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NO20005628L - Fremgangsmåte for utvelgelse av et virus - Google Patents

Fremgangsmåte for utvelgelse av et virus

Info

Publication number
NO20005628L
NO20005628L NO20005628A NO20005628A NO20005628L NO 20005628 L NO20005628 L NO 20005628L NO 20005628 A NO20005628 A NO 20005628A NO 20005628 A NO20005628 A NO 20005628A NO 20005628 L NO20005628 L NO 20005628L
Authority
NO
Norway
Prior art keywords
virus
polypeptide
fusion
selecting
propagating
Prior art date
Application number
NO20005628A
Other languages
English (en)
Other versions
NO20005628D0 (no
NO329172B1 (no
Inventor
Lutz Riechmann
Peter Kristensen
Jean-Luc Jestin
Gregory Paul Winter
Original Assignee
Diversys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9810223.9A external-priority patent/GB9810223D0/en
Priority claimed from GBGB9810228.8A external-priority patent/GB9810228D0/en
Application filed by Diversys Ltd filed Critical Diversys Ltd
Publication of NO20005628D0 publication Critical patent/NO20005628D0/no
Publication of NO20005628L publication Critical patent/NO20005628L/no
Publication of NO329172B1 publication Critical patent/NO329172B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/41—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a Myc-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Control Of Indicators Other Than Cathode Ray Tubes (AREA)
  • Saccharide Compounds (AREA)
  • Circuits Of Receivers In General (AREA)
  • Vehicle Body Suspensions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Air Bags (AREA)
NO20005628A 1998-05-13 2000-11-08 Fremgangsmate for seleksjon av et korrekt foldet fusjonspolypeptid NO329172B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9810223.9A GB9810223D0 (en) 1998-05-13 1998-05-13 Selection system
GBGB9810228.8A GB9810228D0 (en) 1998-05-13 1998-05-13 Selection method
PCT/GB1999/001526 WO1999058655A2 (en) 1998-05-13 1999-05-13 Phage display selection system for folded proteins

Publications (3)

Publication Number Publication Date
NO20005628D0 NO20005628D0 (no) 2000-11-08
NO20005628L true NO20005628L (no) 2001-01-12
NO329172B1 NO329172B1 (no) 2010-09-06

Family

ID=26313668

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20005628A NO329172B1 (no) 1998-05-13 2000-11-08 Fremgangsmate for seleksjon av et korrekt foldet fusjonspolypeptid

Country Status (14)

Country Link
US (2) US7442159B1 (no)
EP (2) EP1078051B1 (no)
JP (2) JP4493846B2 (no)
AT (1) ATE380865T1 (no)
AU (1) AU762814B2 (no)
CA (1) CA2328422A1 (no)
CY (1) CY1107293T1 (no)
DE (1) DE69937735T2 (no)
DK (1) DK1078051T3 (no)
ES (1) ES2299244T3 (no)
GB (1) GB2361237A (no)
NO (1) NO329172B1 (no)
PT (1) PT1078051E (no)
WO (1) WO1999058655A2 (no)

