NO20002050D0 - Aggregater av humaninsulinderivater - Google Patents

Aggregater av humaninsulinderivater

Info

Publication number: NO20002050D0
Authority: NO; Norway
Prior art keywords: aggregates; derivatives; human insulin; soluble; insulin derivatives
Prior art date: 1997-10-24

Application number

NO20002050A

Other languages

English (en)

Other versions

NO20002050L (no

Inventor

Svend Havelund

Per Balschmidt

Ib Jonassen

Thomas Hoeg-Jensen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-24

Filing date

2000-04-18

Publication date

2000-04-18

2000-04-18 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2000-04-18 Publication of NO20002050D0 publication Critical patent/NO20002050D0/no

2000-06-23 Publication of NO20002050L publication Critical patent/NO20002050L/no

Links

PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title abstract 2
102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 abstract 1
108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000002523 gelfiltration Methods 0.000 abstract 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

Health & Medical Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Immunology (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Obesity (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NO20002050A 1997-10-24 2000-04-18 Aggregater av humaninsulinderivater NO20002050L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK121897		1997-10-24
US6417097P	1997-11-04	1997-11-04
PCT/DK1998/000461 WO1999021888A1 (en)	1997-10-24	1998-10-23	Aggregates of human insulin derivatives

Publications (2)

Publication Number	Publication Date
NO20002050D0 true NO20002050D0 (no)	2000-04-18
NO20002050L NO20002050L (no)	2000-06-23

Family

ID=26065414

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20002050A NO20002050L (no)	1997-10-24	2000-04-18	Aggregater av humaninsulinderivater

Country Status (20)

Country	Link
EP (1)	EP1025125B1 (no)
JP (1)	JP2003525846A (no)
KR (1)	KR100539193B1 (no)
CN (1)	CN1240718C (no)
AT (1)	ATE243711T1 (no)
AU (1)	AU757933B2 (no)
BR (1)	BR9813128A (no)
CA (1)	CA2308705A1 (no)
DE (1)	DE69815877T2 (no)
DK (1)	DK1025125T3 (no)
ES (1)	ES2202899T3 (no)
HU (1)	HUP0004096A3 (no)
IL (2)	IL135400A0 (no)
NO (1)	NO20002050L (no)
PL (1)	PL195845B1 (no)
PT (1)	PT1025125E (no)
RU (1)	RU2218349C2 (no)
UA (1)	UA69393C2 (no)
WO (1)	WO1999021888A1 (no)
ZA (1)	ZA989722B (no)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7316999B2 (en)	2000-06-02	2008-01-08	Novo Nordisk A/S	Glucose dependent release of insulin from glucose sensing insulin derivatives
BR0209896A (pt)	2001-05-21	2004-08-17	Nektar Therapeutics	Composição de insulina para administração pulmonar, e, métodos para suprir insulina a um indivìduo mamìfero, para prover uma composição de insulina não-imunogênica e uma composição de insulina de efeito prolongado para administração ao pulmão de um indivìduo
US7317000B2 (en)	2001-12-02	2008-01-08	Novo Nordisk A/S	Glucose-dependent insulins
CN101955527B (zh) *	2003-08-05	2016-04-20	诺沃挪第克公司	新型胰岛素衍生物
EP2107069B1 (en) *	2003-08-05	2013-01-16	Novo Nordisk A/S	Novel insulin derivatives
US7872095B2 (en) *	2004-07-19	2011-01-18	Biocon Limited	Insulin-oligomer conjugates, formulations and uses thereof
WO2006125765A2 (en) *	2005-05-26	2006-11-30	Novo Nordisk A/S	Acylated insulin with high purity
PL1969004T3 (pl)	2005-12-28	2012-01-31	Novo Nordisk As	Kompozycje zawierające acylowaną insulinę i cynk oraz sposób wytwarzania tych kompozycji
WO2007096431A1 (en)	2006-02-27	2007-08-30	Novo Nordisk A/S	Insulin derivatives
WO2007140619A1 (en) *	2006-06-08	2007-12-13	Diabecore Medical Inc.	Derivatized insulin oligomers
WO2008015099A2 (en)	2006-07-31	2008-02-07	Novo Nordisk A/S	Pegylated, extended insulins
JP5864834B2 (ja)	2006-09-22	2016-02-17	ノボ・ノルデイスク・エー／エス	プロテアーゼ耐性のインスリンアナログ
ES2563038T3 (es)	2007-04-30	2016-03-10	Novo Nordisk A/S	Método para secar una composición proteica, una composición proteica seca y una composición farmacéutica que comprende la proteína seca
WO2008152106A1 (en)	2007-06-13	2008-12-18	Novo Nordisk A/S	Pharmaceutical formulation comprising an insulin derivative
CN101970477B (zh)	2008-03-14	2014-12-31	诺沃-诺迪斯克有限公司	蛋白酶稳定的胰岛素类似物
JP5749155B2 (ja)	2008-03-18	2015-07-15	ノボ・ノルデイスク・エー／エス	プロテアーゼ安定化アシル化インスリンアナログ
KR20110085985A (ko)	2008-10-30	2011-07-27	노보 노르디스크 에이/에스	하루 한번 주사 빈도보다 적은 인슐린 주사를 사용한 진성 당뇨병의 치료
DK2632478T3 (da)	2010-10-27	2019-10-07	Novo Nordisk As	Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
CN103191416A (zh) *	2012-01-05	2013-07-10	四川大学	一种猪胰岛素超分子聚集体及其制备方法
BR112014025132A2 (pt)	2012-04-11	2017-07-11	Novo Nordisk As	formulações de insulina
EP2991672A1 (en)	2013-04-30	2016-03-09	Novo Nordisk A/S	Novel administration regime
ES2676065T3 (es)	2013-10-07	2018-07-16	Novo Nordisk A/S	Nuevo derivado de un análogo de la insulina
AR099569A1 (es)	2014-02-28	2016-08-03	Novo Nordisk As	Derivados de insulina y los usos médicos de estos
HUE060149T2 (hu)	2016-12-16	2023-02-28	Novo Nordisk As	Inzulint tartalmazó gyógyászati készítmények
MX2020001525A (es)	2017-08-24	2020-03-20	Novo Nordisk As	Composiciones de peptido similar al glucagon tipo 1 (glp-1) y sus usos.
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
US12343383B2 (en)	2019-07-12	2025-07-01	Novo Nordisk A/S	High concentration insulin formulation
IL294521A (en)	2020-02-18	2022-09-01	Novo Nordisk As	glp-1 compounds and their uses

