NO20002038D0 - Uløselig insulinsammensetning - Google Patents
Uløselig insulinsammensetningInfo
- Publication number
- NO20002038D0 NO20002038D0 NO20002038A NO20002038A NO20002038D0 NO 20002038 D0 NO20002038 D0 NO 20002038D0 NO 20002038 A NO20002038 A NO 20002038A NO 20002038 A NO20002038 A NO 20002038A NO 20002038 D0 NO20002038 D0 NO 20002038D0
- Authority
- NO
- Norway
- Prior art keywords
- insulin composition
- insoluble insulin
- insoluble
- composition
- insulin
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6310497P | 1997-10-24 | 1997-10-24 | |
| US8893098P | 1998-06-11 | 1998-06-11 | |
| PCT/US1998/022434 WO1999021578A1 (en) | 1997-10-24 | 1998-10-22 | Insoluble insulin compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20002038D0 true NO20002038D0 (no) | 2000-04-18 |
| NO20002038L NO20002038L (no) | 2000-06-26 |
Family
ID=26743043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20002038A NO20002038L (no) | 1997-10-24 | 2000-04-18 | Uløselige insulinsammensetninger |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US6268335B1 (no) |
| EP (1) | EP1039920A4 (no) |
| JP (2) | JP2001521004A (no) |
| KR (1) | KR20010024556A (no) |
| CN (1) | CN1276731A (no) |
| AR (1) | AR020047A1 (no) |
| AU (2) | AU1111799A (no) |
| BR (1) | BR9813111A (no) |
| CA (2) | CA2306877A1 (no) |
| CO (1) | CO4970769A1 (no) |
| EA (1) | EA200000453A1 (no) |
| HR (1) | HRP20000236A2 (no) |
| HU (1) | HUP0004169A3 (no) |
| ID (1) | ID24890A (no) |
| IL (1) | IL134901A0 (no) |
| NO (1) | NO20002038L (no) |
| PE (1) | PE123799A1 (no) |
| PL (1) | PL340255A1 (no) |
| SV (1) | SV1998000125A (no) |
| TR (1) | TR200001050T2 (no) |
| WO (2) | WO1999021573A1 (no) |
Families Citing this family (114)
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|---|---|---|---|---|
| US6444641B1 (en) | 1997-10-24 | 2002-09-03 | Eli Lilly Company | Fatty acid-acylated insulin analogs |
| US6531448B1 (en) * | 1997-12-23 | 2003-03-11 | Eli Lilly And Company | Insoluble compositions for controlling blood glucose |
| US7169889B1 (en) * | 1999-06-19 | 2007-01-30 | Biocon Limited | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin |
| EP1346726A4 (en) * | 2000-12-25 | 2004-09-15 | Shiseido Co Ltd | Sympathetic-activating perfume composition |
| US6867183B2 (en) | 2001-02-15 | 2005-03-15 | Nobex Corporation | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
| US7060675B2 (en) * | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
| US20020155614A1 (en) * | 2001-02-21 | 2002-10-24 | Tomlinson Andrew J. | Peptide esterification |
| US7713932B2 (en) | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
| US6828305B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US6828297B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US6713452B2 (en) | 2001-06-04 | 2004-03-30 | Nobex Corporation | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US6858580B2 (en) | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
| US7238663B2 (en) * | 2001-08-28 | 2007-07-03 | Eli Lilly And Company | Pre-mixes of GLP-1 and basal insulin |
| US7312192B2 (en) * | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
| US6770625B2 (en) | 2001-09-07 | 2004-08-03 | Nobex Corporation | Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith |
| US7030082B2 (en) * | 2001-09-07 | 2006-04-18 | Nobex Corporation | Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith |
| US7196059B2 (en) | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
