NO20054767L - Compositions comprising apomorphine for lung inhalation - Google Patents
Compositions comprising apomorphine for lung inhalationInfo
- Publication number
- NO20054767L NO20054767L NO20054767A NO20054767A NO20054767L NO 20054767 L NO20054767 L NO 20054767L NO 20054767 A NO20054767 A NO 20054767A NO 20054767 A NO20054767 A NO 20054767A NO 20054767 L NO20054767 L NO 20054767L
- Authority
- NO
- Norway
- Prior art keywords
- apomorphine
- formulations
- compositions
- present
- sexual dysfunction
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 title abstract 4
- 229960004046 apomorphine Drugs 0.000 title abstract 4
- 210000004072 lung Anatomy 0.000 title 1
- 238000009472 formulation Methods 0.000 abstract 4
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 3
- 231100000872 sexual dysfunction Toxicity 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Foreliggende oppfinnelse angår inhalerbare formuleringer av apomorfin eller farmasøytisk akseptable salter derav eller estere, for anvendelse ved behandling av seksuell dysfunksjon. Foreliggende oppfinnelse angår også metoder for fremstilling av apomorfin-formuleringene, så vel som metoder for behandling av seksuell dysfunksjon ved anvendelse av de nevnte formuleringer og inhalatorer som omfatter de nevnte formuleringer. Foreliggende oppfinnelse angår videre anvendelsen av apomorfin ved fremstilling av et legemiddel for behandling av seksuell dysfunksjon.The present invention relates to inhalable formulations of apomorphine or pharmaceutically acceptable salts thereof or esters, for use in the treatment of sexual dysfunction. The present invention also relates to methods for preparing the apomorphine formulations, as well as methods for treating sexual dysfunction using said formulations and inhalers comprising said formulations. The present invention further relates to the use of apomorphine in the manufacture of a medicament for the treatment of sexual dysfunction.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/413,022 US20040204439A1 (en) | 2003-04-14 | 2003-04-14 | Composition, device, and method for treating sexual dysfunction via inhalation |
| US10/621,964 US20040204440A1 (en) | 2003-04-14 | 2003-07-17 | Composition, device, and method for treating sexual dysfunction via inhalation |
| PCT/GB2004/001627 WO2004089374A1 (en) | 2003-04-14 | 2004-04-14 | Pharmaceutical compositions comprising apomorphine for pulmonary inhalation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20054767D0 NO20054767D0 (en) | 2005-10-17 |
| NO20054767L true NO20054767L (en) | 2005-12-21 |
Family
ID=33161980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20054767A NO20054767L (en) | 2003-04-14 | 2005-10-17 | Compositions comprising apomorphine for lung inhalation |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20060178394A1 (en) |
| EP (1) | EP1613323A1 (en) |
| JP (1) | JP2006522785A (en) |
| AU (1) | AU2004228757A1 (en) |
| BR (1) | BRPI0409380A (en) |
| CA (1) | CA2522231A1 (en) |
| NO (1) | NO20054767L (en) |
| RU (1) | RU2364400C2 (en) |
| WO (1) | WO2004089374A1 (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0321607D0 (en) | 2003-09-15 | 2003-10-15 | Vectura Ltd | Manufacture of pharmaceutical compositions |
| GB0425758D0 (en) | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
| GB0426301D0 (en) * | 2004-11-30 | 2004-12-29 | Vectura Ltd | Pharmaceutical formulations |
| RU2440100C2 (en) * | 2005-03-28 | 2012-01-20 | Орексо Аб | New pharmaceutical compositions effective in treating parkinson's disease |
| GB0721394D0 (en) * | 2007-10-31 | 2007-12-12 | Vectura Group Plc | Compositions for trating parkinson's disease |
| MX2011011123A (en) * | 2009-04-24 | 2011-11-04 | Schering Corp | Agglomerate formulations useful in dry powder inhalers. |
