexylmethoxyacetic acid derivatives and similar compounds as PPAR modulators for the treatment of type 2 diabetes and arteriosclerosis | |
| WO2005016528A3 (en) | 6-substituted anilino purines as rtk inhibitors | |
| WO2009010416A3 (en) | Inhibitors of 11b-hydroxysteroid dehydrogenase | |
| NO20085068L (en) | Phenylamino-benzoxazole-substituted carboxylic acids, process for their preparation and use thereof as medicaments | |
| WO2007061661A3 (en) | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 | |
| NO20084321L (en) | Triazole derivative or salt thereof | |
| NO20081942L (en) | Carbamoylbenzotriazole derivatives as inhibitors of lipases and phospholipases | |
| NO20083058L (en) | Cyclohexylsulfonamide derivatives with H3 receptor activity | |
| NO20081681L (en) | N- [1,3,4] -thiadiazol-2-yl-benzenesulfonamides, process for their preparation and their use as pharmaceuticals | |
| NO20064981L (en) | Oxadiazolone derivatives such as PPAR participate in agonists | |
| MX2007002689A (en) | 7-azaindoles and their use as ppar agonists. | |
| WO2008071790A3 (en) | Novel compositions and uses thereof | |
| NO20054381L (en) | 1,3-substituted cycloalkyl derivatives with acidic, usually heterocyclic groups, their preparation and their use as a drug | |
| UY29065A1 (en) | ARILCICLOALQUIL-SUBSTITUTED ALCANOIC ACID DERIVATIVES, PROCEDURES FOR THEIR PREPARATION AND ITS USE AS PHARMACEUTICAL PRODUCTS. | |
| NO20081676L (en) | Bicyclic aryl sulfonyl acid [1,3,4] thiadlazol-2-yl amides, process for their preparation and their use as pharmaceuticals |