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NO20013856D0 - Eplerenone crystalline form with a high dissolution rate - Google Patents

Eplerenone crystalline form with a high dissolution rate

Info

Publication number
NO20013856D0
NO20013856D0 NO20013856A NO20013856A NO20013856D0 NO 20013856 D0 NO20013856 D0 NO 20013856D0 NO 20013856 A NO20013856 A NO 20013856A NO 20013856 A NO20013856 A NO 20013856A NO 20013856 D0 NO20013856 D0 NO 20013856D0
Authority
NO
Norway
Prior art keywords
crystalline form
dissolution rate
high dissolution
eplerenone crystalline
eplerenone
Prior art date
Application number
NO20013856A
Other languages
Norwegian (no)
Other versions
NO20013856L (en
Inventor
Kathleen P Barton
Thomas Borchardt
Marlon V Carlos
Subhash Desai
Leonard J Ferro
Henry T Gaud
Scott Ganser
Clay R Little
Partha S Mudipalli
Mark A Pietz
Daniel R Pilipauskas
Yuen-Lung L Sing
Glenn L Stahl
Joseph J Wieczorek
Chris Y Yan
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of NO20013856D0 publication Critical patent/NO20013856D0/en
Publication of NO20013856L publication Critical patent/NO20013856L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
NO20013856A 1999-12-08 2001-08-08 Crystalline form of eplerenone with octal dissolution rate NO20013856L (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US16969099P 1999-12-08 1999-12-08
US16968299P 1999-12-08 1999-12-08
US16963999P 1999-12-08 1999-12-08
US16955699P 1999-12-08 1999-12-08
US16980799P 1999-12-08 1999-12-08
US16960899P 1999-12-08 1999-12-08
PCT/US2000/032416 WO2001042272A2 (en) 1999-12-08 2000-12-04 Eplerenone crystalline form exhibiting enhanced dissolution rate

Publications (2)

Publication Number Publication Date
NO20013856D0 true NO20013856D0 (en) 2001-08-08
NO20013856L NO20013856L (en) 2001-10-08

Family

ID=27558585

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20013856A NO20013856L (en) 1999-12-08 2001-08-08 Crystalline form of eplerenone with octal dissolution rate

Country Status (17)

Country Link
EP (1) EP1177204A2 (en)
JP (1) JP2003516414A (en)
KR (1) KR100607923B1 (en)
CN (2) CN1152886C (en)
AU (1) AU784946B2 (en)
BR (1) BR0008057A (en)
CA (1) CA2362669A1 (en)
CO (1) CO5280211A1 (en)
EA (1) EA007934B1 (en)
HU (1) HUP0203032A3 (en)
IL (3) IL144764A0 (en)
MX (1) MXPA01008056A (en)
MY (1) MY131878A (en)
NO (1) NO20013856L (en)
NZ (2) NZ513961A (en)
PE (1) PE20010917A1 (en)
WO (1) WO2001042272A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04009037A (en) * 2002-03-20 2005-01-25 Pharmacia Corp Storage stable eplerenone formulation.
US7235655B2 (en) 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
CA2582496A1 (en) 2007-03-20 2008-09-20 Apotex Pharmachem Inc. Improved process for the preparation and purification of eplerenone
EP2568986B1 (en) 2010-05-10 2016-01-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for the treatment of fluid accumulation in and/ or under the retina
JP6180930B2 (en) 2010-06-16 2017-08-16 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Methods and compositions for stimulating reepithelialization during wound healing processes
ES2846835T3 (en) 2015-10-13 2021-07-29 Inst Nat Sante Rech Med Methods and pharmaceutical compositions for the treatment of choroidal neovascularization
GB201609607D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
ES2973248T3 (en) 2016-07-26 2024-06-19 Inst Nat Sante Rech Med Mineralocorticoid receptor antagonist for the treatment of osteoarthritis
GB201719881D0 (en) 2017-11-29 2018-01-10 Kalvista Pharmaceuticals Ltd Solid forms of plasma kallikrein inhibitor and salts thereof
CN108059648A (en) * 2017-12-30 2018-05-22 合肥久诺医药科技有限公司 A kind of eplerenone solvate and preparation method thereof
US20240366632A1 (en) 2021-08-31 2024-11-07 Institut National de la Santé et de la Recherche Médicale Methods for the treatment of ocular rosacea
WO2023204729A1 (en) * 2022-04-19 2023-10-26 Общество с ограниченной ответственностью "Гелеспон" Pharmaceutical compositions based on a novel substance of 4-[2-(1н-imidazol-4-yl)-ethylcarbamoyl]-butanoic acid and method for producing said substance
CN120754115A (en) * 2025-05-23 2025-10-10 远大医药（中国）有限公司 Eplerenone-containing composition and pharmaceutical preparation, preparation method and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559332A (en) * 1983-04-13 1985-12-17 Ciba Geigy Corporation 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof
PL189459B1 (en) * 1996-12-11 2005-08-31 Searle & Co Processes for preparation of 3-keto-7alpha-alkoxycarbonyl-delta-4,5- steroids and intermediates useful therein
AU778559B2 (en) * 1999-03-05 2004-12-09 G.D. Searle Llc Combination therapy of angiotensin converting enzyme inhibitor and epoxy-steroidal aldosterone antagonist for treatment of cardiovascular disease

Also Published As

Publication number Publication date
CN1557833A (en) 2004-12-29
IL144764A0 (en) 2002-06-30
KR20010112261A (en) 2001-12-20
NO20013856L (en) 2001-10-08
WO2001042272A3 (en) 2001-11-29
WO2001042272A2 (en) 2001-06-14
EP1177204A2 (en) 2002-02-06
HUP0203032A2 (en) 2002-12-28
IL176511A (en) 2007-08-19
EA200100871A1 (en) 2002-04-25
PE20010917A1 (en) 2001-09-10
EA007934B1 (en) 2007-02-27
CA2362669A1 (en) 2001-06-14
AU784946B2 (en) 2006-08-03
IL144764A (en) 2007-08-19
CN1152886C (en) 2004-06-09
BR0008057A (en) 2002-04-23
HK1050536A1 (en) 2003-06-27
WO2001042272A9 (en) 2002-12-12
MY131878A (en) 2007-09-28
KR100607923B1 (en) 2006-08-04
CN1377365A (en) 2002-10-30
HUP0203032A3 (en) 2003-04-28
CO5280211A1 (en) 2003-05-30
NZ513961A (en) 2004-02-27
JP2003516414A (en) 2003-05-13
NZ530028A (en) 2005-08-26
MXPA01008056A (en) 2003-07-21
AU2049201A (en) 2001-06-18

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application