| TW201304822A (en) * | 2010-11-15 | 2013-02-01 | Vectura Ltd | Compositions and uses |
| HK1254812A1 (en) * | 2015-06-23 | 2019-07-26 | APIRx Pharmaceuticals, LLC | Anti-microbial compositions comprising cannabinoids |
| US20170071248A1 (en) * | 2015-09-16 | 2017-03-16 | Sansa Corporation (Barbados) Inc. | System and Method for Controlling the Harshness of Nicotine-Based Dry Powder Formulations |
| US11224594B2 (en) | 2015-09-16 | 2022-01-18 | Philip Morris Products S.A. | Nicotine formulations and methods of making and using the same |
| WO2018007997A1 (en) | 2016-07-08 | 2018-01-11 | Trudell Medical International | Smart oscillating positive expiratory pressure device |
| ES2920151T3 (en) | 2016-12-09 | 2022-08-01 | Trudell Medical Int | smart nebulizer |
| EP4585247A3 (en) | 2018-01-04 | 2025-07-23 | Trudell Medical International Inc. | Smart oscillating positive expiratory pressure device |
| EP4021542B1 (en) | 2019-08-27 | 2025-07-16 | Trudell Medical International Inc. | Respiratory therapy device comprising a visual feedback array |
| GB201912686D0 (en) * | 2019-09-04 | 2019-10-16 | Reown Pharma Inc | Pharmaceutical composition |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4080456A (en) * | 1971-10-26 | 1978-03-21 | Schering Aktiengesellschaft | Diacylapomorphines |
| US4687773A (en) * | 1983-03-28 | 1987-08-18 | Mclean Hospital | (+)-N-N-propylnorapomorphine and selective limbic activity |
| US4521421A (en) * | 1983-09-26 | 1985-06-04 | Eli Lilly And Company | Treatment of sexual dysfunction |
| US5292520A (en) * | 1990-09-13 | 1994-03-08 | Akzo N.V. | Stabilized solid pharmaceutical composition containing acid addition salts of a basic drug and an alkaline stabilizer |
| US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| DK0865789T3 (en) * | 1993-03-26 | 2005-07-18 | Franciscus Wilhelmus He Merkus | Pharmaceuticals for intranasal administration of dihydroergotamine |
| DK0978282T3 (en) * | 1994-04-22 | 2006-04-10 | Pentech Pharmaceuticals Inc | Sublingual preparation containing apomorphine for the diagnosis of functional impotence |
| US6121276A (en) * | 1994-04-22 | 2000-09-19 | Pentech Pharmaceuticals, Inc. | Apomorphine-containing dosage forms for ameliorating male erectile dysfunction |
| US20020165122A1 (en) * | 1994-04-22 | 2002-11-07 | Heaton Jeremy P. W. | Method and compositions for the treatment or amelioration of female sexual dysfunction |
| US6566368B2 (en) * | 1994-04-22 | 2003-05-20 | Pentech Pharmaceuticals, Inc. | Apomorphine-containing dosage form for ameliorating male erectile dysfunction |
| US6395744B1 (en) * | 1994-04-22 | 2002-05-28 | Queen's University At Kingston | Method and compositions for the treatment or amelioration of female sexual dysfunction |
| US5699789A (en) * | 1996-03-11 | 1997-12-23 | Hendricks; Mark R. | Dry powder inhaler |
| GB9606677D0 (en) * | 1996-03-29 | 1996-06-05 | Glaxo Wellcome Inc | Process and device |
| ES2236832T3 (en) * | 1997-01-16 | 2005-07-16 | Massachusetts Institute Of Technology | PREPARATION OF PARTICLES FOR INHALATION. |
| JP4754067B2 (en) * | 1997-12-02 | 2011-08-24 | アルキメデス ディヴェロプメント リミテッド | Composition for nasal administration |
| US5945117A (en) * | 1998-01-30 | 1999-08-31 | Pentech Pharmaceuticals, Inc. | Treatment of female sexual dysfunction |
| US6403605B1 (en) * | 1998-05-29 | 2002-06-11 | Queen's University At Kingston | Methods for the normalization of sexual response and amelioration of long term genital tissue degradation |
| US6200591B1 (en) * | 1998-06-25 | 2001-03-13 | Anwar A. Hussain | Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction |
| US20020002175A1 (en) * | 2000-09-19 | 2002-01-03 | Charanjit Behl | Nasal delivery of apomorphine in combination with glycol derivatives |
