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NO20015536L - FAP-aktiverte anti-tumor-forbindelser - Google Patents

FAP-aktiverte anti-tumor-forbindelser

Info

Publication number
NO20015536L
NO20015536L NO20015536A NO20015536A NO20015536L NO 20015536 L NO20015536 L NO 20015536L NO 20015536 A NO20015536 A NO 20015536A NO 20015536 A NO20015536 A NO 20015536A NO 20015536 L NO20015536 L NO 20015536L
Authority
NO
Norway
Prior art keywords
fap
activated anti
tumor compounds
tumor
compounds
Prior art date
Application number
NO20015536A
Other languages
English (en)
Norwegian (no)
Other versions
NO20015536D0 (no
Inventor
Pilar Garin-Chesa
Martin Lenter
John Edward Park
Stefan Peters
Wolfgang Rettig
Raymond Armand Firestone
Dietmar Leipert
Juergen Mack
Leila A Telan
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of NO20015536D0 publication Critical patent/NO20015536D0/no
Publication of NO20015536L publication Critical patent/NO20015536L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/66—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
    • A61K47/67—Enzyme prodrug therapy, e.g. gene directed enzyme drug therapy [GDEPT] or VDEPT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nanotechnology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO20015536A 1999-05-14 2001-11-13 FAP-aktiverte anti-tumor-forbindelser NO20015536L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13413699P 1999-05-14 1999-05-14
PCT/EP2000/004261 WO2000071571A2 (fr) 1999-05-14 2000-05-11 Composes anti-tumoraux actives par la proteine fap

Publications (2)

Publication Number Publication Date
NO20015536D0 NO20015536D0 (no) 2001-11-13
NO20015536L true NO20015536L (no) 2002-01-10

Family

ID=22461925

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20015536A NO20015536L (no) 1999-05-14 2001-11-13 FAP-aktiverte anti-tumor-forbindelser

Country Status (28)

Country Link
US (1) US6613879B1 (fr)
EP (1) EP1180116A2 (fr)
JP (1) JP3607201B2 (fr)
KR (1) KR20020030270A (fr)
CN (1) CN1213058C (fr)
AR (1) AR033792A1 (fr)
AU (1) AU777521B2 (fr)
BG (1) BG106096A (fr)
BR (1) BR0010564A (fr)
CA (1) CA2369933A1 (fr)
CO (1) CO5170516A1 (fr)
CZ (1) CZ20014097A3 (fr)
EA (1) EA005204B1 (fr)
EE (1) EE200100600A (fr)
HK (1) HK1048642B (fr)
HU (1) HUP0202367A3 (fr)
IL (1) IL145798A0 (fr)
MX (1) MXPA01011401A (fr)
MY (1) MY125939A (fr)
NO (1) NO20015536L (fr)
NZ (1) NZ516075A (fr)
PL (1) PL351680A1 (fr)
SK (1) SK16452001A3 (fr)
TW (1) TWI248444B (fr)
UA (1) UA73506C2 (fr)
WO (1) WO2000071571A2 (fr)
YU (1) YU80901A (fr)
ZA (1) ZA200109151B (fr)

