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NO20030302L - Nye heteroarylderivater og deres anvendelse som medikamenter - Google Patents

Nye heteroarylderivater og deres anvendelse som medikamenter

Info

Publication number
NO20030302L
NO20030302L NO20030302A NO20030302A NO20030302L NO 20030302 L NO20030302 L NO 20030302L NO 20030302 A NO20030302 A NO 20030302A NO 20030302 A NO20030302 A NO 20030302A NO 20030302 L NO20030302 L NO 20030302L
Authority
NO
Norway
Prior art keywords
drugs
heteroaryl derivatives
new heteroaryl
new
derivatives
Prior art date
Application number
NO20030302A
Other languages
English (en)
Norwegian (no)
Other versions
NO20030302D0 (no
Inventor
Peter Emig
Eckhard Guenther
Juergen Schmidt
Bernhard Kutscher
Bernd Nickel
Anita Storch
Original Assignee
Zentaris Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Ag filed Critical Zentaris Ag
Publication of NO20030302D0 publication Critical patent/NO20030302D0/no
Publication of NO20030302L publication Critical patent/NO20030302L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20030302A 2000-07-21 2003-01-20 Nye heteroarylderivater og deres anvendelse som medikamenter NO20030302L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10035908A DE10035908A1 (de) 2000-07-21 2000-07-21 Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
PCT/EP2001/008262 WO2002008190A2 (fr) 2000-07-21 2001-07-18 Nouveaux derives d'heteroaryle et leur utilisation en tant que medicaments

Publications (2)

Publication Number Publication Date
NO20030302D0 NO20030302D0 (no) 2003-01-20
NO20030302L true NO20030302L (no) 2003-02-07

Family

ID=7649970

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20030302A NO20030302L (no) 2000-07-21 2003-01-20 Nye heteroarylderivater og deres anvendelse som medikamenter

Country Status (21)

Country Link
US (1) US6638935B2 (fr)
EP (1) EP1305289A2 (fr)
JP (1) JP2004516243A (fr)
KR (1) KR20030015894A (fr)
CN (1) CN1447796A (fr)
AR (1) AR032467A1 (fr)
AU (2) AU8198901A (fr)
BG (1) BG107506A (fr)
BR (1) BR0112711A (fr)
CA (1) CA2353353A1 (fr)
DE (1) DE10035908A1 (fr)
HU (1) HUP0300743A2 (fr)
IL (1) IL153931A0 (fr)
MX (1) MXPA03000596A (fr)
NO (1) NO20030302L (fr)
NZ (1) NZ524156A (fr)
PL (1) PL361354A1 (fr)
RU (1) RU2003105238A (fr)
SK (1) SK1942003A3 (fr)
WO (1) WO2002008190A2 (fr)
ZA (1) ZA200300545B (fr)

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CA2512243A1 (fr) * 2003-01-28 2004-09-16 Aventis Pharma S.A. Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation
FR2855825B1 (fr) * 2003-06-04 2008-08-22 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
PE20050226A1 (es) * 2003-06-04 2005-05-18 Aventis Pharma Sa Productos aril-heteroaromaticos y composiciones que los contienen
US7592466B2 (en) 2003-10-09 2009-09-22 Abbott Laboratories Ureas having antiangiogenic activity
FR2871157A1 (fr) * 2004-06-04 2005-12-09 Aventis Pharma Sa Produits biaryl aromatiques, compositions les contenant et utilisation
EP1645556A1 (fr) * 2004-10-07 2006-04-12 Boehringer Ingelheim International GmbH Derives d'arylpiperazine-benzoylamide utiles comme agents pharmaceutiques
EP2121613A2 (fr) 2007-01-31 2009-11-25 Vertex Pharmaceuticals, Inc. Inhibiteurs de kinase
CA2678577A1 (fr) * 2007-02-26 2008-09-04 Vitae Pharmaceuticals, Inc. Inhibiteurs d'uree et de carbamate de 11b-hydroxysteroide deshydrogenase 1 cycliques
WO2009017664A1 (fr) * 2007-07-26 2009-02-05 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques de la 11β-hydroxystéroïde déshydrogénase 1
ES2389992T3 (es) 2007-11-02 2012-11-05 Vertex Pharmaceuticals Incorporated Derivados de [1H-pirazolo[3,4-b]piridin-4-il]-fenilo o -piridin-2-ilo como proteína cinasa c-theta
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
WO2009075835A1 (fr) 2007-12-11 2009-06-18 Vitae Pharmaceutical, Inc Inhibiteurs cycliques d'urée de la 11-hydroxystéroïde déhydrogénase 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
US8592409B2 (en) 2008-01-24 2013-11-26 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1
WO2009102428A2 (fr) * 2008-02-11 2009-08-20 Vitae Pharmaceuticals, Inc. INHIBITEURS 1,3-OXAZEPAN-2-ONE ET 1,3-DIAZEPAN-2-ONE DE LA 11β-HYDROXYSTÉROÏDE DÉSHYDROGÉNASE (TYPE1)
EP2254872A2 (fr) * 2008-02-15 2010-12-01 Vitae Pharmaceuticals, Inc. Inhibiteurs de 11beta-hydroxystéroïde deshydrogénase 1
EP2274287B1 (fr) * 2008-03-18 2016-03-09 Vitae Pharmaceuticals, Inc. Inhibiteurs de la 11-bêta-hydroxystéroïde déshydrogénase de type 1
ES2421537T3 (es) * 2008-05-01 2013-09-03 Vitae Pharmaceuticals Inc Inhibidores cíclicos de la 11beta-hidroxiesteroide deshidrogenasa 1
US8592410B2 (en) 2008-05-01 2013-11-26 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11BETA-hydroxysteroid dehydrogenase 1
JP5696037B2 (ja) 2008-05-01 2015-04-08 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
CA2723032A1 (fr) * 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques de la 11-beta-hydroxysteroide dehydrogenase 1
US8569337B2 (en) 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
MX2011000837A (es) 2008-07-23 2011-04-05 Vertex Pharma Inhibidores de pirazolpiridina cinasa triciclica.
EP2318407B1 (fr) 2008-07-23 2013-01-02 Vertex Pharmaceuticals Incorporated Inhibiteurs de la pyrazolopyridine kinase
CA2730499A1 (fr) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Inhibiteurs cycliques de la 11 beta-hydroxysteroide deshydrogenase 1
CA2729998A1 (fr) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Inhibiteurs de la 11 beta-hydroxysteroide deshydrogenase 1
AU2009279611A1 (en) * 2008-08-06 2010-02-11 Vertex Pharmaceuticals Incorporated Aminopyridine kinase inhibitors
WO2010089303A1 (fr) 2009-02-04 2010-08-12 Boehringer Ingelheim International Gmbh Inhibiteurs cycliques de la 11β-hydroxystéroïde déshydrogénase de type 1
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
GEP20156309B (en) * 2009-04-30 2015-07-10 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
EP2427464A1 (fr) 2009-05-06 2012-03-14 Vertex Pharmaceuticals Incorporated Pyrazolopyridines
EP2440537A1 (fr) 2009-06-11 2012-04-18 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déshydrogénase 1 basée sur la structure 1,3-oxazinan-2-one
US8883778B2 (en) 2009-07-01 2014-11-11 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
MX2012008643A (es) 2010-01-27 2013-02-26 Vertex Pharma Inhibidores de cinasas de pirazolopiridinas.
US9067932B2 (en) 2010-01-27 2015-06-30 Vertex Pharmaceuticals Incorporated Pyrazolopyridine kinase inhibitors
JP2013518113A (ja) 2010-01-27 2013-05-20 バーテックス ファーマシューティカルズ インコーポレイテッド ピラゾロピラジンキナーゼ阻害剤
WO2011159760A1 (fr) 2010-06-16 2011-12-22 Vitae Pharmaceuticals, Inc. Hétérocycles à 5, 6 et 7 chaînons substitués, médicaments contenant ces composés et leur utilisation
EP2585444B1 (fr) 2010-06-25 2014-10-22 Boehringer Ingelheim International GmbH Azaspirohexanones comme inhibiteurs de 11-beta -hsd1 pour le traitement de troubles métaboliques
MX2013004699A (es) 2010-11-02 2013-05-22 Boehringer Ingelheim Int Combinaciones farmaceuticas para el tratamiento de trastornos metabolicos.

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JPS50151886A (fr) * 1974-05-29 1975-12-06
HU175075B (hu) * 1977-06-30 1980-05-28 Egyt Gyogyszervegyeszeti Gyar Sposob poluchenija piperazidov piridin-karbonovoj kisloty
EP0040793B1 (fr) * 1980-05-22 1985-08-28 Masayuki Ishikawa Dérivés de la quinazolindione, procédé pour leur préparation et leur utilisation pharmaceutique
US4937246A (en) * 1987-11-25 1990-06-26 Takeda Chemical Industries, Ltd. PAF antagonist, 1,4-disubstituted piperazine compounds and production thereof
MX16687A (es) * 1988-07-07 1994-01-31 Ciba Geigy Ag Compuestos de biarilo y procedimiento para su preparacion.
EP0703905A1 (fr) * 1993-06-18 1996-04-03 Merck & Co. Inc. Inhibiteurs de farnesyle-proteine transferase
CZ288002B6 (cs) * 1995-01-11 2001-03-14 Samjin Pharmaceutical Co., Ltd. Piperazinové deriváty a farmaceutický prostředek s protinádorovou aktivitou je obsahující
CA2214685C (fr) * 1995-03-10 2008-05-20 Berlex Laboratories, Inc. Derives de benzamidine et utilisation de ces derives en tant qu'anticoagulants
US6028195A (en) * 1996-06-29 2000-02-22 Samjin Pharmaceutical Co., Ltd. Piperazine derivatives and process for the preparation thereof
ES2125206B1 (es) * 1997-07-21 1999-11-16 Esteve Labor Dr Derivados de acil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos.
US6166203A (en) * 1998-02-26 2000-12-26 Neurogen Corporation Heterocyclic amino substituted heteroaryl fused pyridines; GABA brain receptor ligands
CN1261098C (zh) * 1998-08-28 2006-06-28 西奥斯股份有限公司 p38－α激酶的抑制剂
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HK1045503A1 (zh) * 1999-12-16 2002-11-29 Schering Corporation 取代的咪唑神经肽yy5受体拮抗物

Also Published As

Publication number Publication date
SK1942003A3 (en) 2003-12-02
EP1305289A2 (fr) 2003-05-02
US20020111354A1 (en) 2002-08-15
HUP0300743A2 (hu) 2003-10-28
CA2353353A1 (fr) 2002-01-21
PL361354A1 (en) 2004-10-04
JP2004516243A (ja) 2004-06-03
KR20030015894A (ko) 2003-02-25
MXPA03000596A (es) 2003-05-14
NO20030302D0 (no) 2003-01-20
IL153931A0 (en) 2003-07-31
BG107506A (bg) 2003-09-30
AR032467A1 (es) 2003-11-12
CN1447796A (zh) 2003-10-08
DE10035908A1 (de) 2002-03-07
NZ524156A (en) 2005-10-28
BR0112711A (pt) 2003-05-20
WO2002008190A2 (fr) 2002-01-31
ZA200300545B (en) 2003-02-12
US6638935B2 (en) 2003-10-28
WO2002008190A3 (fr) 2002-08-01
AU8198901A (en) 2002-02-05
AU2001281989B2 (en) 2005-05-12
RU2003105238A (ru) 2004-08-10

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