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NO20035206L - Pyrimidin-derivater anvendelige som selektive COX-2- inhibitorer - Google Patents

Pyrimidin-derivater anvendelige som selektive COX-2- inhibitorer

Info

Publication number
NO20035206L
NO20035206L NO20035206A NO20035206A NO20035206L NO 20035206 L NO20035206 L NO 20035206L NO 20035206 A NO20035206 A NO 20035206A NO 20035206 A NO20035206 A NO 20035206A NO 20035206 L NO20035206 L NO 20035206L
Authority
NO
Norway
Prior art keywords
inhibitors
pyrimidine derivatives
derivatives useful
selective cox
cox
Prior art date
Application number
NO20035206A
Other languages
English (en)
Other versions
NO326949B1 (no
NO20035206D0 (no
Inventor
Alan Naylor
Neil Anthony Pegg
Jeremy John Payne
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NO20035206L publication Critical patent/NO20035206L/no
Publication of NO20035206D0 publication Critical patent/NO20035206D0/no
Publication of NO326949B1 publication Critical patent/NO326949B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20035206A 2001-05-25 2003-11-24 Pyrimidin-derivater samt anvendelse og fremgangsmate for frmstilling derav og farmasoytisk sammensetning NO326949B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0112802.4A GB0112802D0 (en) 2001-05-25 2001-05-25 Pyrimidine derivatives
PCT/GB2002/002415 WO2002096885A1 (en) 2001-05-25 2002-05-23 Pyrimidine derivatives useful as selective cox-2 inhibitors

Publications (3)

Publication Number Publication Date
NO20035206L true NO20035206L (no) 2003-11-24
NO20035206D0 NO20035206D0 (no) 2003-11-24
NO326949B1 NO326949B1 (no) 2009-03-16

Family

ID=9915322

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20035206A NO326949B1 (no) 2001-05-25 2003-11-24 Pyrimidin-derivater samt anvendelse og fremgangsmate for frmstilling derav og farmasoytisk sammensetning

Country Status (28)

Country Link
US (2) US7026327B2 (no)
EP (2) EP1493735B1 (no)
JP (1) JP4291688B2 (no)
KR (1) KR100889427B1 (no)
CN (1) CN1255387C (no)
AR (1) AR036028A1 (no)
AT (2) ATE325103T1 (no)
AU (1) AU2002302764B2 (no)
BR (1) BR0209787A (no)
CA (1) CA2448192A1 (no)
CO (1) CO5540311A2 (no)
CZ (1) CZ20033204A3 (no)
DE (2) DE60229669D1 (no)
DK (1) DK1390351T3 (no)
ES (2) ES2262809T3 (no)
GB (1) GB0112802D0 (no)
HU (1) HUP0401280A3 (no)
IL (1) IL158799A0 (no)
MX (1) MXPA03010583A (no)
MY (1) MY130750A (no)
NO (1) NO326949B1 (no)
NZ (1) NZ529719A (no)
PL (1) PL366514A1 (no)
PT (1) PT1390351E (no)
SI (1) SI1390351T1 (no)
TW (1) TWI327140B (no)
WO (1) WO2002096885A1 (no)
ZA (1) ZA200308826B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0021494D0 (en) 2000-09-01 2000-10-18 Glaxo Group Ltd Chemical comkpounds
GB0112810D0 (en) 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
GB0112802D0 (en) 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
DE60305053T2 (de) 2002-08-19 2006-08-31 Glaxo Group Ltd., Greenford Pyrimidinderivate als selektive cox-2-inhibitoren
GB0221443D0 (en) 2002-09-16 2002-10-23 Glaxo Group Ltd Pyridine derivates
GB0227443D0 (en) * 2002-11-25 2002-12-31 Glaxo Group Ltd Pyrimidine derivatives
US20070142411A1 (en) * 2003-11-19 2007-06-21 James Hagan Use of cyclooxygenase-2 selective inhibitors for the treatment of schizophrenic disorders
US20070270428A1 (en) * 2003-11-19 2007-11-22 James Hagan Use of Cyclooxygenase-2 Inhibitors for the Treatment of Depressive Disorders
EP4027993A4 (en) * 2019-09-13 2023-09-20 The Broad Institute Inc. CYCLO-OXYGENASE 2 INHIBITORS AND THEIR USES

