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NO20020487L - 2-pyrazoline-5-ones - Google Patents

2-pyrazoline-5-ones

Info

Publication number
NO20020487L
NO20020487L NO20020487A NO20020487A NO20020487L NO 20020487 L NO20020487 L NO 20020487L NO 20020487 A NO20020487 A NO 20020487A NO 20020487 A NO20020487 A NO 20020487A NO 20020487 L NO20020487 L NO 20020487L
Authority
NO
Norway
Prior art keywords
chemical compounds
compounds
pyrazoline
ones
angiogenesis
Prior art date
Application number
NO20020487A
Other languages
Norwegian (no)
Other versions
NO20020487D0 (en
Inventor
Marina Moran Moset
Jose Maria Castellano Berlanga
Isabel F Fernandez
David J Calderwood
Paul Rafferty
Lee Daniel Arnold
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of NO20020487D0 publication Critical patent/NO20020487D0/en
Publication of NO20020487L publication Critical patent/NO20020487L/en

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
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    • A—HUMAN NECESSITIES
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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Abstract

Kjemiske forbindelser som har strukturell formel I og fysiologisk akseptable salter derav, er inhibitorer av serin/treonin- og tyrosinkinaseaktivitet . Flere av tyrosin- kinasene, hvis aktivitet hemmes av disse kjemiske forbindelser, er involvert i angiogene prosesser. Således kan disse kjemiske forbindelser bedre sykdomstilstander hvor angiogenese eller endotelcellehyperprolif eras jon er en faktor. Disse forbindelser kan anvendes for å behandle cancer og hyperproliferative forstyrrelser.Chemical compounds having structural formula I and their physiologically acceptable salts are inhibitors of serine / threonine and tyrosine kinase activity. Several of the tyrosine kinases, whose activity is inhibited by these chemical compounds, are involved in angiogenic processes. Thus, these chemical compounds can improve disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyperproliferative disorders.

NO20020487A 1999-07-30 2002-01-30 2-pyrazoline-5-ones NO20020487L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14656399P 1999-07-30 1999-07-30
PCT/US2000/020628 WO2001009121A2 (en) 1999-07-30 2000-07-28 2-pyrazolin-5-ones_as tyrosine kinase inhibitors

Publications (2)

Publication Number Publication Date
NO20020487D0 NO20020487D0 (en) 2002-01-30
NO20020487L true NO20020487L (en) 2002-03-12

Family

ID=22517965

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20020487A NO20020487L (en) 1999-07-30 2002-01-30 2-pyrazoline-5-ones

Country Status (21)

Country Link
EP (1) EP1218373A2 (en)
JP (1) JP2003506368A (en)
KR (1) KR20020091829A (en)
CN (1) CN1193026C (en)
AR (1) AR032279A1 (en)
AU (1) AU6388900A (en)
BG (1) BG106392A (en)
BR (1) BR0012896A (en)
CA (1) CA2380644A1 (en)
CZ (1) CZ2002302A3 (en)
HK (1) HK1049154A1 (en)
HU (1) HUP0400540A3 (en)
IL (1) IL147757A0 (en)
MX (1) MXPA02001088A (en)
NO (1) NO20020487L (en)
NZ (1) NZ516850A (en)
PL (1) PL354144A1 (en)
SK (1) SK1512002A3 (en)
TR (1) TR200200928T2 (en)
WO (1) WO2001009121A2 (en)
ZA (1) ZA200200477B (en)

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AU6388900A (en) 2001-02-19
WO2001009121A2 (en) 2001-02-08
HUP0400540A3 (en) 2004-09-28
NO20020487D0 (en) 2002-01-30
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SK1512002A3 (en) 2002-11-06
EP1218373A2 (en) 2002-07-03
CA2380644A1 (en) 2001-02-08
BG106392A (en) 2002-12-29
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WO2001009121A3 (en) 2002-05-02
CN1193026C (en) 2005-03-16
BR0012896A (en) 2002-06-18
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CN1377346A (en) 2002-10-30

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