NO20003828D0 - 2,3,4,5-Tetrahydro-1H- [1,4] -benzodiazepine-3-hydroxamic acids as matrix metalloproteinase inhibitors - Google Patents

2,3,4,5-Tetrahydro-1H- [1,4] -benzodiazepine-3-hydroxamic acids as matrix metalloproteinase inhibitors

Info

Publication number: NO20003828D0
Authority: NO; Norway
Prior art keywords: benzodiazepine; tetrahydro; matrix metalloproteinase; metalloproteinase inhibitors; hydroxamic acids
Prior art date: 1998-01-27

Application number

NO20003828A

Other languages

Norwegian (no)

Other versions

NO20003828L (en

Inventor

Jay Donald Albright

Efren Guillermo Delos Santos

Xuemei Du

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-01-27

Filing date

2000-07-26

Publication date

2000-07-26

2000-07-26 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

2000-07-26 Publication of NO20003828D0 publication Critical patent/NO20003828D0/en

2000-09-26 Publication of NO20003828L publication Critical patent/NO20003828L/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO20003828A 1998-01-27 2000-07-26 2,3,4,5-tetrahydro-1H- [1,4] benzodiazepine-3-hydroxamic acids as matrix metalloproteinase inhibitors NO20003828L (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1437498A	1998-01-27	1998-01-27
PCT/US1999/001325 WO1999037625A1 (en)	1998-01-27	1999-01-22	2,3,4,5-tetrahydro-1h-[1,4]-benzodiazepine-3-hydroxamic acids as matrix metalloproteinase inhibitors

Publications (2)

Publication Number	Publication Date
NO20003828D0 true NO20003828D0 (en)	2000-07-26
NO20003828L NO20003828L (en)	2000-09-26

Family

ID=21765097

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20003828A NO20003828L (en)	1998-01-27	2000-07-26	2,3,4,5-tetrahydro-1H- [1,4] benzodiazepine-3-hydroxamic acids as matrix metalloproteinase inhibitors

Country Status (14)

Country	Link
EP (1)	EP1051407A1 (en)
JP (1)	JP2002501056A (en)
KR (1)	KR20010034406A (en)
CN (1)	CN1293663A (en)
AR (1)	AR017230A1 (en)
AU (1)	AU2240299A (en)
BR (1)	BR9907746A (en)
CA (1)	CA2317546A1 (en)
HU (1)	HUP0100277A3 (en)
IL (1)	IL137162A0 (en)
NO (1)	NO20003828L (en)
PL (1)	PL342045A1 (en)
WO (1)	WO1999037625A1 (en)
ZA (1)	ZA99569B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6458783B1 (en) *	1997-09-29	2002-10-01	Bristol-Myers Squibb Company	Non-imidazole benzodiazepine inhibitors of farnesyl protein transferase
US6544984B1 (en)	1999-01-27	2003-04-08	American Cyanamid Company	2,3,4,5-tetrahydro-1H-(1,4)benzodiazepine-3-hydroxamic acids
AR022423A1 (en) *	1999-01-27	2002-09-04	American Cyanamid Co	COMPOUNDS DERIVED FROM ACIDS 2,3,4,5-TETRAHIDRO-1H- [1,4] BENZODIAZEPINA-3-HYDROXAMICS, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM, AND THE USE OF THEM FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
US6808902B1 (en)	1999-11-12	2004-10-26	Amgen Inc.	Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
US7090830B2 (en)	2001-05-24	2006-08-15	Alexza Pharmaceuticals, Inc.	Drug condensation aerosols and kits
US20070122353A1 (en)	2001-05-24	2007-05-31	Hale Ron L	Drug condensation aerosols and kits
US7766013B2 (en)	2001-06-05	2010-08-03	Alexza Pharmaceuticals, Inc.	Aerosol generating method and device
US7585493B2 (en)	2001-05-24	2009-09-08	Alexza Pharmaceuticals, Inc.	Thin-film drug delivery article and method of use
US7458374B2 (en)	2002-05-13	2008-12-02	Alexza Pharmaceuticals, Inc.	Method and apparatus for vaporizing a compound
CN103232539B (en)	2001-06-26	2015-06-03	安姆根弗里蒙特公司	Antibodies to opgl
PE20030701A1 (en)	2001-12-20	2003-08-21	Schering Corp	COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS
US7540286B2 (en)	2004-06-03	2009-06-02	Alexza Pharmaceuticals, Inc.	Multiple dose condensation aerosol devices and methods of forming condensation aerosols
EP2246086A3 (en)	2004-08-12	2012-11-21	Alexza Pharmaceuticals, Inc.	Aerosol drug delivery device incorporating percussively activated heating unit
ES2594867T3 (en)	2007-03-09	2016-12-23	Alexza Pharmaceuticals, Inc.	Heating unit for use in a drug delivery device
FR2950057B1 (en)	2009-09-17	2011-08-26	Galderma Res & Dev	NOVEL BENZENE CARBOXYLAMIDE COMPOUNDS, PROCESS FOR THEIR SYNTHESIS AND THEIR USE IN MEDICINE AND COSMETICS
FR2950056B1 (en)	2009-09-17	2011-08-26	Galderma Res & Dev	NOVEL BENZENE CARBOXYLAMIDE COMPOUNDS, PROCESS FOR THEIR SYNTHESIS AND THEIR USE IN MEDICINE AND COSMETICS
KR102852740B1 (en)	2018-02-02	2025-08-29	알렉스자 파마스티칼즈, 인크.	Electrical Condensation Aerosol Device
EP3860608A1 (en)	2018-10-04	2021-08-11	INSERM (Institut National de la Santé et de la Recherche Médicale)	Egfr inhibitors for treating keratodermas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0861236B2 (en) *	1995-11-13	2006-08-16	Sanofi-Aventis Deutschland GmbH	Cyclic and heterocyclic n-substituted alpha-iminohydroxamic and carboxylic acids
IL124559A (en) *	1995-12-08	2004-07-25	Agouron Pharma	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical use

