[go: up one dir, main page]

NO20035571D0 - N-formyl hydroksylaminforbindelser som PDF-inhibitorer - Google Patents

N-formyl hydroksylaminforbindelser som PDF-inhibitorer

Info

Publication number
NO20035571D0
NO20035571D0 NO20035571A NO20035571A NO20035571D0 NO 20035571 D0 NO20035571 D0 NO 20035571D0 NO 20035571 A NO20035571 A NO 20035571A NO 20035571 A NO20035571 A NO 20035571A NO 20035571 D0 NO20035571 D0 NO 20035571D0
Authority
NO
Norway
Prior art keywords
hydroxylamine compounds
formyl hydroxylamine
pdf inhibitors
pdf
inhibitors
Prior art date
Application number
NO20035571A
Other languages
English (en)
Other versions
NO20035571L (no
NO327420B1 (no
Inventor
Dinesh V Patel
Zhengyu Yuan
Rakesh K Jain
Salvador Garcia Alvarez
Jeffrey Jacobs
Original Assignee
Vicuron Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vicuron Pharm Inc filed Critical Vicuron Pharm Inc
Publication of NO20035571D0 publication Critical patent/NO20035571D0/no
Publication of NO20035571L publication Critical patent/NO20035571L/no
Publication of NO327420B1 publication Critical patent/NO327420B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO20035571A 2001-06-15 2003-12-12 N-formylhydroksylaminforbindelser, fremgangsmate til fremstilling derav, farmasoytiske sammensetninger og celledyrkningsmedium inneholdende slike forbindelser, samt anvendelse derav som legemiddel. NO327420B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29841901P 2001-06-15 2001-06-15
US36031302P 2002-02-27 2002-02-27
PCT/EP2002/006604 WO2002102790A1 (en) 2001-06-15 2002-06-14 N-formyl hydroxylamine compounds as inhibitors of pdf

Publications (3)

Publication Number Publication Date
NO20035571D0 true NO20035571D0 (no) 2003-12-12
NO20035571L NO20035571L (no) 2004-02-16
NO327420B1 NO327420B1 (no) 2009-06-29

Family

ID=26970649

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20035571A NO327420B1 (no) 2001-06-15 2003-12-12 N-formylhydroksylaminforbindelser, fremgangsmate til fremstilling derav, farmasoytiske sammensetninger og celledyrkningsmedium inneholdende slike forbindelser, samt anvendelse derav som legemiddel.

Country Status (30)

