[go: up one dir, main page]

NO20004698L - Quinoksalinoner som serin protease inhibitorer sÕ som faktor XA og trombin - Google Patents

Quinoksalinoner som serin protease inhibitorer sÕ som faktor XA og trombin

Info

Publication number
NO20004698L
NO20004698L NO20004698A NO20004698A NO20004698L NO 20004698 L NO20004698 L NO 20004698L NO 20004698 A NO20004698 A NO 20004698A NO 20004698 A NO20004698 A NO 20004698A NO 20004698 L NO20004698 L NO 20004698L
Authority
NO
Norway
Prior art keywords
quinoxalinones
thrombin
factor
protease inhibitors
serine protease
Prior art date
Application number
NO20004698A
Other languages
English (en)
Other versions
NO20004698D0 (no
Inventor
Kent Alan Berryman
Dennis Michael Downing
Danette Andrea Dudley
Jeremy John Edmunds
Lakshmi Sourirajan Narasimhan
Stephen Taras Rapundalo
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO20004698D0 publication Critical patent/NO20004698D0/no
Publication of NO20004698L publication Critical patent/NO20004698L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
NO20004698A 1998-03-31 2000-09-20 Quinoksalinoner som serin protease inhibitorer sÕ som faktor XA og trombin NO20004698L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8014298P 1998-03-31 1998-03-31
PCT/US1998/026708 WO1999050257A1 (en) 1998-03-31 1998-12-15 Benzoxazinones/benzothiazinones as serine protease inhibitors

Publications (2)

Publication Number Publication Date
NO20004698D0 NO20004698D0 (no) 2000-09-20
NO20004698L true NO20004698L (no) 2000-09-20

Family

ID=22155527

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20004698A NO20004698L (no) 1998-03-31 2000-09-20 Quinoksalinoner som serin protease inhibitorer sÕ som faktor XA og trombin

Country Status (15)