1999
- 1999-01-22 KR KR1020007008171A patent/KR20010034406A/en not_active Withdrawn
- 1999-01-22 JP JP2000528549A patent/JP2002501056A/en active Pending
- 1999-01-22 HU HU0100277A patent/HUP0100277A3/en unknown
- 1999-01-22 BR BR9907746-9A patent/BR9907746A/en not_active Application Discontinuation
- 1999-01-22 EP EP99902417A patent/EP1051407A1/en not_active Withdrawn
- 1999-01-22 CA CA002317546A patent/CA2317546A1/en not_active Abandoned
- 1999-01-22 PL PL99342045A patent/PL342045A1/en unknown
- 1999-01-22 AU AU22402/99A patent/AU2240299A/en not_active Abandoned
- 1999-01-22 WO PCT/US1999/001325 patent/WO1999037625A1/en not_active Ceased
- 1999-01-22 IL IL13716299A patent/IL137162A0/en unknown
- 1999-01-22 CN CN99804237A patent/CN1293663A/en active Pending
- 1999-01-26 AR ARP990100299A patent/AR017230A1/en unknown
- 1999-01-26 ZA ZA9900569A patent/ZA99569B/en unknown
2000
- 2000-07-26 NO NO20003828A patent/NO20003828L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2002501056A (en)	2002-01-15
PL342045A1 (en)	2001-05-21
AR017230A1 (en)	2001-08-22
CN1293663A (en)	2001-05-02
NO20003828L (en)	2000-09-26
HUP0100277A3 (en)	2002-03-28
EP1051407A1 (en)	2000-11-15
BR9907746A (en)	2000-10-17
HUP0100277A2 (en)	2002-02-28
AU2240299A (en)	1999-08-09
IL137162A0 (en)	2001-07-24
ZA99569B (en)	2000-07-26
WO1999037625A1 (en)	1999-07-29
CA2317546A1 (en)	1999-07-29
KR20010034406A (en)	2001-04-25

Publication	Publication Date	Title
NO20013675L (en)	2001-09-21	2,3,4,5-tetrahydro-1H- [1,4) benzodiazepine-3-hydroxamic acid as matrix metalloproteinase inhibitors
DK2253620T3 (en)	2014-03-31	SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN-TYROSINKINASE INHIBITORS
DK1114032T3 (en)	2004-08-16	4-Amino-substituted-2-substituted-1,2,3,4-tetrahydroquinolines as CETB inhibitors
TR199501472A2 (en)	1996-07-21	Matrix metalloprotease inhibitors.
DK0925303T3 (en)	2003-02-24	Phosphinic acid amides as matrix metalloprotease inhibitors
ATE227274T1 (en)	2002-11-15	1,3-DIHETEROCYCLIC METALLOPROTEASE INHIBITORS
ID27884A (en)	2001-05-03	INDOLEALANIC ACIDS SUBSTITUTED.
DK1244647T3 (en)	2006-09-25	Quinzoline derivatives as VIGF inhibitors
EE200000720A (en)	2002-04-15	Novel 3-aryl-2-hydroxypropanoic acid derivative (I)
FI965156A7 (en)	1996-12-20	Arylsulfonamido-substituted hydroxamic acids as matrix metalloproteinase inhibitors
DE69914199D1 (en)	2004-02-19	SLOW RUNNING HIGH PRESSURE BOOLER
NO20003828D0 (en)	2000-07-26	2,3,4,5-Tetrahydro-1H- [1,4] -benzodiazepine-3-hydroxamic acids as matrix metalloproteinase inhibitors
EE200200069A (en)	2003-04-15	Pyrimidine-3,4,6-triones which are metalloproteinase inhibitors
DE69934483D1 (en)	2007-02-01	HYDRAULIC DRIVE
DK0934259T3 (en)	2003-01-27	Beta-sulfonamidohydroxamic acids as matrix metalloproteinase and TACE inhibitors
DK0975623T3 (en)	2002-10-14	Indazolamide compounds as sertoninergic agents
DK1023268T3 (en)	2003-06-10	Isoquinolines as urokinase inhibitors.
DK0937036T3 (en)	2002-04-02	Substituted 4-biphenyl-4-hydroxybutyric acid derivatives as matrix metal protease inhibitors
TR199800841A3 (en)	1998-12-21	Substituted 6- and 7-aminotetrahydroisoquinolinecarbon acids.
DK1047665T3 (en)	2004-02-02	Matrix metalloprotease inhibitors
DZ2815A1 (en)	2003-12-01	Protease inhibitors.
ZA974032B (en)	1998-02-19	Substituted oxobutyric acids as matrix metalloproteinases inhibitors.
NO20011654D0 (en)	2001-04-02	Benzamide derivatives as thrombin inhibitors
DK1147095T3 (en)	2004-11-15	2,3,4,5-Tetrahydro-1H- [1,4] benzodiazepine-3-hydroxamic acids as matrix metalloproteinase inhibitors
HK1038013A (en)	2002-03-01	2,3,4,5-tetrahydro-1h-[1,4] benzodiazepine-3-hydroxamic acids as matrix metalloproteinase inhibitors

Legal Events

Date	Code	Title	Description
2001-09-10	FC2A	Withdrawal, rejection or dismissal of laid open patent application