Country Link
US (1) US7148242B2 (no)
EP (1) EP1401828B1 (no)
JP (1) JP4361365B2 (no)
KR (2) KR100589544B1 (no)
CN (1) CN1511152A (no)
AR (1) AR036053A1 (no)
AT (1) ATE323081T1 (no)
AU (1) AU2002321062B2 (no)
BR (1) BR0210377A (no)
CA (1) CA2448526A1 (no)
CO (1) CO5640131A2 (no)
CY (1) CY1105085T1 (no)
CZ (1) CZ20033388A3 (no)
DE (1) DE60210612T2 (no)
DK (1) DK1401828T3 (no)
ES (1) ES2262824T3 (no)
HU (1) HUP0400208A3 (no)
IL (1) IL158770A0 (no)
MX (1) MXPA03011628A (no)
MY (1) MY138619A (no)
NO (1) NO327420B1 (no)
NZ (1) NZ529489A (no)
PE (1) PE20030100A1 (no)
PL (1) PL364476A1 (no)
PT (1) PT1401828E (no)
RU (1) RU2325386C2 (no)
SI (1) SI1401828T1 (no)
SK (1) SK15242003A3 (no)
WO (1) WO2002102790A1 (no)
ZA (1) ZA200308379B (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE360014T1 (de) * 2001-06-15 2007-05-15 Vicuron Pharm Inc Bicyclische pyrrolidinverbindungen
GB0208579D0 (en) * 2002-04-13 2002-05-22 British Biotech Pharm Antibacterial agents
CA2499426A1 (en) 2002-09-19 2004-04-01 Novartis Ag Process for preparing n-hydroxylamine compounds
WO2004076053A2 (en) * 2003-02-21 2004-09-10 Novartis Ag Chemical process for the preparation of intermediates to obtain n-formyl hydroxylamine compounds
TW200427458A (en) * 2003-04-02 2004-12-16 Novartis Ag Crystalline N-formyl hydroxylamine compounds
KR20060026445A (ko) * 2003-06-26 2006-03-23 노파르티스 아게 특정 항박테리아성 n-포르밀 히드록실아민의 제조에유용한 중간체의 제조 방법
KR100527624B1 (ko) * 2003-08-21 2005-11-22 한기종 질소에 포밀기를 갖는 아민유도체의 새로운 제조방법
RU2007103299A (ru) * 2004-06-30 2008-08-10 Новартис АГ (CH) Способ повышения чувствительности к ингибиторам пептиддеформилазы с помощью ингибиторов откачивающего насоса
US20080161249A1 (en) * 2004-11-17 2008-07-03 Smithkline Beecham Corporation Use of Novel Antibacterial Compounds
GT200600196A (es) * 2005-05-23 2007-01-15 Compuestos n-formil de hidroxilamina
DE102005026231A1 (de) * 2005-06-07 2006-12-14 Origenis Ag Peptid-Deformylase (PDF) Inhibitoren 3
EP1893574A2 (en) * 2005-06-07 2008-03-05 Novartis AG Peptide deformylase (pdf) inhibitors 4
SG133452A1 (en) * 2005-12-30 2007-07-30 Novartis Ag Peptide deformylase inhibitors for treatment of mycobacterial and other parasitic diseases
WO2007106670A2 (en) * 2006-03-03 2007-09-20 Novartis Ag N-formyl hydroxylamine compounds
CN101328155B (zh) * 2007-06-20 2010-11-03 上海医药工业研究院 噁唑烷衍生物及其制备方法和应用
CN101434570B (zh) * 2007-11-16 2011-02-02 上海医药工业研究院 吡咯烷衍生物及其制备方法和应用
CN101584694B (zh) * 2009-06-15 2011-01-12 华东师范大学 含2,5-二氢吡咯的肽脱甲酰基酶抑制剂及合成方法
BR112012008147A2 (pt) * 2009-09-04 2016-03-01 Novartis Ag compostos heteroarílicos como inibidores da quinase
KR20130016244A (ko) * 2010-03-10 2013-02-14 인게니움 파르마코이티칼스 게엠베하 단백질 키나아제의 억제제
JP5825086B2 (ja) 2011-12-19 2015-12-02 住友化学株式会社 α−置換−β−アミノ酸エステル誘導体不斉加水分解酵素
US9512084B2 (en) 2013-11-29 2016-12-06 Novartis Ag Amino pyrimidine derivatives
ES2876974T3 (es) 2015-04-07 2021-11-15 Novartis Ag Combinación de terapia con receptor de antígeno quimérico y derivados de amino pirimidina
WO2017193924A1 (zh) * 2016-05-11 2017-11-16 如东瑞恩医药科技有限公司 螺三元环、螺五元环类肽脱甲酰基酶抑制剂及其在抗菌和抗肿瘤中的应用

