NO20012567L - Azepinoindolderivater, fremstilling og anvendelse derav - Google Patents

Azepinoindolderivater, fremstilling og anvendelse derav

Info

Publication number: NO20012567L
Authority: NO; Norway
Prior art keywords: preparation; azepinoindole derivatives; azepinoindole; derivatives; forms
Prior art date: 1999-09-28

Application number

NO20012567A

Other languages

English (en)

Norwegian (no)

Other versions

NO20012567D0 (no

Inventor

Wilfred Lubisch

Michael Kock

Thomas Hoeger

Sabine Schult

Roland Grandel

Reinhold Mueller

Original Assignee

Basf Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-28

Filing date

2001-05-25

Publication date

2001-06-25

1999-09-28 Priority claimed from DE19946289A external-priority patent/DE19946289A1/de

2000-08-09 Priority claimed from DE10039610A external-priority patent/DE10039610A1/de

2001-05-25 Application filed by Basf Ag filed Critical Basf Ag

2001-05-25 Publication of NO20012567D0 publication Critical patent/NO20012567D0/no

2001-06-25 Publication of NO20012567L publication Critical patent/NO20012567L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO20012567A 1999-09-28 2001-05-25 Azepinoindolderivater, fremstilling og anvendelse derav NO20012567L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19946289A DE19946289A1 (de)	1999-09-28	1999-09-28	Benzodiazepin-Derivate, deren Herstellung und Anwendung
DE10039610A DE10039610A1 (de)	2000-08-09	2000-08-09	Azepinoindol-Derivate, deren Herstellung und Anwendung
PCT/EP2000/009024 WO2001023390A2 (de)	1999-09-28	2000-09-15	Azepinoindol-derivate, deren herstellung und anwendung

Publications (2)

Publication Number	Publication Date
NO20012567D0 NO20012567D0 (no)	2001-05-25
NO20012567L true NO20012567L (no)	2001-06-25

Family

ID=26006691

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20012567A NO20012567L (no)	1999-09-28	2001-05-25	Azepinoindolderivater, fremstilling og anvendelse derav

Country Status (17)

Country	Link
EP (1)	EP1183259A2 (de)
JP (1)	JP2003510328A (de)
KR (1)	KR20010087401A (de)
CN (1)	CN1374961A (de)
AU (1)	AU1271201A (de)
BG (1)	BG105650A (de)
BR (1)	BR0007174A (de)
CA (1)	CA2352194A1 (de)
CZ (1)	CZ20012373A3 (de)
HK (1)	HK1048999A1 (de)
HU (1)	HUP0104917A3 (de)
IL (1)	IL143349A0 (de)
NO (1)	NO20012567L (de)
PL (1)	PL347885A1 (de)
SK (1)	SK8842001A3 (de)
TR (1)	TR200101499T1 (de)
WO (1)	WO2001023390A2 (de)

Families Citing this family (42)

