NO20025054L - Oksidasjonsprosess for fremstilling av mellomproduktet 6.alfa., 9.alfa.-difluor-11.beta., 17.alfa.-dihydroksy-16.alfa.-metyl-androst-1,4-dien-3-on 17.beta.-karboksylsyre - Google Patents

Oksidasjonsprosess for fremstilling av mellomproduktet 6.alfa., 9.alfa.-difluor-11.beta., 17.alfa.-dihydroksy-16.alfa.-metyl-androst-1,4-dien-3-on 17.beta.-karboksylsyre

Info

Publication number: NO20025054L
Authority: NO; Norway
Prior art keywords: alpha; beta; preparation; androst; dien
Prior art date: 2000-07-21

Application number

NO20025054A

Other languages

English (en)

Other versions

NO20025054D0 (no

NO324836B1 (no

Inventor

Frederick David Albinson

Steven John Coote

John Malcolm Robinson

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-21

Filing date

2002-10-21

Publication date

2002-11-05

2002-10-21 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2002-10-21 Publication of NO20025054D0 publication Critical patent/NO20025054D0/no

2002-11-05 Publication of NO20025054L publication Critical patent/NO20025054L/no

2007-12-17 Publication of NO324836B1 publication Critical patent/NO324836B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

NO20025054A 2000-07-21 2002-10-21 Fremgangsmate for fremstilling av mellomproduktet 6.alfa., 9.alfa.-difluor-11.beta., 17.alfa.-dihydroksy-16.alfa.-metyl-androst-1,4-dien-3-on 17.beta.-karboksylsyre NO324836B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0017988.7A GB0017988D0 (en)	2000-07-21	2000-07-21	Novel process
PCT/GB2001/003289 WO2002008243A1 (en)	2000-07-21	2001-07-20	Oxidation process for preparing the intermediate 6.alpha.,9.alpha.-difluoro-11.beta.,17.alpha.-dihydroxy-16.alpha.-methyl-androst-1,4-dien-3-one 17.beta.-carboxylic acid

Publications (3)

Publication Number	Publication Date
NO20025054D0 NO20025054D0 (no)	2002-10-21
NO20025054L true NO20025054L (no)	2002-11-05
NO324836B1 NO324836B1 (no)	2007-12-17

Family

ID=9896132

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20025054A NO324836B1 (no)	2000-07-21	2002-10-21	Fremgangsmate for fremstilling av mellomproduktet 6.alfa., 9.alfa.-difluor-11.beta., 17.alfa.-dihydroksy-16.alfa.-metyl-androst-1,4-dien-3-on 17.beta.-karboksylsyre

Country Status (26)

Country	Link
US (1)	US20040043974A1 (no)
EP (1)	EP1301526B1 (no)
JP (1)	JP2004504403A (no)
KR (1)	KR100787293B1 (no)
CN (1)	CN1315864C (no)
AT (1)	ATE398628T1 (no)
AU (2)	AU7090601A (no)
BR (1)	BR0110430A (no)
CA (1)	CA2406963A1 (no)
CY (1)	CY1108553T1 (no)
CZ (1)	CZ302592B6 (no)
DE (1)	DE60134472D1 (no)
DK (1)	DK1301526T3 (no)
ES (1)	ES2307628T3 (no)
GB (1)	GB0017988D0 (no)
HK (1)	HK1056179B (no)
HU (1)	HUP0301108A3 (no)
IL (2)	IL152348A0 (no)
MX (1)	MXPA02010967A (no)
NO (1)	NO324836B1 (no)
NZ (1)	NZ522083A (no)
PL (1)	PL206652B1 (no)
PT (1)	PT1301526E (no)
SI (1)	SI1301526T1 (no)
WO (1)	WO2002008243A1 (no)
ZA (1)	ZA200208372B (no)

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* Cited by examiner, † Cited by third party
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US6777400B2 (en)	2000-08-05	2004-08-17	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
US6787532B2 (en)	2000-08-05	2004-09-07	Smithkline Beecham Corporation	Formulation containing anti-inflammatory androstane derivatives
US6858596B2 (en)	2000-08-05	2005-02-22	Smithkline Beecham Corporation	Formulation containing anti-inflammatory androstane derivative
US6759398B2 (en)	2000-08-05	2004-07-06	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative
GB0019172D0 (en)	2000-08-05	2000-09-27	Glaxo Group Ltd	Novel compounds
US6750210B2 (en)	2000-08-05	2004-06-15	Smithkline Beecham Corporation	Formulation containing novel anti-inflammatory androstane derivative
US6777399B2 (en)	2000-08-05	2004-08-17	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
WO2002012265A1 (en)	2000-08-05	2002-02-14	Glaxo Group Limited	6.ALPHA., 9.ALPHA.-DIFLUORO-17.ALPHA.-`(2-FURANYLCARBOXYL) OXY&excl;-11.BETA.-HYDROXY-16.ALPHA.-METHYL-3-OXO-ANDROST-1,4,-DIENE-17-CARBOTHIOIC ACID S-FLUOROMETHYL ESTER AS AN ANTI-INFLAMMATORY AGENT
US6858593B2 (en)	2000-08-05	2005-02-22	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
UA77656C2 (en)	2001-04-07	2007-01-15	Glaxo Group Ltd	S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
US7291608B2 (en)	2001-04-30	2007-11-06	Glaxo Group Limited	Anti-inflammatory 17.β.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.α
GB2389530B (en)	2002-06-14	2007-01-10	Cipla Ltd	Pharmaceutical compositions
IL150654A (en)	2002-07-09	2006-12-10	Ori Lerman	Method for acid isolation 6α, 9α - difluoro - ß, 17α11 - dihydroxy - 16α - methylfargana - 3 - oxo - 1, 4 - diene - 17ß - carboxylate
JP2006522028A (ja) *	2003-04-04	2006-09-28	アルファーマエーピーエス	ステロイド性カルボチオ酸誘導体の製造方法および中間体
EP1466920A1 (en) *	2003-04-04	2004-10-13	Alpharma APS	Process for the preparation of steroidal 17 beta-carbothioates
EP1526139A1 (en) *	2003-10-24	2005-04-27	S.N.I.F.F. Italia S.P.A.	A process for preparing highly pure androstane 17-beta-carboxylic acids and androstane 17-beta-carbothioic acid fluoromethyl esters
GB0612027D0 (en)	2006-06-16	2006-07-26	Glaxo Group Ltd	Novel process
NO331891B1 (no) *	2007-03-20	2012-04-30	Clavis Pharma Asa	Kjemiske forbindelser, et farmasoytisk preparat inneholdende slike forbindelser, samt anvendelse derav for behandling av kreft, inflammasjon og KOLS
PT105139B (pt) *	2010-06-01	2013-01-29	Hovione Farmaciencia S A	Método para a monofluorometilação de substratos orgânicos para preparação de compostos orgânicos biologicamente activos
JP2013536835A (ja)	2010-09-01	2013-09-26	カディラ・ヘルスケア・リミテッド	プロピオン酸／フロ酸フルチカゾンを調製するための方法

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US3636010A (en) *	1968-12-23	1972-01-18	Ciba Geigy Corp	Esters of steroid-17-carboxylic acids
US4263289A (en) *	1978-04-05	1981-04-21	Syntex (U.S.A.) Inc.	Thio etianic acid derivatives
NL187577C (nl) *	1978-04-05	1991-11-18	Sibla Srl	3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
US4188385A (en) *	1978-04-05	1980-02-12	Syntex (U.S.A.) Inc.	Thioetianic acid derivatives
US4198336A (en) *	1978-04-05	1980-04-15	Syntex (U.S.A.) Inc.	Chemical process for preparing androsta-4-ene 17α-carboxylic acids
CY1291A (en) *	1980-02-15	1985-10-18	Glaxo Group Ltd	Androstane 17 beta carbothioates
US5646136A (en) *	1994-01-04	1997-07-08	Duke University	Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids
US6197761B1 (en) *	1995-12-29	2001-03-06	Glaxo Wellcome Inc.	17β-2-oxo-tetrahydrofuranyl)-carbothioic acid ester, -carboxylic acid ester and -carboxylic acid amide androstane derivatives
US20020133032A1 (en) *	2000-02-25	2002-09-19	Jufang Barkalow	Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods
CZ20023320A3 (cs) *	2000-04-04	2003-04-16	Celanese International Corporation	Prostředek pro tvorbu povlaku
US6777400B2 (en) *	2000-08-05	2004-08-17	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions

2000
- 2000-07-21 GB GBGB0017988.7A patent/GB0017988D0/en not_active Ceased
2001
- 2001-07-20 WO PCT/GB2001/003289 patent/WO2002008243A1/en not_active Ceased
- 2001-07-20 AT AT01949791T patent/ATE398628T1/de active
- 2001-07-20 AU AU7090601A patent/AU7090601A/xx active Pending
- 2001-07-20 NZ NZ522083A patent/NZ522083A/en not_active IP Right Cessation
- 2001-07-20 CZ CZ20023472A patent/CZ302592B6/cs not_active IP Right Cessation
- 2001-07-20 HK HK03106680.9A patent/HK1056179B/en not_active IP Right Cessation
- 2001-07-20 ES ES01949791T patent/ES2307628T3/es not_active Expired - Lifetime
- 2001-07-20 CA CA002406963A patent/CA2406963A1/en not_active Abandoned
- 2001-07-20 PT PT01949791T patent/PT1301526E/pt unknown
- 2001-07-20 CN CNB018114407A patent/CN1315864C/zh not_active Expired - Fee Related
- 2001-07-20 KR KR1020027014367A patent/KR100787293B1/ko not_active Expired - Fee Related
- 2001-07-20 PL PL359462A patent/PL206652B1/pl not_active IP Right Cessation
- 2001-07-20 EP EP01949791A patent/EP1301526B1/en not_active Expired - Lifetime
- 2001-07-20 HU HU0301108A patent/HUP0301108A3/hu unknown
- 2001-07-20 IL IL15234801A patent/IL152348A0/xx active IP Right Grant
- 2001-07-20 AU AU2001270906A patent/AU2001270906B2/en not_active Ceased
- 2001-07-20 US US10/333,537 patent/US20040043974A1/en not_active Abandoned
- 2001-07-20 SI SI200130851T patent/SI1301526T1/sl unknown
- 2001-07-20 MX MXPA02010967A patent/MXPA02010967A/es active IP Right Grant
- 2001-07-20 DE DE60134472T patent/DE60134472D1/de not_active Expired - Lifetime
- 2001-07-20 DK DK01949791T patent/DK1301526T3/da active
- 2001-07-20 BR BR0110430-6A patent/BR0110430A/pt not_active Application Discontinuation
- 2001-07-20 JP JP2002514148A patent/JP2004504403A/ja active Pending
2002
- 2002-10-17 IL IL152348A patent/IL152348A/en not_active IP Right Cessation
- 2002-10-17 ZA ZA200208372A patent/ZA200208372B/en unknown
- 2002-10-21 NO NO20025054A patent/NO324836B1/no not_active IP Right Cessation
2008
- 2008-09-03 CY CY20081100942T patent/CY1108553T1/el unknown

Also Published As

Publication number	Publication date
HK1056179A1 (en)	2004-02-06
NO20025054D0 (no)	2002-10-21
JP2004504403A (ja)	2004-02-12
HUP0301108A2 (hu)	2003-08-28
CA2406963A1 (en)	2002-01-31
PL359462A1 (en)	2004-08-23
CZ302592B6 (cs)	2011-07-27
IL152348A (en)	2008-08-07
GB0017988D0 (en)	2000-09-13
EP1301526B1 (en)	2008-06-18
HUP0301108A3 (en)	2008-04-28
DK1301526T3 (da)	2008-10-06
PT1301526E (pt)	2008-09-09
ATE398628T1 (de)	2008-07-15
CN1437610A (zh)	2003-08-20
CY1108553T1 (el)	2014-04-09
NZ522083A (en)	2004-06-25
AU2001270906B2 (en)	2005-10-13
KR100787293B1 (ko)	2007-12-20
EP1301526A1 (en)	2003-04-16
DE60134472D1 (de)	2008-07-31
MXPA02010967A (es)	2003-03-27
BR0110430A (pt)	2003-07-08
IL152348A0 (en)	2003-05-29
AU7090601A (en)	2002-02-05
SI1301526T1 (sl)	2008-10-31
ES2307628T3 (es)	2008-12-01
ZA200208372B (en)	2004-02-11
HK1056179B (en)	2009-07-17
CZ20023472A3 (cs)	2003-04-16
KR20030028736A (ko)	2003-04-10
NO324836B1 (no)	2007-12-17
PL206652B1 (pl)	2010-09-30
WO2002008243A1 (en)	2002-01-31
US20040043974A1 (en)	2004-03-04
CN1315864C (zh)	2007-05-16

Publication	Publication Date	Title
NO20025054D0 (no)	2002-10-21	Oksidasjonsprosess for fremstilling av mellomproduktet 6.alfa., 9.alfa.-difluor-11.beta., 17.alfa.-dihydroksy-16.alfa.-metyl-androst-1,4-dien-3-on 17.beta.-karboksylsyre
BG105457A (en)	2001-12-29	Method for the preparation of citalopram
CO4970765A1 (es)	2000-11-07	Composiciones de bajo ph que contienen acido para el cuidado personal que exhiben picazon reducida
BR0314227A (pt)	2005-10-25	Derivados de amido de hidroxialquila
MXPA04000634A (es)	2004-04-20	Barra de detergente mejorada y un proceso para fabricacion.
ATE242183T1 (de)	2003-06-15	Glaszusammensetzung zur vermeidung der alkali- kiesel-kieselsäure reaktion
PL367298A1 (en)	2005-02-21	Process for the production of beraprost and its salts
BG106939A (en)	2003-03-31	Method for the preparation of citalopram
TR199800624T1 (xx)	1998-06-22	Yeni 5-0- deosaminil 6-0-metil eritronolid a t�revleri, bunlar�n kullan�m�.
BR0213814A (pt)	2004-10-19	Processos para a fabricação de 3-hidroxi-n, 1,6-trialquil-4-oxo-1, 4-diidro piridino-2-carboxamida
ATE266618T1 (de)	2004-05-15	Verfahren zur herstellung von zwischenprodukten für pestizide
DE502005008867D1 (de)	2010-03-04	Verfahren zur herstellung von 2,5-dimethylphenylessigsäure
JO2433B1 (en)	2008-04-17	Preparation of heterocyclic lindane landscapes
ATE299862T1 (de)	2005-08-15	Verfahren zur herstellung von ketiminen
ATE257145T1 (de)	2004-01-15	Verfahren zur herstellung von isobornylmethacrylat
EA200300400A1 (ru)	2003-10-30	17α-ФТОРАЛКИЛСТЕРОИДЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И СОДЕРЖАЩИЕ ЭТИ СОЕДИНЕНИЯ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ
ATE277051T1 (de)	2004-10-15	Verfahren zur herstellung von debromohymenialdisin und deren analogen
DE60204014D1 (de)	2005-06-09	Chlormethylierung von thiophene
CN105646251B (zh)	2017-12-15	一种曲马胺化合物及其合成方法
ES8704895A1 (es)	1987-04-16	Un metodo para preparar 1-aminoalquilamino-4-ariloxipiperidinas sustituidas
ATE247632T1 (de)	2003-09-15	Verfahren zur herstellung von cyanessigsäureestern
HU0001287D0 (en)	2000-06-28	New intermediate and process for its production
WO2003029267A3 (es)	2003-06-19	PROCEDIMIENTO PARA LA OBTENCION DE 17β-(SUSTITUIDO)-3-OXO-Δ1,2-4-AZAESTEROIDES E INTERMEDIOS
JPS55147234A (en)	1980-11-17	Preparation of (+)-2-isopropyl-5-methyl-cyclohexanone
DK0474666T3 (da)	1995-02-06	Oxidativ fremstilling af A-nor-17-beta-carboxy-3,5-seco-androstan-5-on-syre

Legal Events

Date	Code	Title	Description
2014-02-24	MM1K	Lapsed by not paying the annual fees