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3206411A (en) * 1963-10-11 1965-09-14 American Cyanamid Co Novel substituted 3-formyl-and 3-lower alkanoyl-4,5-indoloquinones and novel methodsof preparing the same
US4052511A (en) 1976-02-13 1977-10-04 E. R. Squibb & Sons, Inc. Carboxyacylproline derivatives
US4311705A (en) 1980-10-06 1982-01-19 E. R. Squibb & Sons, Inc. Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines
US4321383A (en) 1980-11-24 1982-03-23 E. R. Squibb & Sons, Inc. Heterobicyclo intermediates
US4303662A (en) 1980-11-24 1981-12-01 E. R. Squibb & Sons, Inc. Carboxyacyl, mercapto and acylmercapto derivatives of heterobicyclo compounds
JPS6188884A (ja) 1984-10-04 1986-05-07 Sankyo Co Ltd エンケフアリナ−ゼb阻害物質およびその製法
AU580855B2 (en) * 1985-03-29 1989-02-02 Shionogi & Co., Ltd. Alkeneamidocephalosporin esters
US4599361A (en) 1985-09-10 1986-07-08 G. D. Searle & Co. Hydroxamic acid based collagenase inhibitors
DK77487A (da) 1986-03-11 1987-09-12 Hoffmann La Roche Hydroxylaminderivater
FR2609289B1 (fr) 1987-01-06 1991-03-29 Bellon Labor Sa Roger Nouveaux composes a activite d'inhibiteurs de collagenase, procede pour les preparer et compositions pharmaceutiques contenant ces composes
US5128346A (en) 1987-09-21 1992-07-07 Abbott Laboratories Derivatives of D-glutamic acid and D-aspartic acid
EP0334244A3 (en) 1988-03-25 1991-05-29 The Procter & Gamble Company Bradykinin antagonist peptides
GB8827308D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
GB8919251D0 (en) 1989-08-24 1989-10-04 British Bio Technology Compounds
GB8921326D0 (en) 1989-09-21 1989-11-08 Beecham Group Plc Novel treatment
US5268384A (en) 1990-11-21 1993-12-07 Galardy Richard E Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors
FI923494A7 (fi) 1990-12-03 1992-08-03 Celltech Ltd Peptidyylijohdannaisia
CA2058797A1 (en) 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
GB9102635D0 (en) 1991-02-07 1991-03-27 British Bio Technology Compounds
IT1245712B (it) 1991-04-09 1994-10-14 Boehringer Mannheim Italia Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree
WO1992022523A2 (en) 1991-06-14 1992-12-23 Research Corporation Technologies, Inc. Peptide derivatives of collagenase inhibitor
US5256657A (en) 1991-08-19 1993-10-26 Sterling Winthrop, Inc. Succinamide derivative matrix-metalloprotease inhibitors
JPH05125029A (ja) 1991-11-06 1993-05-21 Yamanouchi Pharmaceut Co Ltd 新規なアミド化合物又はその塩
AU661058B2 (en) 1991-11-08 1995-07-13 Sankyo Company Limited Piperazic acid derivatives as collagenase inhibitor
WO1993020047A1 (en) 1992-04-07 1993-10-14 British Bio-Technology Limited Hydroxamic acid based collagenase and cytokine inhibitors
GB9211707D0 (en) 1992-06-03 1992-07-15 Celltech Ltd Peptidyl derivatives
GB9211706D0 (en) 1992-06-03 1992-07-15 Celltech Ltd Peptidyl derivatives
US5318964A (en) 1992-06-11 1994-06-07 Hoffmann-La Roche Inc. Hydroxamic derivatives and pharmaceutical compositions
GB9215665D0 (en) 1992-07-23 1992-09-09 British Bio Technology Compounds
US5552419A (en) 1993-01-06 1996-09-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
WO1994021612A1 (en) 1993-03-18 1994-09-29 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives as matrix metalloproteinases inhibitors
EP0648205B1 (en) 1993-04-27 1999-07-14 Celltech Therapeutics Limited Peptidyl derivatives as metalloproteinase inhibitors
GB9308695D0 (en) 1993-04-27 1993-06-09 Celltech Ltd Peptidyl derivatives
GB9501737D0 (en) 1994-04-25 1995-03-22 Hoffmann La Roche Hydroxamic acid derivatives
GB9411598D0 (en) 1994-06-09 1994-08-03 Hoffmann La Roche Hydroxamic acid derivatives
GB9502858D0 (en) 1995-02-14 1995-04-05 British Biotech Pharm Novel use of matrix metalloproteinase inhibitors
GB9504084D0 (en) 1995-03-01 1995-04-19 British Biotech Pharm Synthesis of carboxylic and hydroxamic acid derivatives
FR2733750B1 (fr) 1995-05-03 1997-06-13 Synthelabo Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique
WO1997030707A1 (en) 1996-02-23 1997-08-28 Eli Lilly And Company NON-PEPTIDYL VASOPRESSIN V1a ANTAGONISTS
TW448172B (en) 1996-03-08 2001-08-01 Pharmacia & Upjohn Co Llc Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation
GB9613547D0 (en) 1996-06-27 1996-08-28 Pharmacia Spa Matrix metalloproteinase inhibitors
AUPO721997A0 (en) 1997-06-06 1997-07-03 Queensland Institute Of Medical Research, The Anticancer compounds
WO1999002510A1 (en) 1997-07-10 1999-01-21 Pharmacia & Upjohn S.P.A. Matrix metalloproteinase inhibitors
GB2349884A (en) * 1998-02-07 2000-11-15 British Biotech Pharm Antibacterial agents