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HRP20010573B1 (en)	1999-01-11	2006-04-30	Agouron Pharmaceuticals	Tricyclic inhibitors of poly(adp-ribose) polymerases
US7151102B2 (en)	2000-10-30	2006-12-19	Kudos Pharmaceuticals Limited	Phthalazinone derivatives
US6887996B2 (en) *	2000-12-01	2005-05-03	Guilford Pharmaceuticals Inc.	Compounds and their use
US7026311B2 (en) *	2002-01-10	2006-04-11	Abbott Gmbh & Co., Kg	Dibenzodiazepine derivatives, their preparation and use
DE60335359D1 (de)	2002-04-30	2011-01-27	Kudos Pharm Ltd	Phthalazinonderivate
US7786344B2 (en)	2002-07-26	2010-08-31	Basf Plant Science Gmbh	Selection method
GB0305681D0 (en)	2003-03-12	2003-04-16	Kudos Pharm Ltd	Phthalazinone derivatives
US7449464B2 (en)	2003-03-12	2008-11-11	Kudos Pharmaceuticals Limited	Phthalazinone derivatives
US7223759B2 (en)	2003-09-15	2007-05-29	Anadys Pharmaceuticals, Inc.	Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds
DK2305221T3 (en)	2003-12-01	2015-08-24	Kudos Pharm Ltd	DNA damage repair inhibitors for the treatment of cancer
US7772271B2 (en)	2004-07-14	2010-08-10	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
US7781478B2 (en)	2004-07-14	2010-08-24	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
US7868037B2 (en)	2004-07-14	2011-01-11	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
MX2007000481A (es)	2004-07-14	2007-03-29	Ptc Therapeutics Inc	Metodos para tratar hepatitis c.
JP2008507518A (ja)	2004-07-22	2008-03-13	ピーティーシーセラピューティクス，インコーポレーテッド	Ｃ型肝炎を治療するためのチエノピリジン
GB0419072D0 (en)	2004-08-26	2004-09-29	Kudos Pharm Ltd	Phthalazinone derivatives
AU2006222012B2 (en)	2005-03-08	2011-03-31	Basf Plant Science Gmbh	Expression enhancing intron sequences
WO2006101937A1 (en)	2005-03-18	2006-09-28	Janssen Pharmaceutica N.V.	Acylhydrazones as kinase modulators
GB0521373D0 (en)	2005-10-20	2005-11-30	Kudos Pharm Ltd	Pthalazinone derivatives
TWI404716B (zh)	2006-10-17	2013-08-11	Kudos Pharm Ltd	酞嗪酮（ｐｈｔｈａｌａｚｉｎｏｎｅ）衍生物
EP2188278A1 (de)	2007-09-14	2010-05-26	AstraZeneca AB	Phthalazinonderivate
AR070221A1 (es)	2008-01-23	2010-03-25	Astrazeneca Ab	Derivados de ftalazinona inhibidores de polimerasas, composiciones farmaceuticas que los contienen y usos de los mismos para prevenir y/o tratar tumores cancerigenos,lesiones isquemicas y otras enfermedades asociadas.
GB0804755D0 (en) *	2008-03-14	2008-04-16	Angeletti P Ist Richerche Bio	Therapeutic compounds
ME02640B (de)	2008-10-07	2017-06-20	Kudos Pharm Ltd	Pharmazeutische formulierung 514
WO2011058367A2 (en)	2009-11-13	2011-05-19	Astrazeneca Ab	Diagnostic test for predicting responsiveness to treatment with poly(adp-ribose) polymerase (parp) inhibitor
WO2011064750A1 (en)	2009-11-27	2011-06-03	Basf Plant Science Company Gmbh	Chimeric endonucleases and uses thereof
BR112012012588B1 (pt)	2009-11-27	2019-03-26	Basf Plant Science Company Gmbh	Endonuclease, método para recombinação homóloga de polinucleotídeos e método para mutação direcionada de polinucleotídeos
AU2010325564A1 (en)	2009-11-27	2012-07-12	Basf Plant Science Company Gmbh	Chimeric endonucleases and uses thereof
JP5813101B2 (ja)	2010-06-04	2015-11-17	アルバニーモレキュラーリサーチ，インコーポレイテッド	グリシントランスポーター−１阻害剤、その作製方法および使用方法
PL3325623T6 (pl)	2015-07-23	2022-05-30	Institut Curie	Zastosowanie skojarzenia cząsteczki dbait i inhibitorów parp do leczenia nowotworu
GB201519573D0 (en)	2015-11-05	2015-12-23	King S College London	Combination
WO2018162439A1 (en)	2017-03-08	2018-09-13	Onxeo	New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule
US20200129476A1 (en)	2017-04-28	2020-04-30	Akribes Biomedical Gmbh	PARP Inhibitor in Combination with a Glucocorticoid and/or Ascorbic Acid and/or a Protein Growth Factor for the Treatment of Impaired Wound Healing
WO2018218025A1 (en) *	2017-05-24	2018-11-29	The Trustees Of The University Of Pennsylvania	Radiolabeled and fluorescent parp inhibitors for imaging and radiotherapy
WO2019175132A1 (en)	2018-03-13	2019-09-19	Onxeo	A dbait molecule against acquired resistance in the treatment of cancer
US11034669B2 (en)	2018-11-30	2021-06-15	Nuvation Bio Inc.	Pyrrole and pyrazole compounds and methods of use thereof
SG11202108399PA (en) *	2019-02-02	2021-09-29	Chia Tai Tianqing Pharmaceutical Group Co Ltd	Indolo heptamyl oxime analogue as parp inhibitor
WO2021018298A1 (zh) *	2019-08-01	2021-02-04	南京明德新药研发有限公司	作为parp抑制剂吲哚并七元酰肟化合物
GB201913030D0 (en)	2019-09-10	2019-10-23	Francis Crick Institute Ltd	Treatment of hr deficient cancer
WO2021148581A1 (en)	2020-01-22	2021-07-29	Onxeo	Novel dbait molecule and its use
TW202214649A (zh) *	2020-07-31	2022-04-16	大陸商正大天晴藥業集團股份有限公司	用作ｐａｒｐ抑制劑的吲哚并七員醯肟類似物的結晶及其製備方法
WO2024261243A1 (en)	2023-06-21	2024-12-26	Hemispherian As	Combination comprising a deoxycytidine derivative and a parp inhibitor for use in a method of treating hr proficient cancer