Country Link
US (2) US6509335B1 (no)
EP (1) EP1068191A1 (no)
JP (1) JP2002509925A (no)
KR (1) KR20010042296A (no)
AU (1) AU765223C (no)
BR (1) BR9815784A (no)
CA (1) CA2319551A1 (no)
HU (1) HUP0101699A3 (no)
IL (1) IL137656A0 (no)
IS (1) IS5590A (no)
NO (1) NO20004698L (no)
NZ (1) NZ506985A (no)
PL (1) PL343317A1 (no)
WO (1) WO1999050257A1 (no)
ZA (1) ZA992445B (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291514B1 (en) 1998-02-09 2001-09-18 3-Dimensional Pharmaceuticals, Inc. Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors
AU5671799A (en) * 1999-02-09 2000-08-29 3-Dimensional Pharmaceuticals, Inc. Heteroaryl amidines, methylamidines and guanidines as protease inhibitors
FR2801885B1 (fr) * 1999-12-06 2002-01-11 Adir Nouveaux derives (dihydro)benzoxaziniques et (dihydro) benzothiaziniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2001236606A1 (en) * 2000-02-01 2001-08-14 Cor Therapeutics, Inc. 3,4-dihydro-2h-benzo(1,4)oxazine inhibitors of factor xa
US6777413B2 (en) 2000-02-01 2004-08-17 Millennium Pharmaceuticals, Inc. 2-[1H]-quinolone and 2-[1H]-quinoxalone inhibitors of factor Xa
US7405158B2 (en) 2000-06-28 2008-07-29 Applied Materials, Inc. Methods for depositing tungsten layers employing atomic layer deposition techniques
US6998408B2 (en) 2001-03-23 2006-02-14 Bristol-Myers Squibb Pharma Company 6-5, 6-6, or 6-7 Heterobicycles as factor Xa inhibitors
US6790845B2 (en) 2001-04-09 2004-09-14 Bristol-Myers Squibb Pharma Company Fused heterocyclic inhibitors of factor Xa
US6794385B2 (en) 2001-08-08 2004-09-21 Pharmacia & Upjohn, S.P.A. Benzoxazine derivatives useful as integrin receptor antagonists
US6750215B2 (en) 2001-08-08 2004-06-15 Pharmacia & Upjohn, S.P.A. Substituted benzoxazines as integrin antagonists
US6916398B2 (en) 2001-10-26 2005-07-12 Applied Materials, Inc. Gas delivery apparatus and method for atomic layer deposition
IL162616A0 (en) * 2001-12-28 2005-11-20 Acadia Pharm Inc Tetrahydroquinoline analogues as muscarinic agonists
US6759298B2 (en) * 2002-06-24 2004-07-06 Micron Technology, Inc. Methods of forming an array of flash field effect transistors and circuitry peripheral to such array
HUE025683T2 (hu) 2002-12-03 2016-04-28 Pharmacyclics Llc VIIA faktor inhibitor 2-(2-hidroxi-bifenil-3-il)-1H-benzoimidazol-5-karboxamidin-származékok
TWI289141B (en) 2003-03-11 2007-11-01 Hoffmann La Roche F. Ag. Quinolinone derivatives and uses thereof
CN1859904A (zh) * 2003-10-03 2006-11-08 默克公司 用于治疗阿尔茨海默氏病的苄醚和苄氨基β－分泌酶抑制剂
SI21658A (sl) * 2003-11-28 2005-06-30 Univerza V Ljubljani Antitrombotične učinkovine z dualnim mehanizmom delovanja na osnovi 3,4-dihidro-2H-1,4-benzoksazinskega skeleta
NZ554515A (en) * 2004-10-12 2009-12-24 Glenmark Pharmaceuticals Sa Novel dipeptidyl peptidase IV inhibitors, pharmaceutical compositions containing them, and process for their preparation
WO2006050054A2 (en) * 2004-11-01 2006-05-11 Nuada, Llc Compounds and methods of use thereof
GB0515323D0 (en) * 2005-07-26 2005-08-31 Electrophoretics Ltd Mass labels
US20070197512A1 (en) * 2006-01-27 2007-08-23 Japan Tobacco Inc. Carboxylic Acid Compounds and Use Thereof
WO2011024987A1 (ja) * 2009-08-31 2011-03-03 塩野義製薬株式会社 芳香族縮合へテロ環誘導体およびそれらを含有する医薬組成物
JP2014515029A (ja) * 2011-04-29 2014-06-26 アイカーン・スクール・オブ・メディシン・アト・マウント・シナイ キナーゼ阻害剤
JP6497808B2 (ja) * 2015-06-12 2019-04-10 アグロカネショウ株式会社 １，４−ベンゾチアジン−１，３−ジオン又は−１，１，３−トリオン誘導体およびこれを有効成分とする殺菌剤
BR112022005881A2 (pt) * 2019-10-01 2022-06-21 Molecular Skin Therapeutics Inc Compostos de benzoxazinona como inibidores duplos de klk5/7

