[go: up one dir, main page]

NO20030033L - Pyrido[2,3-D]pyrimidin- og pyrimido[4,5-D]pyrimidin- nukleosider - Google Patents

Pyrido[2,3-D]pyrimidin- og pyrimido[4,5-D]pyrimidin- nukleosider

Info

Publication number
NO20030033L
NO20030033L NO20030033A NO20030033A NO20030033L NO 20030033 L NO20030033 L NO 20030033L NO 20030033 A NO20030033 A NO 20030033A NO 20030033 A NO20030033 A NO 20030033A NO 20030033 L NO20030033 L NO 20030033L
Authority
NO
Norway
Prior art keywords
pyrimidine
pyrimido
pyrido
nucleosides
pyrimidine nucleosides
Prior art date
Application number
NO20030033A
Other languages
English (en)
Norwegian (no)
Other versions
NO20030033D0 (no
Inventor
Guangyi Wang
Jean-Luc Girardet
Esmir Gunic
Johnson Luc
Zbigniew Pietrzkowski
Original Assignee
Ribapharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribapharm Inc filed Critical Ribapharm Inc
Publication of NO20030033D0 publication Critical patent/NO20030033D0/no
Publication of NO20030033L publication Critical patent/NO20030033L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20030033A 2000-07-06 2003-01-03 Pyrido[2,3-D]pyrimidin- og pyrimido[4,5-D]pyrimidin- nukleosider NO20030033L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21641800P 2000-07-06 2000-07-06
PCT/US2001/041242 WO2002003997A1 (fr) 2000-07-06 2001-07-03 Nucleosides de pyrido[2,3-d]pyrimidine et de pyrimido[4,5-d]pyrimidine

Publications (2)

Publication Number Publication Date
NO20030033D0 NO20030033D0 (no) 2003-01-03
NO20030033L true NO20030033L (no) 2003-01-03

Family

ID=22806989

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20030033A NO20030033L (no) 2000-07-06 2003-01-03 Pyrido[2,3-D]pyrimidin- og pyrimido[4,5-D]pyrimidin- nukleosider

Country Status (19)

Country Link
US (1) US7081449B2 (fr)
EP (1) EP1303282A4 (fr)
JP (1) JP2004522694A (fr)
KR (1) KR20030032944A (fr)
CN (1) CN1440292A (fr)
AU (2) AU2001273670B2 (fr)
BR (1) BR0111531A (fr)
CA (1) CA2405798A1 (fr)
CZ (1) CZ20024052A3 (fr)
HU (1) HUP0301614A3 (fr)
IL (1) IL151849A0 (fr)
MX (1) MXPA02012156A (fr)
NO (1) NO20030033L (fr)
NZ (1) NZ521457A (fr)
PL (1) PL359559A1 (fr)
SK (1) SK112003A3 (fr)
UA (1) UA72612C2 (fr)
WO (1) WO2002003997A1 (fr)
ZA (1) ZA200208010B (fr)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100974917B1 (ko) 2000-04-13 2010-08-09 파마셋 인코포레이티드 간염 바이러스 감염 치료를 위한 3'- 또는2'-하이드록시메틸 치환된 뉴클레오시드 유도체
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
BR0111196A (pt) 2000-05-26 2004-04-06 Idenix Cayman Ltd Composições e uso das mesmas para tratamento de flavivìrus e pestivìrus
US20060115815A1 (en) * 2002-04-26 2006-06-01 Gabriel Birkus Method and compositions for identifying anti-hiv therapeutic compounds
CN101172993A (zh) 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′-c-甲基-3′-o-l-缬氨酸酯核糖呋喃基胞苷
AU2003248748A1 (en) 2002-06-28 2004-01-19 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
IL166640A0 (en) 2002-08-01 2006-01-15 Pharmasset Ltd Compounds with the bicyclo Ä4.2.1Ü nonane system for the treatment of flaviviridae infections
HUE033832T2 (en) 2002-11-15 2018-01-29 Idenix Pharmaceuticals Llc 2'-methyl nucleosides in combination with interferon and Flaviviridae mutation
ES2470771T3 (es) 2002-12-12 2014-06-24 Idenix Pharmaceuticals, Inc Procedimiento para la producción de nucle�sidos ramificados en 2'
US7452901B2 (en) 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
US7470724B2 (en) 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
EP1628685B1 (fr) 2003-04-25 2010-12-08 Gilead Sciences, Inc. Analogues phosphonates antiviraux
US7432261B2 (en) 2003-04-25 2008-10-07 Gilead Sciences, Inc. Anti-inflammatory phosphonate compounds
US7407965B2 (en) 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
US7273716B2 (en) 2003-04-25 2007-09-25 Gilead Sciences, Inc. Methods and compositions for identifying therapeutic compounds with GS-7340 ester hydrolase
WO2005002626A2 (fr) 2003-04-25 2005-01-13 Gilead Sciences, Inc. Composes de phosphonate therapeutiques
EP1620109A2 (fr) 2003-04-25 2006-02-01 Gilead Sciences, Inc. Analogues de phosphonate inhibiteurs de kinase
US7427636B2 (en) 2003-04-25 2008-09-23 Gilead Sciences, Inc. Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
US7300924B2 (en) 2003-04-25 2007-11-27 Gilead Sciences, Inc. Anti-infective phosphonate analogs
US7550442B2 (en) * 2003-05-20 2009-06-23 The Board Of Trustees Of The University Of Illinois Nucleoside analog inhibitors of reverse transcriptase
PL1633766T3 (pl) * 2003-05-30 2019-09-30 Gilead Pharmasset Llc Modyfikowane fluorowane analogi nukleozydów
CA2533367C (fr) 2003-07-25 2013-10-01 Centre National De La Recherche Scientifique Analogues des nucleosides puriques pour traiter flaviviridae et notamment l'hepatite cant l'hepatite c
US7432273B2 (en) 2003-10-24 2008-10-07 Gilead Sciences, Inc. Phosphonate analogs of antimetabolites
WO2005044279A1 (fr) 2003-10-24 2005-05-19 Gilead Sciences, Inc. Conjugues phosphonate / inhibiteur de purine nucleoside phosphorylase
EP1706405B1 (fr) 2003-12-22 2009-03-04 Gilead Sciences, Inc. Derives de carbovir et d'abacavir 4'-substitues et composes associes dotes d'une activite antivirale dirigee contre le vih et le vhc
US20050182252A1 (en) 2004-02-13 2005-08-18 Reddy K. R. Novel 2'-C-methyl nucleoside derivatives
JP4163738B2 (ja) * 2004-06-11 2008-10-08 日本たばこ産業株式会社 癌の治療用の5−アミノ−2,4,7−トリオキソ−3,4,7,8−テトラヒドロ−2H−ピリド’2,3−d!ピリミジン誘導体及び関連化合物
US7378423B2 (en) 2004-06-11 2008-05-27 Japan Tobacco Inc. Pyrimidine compound and medical use thereof
CN101023094B (zh) * 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
CA2574514A1 (fr) 2004-07-27 2006-10-19 Gilead Sciences, Inc. Analogues phosphonates de composes inhibiteurs du vih
BRPI0515279A (pt) 2004-09-14 2008-07-15 Pharmasset Inc preparação de ribofuranosil pirimidinas e purinas 2'fluoro-2'-alquil- substituìdas ou outras opcionalmente substituìdas e seus derivados
AU2006222563A1 (en) * 2005-03-08 2006-09-14 Biota Scientific Management Pty Ltd. Bicyclic nucleosides and nucleotides as therapeutic agents
US7951789B2 (en) * 2006-12-28 2011-05-31 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
AU2008274956B2 (en) * 2007-07-12 2014-08-21 University Of South Florida Inhibitors of Akt/PKB with anti-tumor activity
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
AU2009268681B2 (en) 2008-07-08 2014-10-02 Gilead Sciences, Inc. Salts of HIV inhibitor compounds
CN102325783A (zh) 2008-12-23 2012-01-18 法莫赛特股份有限公司 嘌呤核苷的合成
ES2623016T3 (es) 2008-12-23 2017-07-10 Gilead Pharmasset Llc Fosforamidatos de nucleósido de 2-amino purina 6-O-sustituida
JP6104504B2 (ja) 2008-12-23 2017-03-29 ギリアド ファーマセット エルエルシー ヌクレオシド類似体
MX2011009728A (es) 2009-03-20 2011-10-14 Alios Biopharma Inc Analogos nucleotido y nucleosido sustituidos.
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI598358B (zh) 2009-05-20 2017-09-11 基利法瑪席特有限責任公司 核苷磷醯胺
MX350725B (es) 2010-03-31 2017-09-14 Gilead Pharmasset Llc Fosforamidatos de nucleosido.
PL3290428T3 (pl) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
AU2011305655B2 (en) 2010-09-22 2015-11-05 Alios Biopharma, Inc. Substituted nucleotide analogs
WO2012158197A2 (fr) * 2010-11-11 2012-11-22 Lyndor Biosciences L.L.C. Composés utiles en tant que modulateurs akt/pkb et leurs utilisations
WO2012075140A1 (fr) 2010-11-30 2012-06-07 Pharmasset, Inc. Composés
NZ623396A (en) 2011-09-16 2016-07-29 Gilead Pharmasset Llc Methods for treating hcv
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
WO2013096680A1 (fr) 2011-12-22 2013-06-27 Alios Biopharma, Inc. Analogues de nucléotide phosphorothioate substitués
HUE041509T2 (hu) 2011-12-22 2019-05-28 Janssen Biopharma Inc Szubsztituált nukleozidok, nukleotidok és ezek analógjai
KR102240101B1 (ko) * 2012-03-14 2021-04-14 루핀 리미티드 헤테로사이클릴 화합물
HK1206362A1 (zh) 2012-03-21 2016-01-08 Alios Biopharma, Inc. 硫代氨基磷酸酯核苷酸前藥的固體形式
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2013142157A1 (fr) 2012-03-22 2013-09-26 Alios Biopharma, Inc. Combinaisons pharmaceutiques comprenant un analogue thionucléotidique
PL2861611T3 (pl) 2012-05-25 2017-08-31 Janssen Sciences Ireland Uc Nukleozydy uracylowe spirooksetanu
CN102816197B (zh) * 2012-08-24 2015-04-29 四川大学华西医院 一种新的嘧啶并嘧啶类核苷类似物、制备方法及其形成的超分子结构和应用
WO2014100505A1 (fr) 2012-12-21 2014-06-26 Alios Biopharma, Inc. Nucléosides, nucléotides substitués et leurs analogues
US20140212491A1 (en) 2013-01-31 2014-07-31 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
JP2016529293A (ja) 2013-08-27 2016-09-23 ギリアド ファーマセット エルエルシー 2つの抗ウイルス化合物の組合せ製剤
TW201524990A (zh) 2013-10-11 2015-07-01 Alios Biopharma Inc 經取代之核苷、核苷酸及其類似物
CN106061984A (zh) 2014-02-13 2016-10-26 配体药物公司 前药化合物及其用途
JP2017520545A (ja) 2014-07-02 2017-07-27 リガンド・ファーマシューティカルズ・インコーポレイテッド プロドラッグ化合物およびそれらの使用
SG10201810361TA (en) * 2014-09-26 2018-12-28 Riboscience Llc 4'-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus rna replication
PT3661937T (pt) 2017-08-01 2021-09-24 Gilead Sciences Inc Formas cristalinas de ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-il)-4-fluoro-2,5-dihidrofurano-2-il)oxi)metil)(fenoxi)fosforil)-l-alaninato de etil (gs-9131) para tratamento de infeções virais
CN111788196A (zh) 2018-01-09 2020-10-16 配体药物公司 缩醛化合物及其治疗用途
ES2968459T3 (es) 2018-05-15 2024-05-09 Illumina Inc Composiciones y métodos para escisión química y desprotección de oligonucleótidos unidos a superficie
MA55556A (fr) 2019-04-02 2022-02-09 Aligos Therapeutics Inc Composés ciblant prmt5
CN111995649A (zh) * 2020-04-09 2020-11-27 瀚海新拓(杭州)生物医药有限公司 一种蝶啶酮核苷酸类似物及其药物组合物、制备方法和医药用途
US12252488B2 (en) 2021-02-12 2025-03-18 Nimbus Saturn, Inc. HPK1 antagonists and uses thereof
WO2022187856A1 (fr) 2021-03-05 2022-09-09 Nimbus Saturn, Inc. Antagonistes de hpk1 et leurs utilisations
US12071442B2 (en) 2021-03-29 2024-08-27 Nimbus Saturn, Inc. Substituted pyrrolo[3,4-c]pyridines as HPK1 antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3423398A (en) * 1965-05-10 1969-01-21 Pfizer & Co C Sangivamycin and derivatives thereof
DE3686150T2 (de) * 1985-09-09 1993-03-04 Teijin Ltd Pyridopyrimidin-nukleotid-abkoemmlinge.
US5034393A (en) * 1989-07-27 1991-07-23 Dowelanco Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives

Also Published As

Publication number Publication date
UA72612C2 (en) 2005-03-15
HUP0301614A3 (en) 2005-02-28
HUP0301614A2 (hu) 2003-09-29
EP1303282A4 (fr) 2004-04-07
CZ20024052A3 (cs) 2003-03-12
KR20030032944A (ko) 2003-04-26
WO2002003997A1 (fr) 2002-01-17
NO20030033D0 (no) 2003-01-03
JP2004522694A (ja) 2004-07-29
US7081449B2 (en) 2006-07-25
IL151849A0 (en) 2003-04-10
MXPA02012156A (es) 2004-08-19
EP1303282A1 (fr) 2003-04-23
NZ521457A (en) 2005-03-24
CA2405798A1 (fr) 2002-01-17
AU7367001A (en) 2002-01-21
CN1440292A (zh) 2003-09-03
AU2001273670B2 (en) 2005-07-14
SK112003A3 (en) 2003-04-01
US20030144502A1 (en) 2003-07-31
ZA200208010B (en) 2004-04-28
BR0111531A (pt) 2004-07-06
PL359559A1 (en) 2004-08-23

Similar Documents

Publication Publication Date Title
NO20030033D0 (no) Pyrido[2,3-D]pyrimidin- og pyrimido[4,5-D]pyrimidin- nukleosider
NO20021694L (no) Pyrazolo[4,3-d]pyrimidinderivater
DE69915675D1 (de) Triazolo[4,5-d]pyrimidin-derivate
NO20022738L (no) Pyrrolo(2,3-d)pyrimidinforbindelser
DK1430057T3 (da) Substituerede 2-pyridinyl-6,7,8, 9-tetrahydropyrimido [1,2-a] pyrimidin-4-on- og 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)onderivater
DK1315731T3 (da) 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-on og 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)on-derivater
NO20020931D0 (no) Pyrrolo[2,3-d]pyrimidin-nukleosid-analoger
DE50001191D1 (de) Pyrazolo[4, 3-d]pyrimidine
PL363077A1 (en) Use of pyrazolo[4,3-d]pyrimidines
PL361890A1 (en) Use of pyrazolo[4,3-d]pyrimidines
DE50106542D1 (de) Substituierte 3,4-dihydro-pyrido[1,2-a]pyrimidine
DE50106048D1 (de) Substituierte 3,4-dihydro-pyrimido [1,2-a]pyrimidine und 3,4-dihydropyrazino [1,2-a]pyrimidine
HK1054322A (en) Pyrido[2,3-d] pyrimidine and pyrimido[4,5-d]pyrimidine nucleosides
EP0904271A4 (fr) 5,6,7,8-TETRAHYDROPYRIDO[2,3-d]PYRIMIDINES
DK1326866T3 (da) Substituerede 3,4-dihydro-pyrido[1,2-a]pyrimidiner

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application