| US6436950B1 (en) * | 1998-08-14 | 2002-08-20 | Nastech Pharmaceutical Company, Inc. | Nasal delivery of apomorphine |
| US5994363A (en) * | 1998-08-24 | 1999-11-30 | Pentech Pharmaceuticals, Inc. | Amelioration of apomorphine adverse effects |
| IT1303788B1 (en) * | 1998-11-25 | 2001-02-23 | Chiesi Farma Spa | MEDICINAL AEROSOL FORMULATIONS. |
| GB9827145D0 (en) * | 1998-12-09 | 1999-02-03 | Co Ordinated Drug Dev | Improvements in or relating to powders |
| US7074388B2 (en) * | 1998-12-10 | 2006-07-11 | Kos Life Science, Inc. | Water stabilized medicinal aerosol formulation |
| US6291471B1 (en) * | 1998-12-17 | 2001-09-18 | Abb Holdings, Inc. | Use of apomorphine for the treatment of organic erectile dysfunction in males |
| AU4982300A (en) * | 1999-05-06 | 2000-11-21 | Pentech Pharmaceuticals, Inc. | Regimen and kit for amelioration of premature ejaculation |
| US6858199B1 (en) * | 2000-06-09 | 2005-02-22 | Advanced Inhalation Research, Inc. | High efficient delivery of a large therapeutic mass aerosol |
| JP2001072586A (en) * | 1999-09-06 | 2001-03-21 | Nikken Chem Co Ltd | Powder formulation for inhalation and production method thereof |
| JP2001151673A (en) * | 1999-09-06 | 2001-06-05 | Nikken Chem Co Ltd | Method for producing powder formulation for inhalation |
| BR0005797A (en) * | 2000-03-20 | 2001-10-16 | Abbott Lab | Methods for the treatment of sexual dysfunction with apomorphine at specified plasma concentration levels |
| US6506765B2 (en) * | 2000-04-07 | 2003-01-14 | Tap Pharmaceutical Products, Inc. | Apomorphine derivatives and methods for their use |
| US6948494B1 (en) * | 2000-05-10 | 2005-09-27 | Innovative Devices, Llc. | Medicament container with same side airflow inlet and outlet and method of use |
| US6514482B1 (en) * | 2000-09-19 | 2003-02-04 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
| EP1341536A4 (en) * | 2000-11-15 | 2007-08-01 | Tap Pharmaceutical Prod Inc | Treatment of anti-depression drug-induced sexual dysfunction with apomorphine |
| US20020086876A1 (en) * | 2000-11-15 | 2002-07-04 | Ruff Dustin D. | Treatment of anti-depression drug-induced sexual dysfunction with apomorphine |
| JP2002184831A (en) * | 2000-12-11 | 2002-06-28 | Hirata Corp | FOUP opener |
| WO2003026631A1 (en) * | 2001-05-24 | 2003-04-03 | Alexza Molecular Delivery Corporation | Delivery of drug esters through an inhalation route |
| CA2446904A1 (en) * | 2001-05-24 | 2003-04-03 | Alexza Molecular Delivery Corporation | Delivery of drug esters through an inhalation route |
| US20040204439A1 (en) * | 2003-04-14 | 2004-10-14 | Staniforth John Nicholas | Composition, device, and method for treating sexual dysfunction via inhalation |
-
2004
- 2004-04-14 AU AU2004228757A patent/AU2004228757A1/en not_active Abandoned
- 2004-04-14 JP JP2006506129A patent/JP2006522785A/en active Pending
- 2004-04-14 CA CA002522231A patent/CA2522231A1/en not_active Abandoned
- 2004-04-14 US US10/552,231 patent/US20060178394A1/en not_active Abandoned
- 2004-04-14 WO PCT/GB2004/001627 patent/WO2004089374A1/en not_active Ceased
- 2004-04-14 EP EP04727312A patent/EP1613323A1/en not_active Withdrawn
- 2004-04-14 RU RU2005135133/15A patent/RU2364400C2/en not_active IP Right Cessation
- 2004-04-14 BR BRPI0409380-1A patent/BRPI0409380A/en not_active IP Right Cessation
-
2005
- 2005-10-17 NO NO20054767A patent/NO20054767L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2522231A1 (en) | 2004-10-21 |
| AU2004228757A1 (en) | 2004-10-21 |
| RU2005135133A (en) | 2006-06-10 |
| WO2004089374A1 (en) | 2004-10-21 |
| US20060178394A1 (en) | 2006-08-10 |
| JP2006522785A (en) | 2006-10-05 |
| BRPI0409380A (en) | 2006-04-18 |
| RU2364400C2 (en) | 2009-08-20 |
| NO20054767D0 (en) | 2005-10-17 |
| EP1613323A1 (en) | 2006-01-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |