NO20034496D0 - Dihydro-benzo[b][1,4]diazepin-2-on-derivater som MGLUR2- antagonister I - Google Patents

Dihydro-benzo[b][1,4]diazepin-2-on-derivater som MGLUR2- antagonister I

Info

Publication number: NO20034496D0
Authority: NO; Norway
Prior art keywords: diazepin; benzo; dihydro; derivatives; mglur2 antagonists
Prior art date: 2001-04-12

Application number

NO20034496A

Other languages

English (en)

Other versions

NO325300B1 (no

NO20034496L (no

Inventor

Vincent Mutel

Juergen Wichmann

Geo Adam

Erwin Goetchi

Thomas Johannes Woltering

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-12

Filing date

2003-10-08

Publication date

2003-10-08

2003-10-08 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2003-10-08 Publication of NO20034496D0 publication Critical patent/NO20034496D0/no

2003-10-08 Publication of NO20034496L publication Critical patent/NO20034496L/no

2008-03-25 Publication of NO325300B1 publication Critical patent/NO325300B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO20034496A 2001-04-12 2003-10-08 Dihydro-benzo[b][1,4]diazepin-2-on-derivater, fremgangsmate for fremstilling av slike forbindelser, medikament inneholdende slike forbindelser, slike forbindelser for behandling eller forebygging av sykdommer samt anvendelse av disse forbindelsene for fremstilling av medikamenter for behandling eller forebygging av sykdommer. NO325300B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01109126		2001-04-12
PCT/EP2002/003643 WO2002083665A1 (en)	2001-04-12	2002-04-02	DIHYDRO-BENZO[b][1,4]DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS I

Publications (3)

Publication Number	Publication Date
NO20034496D0 true NO20034496D0 (no)	2003-10-08
NO20034496L NO20034496L (no)	2003-10-08
NO325300B1 NO325300B1 (no)	2008-03-25

Family

ID=8177127

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20034496A NO325300B1 (no)	2001-04-12	2003-10-08	Dihydro-benzo[b][1,4]diazepin-2-on-derivater, fremgangsmate for fremstilling av slike forbindelser, medikament inneholdende slike forbindelser, slike forbindelser for behandling eller forebygging av sykdommer samt anvendelse av disse forbindelsene for fremstilling av medikamenter for behandling eller forebygging av sykdommer.

Country Status (37)

Country	Link
US (1)	US6548495B2 (no)
EP (1)	EP1379522B1 (no)
JP (1)	JP4043953B2 (no)
KR (1)	KR100566178B1 (no)
CN (1)	CN1268626C (no)
AR (1)	AR035456A1 (no)
AT (1)	ATE287883T1 (no)
AU (1)	AU2002310912B2 (no)
BG (1)	BG108253A (no)
BR (1)	BR0208887A (no)
CA (1)	CA2441771C (no)
CZ (1)	CZ20033002A3 (no)
DE (1)	DE60202761T2 (no)
DK (1)	DK1379522T3 (no)
EC (1)	ECSP034796A (no)
ES (1)	ES2235044T3 (no)
GT (1)	GT200200072A (no)
HR (1)	HRP20030791B1 (no)
HU (1)	HUP0400991A3 (no)
IL (2)	IL158021A0 (no)
JO (1)	JO2273B1 (no)
MA (1)	MA27011A1 (no)
MX (1)	MXPA03009317A (no)
MY (1)	MY130369A (no)
NO (1)	NO325300B1 (no)
NZ (1)	NZ528345A (no)
PA (1)	PA8543201A1 (no)
PE (1)	PE20021072A1 (no)
PL (1)	PL367086A1 (no)
PT (1)	PT1379522E (no)
RU (1)	RU2270197C2 (no)
SI (1)	SI1379522T1 (no)
SK (1)	SK13692003A3 (no)
UY (1)	UY27259A1 (no)
WO (1)	WO2002083665A1 (no)
YU (1)	YU79103A (no)
ZA (1)	ZA200307242B (no)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI1224175T1 (en)	1999-10-15	2004-08-31	F. Hoffmann-La Roche Ag	Benzodiazepine derivatives as metabotropic glutamate receptor antagonists
EP1651234B1 (en) *	2003-07-25	2007-09-26	F. Hoffmann-La Roche Ag	Combination of mglur2 antagonist and ache inhibitor for treatment of acute and/or chronic neurological disorders
DE602005008095D1 (de)	2004-11-05	2008-08-21	Hoffmann La Roche	Verfahren zur herstellung von isonikotinsäurederivaten
AR059898A1 (es)	2006-03-15	2008-05-07	Janssen Pharmaceutica Nv	Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200900065A (en)	2007-03-07	2009-01-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en)	2007-03-07	2008-12-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
BRPI0810655A2 (pt) *	2007-04-19	2014-11-04	Hoffmann La Roche	Derivados de di-hidro-benzo[b][1,4] diazepin-2-ona sulfonamida
AU2008297877C1 (en) *	2007-09-14	2013-11-07	Addex Pharma S.A.	1,3-disubstituted-4-phenyl-1 H-pyridin-2-ones
KR20100065191A (ko)	2007-09-14	2010-06-15	오르토-맥닐-얀센 파마슈티칼스 인코포레이티드	１,３-이치환된 ４-(아릴-ｘ-페닐)-１ｈ-피리딘-２-온
DE602008004794D1 (de)	2007-09-14	2011-03-10	Addex Pharmaceuticals Sa	1',3'-disubstituierte 4-phenyl-3,4,5,6-tetrahydro-2h,1'h-ä1,4'übipyridinyl-2'-one
US8785486B2 (en)	2007-11-14	2014-07-22	Janssen Pharmaceuticals, Inc.	Imidazo[1,2-A]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
EP2344470B1 (en)	2008-09-02	2013-11-06	Janssen Pharmaceuticals, Inc.	3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
CN102186477B (zh)	2008-10-16	2013-07-17	奥梅-杨森制药有限公司	作为代谢型谷氨酸受体调节剂的吲哚和苯并吗啉衍生物
CN102232074B (zh)	2008-11-28	2014-12-03	奥梅-杨森制药有限公司	作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物
MY153913A (en)	2009-05-12	2015-04-15	Janssen Pharmaceuticals Inc	7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
WO2010130422A1 (en)	2009-05-12	2010-11-18	Ortho-Mcneil-Janssen Pharmaceuticals, Inc	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
AR076861A1 (es)	2009-05-12	2011-07-13	Addex Pharma Sa	Derivados de 1,2,4-triazolo (4,3-a)piridina y su uso como moduladores alostericos positivos de los receptores de mglur2
CA2814998C (en)	2010-11-08	2019-10-29	Janssen Pharmaceuticals, Inc.	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
ES2552455T3 (es)	2010-11-08	2015-11-30	Janssen Pharmaceuticals, Inc.	Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
US8993591B2 (en)	2010-11-08	2015-03-31	Janssen Pharmaceuticals, Inc.	1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
EP2602248A1 (en)	2011-12-05	2013-06-12	University Of Leicester	Novel pyrrole compounds
KR20150070187A (ko)	2012-10-23	2015-06-24	에프. 호프만-라 로슈 아게	자폐 장애의 치료를 위한 ｍｇｌｕ２／３ 길항제
US9458176B2 (en) *	2013-02-28	2016-10-04	Eisai R&D Management Co., Ltd.	Tetrahydroimidazo(1,5-D)[1,4]oxazepine derivative
JO3368B1 (ar)	2013-06-04	2019-03-13	Janssen Pharmaceutica Nv	مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar)	2013-09-06	2019-03-13	Janssen Pharmaceutica Nv	مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
PH12019500127B1 (en)	2014-01-21	2022-05-04	Janssen Pharmaceutica Nv	Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
SMT201900545T1 (it)	2014-01-21	2019-11-13	Janssen Pharmaceutica Nv	Combinazioni comprendenti modulatori allosterici positivi o agonisti ortosterici del recettore glutammatergico metabotropico sottotipo 2 e loro utilizzo
CA2943877A1 (en)	2014-04-23	2015-10-29	F. Hoffmann-La Roche Ag	Mglu2/3 antagonists for the treatment of intellectual disabilities
WO2015191630A1 (en)	2014-06-10	2015-12-17	Sanford-Burnham Medical Research Institute	Metabotropic glutamate receptor negative allosteric modulators (nams) and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU953819A1 (ru) *	1980-08-25	1991-09-23	Физико-химический институт АН УССР	1-(Гидразинокарбонил)алкил-1,2-дигидро-3Н-1,4-бенздиазепин-2-оны, обладающие транквилизирующими и противосудорожными свойствами
AU6420700A (en) *	1999-08-05	2001-03-05	Prescient Neuropharma Inc.	Novel 1,4-benzodiazepine compounds and derivatives thereof
SI1224175T1 (en) *	1999-10-15	2004-08-31	F. Hoffmann-La Roche Ag	Benzodiazepine derivatives as metabotropic glutamate receptor antagonists
HUP0203142A3 (en) *	1999-10-15	2003-03-28	Hoffmann La Roche	Benzodiazepine derivatives, process for preparation of the compounds, pharmaceutical compositions containing them and their use

2002
- 2002-04-02 SI SI200230075T patent/SI1379522T1/xx unknown
- 2002-04-02 DE DE60202761T patent/DE60202761T2/de not_active Expired - Lifetime
- 2002-04-02 KR KR1020037013398A patent/KR100566178B1/ko not_active Expired - Fee Related
- 2002-04-02 JP JP2002581420A patent/JP4043953B2/ja not_active Expired - Fee Related
- 2002-04-02 CZ CZ20033002A patent/CZ20033002A3/cs unknown
- 2002-04-02 CN CNB028078217A patent/CN1268626C/zh not_active Expired - Fee Related
- 2002-04-02 YU YU79103A patent/YU79103A/sh unknown
- 2002-04-02 BR BR0208887-8A patent/BR0208887A/pt active Search and Examination
- 2002-04-02 AT AT02735209T patent/ATE287883T1/de active
- 2002-04-02 NZ NZ528345A patent/NZ528345A/en unknown
- 2002-04-02 EP EP02735209A patent/EP1379522B1/en not_active Expired - Lifetime
- 2002-04-02 HR HR20030791A patent/HRP20030791B1/xx not_active IP Right Cessation
- 2002-04-02 PL PL02367086A patent/PL367086A1/xx not_active Application Discontinuation
- 2002-04-02 DK DK02735209T patent/DK1379522T3/da active
- 2002-04-02 AU AU2002310912A patent/AU2002310912B2/en not_active Ceased
- 2002-04-02 HU HU0400991A patent/HUP0400991A3/hu not_active Application Discontinuation
- 2002-04-02 SK SK1369-2003A patent/SK13692003A3/sk unknown
- 2002-04-02 ES ES02735209T patent/ES2235044T3/es not_active Expired - Lifetime
- 2002-04-02 CA CA002441771A patent/CA2441771C/en not_active Expired - Fee Related
- 2002-04-02 WO PCT/EP2002/003643 patent/WO2002083665A1/en not_active Ceased
- 2002-04-02 IL IL15802102A patent/IL158021A0/xx unknown
- 2002-04-02 RU RU2003130648/04A patent/RU2270197C2/ru not_active IP Right Cessation
- 2002-04-02 PT PT02735209T patent/PT1379522E/pt unknown
- 2002-04-02 MX MXPA03009317A patent/MXPA03009317A/es active IP Right Grant
- 2002-04-03 US US10/116,597 patent/US6548495B2/en not_active Expired - Lifetime
- 2002-04-09 PA PA20028543201A patent/PA8543201A1/es unknown
- 2002-04-10 AR ARP020101313A patent/AR035456A1/es not_active Application Discontinuation
- 2002-04-10 PE PE2002000299A patent/PE20021072A1/es not_active Application Discontinuation
- 2002-04-10 JO JO200233A patent/JO2273B1/en active
- 2002-04-11 GT GT200200072A patent/GT200200072A/es unknown
- 2002-04-11 MY MYPI20021346A patent/MY130369A/en unknown
- 2002-04-11 UY UY27259A patent/UY27259A1/es not_active Application Discontinuation
2003
- 2003-09-16 ZA ZA200307242A patent/ZA200307242B/en unknown
- 2003-09-18 IL IL158021A patent/IL158021A/en not_active IP Right Cessation
- 2003-10-08 NO NO20034496A patent/NO325300B1/no unknown
- 2003-10-08 EC EC2003004796A patent/ECSP034796A/es unknown
- 2003-10-08 MA MA27345A patent/MA27011A1/fr unknown
- 2003-10-10 BG BG108253A patent/BG108253A/bg unknown

Also Published As

Publication number	Publication date
YU79103A (sh)	2006-05-25
PA8543201A1 (es)	2002-10-31
ZA200307242B (en)	2004-12-16
EP1379522B1 (en)	2005-01-26
BR0208887A (pt)	2004-06-29
ATE287883T1 (de)	2005-02-15
DK1379522T3 (da)	2005-05-30
NZ528345A (en)	2005-04-29
AR035456A1 (es)	2004-05-26
HRP20030791B1 (en)	2006-06-30
EP1379522A1 (en)	2004-01-14
HK1068339A1 (en)	2005-04-29
BG108253A (bg)	2005-03-31
CN1522252A (zh)	2004-08-18
ES2235044T3 (es)	2005-07-01
US6548495B2 (en)	2003-04-15
SK13692003A3 (sk)	2004-05-04
HUP0400991A2 (hu)	2004-08-30
JP4043953B2 (ja)	2008-02-06
IL158021A (en)	2010-04-15
RU2003130648A (ru)	2005-04-10
DE60202761T2 (de)	2006-01-12
HUP0400991A3 (en)	2009-06-29
US20020198197A1 (en)	2002-12-26
PL367086A1 (en)	2005-02-21
KR100566178B1 (ko)	2006-03-29
RU2270197C2 (ru)	2006-02-20
GT200200072A (es)	2003-06-19
PT1379522E (pt)	2005-05-31
PE20021072A1 (es)	2002-12-07
DE60202761D1 (de)	2005-03-03
MA27011A1 (fr)	2004-12-20
UY27259A1 (es)	2002-10-31
MXPA03009317A (es)	2004-02-12
CA2441771A1 (en)	2002-10-24
KR20030088502A (ko)	2003-11-19
SI1379522T1 (en)	2005-04-30
JP2004525965A (ja)	2004-08-26
ECSP034796A (es)	2003-12-01
JO2273B1 (en)	2005-04-07
CZ20033002A3 (cs)	2004-03-17
NO325300B1 (no)	2008-03-25
CA2441771C (en)	2008-12-30
AU2002310912B2 (en)	2005-06-16
WO2002083665A1 (en)	2002-10-24
IL158021A0 (en)	2004-03-28
NO20034496L (no)	2003-10-08
MY130369A (en)	2007-06-29
CN1268626C (zh)	2006-08-09
HRP20030791A2 (en)	2005-06-30

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SE9902902D0 (sv)	1999-08-13	New formulation
ITRM20000199A0 (it)	2000-04-14	Formulazione.