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU217684B (hu) *	1993-09-17	2000-03-28	Novo Nordisk A/S	Acilezett inzulinszármazékok és azokat tartalmazó gyógyszerkészítmények és előállításuk
US5559094A (en) *	1994-08-02	1996-09-24	Eli Lilly And Company	AspB1 insulin analogs
US6451970B1 (en) *	1996-02-21	2002-09-17	Novo Nordisk A/S	Peptide derivatives

1998
- 1998-10-23 PT PT98949960T patent/PT1025125E/pt unknown
- 1998-10-23 JP JP2000517995A patent/JP2003525846A/ja not_active Withdrawn
- 1998-10-23 WO PCT/DK1998/000461 patent/WO1999021888A1/en not_active Ceased
- 1998-10-23 ES ES98949960T patent/ES2202899T3/es not_active Expired - Lifetime
- 1998-10-23 DE DE69815877T patent/DE69815877T2/de not_active Expired - Fee Related
- 1998-10-23 KR KR10-2000-7004229A patent/KR100539193B1/ko not_active Expired - Fee Related
- 1998-10-23 RU RU2000112882/04A patent/RU2218349C2/ru not_active IP Right Cessation
- 1998-10-23 BR BR9813128-1A patent/BR9813128A/pt not_active IP Right Cessation
- 1998-10-23 IL IL13540098A patent/IL135400A0/xx not_active IP Right Cessation
- 1998-10-23 HU HU0004096A patent/HUP0004096A3/hu unknown
- 1998-10-23 CN CNB988104458A patent/CN1240718C/zh not_active Expired - Fee Related
- 1998-10-23 CA CA002308705A patent/CA2308705A1/en not_active Abandoned
- 1998-10-23 AU AU96221/98A patent/AU757933B2/en not_active Ceased
- 1998-10-23 DK DK98949960T patent/DK1025125T3/da active
- 1998-10-23 AT AT98949960T patent/ATE243711T1/de not_active IP Right Cessation
- 1998-10-23 PL PL98340032A patent/PL195845B1/pl unknown
- 1998-10-23 UA UA2000042275A patent/UA69393C2/uk unknown
- 1998-10-23 EP EP98949960A patent/EP1025125B1/en not_active Expired - Lifetime
- 1998-10-26 ZA ZA989722A patent/ZA989722B/xx unknown
2000
- 2000-03-31 IL IL135400A patent/IL135400A/en unknown
- 2000-04-18 NO NO20002050A patent/NO20002050L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
IL135400A (en)	2007-08-19
CN1281466A (zh)	2001-01-24
UA69393C2 (uk)	2004-09-15
CA2308705A1 (en)	1999-05-06
EP1025125A1 (en)	2000-08-09
WO1999021888A1 (en)	1999-05-06
NO20002050L (no)	2000-06-23
PL340032A1 (en)	2001-01-15
DK1025125T3 (da)	2003-10-06
DE69815877D1 (de)	2003-07-31
ATE243711T1 (de)	2003-07-15
HUP0004096A3 (en)	2001-12-28
PT1025125E (pt)	2003-11-28
PL195845B1 (pl)	2007-10-31
DE69815877T2 (de)	2004-05-19
AU757933B2 (en)	2003-03-13
CN1240718C (zh)	2006-02-08
EP1025125B1 (en)	2003-06-25
HUP0004096A2 (hu)	2001-05-28
IL135400A0 (en)	2001-05-20
RU2218349C2 (ru)	2003-12-10
AU9622198A (en)	1999-05-17
ZA989722B (en)	1999-04-26
JP2003525846A (ja)	2003-09-02
ES2202899T3 (es)	2004-04-01
KR100539193B1 (ko)	2005-12-27
KR20010031247A (ko)	2001-04-16
BR9813128A (pt)	2000-08-15