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JP2003526683A (ja) 2000-03-15 2003-09-09 ブリストル−マイヤーズ スクイブ ファーマ カンパニー ペプチダーゼ切断可能な標的抗新生物薬およびそれらの治療への使用
GB0027552D0 (en) * 2000-11-10 2000-12-27 Boehringer Ingelheim Pharma Anti-tumor compounds
GB0027551D0 (en) * 2000-11-10 2000-12-27 Boehringer Ingelheim Pharma Anti-tumor compounds
AU2002314773B2 (en) * 2001-05-09 2008-05-01 Celmed Oncology (Usa), Inc. Peptide deformylase activated prodrugs
US7091186B2 (en) * 2001-09-24 2006-08-15 Seattle Genetics, Inc. p-Amidobenzylethers in drug delivery agents
EP1333033A1 (fr) * 2002-01-30 2003-08-06 Boehringer Ingelheim Pharma GmbH & Co.KG Composés anti-cancéreux activables par l'FAP
US20030211979A1 (en) * 2002-01-30 2003-11-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg FAP-activated anti-tumor compounds
BR0309418A (pt) * 2002-04-18 2007-03-06 Celmed Oncology Usa Inc pró-drogas ativadas por peptìdeos deformilase
US20040033957A1 (en) * 2002-05-10 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg FAP-activated anti-tumor prodrugs
AU2003233238A1 (en) * 2002-05-10 2003-11-11 Boehringer Ingelheim Pharma Gmbh And Co Kg Fap-activated anti-tumor prodrugs
US20040001801A1 (en) * 2002-05-23 2004-01-01 Corvas International, Inc. Conjugates activated by cell surface proteases and therapeutic uses thereof
AU2003290779A1 (en) * 2002-11-14 2004-06-03 Celmed Oncology (Usa), Inc. Peptide deformylase activated prodrugs
GB0310593D0 (en) * 2003-05-08 2003-06-11 Leuven K U Res & Dev Peptidic prodrugs
EP1625122A1 (fr) 2003-05-14 2006-02-15 Takeda San Diego, Inc. Inhibiteurs de dipeptidyl peptidase
US7678909B1 (en) 2003-08-13 2010-03-16 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7169926B1 (en) 2003-08-13 2007-01-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7732446B1 (en) 2004-03-11 2010-06-08 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7687638B2 (en) 2004-06-04 2010-03-30 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
WO2006019965A2 (fr) 2004-07-16 2006-02-23 Takeda San Diego, Inc. Inhibiteurs de la dipeptidyl peptidase
WO2006073167A1 (fr) * 2005-01-07 2006-07-13 Ono Pharmaceutical Co., Ltd. Derives de la pyrrolidine
JP2008545661A (ja) * 2005-05-19 2008-12-18 ジェネンテック・インコーポレーテッド 線維芽細胞活性化タンパク質阻害剤化合物および
EP1963537A4 (fr) * 2005-12-14 2009-11-11 Ludwig Inst For Cancer Res Ltd Procede permettant de diagnostiquer une arthrite rhumatoide par le dosage des synoviocytes de type fibroblastique pour la proteine d'activation des fibroblastes
WO2007087131A2 (fr) * 2006-01-05 2007-08-02 The Johns Hopkins University Promedicaments peptides
WO2007112347A1 (fr) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Inhibiteurs de la dipeptidyl peptidase
WO2008005479A2 (fr) * 2006-07-06 2008-01-10 University Of Wyoming Polymères à charge réversible
WO2008116053A2 (fr) * 2007-03-20 2008-09-25 Trustees Of Tufts College Composés chimiothérapeutiques activés par la protéine fap
JP5781930B2 (ja) * 2008-09-12 2015-09-24 カディラ ファーマシューティカルズ リミテッド 新規なジペプチジルペプチダーゼ（ｄｐ−ｉｖ）化合物
EP2525829A1 (fr) 2010-01-22 2012-11-28 Ascendis Pharma A/S Lieurs de promédicaments à base de dipeptides pour des médicaments à teneur en amine aromatique
DK2525830T3 (en) 2010-01-22 2016-08-15 Ascendis Pharma As DIPEPTID-BASED PRODRUG LINKERS TO ALIFATIC AMINE-CONTAINING MEDICINES
US20150335761A1 (en) * 2012-02-16 2015-11-26 Raymond Firestone Compositions and methods for contraception
CN113476616A (zh) * 2012-12-28 2021-10-08 科比欧尔斯公司 最低毒性的药物前体
CN105121447B (zh) * 2013-04-19 2018-02-02 暨南大学 长春碱类衍生物及其制备方法和应用
LT3066091T (lt) * 2013-11-05 2019-07-10 Astrazeneca Ab Nmda antagonistų pirmtakai
WO2015192124A1 (fr) * 2014-06-13 2015-12-17 Trustees Of Tufts College Agents thérapeutiques activés par fap, et utilisations associées
JP6744826B2 (ja) * 2014-06-13 2020-08-19 バック バイオサイエンシーズ, エルエルシーBach BioSciences, LLC Ｆａｐ活性化治療剤及びそれに関連する使用
CN105524141B (zh) * 2015-11-12 2019-11-26 中山大学 一种FAPa激活式肿瘤诊断多肽磁珠复合物的制备与应用
EP3222292A1 (fr) 2016-03-03 2017-09-27 Heidelberg Pharma GmbH Conjugués d'amanitine
CN107043456B (zh) * 2017-04-19 2019-05-17 川北医学院 对氧环己酮与l-苯丙氨酸氮芥共聚物及其应用
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
CN110128501A (zh) * 2019-05-21 2019-08-16 北京海美源医药科技有限公司 一种靶向fap酶的喜树碱类化合物及其制备方法和应用
CN110128506B (zh) * 2019-05-22 2021-03-30 中国药科大学 一种寡肽及其应用

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FR2546163B1 (fr) * 1983-05-16 1987-10-09 Centre Nat Rech Scient Nouveaux derives acyles hydrosolubles de peptides ou d'amino-acides, leur preparation et leur application
US5047401A (en) * 1985-09-09 1991-09-10 Board Of Regents, The University Of Texas System Use of dipeptide alkyl esters to treat GVHD
ES2053547T3 (es) 1986-07-29 1994-08-01 Sunstar Kk Reactivo para someter a ensayo enfermedades periodontales.
US5776892A (en) * 1990-12-21 1998-07-07 Curative Health Services, Inc. Anti-inflammatory peptides
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
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DE19512484A1 (de) * 1995-04-04 1996-10-17 Bayer Ag Kohlenhydratmodifizierte Cytostatika
EP0855910A4 (fr) 1995-10-18 2000-07-05 Merck & Co Inc Conjugues utiles pour traiter l'adenome prostatique benin
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US5952294A (en) 1996-07-31 1999-09-14 University Of Pittsburgh Of The Commonwealth System Of Higher Education Peptidyl prodrugs and methods of making and using the same
CA2264227A1 (fr) 1996-09-27 1998-04-02 Raymond A. Firestone Promedicaments hydrolysables pour la liberation de medicaments anticancereux dans des cellules metastatiques
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EP1176985A2 (fr) 1999-04-28 2002-02-06 Vectramed, Inc. Conjugues de medicaments polymeres actives par voie enzymatique

Also Published As

Publication number Publication date
CA2369933A1 (fr) 2000-11-30
AU6559100A (en) 2000-12-12
CN1213058C (zh) 2005-08-03
WO2000071571A8 (fr) 2002-03-07
AR033792A1 (es) 2004-01-07
PL351680A1 (en) 2003-06-02
EP1180116A2 (fr) 2002-02-20
HK1048642B (zh) 2005-10-28
HUP0202367A2 (hu) 2002-11-28
IL145798A0 (en) 2002-07-25
TWI248444B (en) 2006-02-01
ZA200109151B (en) 2002-12-17
BG106096A (bg) 2002-05-31
CZ20014097A3 (cs) 2002-02-13
EE200100600A (et) 2003-02-17
KR20020030270A (ko) 2002-04-24
CO5170516A1 (es) 2002-06-27
UA73506C2 (en) 2005-08-15
CN1374969A (zh) 2002-10-16
WO2000071571A3 (fr) 2001-09-07
HUP0202367A3 (en) 2003-10-28
WO2000071571A2 (fr) 2000-11-30
US6613879B1 (en) 2003-09-02
EA200101155A1 (ru) 2002-10-31
HK1048642A1 (en) 2003-04-11
EA005204B1 (ru) 2004-12-30
NO20015536D0 (no) 2001-11-13
AU777521B2 (en) 2004-10-21
JP2003500417A (ja) 2003-01-07
BR0010564A (pt) 2002-02-19
NZ516075A (en) 2004-03-26
YU80901A (sh) 2005-07-19
MXPA01011401A (es) 2002-06-04
SK16452001A3 (sk) 2002-03-05
JP3607201B2 (ja) 2005-01-05
MY125939A (en) 2006-09-29

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