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3124577A (en) * 1964-03-10 Hydroxyalkyl cyclic amlno
US3006916A (en) * 1961-10-31 W-dialkylaminoalkyl
US3089872A (en) * 1961-03-31 1963-05-14 Olin Mathieson Benzothiazine and benzothiazepine compounds
US3401166A (en) 1966-08-01 1968-09-10 Squibb & Sons Inc Therapeutically active benzothiazines
GB1174626A (en) * 1967-05-23 1969-12-17 Bellon Labor Sa Roger New Benzoxazine Derivatives
DE2044530A1 (de) 1970-02-04 1971-08-19 VEB Deutsches Hydrierwerk Rodleben, χ 4530 Roßlau Verfahren zur Herstellung basisch substituierter 2,3 Dihydro 1,4 benzoxazm 3 one
US3725403A (en) 1970-10-20 1973-04-03 Squibb & Sons Inc Benzothiazine derivatives
JPS5265280A (en) * 1975-11-26 1977-05-30 Squibb & Sons Inc Benzoxadinones and their production
US4584300A (en) * 1983-02-07 1986-04-22 Santen Pharmaceutical Co., Ltd. Platelet anti-aggregative- and calcium antagonistic -1,4-benzothiazin-3-one derivatives, compositions, and methods of use therefor
JPS60166674A (ja) 1984-02-09 1985-08-29 Santen Pharmaceut Co Ltd ベンゾチアジン誘導体
EP0237573B1 (en) 1985-07-29 1992-01-15 Santen Pharmaceutical Co., Ltd. Novel benzothiazine derivatives
JPH01272524A (ja) 1988-04-21 1989-10-31 Japan Found Cancer Res 癌化学療法剤
JP2886570B2 (ja) 1989-09-29 1999-04-26 エーザイ株式会社 縮合ヘテロ環を有する化合物
US5652237A (en) * 1994-09-09 1997-07-29 Warner-Lambert Company 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes
JP3118380B2 (ja) 1994-09-30 2000-12-18 三洋電機株式会社 光学レンズの焦点調節装置
JPH09227561A (ja) 1996-02-21 1997-09-02 Tanabe Seiyaku Co Ltd キサンチン誘導体
WO1998021186A1 (en) 1996-11-13 1998-05-22 Cephalon, Inc. Benzothiazo and related heterocyclic group-containing cysteine and serine protease inhibitors
US6191127B1 (en) 1997-05-02 2001-02-20 Schering Aktiengesellschaft Substituted heterocycles and their use in medicaments

Also Published As

Publication number Publication date
AU1918399A (en) 1999-10-18
EP1068191A1 (en) 2001-01-17
ZA992445B (en) 1999-10-01
KR20010042296A (ko) 2001-05-25
US6509335B1 (en) 2003-01-21
BR9815784A (pt) 2000-11-21
HUP0101699A3 (en) 2002-05-28
IL137656A0 (en) 2001-10-31
IS5590A (is) 2000-08-18
AU765223C (en) 2004-03-18
JP2002509925A (ja) 2002-04-02
NO20004698D0 (no) 2000-09-20
HUP0101699A2 (hu) 2002-04-29
WO1999050257A1 (en) 1999-10-07
PL343317A1 (en) 2001-08-13
AU765223B2 (en) 2003-09-11
US20030187256A1 (en) 2003-10-02
CA2319551A1 (en) 1999-10-07
NZ506985A (en) 2003-10-31

Similar Documents

Publication Publication Date Title
NO20004698L (no) Quinoksalinoner som serin protease inhibitorer sÕ som faktor XA og trombin
IL137655A0 (en) Quinoxalinones as serine protease inhibitors such as factor xa and thrombin
DE69819349D1 (de) 1-amino-7-isochinolin-derivate als serin protease inhibitoren
NO20012980L (no) Proteaseinhibitorer
ATE264339T1 (de) Serine protease inhibitoren
NO992734L (no) Serin-protease inhibitorer
EP1140871A4 (en) THROMBIN OR FACTOR XA INHIBITORS
NO995433D0 (no) Protease-inhibitorer
NO983688D0 (no) Serin-protease-inhibitorer
NO20011966D0 (no) Serin-protease-inhibitor
NO20004696D0 (no) Kinoloner som serinproteaseinhibitorer
ATE534622T1 (de) Aspartylprotease-inhibitoren
ID16105A (id) Inhibitor-inhibitor serin protease
NO995435D0 (no) Protease-inhibitorer
ATE268781T1 (de) Thrombininhibitoren
NO995268D0 (no) Proteaseinhibitorer
NO995434L (no) Proteaseinhibitorer
DE69714222D1 (de) Serine-protease-inhibitoren
NO20003814D0 (no) Trombininhibitorer
NO20011388L (no) Hydroksamat-inneholdende cystein- og serinproteasehemmere
GB9800817D0 (en) Serine protease inhibitors
ATE282629T1 (de) Thrombininhibitoren
DE60124397D1 (de) Inhibitoren von serinproteasen
DE19882420T1 (de) Serin Protease und örtliche Retinoid Zusammensetzungen
AU2001289932A1 (en) Low molecular serine protease inhibitors comprising polyhydroxy-alkyl and polyhydroxy-cycloalkyl radicals