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CA2334170A1 (en) 1998-07-27 2000-02-10 Genentech, Inc. Improved transformation efficiency in phage display through modification of a coat protein
PT1144607E (pt) 1999-07-20 2009-04-22 Morphosys Ag Novos métodos para apresentar (poli)peptídeos/ proteínas em partículas bacteriofágicas através de ligações dissulfureto
JP2003523742A (ja) * 2000-02-03 2003-08-12 ドマンティス リミテッド コンビナトリアルタンパク質ドメイン
GB0019049D0 (en) * 2000-08-04 2000-09-27 Neutec Pharma Plc Combinatorial chemistry method
AU2001277614A1 (en) * 2000-08-07 2002-02-18 Domantis Limited Novel proteins
DE10135039C1 (de) * 2001-07-18 2003-03-13 Nemod Immuntherapie Ag Verfahren zur Isolierung großer Varianzen spezifischer Moleküle für ein Zielmolekül aus Phagemid-Gen-Bibliotheken
CA2525120C (en) 2003-05-14 2013-04-30 Domantis Limited A process for recovering polypeptides that unfold reversibly from a polypeptide repertoire
DE602006010386D1 (en) * 2005-07-08 2009-12-24 Univ Zuerich Phagen-display mittels cotranslationaler translokation von fusionspolypeptiden
GB2428293A (en) * 2005-07-13 2007-01-24 Domantis Ltd Phage display libraries
WO2007010525A2 (en) 2005-07-21 2007-01-25 Aebi Ltd. Methods and compositions for identifying a peptide having an intermolecular interaction with a target of interest
GB0515115D0 (en) 2005-07-22 2005-08-31 Isogenica Ltd Peptide characterisation
CA2655933C (en) * 2006-06-23 2014-09-09 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in cancer
MX2009013137A (es) 2007-06-06 2010-04-30 Domantis Ltd Metodos para seleccionar polipeptidos resistentes a la proteasa.
DK2190987T3 (da) 2007-08-21 2013-02-18 Morphosys Ag Fremgangsmåder til dannelse af disulfidbindinger
DE112008003232T5 (de) 2007-11-30 2011-02-24 Glaxo Group Limited, Greenford Antigen-Bindungskonstrukte
KR20110084280A (ko) 2008-11-03 2011-07-21 알레시아 바이오쎄라퓨틱스 인코포레이티드 종양 항원의 생물 활성을 특이적으로 차단하는 항체
US8685895B2 (en) 2008-12-05 2014-04-01 Carolyn Enever Methods for selecting protease resistant polypeptides
CA2753263A1 (en) 2009-02-24 2010-09-02 Glaxo Group Limited Multivalent and/or multispecific rankl-binding constructs
WO2010097385A1 (en) 2009-02-24 2010-09-02 Glaxo Group Limited Antigen-binding constructs
WO2010097386A1 (en) 2009-02-24 2010-09-02 Glaxo Group Limited Antigen-binding constructs
EA201390611A1 (ru) 2010-11-24 2014-01-30 Глаксо Груп Лимитед Мультиспецифические антигенсвязывающие белки, направленные на hgf
CA2888908A1 (en) 2011-03-31 2012-10-04 Alethia Biotherapeutics Inc. Antibodies against kidney associated antigen 1 and antigen binding fragments thereof
PH12014500220A1 (en) 2011-07-27 2019-03-22 Glaxo Group Ltd Anti-vegf single variable domains fused to fc domains
CA2853576A1 (en) * 2011-10-27 2013-05-02 The Governors Of The University Of Alberta Device and method for bacterial culture and assay
HUE043888T2 (hu) 2012-01-09 2019-09-30 Adc Therapeutics Sa Ágensek tripla negatív emlõrák kezelésére
NZ756892A (en) 2013-09-25 2022-05-27 Cytomx Therapeutics Inc Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof
EP3099319A2 (en) 2014-01-31 2016-12-07 Cytomx Therapeutics Inc. Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof
WO2016074683A1 (en) * 2014-11-11 2016-05-19 Lundorf Pedersen Materials Aps Method for identification of molecules with desired characteristics
MA41374A (fr) 2015-01-20 2017-11-28 Cytomx Therapeutics Inc Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci
WO2016156466A1 (en) * 2015-03-31 2016-10-06 Vhsquared Limited Peptide construct having a protease-cleavable linker
HK1250040A1 (zh) 2015-03-31 2018-11-23 Sorriso Pharmaceuticals, Inc. 多肽
JP7723599B2 (ja) 2018-07-23 2025-08-14 ４８アワー ディスカバリー インコーポレイテッド 遺伝的にコードされた二環式ペプチドライブラリー
CN120248140A (zh) 2018-12-06 2025-07-04 西托姆克斯治疗公司 基质金属蛋白酶可裂解的和丝氨酸或半胱氨酸蛋白酶可裂解的底物及其使用方法
AU2020294980A1 (en) 2019-06-21 2022-02-17 Sorriso Pharmaceuticals, Inc. Polypeptides
CN114008195A (zh) * 2019-06-21 2022-02-01 勃林格殷格翰国际有限公司 控制rna病毒复制和基因表达的新机制

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
WO1990005144A1 (en) 1988-11-11 1990-05-17 Medical Research Council Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
CA2016842A1 (en) 1989-05-16 1990-11-16 Richard A. Lerner Method for tapping the immunological repertoire
US5723286A (en) * 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
GB9015198D0 (en) * 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ES2139598T3 (es) 1990-07-10 2000-02-16 Medical Res Council Procedimientos para la produccion de miembros de parejas de union especifica.
EP1279731B1 (en) * 1991-03-01 2007-05-30 Dyax Corporation Process for the development of binding mini-proteins
DE4122599C2 (de) * 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
US5885793A (en) 1991-12-02 1999-03-23 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage

Also Published As

Publication number Publication date
US8680018B2 (en) 2014-03-25
CA2328422A1 (en) 1999-11-18
US7442159B1 (en) 2008-10-28
DE69937735D1 (de) 2008-01-24
EP1078051B1 (en) 2007-12-12
JP2002514413A (ja) 2002-05-21
PT1078051E (pt) 2008-03-17
WO1999058655A2 (en) 1999-11-18
JP5161865B2 (ja) 2013-03-13
GB2361237A (en) 2001-10-17
AU3941399A (en) 1999-11-29
CY1107293T1 (el) 2012-11-21
JP4493846B2 (ja) 2010-06-30
JP2010148507A (ja) 2010-07-08
EP1950295A1 (en) 2008-07-30
NO20005628D0 (no) 2000-11-08
DE69937735T2 (de) 2008-11-27
WO1999058655A3 (en) 2000-01-27
ES2299244T3 (es) 2008-05-16
GB0026143D0 (en) 2000-12-13
ATE380865T1 (de) 2007-12-15
US20090203542A1 (en) 2009-08-13
AU762814B2 (en) 2003-07-03
NO329172B1 (no) 2010-09-06
EP1078051A2 (en) 2001-02-28
DK1078051T3 (da) 2008-04-07

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