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NO20030870L - Bicyclic heterocycles, drugs containing them, their use and the method of preparation thereof - Google Patents

Bicyclic heterocycles, drugs containing them, their use and the method of preparation thereof

Info

Publication number
NO20030870L
NO20030870L NO20030870A NO20030870A NO20030870L NO 20030870 L NO20030870 L NO 20030870L NO 20030870 A NO20030870 A NO 20030870A NO 20030870 A NO20030870 A NO 20030870A NO 20030870 L NO20030870 L NO 20030870L
Authority
NO
Norway
Prior art keywords
preparation
drugs containing
bicyclic heterocycles
heterocycles
bicyclic
Prior art date
Application number
NO20030870A
Other languages
Norwegian (no)
Other versions
NO324866B1 (en
NO20030870D0 (en
Inventor
Frank Himmelsbach
Elke Langkopf
Birgit Jung
Stefan Blech
Flavio Solca
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of NO20030870L publication Critical patent/NO20030870L/en
Publication of NO20030870D0 publication Critical patent/NO20030870D0/en
Publication of NO324866B1 publication Critical patent/NO324866B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20030870A 2000-08-26 2003-02-25 Bicyclic heterocycles, drugs containing them, their use in the manufacture of drugs for the treatment of diseases, and methods for the preparation thereof NO324866B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10042058A DE10042058A1 (en) 2000-08-26 2000-08-26 Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation
PCT/EP2001/009532 WO2002018351A1 (en) 2000-08-26 2001-08-18 Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof

Publications (3)

Publication Number Publication Date
NO20030870L true NO20030870L (en) 2003-02-25
NO20030870D0 NO20030870D0 (en) 2003-02-25
NO324866B1 NO324866B1 (en) 2007-12-17

Family

ID=7653945

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20030870A NO324866B1 (en) 2000-08-26 2003-02-25 Bicyclic heterocycles, drugs containing them, their use in the manufacture of drugs for the treatment of diseases, and methods for the preparation thereof

Country Status (30)

Country Link
EP (1) EP1315705A1 (en)
JP (1) JP4834282B2 (en)
KR (1) KR100862873B1 (en)
CN (1) CN100404517C (en)
AR (1) AR033562A1 (en)
AU (2) AU2001287694B2 (en)
BG (1) BG107559A (en)
BR (1) BR0113519A (en)
CA (1) CA2417897C (en)
CZ (1) CZ302567B6 (en)
DE (1) DE10042058A1 (en)
EA (1) EA005679B1 (en)
EC (1) ECSP034464A (en)
EE (1) EE05269B1 (en)
HR (1) HRP20030138A2 (en)
HU (1) HUP0300819A3 (en)
IL (2) IL154602A0 (en)
ME (1) MEP58708A (en)
MX (1) MXPA03001483A (en)
MY (1) MY126132A (en)
NO (1) NO324866B1 (en)
NZ (1) NZ524668A (en)
PL (1) PL360248A1 (en)
RS (1) RS52279B (en)
SK (1) SK287747B6 (en)
TW (1) TWI294422B (en)
UA (1) UA73004C2 (en)
UY (1) UY26903A1 (en)
WO (1) WO2002018351A1 (en)
ZA (1) ZA200300991B (en)

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MXPA01012899A (en) 1999-06-21 2002-07-30 Boehringer Ingelheim Pharma Bicyclic heterocycles, medicaments containing these compounds, their use and methods for the production thereof.
DE10042059A1 (en) * 2000-08-26 2002-03-07 Boehringer Ingelheim Pharma Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation
US7019012B2 (en) 2000-12-20 2006-03-28 Boehringer Ingelheim International Pharma Gmbh & Co. Kg Quinazoline derivatives and pharmaceutical compositions containing them
TW200813014A (en) * 2002-03-28 2008-03-16 Astrazeneca Ab Quinazoline derivatives
DE10214412A1 (en) * 2002-03-30 2003-10-09 Boehringer Ingelheim Pharma Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and process for their preparation
US6924285B2 (en) 2002-03-30 2005-08-02 Boehringer Ingelheim Pharma Gmbh & Co. Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
MXPA04009536A (en) * 2002-03-30 2005-01-25 Boehringer Ingelheim Pharma 4-(n-phenylamino)-quinazolines / quinolines as tyrosine kinase inhibitors.
US7576074B2 (en) 2002-07-15 2009-08-18 Rice Kenneth D Receptor-type kinase modulators and methods of use
DE10326186A1 (en) 2003-06-06 2004-12-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation
DE10334226A1 (en) * 2003-07-28 2005-02-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of tyrosine kinase inhibitors for the treatment of inflammatory processes
GB0317665D0 (en) 2003-07-29 2003-09-03 Astrazeneca Ab Qinazoline derivatives
ES2305844T3 (en) 2003-09-16 2008-11-01 Astrazeneca Ab DERIVATIVES OF QUINAZOLINE AS INHIBITORS OF THYROSINE KINASE.
DE602004004553T2 (en) 2003-09-19 2007-10-25 Astrazeneca Ab quinazoline derivatives
PL2392565T3 (en) 2003-09-26 2014-08-29 Exelixis Inc c-Met modulators and methods of use
US7456189B2 (en) 2003-09-30 2008-11-25 Boehringer Ingelheim International Gmbh Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation
DE10345875A1 (en) * 2003-09-30 2005-04-21 Boehringer Ingelheim Pharma Bicyclic heterocycles, pharmaceutical compositions containing them, their use and methods of preparation
DE10350717A1 (en) * 2003-10-30 2005-06-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of tyrosine kinase inhibitors for the treatment of inflammatory processes
US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
PE20060777A1 (en) 2004-12-24 2006-10-06 Boehringer Ingelheim Int INDOLINONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES
JP5054544B2 (en) 2005-02-26 2012-10-24 アストラゼネカ アクチボラグ Quinazoline derivatives as tyrosine kinase inhibitors
KR100673775B1 (en) * 2005-04-08 2007-01-24 엘지전자 주식회사 Refrigerator Home Bar
CA2619037A1 (en) * 2005-08-22 2007-03-01 Boehringer Ingelheim International Gmbh Bicyclic heterocycles medicaments comprising said compounds use and method for production thereof
CA2833706C (en) 2005-11-11 2014-10-21 Boehringer Ingelheim International Gmbh Quinazoline derivatives for the treatment of cancer diseases
CA2643363A1 (en) * 2006-03-09 2007-09-13 Boehringer Ingelheim International Gmbh Bicyclic heterocycles, medicaments containing these compounds, their use and process for preparing them
RU2492864C2 (en) 2006-09-18 2013-09-20 Бёрингер Ингельхайм Интернациональ Гмбх Method of treating cancer carrying egfr mutations
EP1921070A1 (en) 2006-11-10 2008-05-14 Boehringer Ingelheim Pharma GmbH & Co. KG Bicyclic heterocycles, medicaments comprising them, their use and process for their preparation
US7998949B2 (en) 2007-02-06 2011-08-16 Boehringer Ingelheim International Gmbh Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof
BRPI0907916A2 (en) 2008-02-07 2015-07-28 Boehringer Ingelheim Int Spirocycle heterocycles, medicaments containing such compounds, and processes for preparing them
WO2009138781A1 (en) 2008-05-13 2009-11-19 Astrazeneca Ab Fumarate salt of 4- (3-chloro-2-fluoroanilino) -7-methoxy-6- { [1- (n-methylcarbamoylmethyl) piperidin- 4-yl] oxy}quinazoline
US8648191B2 (en) 2008-08-08 2014-02-11 Boehringer Ingelheim International Gmbh Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them
TW201920110A (en) 2009-01-16 2019-06-01 美商艾克塞里克斯公司 Containing N-(4-{[6,7-bis(methoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-di Pharmaceutical composition of methotrexate malate and use thereof
LT2451445T (en) 2009-07-06 2019-06-25 Boehringer Ingelheim International Gmbh Process for drying of bibw2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient
UA108618C2 (en) 2009-08-07 2015-05-25 APPLICATION OF C-MET-MODULATORS IN COMBINATION WITH THEMOSOLOMID AND / OR RADIATION THERAPY FOR CANCER TREATMENT
KR101317809B1 (en) 2011-06-07 2013-10-16 한미약품 주식회사 Pharmaceutical composition comprising amide derivative inhibiting the growth of cancer cell and non-metalic salt lubricant
KR20140096571A (en) 2013-01-28 2014-08-06 한미약품 주식회사 Method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one
BR112015020787B1 (en) 2013-03-06 2022-12-06 Astrazeneca Ab 4-(SUBSTITUTED-ANILINE)-6-O-(SUBSTITUTED-PIPERIZINE-CARBONYL)QUINAZOLINIC COMPOUNDS, THEIR SALTS, PHARMACEUTICAL COMPOSITION, USE AND COMBINATION
US9242965B2 (en) 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
DK3126354T3 (en) * 2014-04-04 2020-03-09 H Lundbeck As HALOGENATED QUINAZOLINE-THF AMINES AS PDE1 INHIBITORS
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CN110291104B (en) 2016-11-17 2023-11-03 得克萨斯州大学系统董事会 Compounds with antitumor activity against cancer cells harboring EGFR or HER2 exon 20 mutations
CN112321814B (en) * 2020-12-30 2021-03-23 广州初曲科技有限公司 Preparation and application of gefitinib idebenone conjugate

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GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9624482D0 (en) * 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
BR9707495A (en) * 1996-02-13 1999-07-27 Zeneca Ltd Quinazoline derivative process for the preparation of the same pharmaceutical composition and process for the production of an antiangiogenic effect and / or reduction of vascular permeability in a warm-blooded animal
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
AU719327B2 (en) * 1996-03-05 2000-05-04 Astrazeneca Ab 4-anilinoquinazoline derivatives
NZ332119A (en) * 1996-04-12 2001-08-31 Warner Lambert Co Quinazoline compounds which are irreversible inhibitors of tyrosine kinases
GB9718972D0 (en) * 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
DE19911509A1 (en) * 1999-03-15 2000-09-21 Boehringer Ingelheim Pharma Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation

Also Published As

Publication number Publication date
CA2417897C (en) 2009-03-31
MY126132A (en) 2006-09-29
CN1449390A (en) 2003-10-15
PL360248A1 (en) 2004-09-06
SK287747B6 (en) 2011-08-04
NO324866B1 (en) 2007-12-17
HUP0300819A2 (en) 2003-09-29
AU8769401A (en) 2002-03-13
CA2417897A1 (en) 2003-01-30
AU2001287694B2 (en) 2007-09-06
HUP0300819A3 (en) 2008-03-28
CN100404517C (en) 2008-07-23
EE05269B1 (en) 2010-02-15
YU14003A (en) 2006-01-16
MXPA03001483A (en) 2003-06-06
UA73004C2 (en) 2005-05-16
EP1315705A1 (en) 2003-06-04
ZA200300991B (en) 2004-04-16
BR0113519A (en) 2003-07-01
IL154602A (en) 2008-07-08
UY26903A1 (en) 2002-03-22
NZ524668A (en) 2006-06-30
HRP20030138A2 (en) 2005-04-30
KR100862873B1 (en) 2008-10-15
IL154602A0 (en) 2003-09-17
MEP58708A (en) 2011-05-10
HK1057557A1 (en) 2004-04-08
ECSP034464A (en) 2003-03-31
JP2004507529A (en) 2004-03-11
JP4834282B2 (en) 2011-12-14
CZ302567B6 (en) 2011-07-13
EA005679B1 (en) 2005-04-28
SK2312003A3 (en) 2003-10-07
EE200300077A (en) 2004-12-15
AR033562A1 (en) 2003-12-26
WO2002018351A1 (en) 2002-03-07
EA200300219A1 (en) 2003-08-28
NO20030870D0 (en) 2003-02-25
KR20030024914A (en) 2003-03-26
TWI294422B (en) 2008-03-11
DE10042058A1 (en) 2002-03-07
BG107559A (en) 2003-10-31
RS52279B (en) 2012-10-31

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