Publication	Publication Date	Title
NO20002050D0 (no)	2000-04-18	Aggregater av humaninsulinderivater
TR199600322A2 (tr)	1996-11-21	Arilsülfonil hidroksamik asit türevleri.
CA2119154A1 (en)	1994-02-03	Derivatives of Cyclodextrins Exhibiting Enhanced Aqueous Solubility and the Use Thereof
IS4963A (is)	1999-01-29	Setnar 6,5-heteró-bísýklískar afleiður
JP2001509184A5 (no)	2009-07-23
DE3880465D1 (de)	1993-05-27	Wasserloesliche polymerdispersion.
DK0920429T3 (da)	2003-05-12	Substituerede pyrido- eller pyrimidoholdige, 6,6- eller 6,7-bicykliske derivater
DE69431559D1 (de)	2002-11-21	Zellulosenahrungsmittelhülle
DE69008454D1 (de)	1994-06-01	Nitrolsothiolderivate, ihre Herstellung und Verwendung.
SE9800806D0 (sv)	1998-03-12	Användning av kollagenas
ZA972056B (en)	1997-09-22	Substituted 1,2,3,4-tetrahydronaphthalene derivatives.
MX9803728A (es)	1998-09-30	Agentes floculantes de polimero de alto rendimiento.
PT1140835E (pt)	2004-07-30	Derivados da 3,3-biarilpiperidina e 2,2-biarilmorfolina
AU3657100A (en)	2000-10-04	Use of water-soluble beta-(1,3) glucans as agents for producing therapeutic skintreatment agents
NO980303D0 (no)	1998-01-23	Vandige dispersjoner på basis av vannopplöselige polymerer
DK0861120T3 (da)	2003-12-15	Oliefri, vandopløselig, flydende hydroxyethylcellulosepolymerdispersion
DE50001049D1 (de)	2003-02-13	Dekorative kosmetische zubereitungen
CA2314716A1 (en)	1999-06-17	Modified polysaccharides exhibiting altered biological recognition
IS5731A (is)	2000-11-24	4, 5, 6 og 7-indól og indólín afleiður, framleiðsla þeirra og notkun
ATE220674T1 (de)	2002-08-15	12h-dibenzo(d,g)(1,3)dioxocin derivate
AU4506499A (en)	2000-01-05	Novel 2,4-diaminophenol derivatives and the use thereof
ATE202922T1 (de)	2001-07-15	Ophthalmische cromolyn-gelzubereitung
TR199700219A3 (tr)	1997-10-21	1,25-Dihidroksi-16, 22, 23-Trisdihidro-kolkalsiferol türevleri.
RU96115480A (ru)	1998-10-27	Лекарственное средство, обладающее холелитолитическим действием
DK660589A (da)	1990-07-10	Basebestandigt, silikoneoliefrit antiskummiddel

Legal Events

Date	Code	Title	Description
2008-11-24	FC2A	Withdrawal, rejection or dismissal of laid open patent application