Also Published As

Publication number Publication date
MXPA03011628A (es) 2005-03-07
CO5640131A2 (es) 2006-05-31
NZ529489A (en) 2005-10-28
DE60210612D1 (de) 2006-05-24
HUP0400208A3 (en) 2008-10-28
SK15242003A3 (sk) 2004-07-07
EP1401828A1 (en) 2004-03-31
CZ20033388A3 (en) 2004-03-17
MY138619A (en) 2009-07-31
JP2005502606A (ja) 2005-01-27
PL364476A1 (en) 2004-12-13
US7148242B2 (en) 2006-12-12
SI1401828T1 (sl) 2006-10-31
ES2262824T3 (es) 2006-12-01
RU2325386C2 (ru) 2008-05-27
BR0210377A (pt) 2004-08-10
KR20060014083A (ko) 2006-02-14
RU2003137565A (ru) 2005-05-27
HUP0400208A2 (hu) 2004-06-28
NO20035571L (no) 2004-02-16
EP1401828B1 (en) 2006-04-12
PE20030100A1 (es) 2003-03-28
HK1064370A1 (en) 2005-01-28
JP4361365B2 (ja) 2009-11-11
US20030045479A1 (en) 2003-03-06
DK1401828T3 (da) 2006-07-31
ZA200308379B (en) 2004-05-21
CA2448526A1 (en) 2002-12-27
DE60210612T2 (de) 2006-09-21
AR036053A1 (es) 2004-08-04
ATE323081T1 (de) 2006-04-15
WO2002102790A1 (en) 2002-12-27
CY1105085T1 (el) 2009-11-04
CN1511152A (zh) 2004-07-07
NO327420B1 (no) 2009-06-29
KR100589544B1 (ko) 2006-06-15
KR20040010721A (ko) 2004-01-31
PT1401828E (pt) 2006-08-31
AU2002321062B2 (en) 2006-02-02
IL158770A0 (en) 2004-05-12

Similar Documents

Publication Publication Date Title
NO20035571D0 (no) N-formyl hydroksylaminforbindelser som PDF-inhibitorer
NO20034308L (no) Nye tyrokinase-inhibitorer
DK1492785T3 (da) 2-hydroxy-3-heteroarylindol-derivater som GSK3-inhibitorer
NO20034044L (no) Metallproteinase-inhibitorer
NO20031450L (no) Fumarsyrederivater som NF-kappa B inhibitorer
NO20033593D0 (no) Kinazoliner som MMP-13 inhibitorer
DK1603570T3 (da) Aminoheteroarylforbindelser som proteinkinaseinhibitorer
DE60234125D1 (de) E inhibitoren
DK1699797T3 (da) Pyrrolotriazinforbindelser som kinasehæmmere
DK1585749T3 (da) Diazepinoindol-derivater som kinaseinhibitorer
NO20030867D0 (no) Hydroksamderivater anvendelig som deacetylaseinhibitorer
NO20033618L (no) Ftalayinon-piperidino-derivater som PDE-4-inhibitorer
IS7879A (is) Ný efnasambönd
DK1651621T3 (da) 2-(Quinoxalin-5-ylsulfonylamino)benzamidforbindelser som CCK2-modulatorer
NO20041887L (no) Benzomidazoler anvendelige som proteinkinase-inhibitorer
NO20030135D0 (no) Piperidinforbindelser for bruk som CCR-3 inhibitorer
ATE368042T1 (de) Cephemverbindungen
DK1660090T3 (da) Quinazolin-analoger som receptor-tyrosinkinase-inhibitorer
NO20034032D0 (no) Metallproteinase-inhibitorer
NO20040996L (no) Nye forbindelser og sammensetninger som catepsin-inhibitorer
NO20042938L (no) Nitrogenholdige forbindelser som korrosjonsinhibitorer
IS7585A (is) Ný piperadín efnasambönd
NO20035328D0 (no) Nye forbindelser og preparater som katepsinhibitorer
DK1499622T3 (da) Meterotricyclyl-6-alkylidenpenemer som beta-lactamaseinhibitorer
FI20021531A0 (fi) Muurausmenetelmä

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees