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NO20026195L - Substituerte triazolpyrimidiner som anticancermidler - Google Patents

Substituerte triazolpyrimidiner som anticancermidler

Info

Publication number
NO20026195L
NO20026195L NO20026195A NO20026195A NO20026195L NO 20026195 L NO20026195 L NO 20026195L NO 20026195 A NO20026195 A NO 20026195A NO 20026195 A NO20026195 A NO 20026195A NO 20026195 L NO20026195 L NO 20026195L
Authority
NO
Norway
Prior art keywords
anticancer agents
substituted triazole
triazole pyrimidines
pyrimidines
substituted
Prior art date
Application number
NO20026195A
Other languages
English (en)
Other versions
NO20026195D0 (no
Inventor
Mark R Schmitt
Donald R Kirsch
Jane E Harris
Carl F Beyer
Klaus-Juergen Pees
Paul Carter
Waldemar Pfrengle
Guido Albert
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20026195D0 publication Critical patent/NO20026195D0/no
Publication of NO20026195L publication Critical patent/NO20026195L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO20026195A 2000-06-30 2002-12-23 Substituerte triazolpyrimidiner som anticancermidler NO20026195L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21558500P 2000-06-30 2000-06-30
PCT/US2001/020672 WO2002002563A2 (en) 2000-06-30 2001-06-28 Substituted-triazolopyrimidines as anticancer agents

Publications (2)

Publication Number Publication Date
NO20026195D0 NO20026195D0 (no) 2002-12-23
NO20026195L true NO20026195L (no) 2003-02-27

Family

ID=22803554

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20026195A NO20026195L (no) 2000-06-30 2002-12-23 Substituerte triazolpyrimidiner som anticancermidler

Country Status (24)

Country Link
US (1) US7329663B2 (no)
EP (1) EP1307200A2 (no)
JP (1) JP2004502691A (no)
KR (1) KR20030013475A (no)
CN (1) CN1592624A (no)
AR (1) AR034553A1 (no)
AU (2) AU2001273062B2 (no)
BG (1) BG107277A (no)
BR (1) BR0112038A (no)
CA (1) CA2413802A1 (no)
CZ (1) CZ20024150A3 (no)
EA (1) EA006483B1 (no)
GE (1) GEP20053688B (no)
HK (1) HK1052646A1 (no)
HU (1) HUP0300798A3 (no)
IL (1) IL152869A0 (no)
IN (1) IN2003KO00001A (no)
MX (1) MXPA02011913A (no)
NO (1) NO20026195L (no)
NZ (1) NZ523807A (no)
PL (1) PL360027A1 (no)
SK (1) SK18412002A3 (no)
WO (1) WO2002002563A2 (no)
ZA (1) ZA200300793B (no)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6855718B2 (en) * 2000-11-13 2005-02-15 Basf Aktiengesellschaft 7-(r)-aminotriazolopyrimidines, the production thereof and use of the same for combatting phytopathogenic fungi
ATE274518T1 (de) * 2001-04-11 2004-09-15 Basf Ag 6-(2-chlor-6-fluor-phenyl)-triazolpyrimidine
EP1381609B1 (en) * 2001-04-11 2005-01-19 Basf Aktiengesellschaft 5-halogen-6-phenyl-7-fluoroalkylamino-triazolopyrimidines as fungicides
DE10121101A1 (de) * 2001-04-27 2002-10-31 Bayer Ag Triazolopyrimidine
DE10121162A1 (de) * 2001-04-30 2002-10-31 Bayer Ag Triazolopyrimidine
DE10124208A1 (de) † 2001-05-18 2002-11-21 Bayer Ag Verwendung von Triazolopyrimidin-Derivaten als Mikrobizide
PL367621A1 (en) * 2001-07-18 2005-03-07 Basf Aktiengesellschaft Substituted 6-(2-tolyl)-triazolopyrimidines as fungicides
KR20040105772A (ko) * 2002-03-21 2004-12-16 바스프 악티엔게젤샤프트 살진균성 트리아졸로피리미딘, 이의 제조방법 및 유해진균 방제를 위한 이의 용도 및 상기 성분을 함유하는조성물
JPWO2004011467A1 (ja) * 2002-07-29 2005-12-15 北興化学工業株式会社 トリアゾロピリミジン誘導体および農園芸用殺菌剤
UA80304C2 (en) * 2002-11-07 2007-09-10 Basf Ag Substituted 6-(2-halogenphenyl)triazolopyrimidines
KR20050119172A (ko) * 2003-03-31 2005-12-20 바스프 악티엔게젤샤프트 7-알케닐아미노-트리아졸로피리미딘, 그의 제조 방법 및유해 진균류를 방제하기 위한 그의 용도와 상기트리아졸로피리미딘을 함유하는 물질
DE10325133A1 (de) * 2003-06-04 2004-12-23 Bayer Cropscience Ag Triazolopyrimidine
EP1644003A1 (en) * 2003-06-04 2006-04-12 Vernalis (Cambridge) Limited Triazolo ´1,5-a!pyrimidines and their use in medicine
DE10328171A1 (de) * 2003-06-24 2005-01-13 Bayer Cropscience Ag Triazolopyrimidine
DE10328173A1 (de) * 2003-06-24 2005-01-13 Bayer Cropscience Ag Triazolopyrimidine
DE10328481A1 (de) * 2003-06-25 2005-01-13 Bayer Ag Triazolopyrimidine
DK1684763T3 (da) 2003-09-24 2008-09-01 Wyeth Corp 6-Aryl-7-halogen-imidazo(1,2-a)pyrimidiner som anticancermiddel
US7419982B2 (en) 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
DK1680425T3 (da) * 2003-09-24 2007-03-19 Wyeth Corp 6-[(substitueret)phenyl]triazolopyrimidiner som anticancermidler
WO2005037837A1 (ja) * 2003-10-17 2005-04-28 Nippon Kayaku Kabushiki Kaisha 置換２−アミノ−[１，２，４]トリアゾロ[１，５−a]ピリミジン誘導体及びその用途
JP4606015B2 (ja) * 2003-11-25 2011-01-05 日本化薬株式会社 ［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体の新規医薬用途
MY179926A (en) 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
JP2007514680A (ja) * 2003-12-17 2007-06-07 ビーエーエスエフ　アクチェンゲゼルシャフト ６−（２，４，６−トリハロフェニル）トリアゾロピリミジン、その製造方法、および植物病原性真菌類を防除するためのその使用、ならびにその物質を含有している農薬
US20070149588A1 (en) * 2003-12-17 2007-06-28 Tormo I Blasco Jordi 6-(2,3,6-Trifluorophenyl)triazolopyrimidines, their preparation and their use for controlling harmful fungi, and compositions comprising these compounds
BRPI0508717A (pt) * 2004-03-30 2007-08-07 Basf Ag compostos, processo para preparar os mesmos, agente, semente, e, processo para combater fungos nocivos fitopatogênicos
WO2005113555A1 (de) * 2004-05-17 2005-12-01 Basf Aktiengesellschaft Triazolopyrimidin-verbindungen und ihre verwendung zur bekämpfung von schadpilzen
JP2008501754A (ja) * 2004-06-09 2008-01-24 ビーエーエスエフ　アクチェンゲゼルシャフト トリアゾロピリミジン化合物および有害菌類を防除するためのその使用
WO2006000436A1 (de) * 2004-06-25 2006-01-05 Basf Aktiengesellschaft Triazolopyrimidin-verbindungen und ihre verwendung zur bekämpfung von schadpilzen
US20070155738A1 (en) * 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
AU2006251989B2 (en) * 2005-05-20 2010-05-27 Alantos-Pharmaceuticals, Inc. Pyrimidine or triazine fused bicyclic metalloprotease inhibitors
WO2007011759A2 (en) * 2005-07-15 2007-01-25 Kalypsys, Inc. Inhibitors of mitotic kinesin
CA2633962A1 (en) * 2005-12-16 2007-07-05 Wyeth Dimers and adducts of 6-[(substituted) phenyl] triazolopyrimidines useful as anticancer agents
TW200800026A (en) * 2006-02-28 2008-01-01 Basf Ag Substituted 6-phenyl-7-amino-[1,2,4]-triazolo[1,5-a] pyrimidines and their use for controlling harmful fungi
WO2007116011A2 (de) * 2006-04-10 2007-10-18 Basf Se Substituierte triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
JP5231829B2 (ja) * 2007-02-15 2013-07-10 石原産業株式会社 ピリジル−トリアゾロピリミジン誘導体又はその塩、それらを含有する有害生物防除剤並びにそれらの製造方法
AU2008288392B2 (en) 2007-08-14 2013-10-24 Bayer Intellectual Property Gmbh Fused bicyclic pyrimidines
CN103889428A (zh) 2010-10-04 2014-06-25 肝炎与病毒研究所 乙型肝炎病毒抗原分泌的新型抑制剂
BR112014030147B1 (pt) * 2012-06-22 2019-10-15 Sumitomo Chemical Company, Limited Compostos heterocíclicos fundidos, composição e método para controlar pestes
CN103360398B (zh) * 2013-07-22 2015-03-25 山东大学 一种三唑并嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用
GB201504565D0 (en) 2015-03-18 2015-05-06 Takeda Pharmaceutical Novel compounds
KR101995533B1 (ko) * 2017-03-21 2019-07-02 한국화학연구원 [1,2,4]트리아졸로[4,3-a]퀴노잘린 아미노 페닐 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 BET 단백질 관련 질환의 예방 또는 치료용 약학적 조성물
WO2022011171A1 (en) * 2020-07-08 2022-01-13 Klotho Therapeutics, Inc. Novel compounds and methods for increasing klotho gene expression
WO2020159942A1 (en) * 2019-01-29 2020-08-06 Tosk, Inc. Pyrazolopyrimidine modulators of ras gtpase
US12528796B2 (en) 2019-04-15 2026-01-20 Tosk, Inc. Modulators of RAS GTPase
JP7646140B2 (ja) * 2020-04-14 2025-03-17 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 置換された｛１，２，４，｝トリアゾロ｛１，５－ａ｝ピリミジン化合物および微小管の安定化におけるその使用
JP7564888B2 (ja) * 2020-05-01 2024-10-09 ギリアード サイエンシーズ， インコーポレイテッド Ｃｄ７３阻害性２，４－ジオキソピリミジン化合物
US12180220B2 (en) 2020-10-14 2024-12-31 Tosk, Inc. Heteroaryl modulators of RAS GTPase
PE20241186A1 (es) 2021-10-29 2024-06-03 Gilead Sciences Inc Compuestos de cd73
WO2023143194A1 (zh) * 2022-01-25 2023-08-03 瑞石生物医药有限公司 一种ccr4小分子拮抗剂及其用途

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE55956C (de) CH. GROOMBRIDGE und W. A. SOUTH in London, 40 New Bond Street Bremskurbel für Pferdebahn- und andere Wagen
DD55956A (no) *
DE61269C (de) 1891-04-01 1892-03-23 J. NEWBURG in Berlin O., Am Schlesischen Bahnhof Nr. 5 Waschmaschine
JPS5827773B2 (ja) * 1980-02-08 1983-06-11 持田製薬株式会社 癌転移抑制剤
US4444774A (en) * 1982-07-29 1984-04-24 American Cyanamid Company 7-Heteroaryl[1,2,4]triazolo[1,5-a]pyrimidines
GB8719368D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Heterocyclic compounds
JPH02212488A (ja) * 1989-02-13 1990-08-23 Shinichiro Shimizu トリアゾールピリミジン誘導体
US5593996A (en) * 1991-12-30 1997-01-14 American Cyanamid Company Triazolopyrimidine derivatives
US5387747A (en) * 1992-02-24 1995-02-07 Laboratoires Upsa Triazolopyrimidine derivatives which are angiotensin II receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present
IL108747A (en) * 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
GB9321162D0 (en) * 1993-10-13 1993-12-01 Boots Co Plc Therapeutic agents
US5869486A (en) * 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US5948783A (en) * 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6117876A (en) * 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US5994360A (en) * 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
US6020338A (en) * 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
US6165940A (en) * 1998-09-25 2000-12-26 American Cyanamid Co. Non-aqueous suspension concentrate
FR2784380B1 (fr) * 1998-09-25 2002-09-06 American Cyanamid Co Triazolopyrimidines 7-oxy- et 7-thio-substituees fongicides
US6380202B1 (en) * 1998-09-25 2002-04-30 Basf Aktiengesellschaft Fungicidal fluoro-substituted 7-heterocyclyl-triazolopyrimidines
MY125533A (en) * 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
JP2001322933A (ja) * 2000-05-15 2001-11-20 Ucb Sa Ｃｄ４０シグナル遮断剤
DE10121101A1 (de) * 2001-04-27 2002-10-31 Bayer Ag Triazolopyrimidine
DE10121102A1 (de) * 2001-04-27 2002-11-07 Bayer Ag Triazolopyrimidine
DE10121162A1 (de) * 2001-04-30 2002-10-31 Bayer Ag Triazolopyrimidine
US7037902B2 (en) * 2002-07-03 2006-05-02 Receptron, Inc. Affinity small molecules for the EPO receptor
US7419982B2 (en) * 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
DK1680425T3 (da) * 2003-09-24 2007-03-19 Wyeth Corp 6-[(substitueret)phenyl]triazolopyrimidiner som anticancermidler

Also Published As

Publication number Publication date
HUP0300798A3 (en) 2006-02-28
ZA200300793B (en) 2004-07-20
MXPA02011913A (es) 2003-04-22
AU2001273062B2 (en) 2005-11-24
HUP0300798A2 (hu) 2003-07-28
AU7306201A (en) 2002-01-14
EP1307200A2 (en) 2003-05-07
BR0112038A (pt) 2003-04-01
CA2413802A1 (en) 2002-01-10
CN1592624A (zh) 2005-03-09
NO20026195D0 (no) 2002-12-23
WO2002002563A2 (en) 2002-01-10
US20020068744A1 (en) 2002-06-06
GEP20053688B (en) 2005-12-12
NZ523807A (en) 2004-09-24
AR034553A1 (es) 2004-03-03
IL152869A0 (en) 2003-06-24
EA200300091A1 (ru) 2003-08-28
SK18412002A3 (sk) 2003-06-03
IN2003KO00001A (no) 2005-12-02
EA006483B1 (ru) 2005-12-29
JP2004502691A (ja) 2004-01-29
KR20030013475A (ko) 2003-02-14
HK1052646A1 (zh) 2003-09-26
CZ20024150A3 (cs) 2003-09-17
US7329663B2 (en) 2008-02-12
PL360027A1 (en) 2004-09-06
WO2002002563A3 (en) 2003-01-03
BG107277A (bg) 2004-01-30

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