NO20026168L - Hexane derivatives having opioid receptor affinity - Google Patents

Hexane derivatives having opioid receptor affinity

Info

Publication number: NO20026168L
Authority: NO; Norway
Prior art keywords: opioid receptor; receptor affinity; hexane derivatives; hexane; derivatives
Prior art date: 2000-06-23

Application number

NO20026168A

Other languages

Norwegian (no)

Other versions

NO20026168D0 (en

Inventor

Bernard Joseph

Douglas James Critcher

Ashley FENWICK

David Morris Gethin

Stephen Paul Gibson

Graham Lunn

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-23

Filing date

2002-12-20

Publication date

2003-02-18

2002-12-20 Application filed by Pfizer filed Critical Pfizer

2002-12-20 Publication of NO20026168D0 publication Critical patent/NO20026168D0/en

2003-02-18 Publication of NO20026168L publication Critical patent/NO20026168L/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Addiction (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Reproductive Health (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Otolaryngology (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Nutrition Science (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

NO20026168A 2000-06-23 2002-12-20 Hexane derivatives having opioid receptor affinity NO20026168L (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0015562.2A GB0015562D0 (en)	2000-06-23	2000-06-23	Heterocycles
PCT/IB2001/001035 WO2001098267A1 (en)	2000-06-23	2001-06-07	3-azabicyclo (3.1.0) hexane derivatives having opioid receptor affinity

Publications (2)

Publication Number	Publication Date
NO20026168D0 NO20026168D0 (en)	2002-12-20
NO20026168L true NO20026168L (en)	2003-02-18

Family

ID=9894368

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20026168A NO20026168L (en)	2000-06-23	2002-12-20	Hexane derivatives having opioid receptor affinity

Country Status (34)

Country	Link
EP (1)	EP1292574A1 (en)
JP (1)	JP2004512263A (en)
KR (1)	KR20040002386A (en)
CN (1)	CN1639121A (en)
AP (1)	AP2002002698A0 (en)
AR (1)	AR028969A1 (en)
AU (1)	AU781837B2 (en)
BG (1)	BG107329A (en)
BR (1)	BR0111867A (en)
CA (1)	CA2412188A1 (en)
CZ (1)	CZ20023967A3 (en)
DO (1)	DOP2001000187A (en)
DZ (1)	DZ3368A1 (en)
EA (1)	EA005117B1 (en)
GB (1)	GB0015562D0 (en)
HR (1)	HRP20020998A2 (en)
HU (1)	HUP0301228A3 (en)
IL (1)	IL153427A0 (en)
IS (1)	IS6637A (en)
MA (1)	MA26915A1 (en)
MX (1)	MXPA02012878A (en)
NO (1)	NO20026168L (en)
NZ (1)	NZ523141A (en)
OA (1)	OA12293A (en)
PA (1)	PA8519401A1 (en)
PE (1)	PE20020253A1 (en)
PL (1)	PL365956A1 (en)
SK (1)	SK17172002A3 (en)
TN (1)	TNSN01094A1 (en)
UA (1)	UA73176C2 (en)
UY (1)	UY26787A1 (en)
WO (1)	WO2001098267A1 (en)
YU (1)	YU91802A (en)
ZA (1)	ZA200210278B (en)

Families Citing this family (18)

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BR0213464A (en) *	2001-10-22	2004-11-09	Pfizer Prod Inc	3-Azabicyclo [3.1.0] hexane derivatives as opioid receptor antagonists
DK1505974T3 (en) *	2002-05-17	2009-08-17	Tioga Pharmaceuticals Inc	Use of compounds that are effective as selective opiate receptor modulators
DE10259245A1 (en)	2002-12-17	2004-07-01	Merck Patent Gmbh	Derivatives of asimadolin with covalently bound acids
CN1946714B (en) *	2004-02-23	2011-06-15	葛兰素集团有限公司	Azabicyclo (3.1.0) hexane derivatives useful as modulators of dopamine d3 receptors
GB0507680D0 (en)	2005-04-15	2005-05-25	Glaxo Group Ltd	Compounds
US7807698B2 (en)	2005-06-14	2010-10-05	Glaxo Group Limited	Azabicyclo[3.1.0]hexane derivatives as modulators of the dopamine D3 receptor
WO2007113258A1 (en) *	2006-04-03	2007-10-11	Glaxo Group Limited	Azabicyclo [3. 1. o] hexane derivatives as modulators of dopamine d3 receptors
ES2393815T3 (en)	2007-03-30	2012-12-28	Tioga Pharmaceuticals, Inc.	Kappa opioid agonists for the treatment of irritable bowel syndrome with predominant and alternating diarrhea
TWI423801B (en) *	2007-08-27	2014-01-21	Theravance Inc	8-azabicyclo[3.2.1]octyl-2-hydroxybenzamide compounds as mu opioid receptor antagonists
JP5736040B2 (en)	2010-06-11	2015-06-17	ローズテクノロジーズ	Transition metal catalyzed process and its use for the preparation of N-allyl compounds
BR112013007566A2 (en)	2010-09-28	2016-08-02	Panacea Biotec Ltd	new bicyclic compounds
WO2015076310A1 (en) *	2013-11-20	2015-05-28	株式会社三和化学研究所	Novel 3-azabicyclo[3.1.0]hexane derivative and use thereof for medical purposes
MX388953B (en)	2015-05-20	2025-03-20	Ube Industries	NOVEL 3-AZABICICLO[3.1.0]HEXANE DERIVATIVE SALT CRYSTAL AND MEDICATIONAL USES THEREOF.
WO2018152286A1 (en)	2017-02-17	2018-08-23	Trevena, Inc.	7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
KR20190129867A (en) *	2017-02-17	2019-11-20	트레베나, 인코포레이티드.	5-membered aza-heterocycle-containing delta-opioid receptor modulating compounds, and methods of using and preparing the same
KR20190120212A (en)	2017-03-02	2019-10-23	가부시키가이샤산와카가쿠켄큐쇼	Drug of alcohol use disorder
CN108250088B (en) *	2018-01-04	2020-10-30	四川之江高新材料股份有限公司	The preparation method of N,N,N'-trimethyl-N'-hydroxyethyl bisaminoethyl ether
CN115825305B (en) *	2022-10-21	2024-09-20	昆明理工大学	Molecularly imprinted solid-phase microextraction fiber and preparation method and application thereof

Family Cites Families (6)

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Publication number	Priority date	Publication date	Assignee	Title
US3065230A (en) *	1959-03-16	1962-11-20	Burroughs Wellcome Co	Azabicyclohexanes and method of preparing them
NZ224236A (en) *	1987-04-16	1990-08-28	Lilly Co Eli	Trans 3,4 pyridine derivatives and pharmaceutical compositions
US5159081A (en) *	1991-03-29	1992-10-27	Eli Lilly And Company	Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
DE4341403A1 (en) *	1993-12-04	1995-06-08	Basf Ag	N-substituted 3-azabicycloalkane derivatives, their preparation and use
TWI244481B (en) *	1998-12-23	2005-12-01	Pfizer	3-azabicyclo[3.1.0]hexane derivatives useful in therapy
PE20001420A1 (en) *	1998-12-23	2000-12-18	Pfizer	CCR5 MODULATORS

2000
- 2000-06-23 GB GBGB0015562.2A patent/GB0015562D0/en not_active Ceased
2001
- 2001-06-06 DO DO2001000187A patent/DOP2001000187A/en unknown
- 2001-06-07 BR BR0111867-6A patent/BR0111867A/en not_active IP Right Cessation
- 2001-06-07 HU HU0301228A patent/HUP0301228A3/en unknown
- 2001-06-07 AU AU62591/01A patent/AU781837B2/en not_active Ceased
- 2001-06-07 JP JP2002504223A patent/JP2004512263A/en not_active Withdrawn
- 2001-06-07 PL PL01365956A patent/PL365956A1/en not_active Application Discontinuation
- 2001-06-07 CN CNA018116086A patent/CN1639121A/en active Pending
- 2001-06-07 HR HR20020998A patent/HRP20020998A2/en not_active Application Discontinuation
- 2001-06-07 KR KR1020027017503A patent/KR20040002386A/en not_active Ceased
- 2001-06-07 CA CA002412188A patent/CA2412188A1/en not_active Abandoned
- 2001-06-07 EP EP01936728A patent/EP1292574A1/en not_active Withdrawn
- 2001-06-07 CZ CZ20023967A patent/CZ20023967A3/en unknown
- 2001-06-07 IL IL15342701A patent/IL153427A0/en unknown
- 2001-06-07 YU YU91802A patent/YU91802A/en unknown
- 2001-06-07 WO PCT/IB2001/001035 patent/WO2001098267A1/en not_active Ceased
- 2001-06-07 OA OA1200200386A patent/OA12293A/en unknown
- 2001-06-07 AP APAP/P/2002/002698A patent/AP2002002698A0/en unknown
- 2001-06-07 NZ NZ523141A patent/NZ523141A/en unknown
- 2001-06-07 SK SK1717-2002A patent/SK17172002A3/en unknown
- 2001-06-07 EA EA200201269A patent/EA005117B1/en not_active IP Right Cessation
- 2001-06-07 DZ DZ013368A patent/DZ3368A1/en active
- 2001-06-07 MX MXPA02012878A patent/MXPA02012878A/en unknown
- 2001-06-12 PA PA20018519401A patent/PA8519401A1/en unknown
- 2001-06-21 UY UY26787A patent/UY26787A1/en not_active Application Discontinuation
- 2001-06-21 PE PE2001000604A patent/PE20020253A1/en not_active Application Discontinuation
- 2001-06-21 AR ARP010102957A patent/AR028969A1/en unknown
- 2001-06-22 TN TNTNSN01094A patent/TNSN01094A1/en unknown
- 2001-07-06 UA UA20021210406A patent/UA73176C2/en unknown
2002
- 2002-11-28 IS IS6637A patent/IS6637A/en unknown
- 2002-11-28 BG BG107329A patent/BG107329A/en unknown
- 2002-12-16 MA MA26955A patent/MA26915A1/en unknown
- 2002-12-19 ZA ZA200210278A patent/ZA200210278B/en unknown
- 2002-12-20 NO NO20026168A patent/NO20026168L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUP0301228A2 (en)	2003-08-28
PL365956A1 (en)	2005-01-24
BG107329A (en)	2003-07-31
UY26787A1 (en)	2002-01-31
CN1639121A (en)	2005-07-13
JP2004512263A (en)	2004-04-22
PA8519401A1 (en)	2002-12-30
MA26915A1 (en)	2004-12-20
PE20020253A1 (en)	2002-04-08
BR0111867A (en)	2003-07-01
AR028969A1 (en)	2003-05-28
TNSN01094A1 (en)	2005-11-10
WO2001098267A1 (en)	2001-12-27
EP1292574A1 (en)	2003-03-19
HRP20020998A2 (en)	2004-02-29
YU91802A (en)	2006-05-25
NO20026168D0 (en)	2002-12-20
MXPA02012878A (en)	2003-05-14
DOP2001000187A (en)	2002-03-30
OA12293A (en)	2004-03-18
DZ3368A1 (en)	2001-12-27
IS6637A (en)	2002-11-28
ZA200210278B (en)	2003-12-19
UA73176C2 (en)	2005-06-15
AU781837B2 (en)	2005-06-16
NZ523141A (en)	2005-06-24
AU6259101A (en)	2002-01-02
WO2001098267A8 (en)	2003-02-27
IL153427A0 (en)	2003-07-06
GB0015562D0 (en)	2000-08-16
EA200201269A1 (en)	2003-06-26
KR20040002386A (en)	2004-01-07
AP2002002698A0 (en)	2002-12-31
CZ20023967A3 (en)	2004-02-18
SK17172002A3 (en)	2004-09-08
CA2412188A1 (en)	2001-12-27
HUP0301228A3 (en)	2005-08-29
EA005117B1 (en)	2004-10-28

Publication	Publication Date	Title
NO20026168L (en)	2003-02-18	Hexane derivatives having opioid receptor affinity
DE60140155D1 (en)	2009-11-26	Location Dependent Service Deployment
DK1414440T3 (en)	2007-05-21	N-phenylpyrrolguanidine derivatives as melanocortin receptor ligands
DE60227072D1 (en)	2008-07-24	SEAT
DE60218849D1 (en)	2007-04-26	HEADREST ARRANGEMENT
DE50106084D1 (en)	2005-06-09	headrest
DE10196653T1 (en)	2003-08-07	headrest
DE50115672D1 (en)	2010-12-02	bracket
NO20042955L (en)	2004-07-12	Substituted phenylaphthalenes as estrogenic agents
DK1596887T3 (en)	2022-06-20	Polymer-Factor VIII conjugate
DE60231490D1 (en)	2009-04-23	ADJUSTABLE SEAT
NO20032920D0 (en)	2003-06-25	Thinner for invertible emulsions
DK1446379T3 (en)	2009-07-27	Arylanilin-beta2-adrenergic receptor agonists
FI20002173L (en)	2002-04-03	Micromechanical structure
ATE450505T1 (en)	2009-12-15	CB 1 RECEPTOR INVERSAGONISTS
DK1309559T3 (en)	2006-10-02	4-phenyl-pyridine derivatives as neurokinin-1 receptor antagonists
NO20032921D0 (en)	2003-06-25	Thinner for invertible emulsions
NO20032382D0 (en)	2003-05-27	LFA-1 antagonist
DK1440059T3 (en)	2008-07-14	3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists
NO20032142D0 (en)	2003-05-13	Substituted 2-phenylaminoimidazoline-phenylketone derivatives as IP antagonists
IS6704A (en)	2003-01-30	Phenoxybenzylamine derivatives which selectively inhibit serotonin reuptake
DE60209431D1 (en)	2006-04-27	seat structure
DK1305319T3 (en)	2006-08-14	4-phenyl-pyridine derivatives as neurokinin-1 receptor antagonists
DE60219736D1 (en)	2007-06-06	hydrogenation
DE50213154D1 (en)	2009-02-05	SEAT

Legal Events

Date	Code	Title	Description
2006-01-30	FC2A	Withdrawal, rejection or dismissal of laid open patent application