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Publication number	Priority date	Publication date	Assignee	Title
WO1999011644A1 (en) *	1997-09-03	1999-03-11	Guilford Pharmaceuticals Inc.	Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity
HRP20010573B1 (en) *	1999-01-11	2006-04-30	Agouron Pharmaceuticals	Tricyclic inhibitors of poly(adp-ribose) polymerases
ECSP003637A (es) *	1999-08-31	2002-03-25	Agouron Pharma	Inhibidores triciclicos de poli (adp-ribosa) polimerasas

2000
- 2000-09-15 CZ CZ20012373A patent/CZ20012373A3/cs unknown
- 2000-09-15 JP JP2001526542A patent/JP2003510328A/ja active Pending
- 2000-09-15 PL PL00347885A patent/PL347885A1/xx not_active Application Discontinuation
- 2000-09-15 HK HK03101179.8A patent/HK1048999A1/zh unknown
- 2000-09-15 HU HU0104917A patent/HUP0104917A3/hu unknown
- 2000-09-15 KR KR1020017006614A patent/KR20010087401A/ko not_active Ceased
- 2000-09-15 CA CA002352194A patent/CA2352194A1/en not_active Abandoned
- 2000-09-15 TR TR2001/01499T patent/TR200101499T1/xx unknown
- 2000-09-15 WO PCT/EP2000/009024 patent/WO2001023390A2/de not_active Ceased
- 2000-09-15 BR BR0007174-9A patent/BR0007174A/pt not_active IP Right Cessation
- 2000-09-15 EP EP00974379A patent/EP1183259A2/de not_active Withdrawn
- 2000-09-15 CN CN00802408A patent/CN1374961A/zh active Pending
- 2000-09-15 AU AU12712/01A patent/AU1271201A/en not_active Abandoned
- 2000-09-15 SK SK884-2001A patent/SK8842001A3/sk unknown
- 2000-09-15 IL IL14334900A patent/IL143349A0/xx unknown
2001
- 2001-05-25 NO NO20012567A patent/NO20012567L/no not_active Application Discontinuation
- 2001-06-26 BG BG105650A patent/BG105650A/xx unknown

Also Published As

Publication number	Publication date
CZ20012373A3 (cs)	2002-05-15
HK1048999A1 (zh)	2003-04-25
BR0007174A (pt)	2001-09-04
CA2352194A1 (en)	2001-04-05
IL143349A0 (en)	2002-04-21
BG105650A (en)	2002-02-28
TR200101499T1 (tr)	2002-09-23
WO2001023390A3 (de)	2001-12-27
HUP0104917A2 (hu)	2002-04-29
WO2001023390A2 (de)	2001-04-05
KR20010087401A (ko)	2001-09-15
SK8842001A3 (en)	2002-01-07
NO20012567D0 (no)	2001-05-25
HUP0104917A3 (en)	2002-12-28
AU1271201A (en)	2001-04-30
EP1183259A2 (de)	2002-03-06
JP2003510328A (ja)	2003-03-18
PL347885A1 (en)	2002-04-22
CN1374961A (zh)	2002-10-16

Publication	Publication Date	Title
NO20012567L (no)	2001-06-25	Azepinoindolderivater, fremstilling og anvendelse derav
NO20021379L (no)	2002-03-20	Benzodiazepin-derivater, fremstilling og anvendelse derav
NO20021328L (no)	2002-05-21	Pyrazolopyrimidier som terapeutiske midler
DE60038481D1 (de)	2008-05-15	Kristalline form des (r)-2-äää3-methyl-4-(2,2,2-trifluorethoxy)-2-pyridinylümethylüsulfinylü-1h-benzimidazols
TR200201205T2 (tr)	2002-08-21	N-ikame edilmiş karbamoiloksialkil-azolyum türevleri.
BG106867A (en)	2003-02-28	Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory autoimmune and respiratory diseases
PL377285A1 (pl)	2006-01-23	Podstawione pochodne pirolo-pirazolowe jako inhibitory kinazy
EE200200710A (et)	2004-06-15	Asendatud bitsüklilised derivaadid ebanormaalse rakukasvu raviks
NO20073465L (no)	2002-12-12	Benzotiazol-derivater
TR200200579T2 (tr)	2002-12-23	Amino-tirazolpiridin türevleri.
MA26812A1 (fr)	2004-12-20	Pyrimidine-2,4,6-triones inhibitrices de metalloproteinases
DE60005054D1 (de)	2003-10-09	Chinuclidin-acrylamide
NO20060665L (no)	2006-05-16	N-substituerte pyrazolyl-amidyl-benzimidazolyl C-kit inhibitorer
PT1159279E (pt)	2003-02-28	4-oxo-4,7-di-hidrotieno¬2,3-b\|piridino-5-carboxamidas como agentes antivirais
SG128491A1 (en)	2007-01-30	Heterocyclic sulfonamide inhibitors of beta amyloid production
DK1104420T3 (da)	2003-01-13	Substituerede 1,8-naphthyridin-4(1H)-oner som phosphodiesterase-4-inhibitorer
PT923554E (pt)	2002-07-31	N-benzilpiperidina e derivados tetrahidropiridina
NO990662L (no)	1999-02-12	Trombin-inhibitorer
TR200403436T2 (tr)	2005-03-21	Kristalin 1-metilkarbapenem türevleri.
PE20030061A1 (es)	2003-02-08	1-biaril-1,8-naftiridin-4-ona como inhibidores de fosfodiesterasa-4
MXPA04005809A (es)	2004-09-13	Inhibidores de proteinas quinasas.
IL150357A0 (en)	2002-12-01	Substituted piperazine derivatives as mtp inhibitors
DK1463731T3 (da)	2006-02-13	Dibenzodiazepinderivater, deres fremstilling og anvendelse
NO20006547D0 (no)	2000-12-21	Salter av paroxetine
NO20062202L (no)	2006-07-03	Amidometylsubstituerte 2-(4-sulfonylamino)-3-hydroksy-3,4-dihydro-2H-kromen-6-yl-derivater, fremgangsmate og mellomprodukter for deres fremstilling, og legemidler som inneholder disse forbindelsene

Legal Events

Date	Code	Title	Description
2003-06-02	FC2A	Withdrawal, rejection or dismissal of laid open patent application