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3149109A (en) 1962-02-20 1964-09-15 Searle & Co Certain 4-trifluoromethyl-2-(oxy/thio) pyrimidines
GB1121922A (en) * 1966-06-17 1968-07-31 Ici Ltd Pyrimidine derivatives
US5474995A (en) 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
CA2276946A1 (en) 1993-11-30 1995-06-08 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides and pharmaceutical compositions containing the same
US5945426A (en) 1994-09-09 1999-08-31 Nippon Shinyaku Co., Ltd. Derivatives of pyrimidine for treating acute cerebrovascular disorders
US5596008A (en) 1995-02-10 1997-01-21 G. D. Searle & Co. 3,4-Diaryl substituted pyridines for the treatment of inflammation
US5700816A (en) 1995-06-12 1997-12-23 Isakson; Peter C. Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
US6342510B1 (en) 1995-06-12 2002-01-29 G. D. Searle & Co. Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitors and a leukotriene B4 receptor antagonist
US6020343A (en) 1995-10-13 2000-02-01 Merck Frosst Canada, Inc. (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
JPH09241161A (ja) 1996-03-08 1997-09-16 Nippon Shinyaku Co Ltd 医 薬
JPH09266197A (ja) * 1996-03-28 1997-10-07 Mitsubishi Electric Corp 半導体装置およびその製造方法
IL127441A (en) * 1996-07-18 2003-02-12 Merck Frosst Canada Inc Substituted pyridines, pharmaceutical compositions comprising them and their use in the preparation of anti-inflammatory medicaments or as selective cyclooxygenase-2 inhibitors
CN100558356C (zh) 1996-10-15 2009-11-11 G.D.瑟尔公司 应用环加氧酶-2抑制剂治疗和预防肿瘤形成的方法
AR038955A1 (es) 1996-12-05 2005-02-02 Amgen Inc Compuestos de pirimidinona y piridona sustituidos y metodos para su uso
EP0994860A1 (en) 1997-07-03 2000-04-26 Du Pont Pharmaceuticals Company Aryl-and arylamino-substituted heterocycles as corticotropin releasing hormone antagonists
ATE317845T1 (de) * 1997-09-05 2006-03-15 Glaxo Group Ltd Pharmazeutische zusammensetzung, enthaltend 2,3- diaryl-pyrazolo(1,5-b)pyridazin derivate
US5972986A (en) 1997-10-14 1999-10-26 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
DE19909541A1 (de) 1998-03-06 1999-10-14 American Cyanamid Co Herbizide 2-Aryloxy- bzw. 2-Arylthio-6-arylpyrimidine
US6306866B1 (en) 1998-03-06 2001-10-23 American Cyanamid Company Use of aryl-substituted pyrimidines as insecticidal and acaricidal agents
US6313072B1 (en) 1999-02-18 2001-11-06 American Cyanamid Company Herbicidal 2-aryloxy-or 2-arylthio-6-arylpyrimidines
WO2000052008A1 (en) * 1999-02-27 2000-09-08 Glaxo Group Limited Pyrazolopyridines
GB9927844D0 (en) * 1999-11-26 2000-01-26 Glaxo Group Ltd Chemical compounds
GB9930358D0 (en) * 1999-12-22 2000-02-09 Glaxo Group Ltd Process for the preparation of chemical compounds
GB0002336D0 (en) * 2000-02-01 2000-03-22 Glaxo Group Ltd Medicaments
GB0002312D0 (en) 2000-02-01 2000-03-22 Glaxo Group Ltd Medicaments
GB0003224D0 (en) 2000-02-11 2000-04-05 Glaxo Group Ltd Chemical compounds
GB0021494D0 (en) 2000-09-01 2000-10-18 Glaxo Group Ltd Chemical comkpounds
US6756498B2 (en) * 2001-04-27 2004-06-29 Smithkline Beecham Corporation Process for the preparation of chemical compounds
GB0112803D0 (en) 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
GB0112802D0 (en) 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
GB0112810D0 (en) 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
US6861249B1 (en) * 2002-04-09 2005-03-01 David Kent Microbial spray for animal waste

Also Published As

Publication number Publication date
HUP0401280A2 (hu) 2004-12-28
US7026327B2 (en) 2006-04-11
BR0209787A (pt) 2004-06-01
US20050032821A1 (en) 2005-02-10
DE60211149D1 (de) 2006-06-08
CN1537104A (zh) 2004-10-13
SI1390351T1 (sl) 2006-10-31
EP1390351B1 (en) 2006-05-03
DE60229669D1 (de) 2008-12-11
ES2262809T3 (es) 2006-12-01
EP1493735A1 (en) 2005-01-05
NZ529719A (en) 2006-02-24
HK1063311A1 (en) 2004-12-24
PL366514A1 (en) 2005-02-07
JP2005511485A (ja) 2005-04-28
ES2316918T3 (es) 2009-04-16
DK1390351T3 (da) 2006-08-07
AU2002302764B2 (en) 2005-12-01
TWI327140B (en) 2010-07-11
KR100889427B1 (ko) 2009-03-23
DE60211149T2 (de) 2006-09-07
AR036028A1 (es) 2004-08-04
GB0112802D0 (en) 2001-07-18
CO5540311A2 (es) 2005-07-29
EP1493735B1 (en) 2008-10-29
NO326949B1 (no) 2009-03-16
IL158799A0 (en) 2004-05-12
JP4291688B2 (ja) 2009-07-08
US20050187235A1 (en) 2005-08-25
HUP0401280A3 (en) 2009-06-29
CN1255387C (zh) 2006-05-10
PT1390351E (pt) 2006-06-30
MXPA03010583A (es) 2004-03-09
CA2448192A1 (en) 2002-12-05
ATE412637T1 (de) 2008-11-15
MY130750A (en) 2007-07-31
WO2002096885A1 (en) 2002-12-05
KR20040030629A (ko) 2004-04-09
EP1390351A1 (en) 2004-02-25
ZA200308826B (en) 2005-02-14
ATE325103T1 (de) 2006-06-15
CZ20033204A3 (en) 2004-03-17
NO20035206D0 (no) 2003-11-24

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Legal Events

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