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NO20022320D0 - Spiro(2H-1-benzopyran-2,4'-piperidin)derivater som glycin- transport-inhibitorer - Google Patents

Spiro(2H-1-benzopyran-2,4'-piperidin)derivater som glycin- transport-inhibitorer

Info

Publication number
NO20022320D0
NO20022320D0 NO20022320A NO20022320A NO20022320D0 NO 20022320 D0 NO20022320 D0 NO 20022320D0 NO 20022320 A NO20022320 A NO 20022320A NO 20022320 A NO20022320 A NO 20022320A NO 20022320 D0 NO20022320 D0 NO 20022320D0
Authority
NO
Norway
Prior art keywords
benzopyran
spiro
piperidine
derivatives
transport inhibitors
Prior art date
Application number
NO20022320A
Other languages
English (en)
Other versions
NO327743B1 (no
NO20022320L (no
Inventor
Samuel George Gibson
David John Miller
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of NO20022320L publication Critical patent/NO20022320L/no
Publication of NO20022320D0 publication Critical patent/NO20022320D0/no
Publication of NO327743B1 publication Critical patent/NO327743B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20022320A 1999-11-17 2002-05-15 Spiro(2H-1-benzopyran-2,4'-piperidin)derivater som glycin-transport-inhibitorer, samt anvendelse derav og farmasoytisk preparat NO327743B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99309137 1999-11-17
PCT/EP2000/011351 WO2001036423A1 (en) 1999-11-17 2000-11-13 Spiro(2h-1-benzopyran-2,4'-piperidine) derivates as glycine transport inhibitors

Publications (3)

Publication Number Publication Date
NO20022320L NO20022320L (no) 2002-05-15
NO20022320D0 true NO20022320D0 (no) 2002-05-15
NO327743B1 NO327743B1 (no) 2009-09-14

Family

ID=8241739

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20022320A NO327743B1 (no) 1999-11-17 2002-05-15 Spiro(2H-1-benzopyran-2,4'-piperidin)derivater som glycin-transport-inhibitorer, samt anvendelse derav og farmasoytisk preparat

Country Status (29)

Country Link
US (2) US6645973B1 (no)
EP (1) EP1232160B1 (no)
JP (1) JP4825386B2 (no)
KR (1) KR100776226B1 (no)
CN (1) CN1199974C (no)
AR (1) AR026487A1 (no)
AT (1) ATE398622T1 (no)
AU (1) AU779518B2 (no)
BR (1) BR0015586A (no)
CA (1) CA2389491C (no)
CO (1) CO5261618A1 (no)
CY (1) CY1108339T1 (no)
CZ (1) CZ293920B6 (no)
DE (1) DE60039247D1 (no)
DK (1) DK1232160T3 (no)
ES (1) ES2307536T3 (no)
HK (1) HK1047282B (no)
HU (1) HUP0204162A3 (no)
IL (2) IL149286A0 (no)
NO (1) NO327743B1 (no)
NZ (1) NZ518671A (no)
PE (1) PE20010750A1 (no)
PL (1) PL206071B1 (no)
PT (1) PT1232160E (no)
RU (1) RU2250211C2 (no)
SK (1) SK287040B6 (no)
TW (1) TWI243173B (no)
WO (1) WO2001036423A1 (no)
ZA (1) ZA200203320B (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI243173B (en) * 1999-11-17 2005-11-11 Akzo Nobel Nv Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives
FR2842804B1 (fr) * 2002-07-29 2004-09-03 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
EP1675847B1 (en) * 2003-10-01 2012-12-05 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
ATE499373T1 (de) * 2004-01-08 2011-03-15 Hoffmann La Roche Diazaspiropiperidinderivate
DE602004010186T2 (de) * 2004-01-08 2008-07-03 F. Hoffmann-La Roche Ag Diazaspiropiperidinderivate als inhibitoren von glycintransporter 1 und glycintransporter 2
CA2609972C (en) * 2004-03-22 2013-05-14 Apkarian Technologies Llc Method and compositions for treatment of chronic neuropathic pain
PT1848694E (pt) * 2005-02-07 2010-02-02 Hoffmann La Roche Fenil-metanonas heterocíclicas substituídas, como inibidores do transportador de glicina 1
US7598261B2 (en) * 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
CN101184749B (zh) * 2005-03-31 2012-12-05 阿得罗公司 螺环杂环衍生物及其使用方法
CA2614963C (en) * 2005-07-19 2014-10-07 Merck & Co., Inc. Spirochromanone derivatives as acetyl coenzyme a carboxylase (acc) inhibitors
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
EP2024370A1 (en) * 2006-05-05 2009-02-18 Boehringer Ingelheim International GmbH Spiro- (tho) benzopyran-2, 4' -piperidine-and cyclohexane derivatives as inhibitors of specific cell cycle enzymes
JP4937347B2 (ja) * 2006-06-22 2012-05-23 エフ．ホフマン−ラ ロシュ アーゲー 置換フェニルメタノン誘導体
CA2662115A1 (en) * 2006-09-12 2008-03-20 Adolor Corporation Methods for enhancing cognitive function
TWI366565B (en) 2007-06-06 2012-06-21 Otsuka Pharma Co Ltd Quinolone compound and pharmaceutical composition
KR100888468B1 (ko) * 2007-08-31 2009-03-11 한국화학연구원 항암활성을 갖는1'-알킬피페리딘-4'-스피로-2-6-(아미도)-2ｈ-벤조피란유도체
US20100317679A1 (en) * 2007-09-21 2010-12-16 Ligand Pharmaceuticals, Inc. Substituted aryl-fused spirocyclic amines
RU2358977C1 (ru) * 2008-04-02 2009-06-20 Московская государственная академия тонкой химической технологии им. М.В. Ломоносова Государственное образовательное учреждение высшего профессионального образования 5-формил-замещенные индолиновые спиробензопираны и способ их получения
EP2380595A1 (en) 2010-04-19 2011-10-26 Nlife Therapeutics S.L. Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types
RU2435774C1 (ru) * 2010-07-05 2011-12-10 Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" Этил-2-амино-7,7-диметил-2',5-диоксо-5'-фенил-1',2',5,6,7,8-гексагидроспиро[хромен-4,3'-пиррол]-4'-карбоксилаты и способ их получения
TWI543984B (zh) * 2010-07-09 2016-08-01 艾伯維公司 作為s1p調節劑的螺-哌啶衍生物
US20170143681A1 (en) 2015-11-02 2017-05-25 Apkarian Technologies Llc Methods and compositions for treating pain
CN116621187B (zh) * 2023-07-24 2023-09-22 江苏泓顺硅基半导体科技有限公司 一种用于高温氯化提纯石英砂的设备

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
FR2689509B1 (fr) * 1992-04-01 1994-06-03 Adir Nouveaux derives spiraniques du 3-amino chromane, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
DK78692D0 (da) 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
IL107881A0 (en) * 1992-12-05 1994-04-12 Fisons Corp Furanone derivatives and pharmaceutical compositions containing them
US5698566A (en) * 1993-02-12 1997-12-16 Merck & Co., Inc. Nitrogen-containing spirocycles
US5484923A (en) * 1993-06-10 1996-01-16 Merck & Co., Inc. Process of making spirocycles and analogs thereof
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
GB9421003D0 (en) * 1994-10-18 1994-12-07 Smithkline Beecham Plc Novel compounds
US5654316A (en) 1995-06-06 1997-08-05 Schering Corporation Piperidine derivatives as neurokinin antagonists
WO1997020553A1 (en) 1995-12-07 1997-06-12 Javitt Daniel C Treatment of negative and cognitive symptoms of schizophrenia with glycine uptake antagonists
HUP9600928A3 (en) * 1996-04-10 1999-03-29 Richter Gedeon Vegyeszet Use of spiro[2h-1-benzopyran-2,4'-piperidin]-4(3h)-one derivatives for the preparation of pharmaceutical compositions treating dementia, novel derivatives and process for their preparation
HUP0100815A3 (en) 1996-05-31 2002-11-28 Allelix Neuroscience Inc South Pharmaceutical for treatment of neurological and neuropsychiatric disorders
JP4403212B2 (ja) 1996-05-31 2010-01-27 エヌピーエス ファーマシューティカルズ インコーポレイテッド 神経障害および神経心理学的障害の治療のための製剤学的薬剤
US5919653A (en) 1996-08-20 1999-07-06 Allelix Neuroscience Inc. Nucleic acids encoding a human glycine transporter
AU2030999A (en) 1998-01-09 1999-07-26 Allelix Neuroscience, Inc. Glycine transport inhibitors
TW555757B (en) 1998-07-31 2003-10-01 Akzo Nobel Nv Aminomethylcarboxylic acid derivatives
TWI243173B (en) * 1999-11-17 2005-11-11 Akzo Nobel Nv Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives
AU2001252269A1 (en) * 2000-04-27 2001-11-12 Basilea Pharmaceutica Ag Chromenylmethyl pyrimidinediamines as antibacterial agents

Also Published As

Publication number Publication date
WO2001036423A1 (en) 2001-05-25
SK8432002A3 (en) 2002-10-08
DK1232160T3 (da) 2008-10-06
EP1232160B1 (en) 2008-06-18
SK287040B6 (sk) 2009-10-07
ES2307536T3 (es) 2008-12-01
US7507824B2 (en) 2009-03-24
TWI243173B (en) 2005-11-11
CN1199974C (zh) 2005-05-04
HK1047282B (en) 2008-08-29
CA2389491A1 (en) 2001-05-25
KR100776226B1 (ko) 2007-11-16
JP2003527340A (ja) 2003-09-16
EP1232160A1 (en) 2002-08-21
NO327743B1 (no) 2009-09-14
CZ20021724A3 (cs) 2002-08-14
AU1521901A (en) 2001-05-30
AU779518B2 (en) 2005-01-27
CZ293920B6 (cs) 2004-08-18
CN1390221A (zh) 2003-01-08
US20040029904A1 (en) 2004-02-12
CO5261618A1 (es) 2003-03-31
NO20022320L (no) 2002-05-15
ATE398622T1 (de) 2008-07-15
PT1232160E (pt) 2008-09-30
IL149286A0 (en) 2002-11-10
HK1047282A1 (en) 2003-02-14
IL149286A (en) 2008-08-07
BR0015586A (pt) 2002-07-09
NZ518671A (en) 2003-10-31
PE20010750A1 (es) 2001-07-19
JP4825386B2 (ja) 2011-11-30
PL206071B1 (pl) 2010-06-30
ZA200203320B (en) 2003-08-27
KR20020050287A (ko) 2002-06-26
HUP0204162A3 (en) 2006-01-30
RU2250211C2 (ru) 2005-04-20
US6645973B1 (en) 2003-11-11
HUP0204162A2 (hu) 2003-04-28
CY1108339T1 (el) 2014-02-12
PL355975A1 (en) 2004-05-31
CA2389491C (en) 2010-11-02
AR026487A1 (es) 2003-02-12
DE60039247D1 (de) 2008-07-31

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