| US7166571B2 (en) * | 2001-09-07 | 2007-01-23 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
| US6913903B2 (en) * | 2001-09-07 | 2005-07-05 | Nobex Corporation | Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
| ES2280582T3 (es) * | 2001-09-19 | 2007-09-16 | Elan Pharma International Limited | Formulaciones de insulina en nanoparticulas. |
| WO2003053460A1 (en) * | 2001-12-19 | 2003-07-03 | Eli Lilly And Company | Crystalline compositions for controlling blood glucose |
| SK2432004A3 (sk) * | 2001-12-20 | 2005-04-01 | Eli Lilly And Company | Inzulínová zlúčenina s protrahovaným účinkom |
| US7601688B2 (en) | 2002-06-13 | 2009-10-13 | Biocon Limited | Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus |
| US20040038864A1 (en) * | 2002-06-27 | 2004-02-26 | Per Balschmidt | Use of dimethyl sulfone as isotonicity agent |
| EP1605967A1 (en) * | 2003-03-13 | 2005-12-21 | Novo Nordisk A/S | Novel nph insulin preparations |
| US20060258561A1 (en) * | 2003-03-13 | 2006-11-16 | Novo Nordisk A/S | Novel NPH insulin preparations |
| US20050054818A1 (en) * | 2003-07-02 | 2005-03-10 | Brader Mark Laurence | Crystalline compositions for controlling blood glucose |
| US20060241019A1 (en) * | 2003-07-25 | 2006-10-26 | Bridon Dominique P | Long lasting insulin derivatives and methods thereof |
| EP2107069B1 (en) | 2003-08-05 | 2013-01-16 | Novo Nordisk A/S | Novel insulin derivatives |
| ATE517119T1 (de) * | 2003-12-03 | 2011-08-15 | Novo Nordisk As | Einzelketteninsulin |
| US7872095B2 (en) | 2004-07-19 | 2011-01-18 | Biocon Limited | Insulin-oligomer conjugates, formulations and uses thereof |
| JP4874989B2 (ja) | 2004-11-22 | 2012-02-15 | ノヴォ ノルディスク アー／エス | 可溶性で安定なインスリン含有調合物 |
| EP1679065A1 (en) * | 2005-01-07 | 2006-07-12 | OctoPlus Sciences B.V. | Controlled release compositions for interferon based on PEGT/PBT block copolymers |
| EP1863840A1 (en) * | 2005-03-18 | 2007-12-12 | Novo Nordisk A/S | Pegylated single-chain insulin |
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| WO2007121318A2 (en) * | 2006-04-12 | 2007-10-25 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
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| JP5864834B2 (ja) | 2006-09-22 | 2016-02-17 | ノボ・ノルデイスク・エー／エス | プロテアーゼ耐性のインスリンアナログ |
| EP2074140B8 (en) | 2006-10-04 | 2015-10-28 | Case Western Reserve University | Fibrillation-resistant insulin and insulin analogues |
| ES2563038T3 (es) | 2007-04-30 | 2016-03-10 | Novo Nordisk A/S | Método para secar una composición proteica, una composición proteica seca y una composición farmacéutica que comprende la proteína seca |
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| PT2349324T (pt) | 2008-10-17 | 2017-12-06 | Sanofi Aventis Deutschland | Combinação de uma insulina e de um agonista do glp-1 |
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| BR112014025132A2 (pt) | 2012-04-11 | 2017-07-11 | Novo Nordisk As | formulações de insulina |
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| EP3893934B1 (en) | 2018-12-11 | 2025-09-10 | Sanofi | Insulin conjugates |
| CN110063932A (zh) * | 2019-04-12 | 2019-07-30 | 浙江大学 | 一种多肽蛋白类药物的缓释组合物制剂及其制备方法 |
| US12343383B2 (en) | 2019-07-12 | 2025-07-01 | Novo Nordisk A/S | High concentration insulin formulation |
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-
1998
- 1998-10-22 KR KR1020007004395A patent/KR20010024556A/ko not_active Ceased
- 1998-10-22 AU AU11117/99A patent/AU1111799A/en not_active Abandoned
- 1998-10-22 IL IL13490198A patent/IL134901A0/xx unknown
- 1998-10-22 CO CO98061475A patent/CO4970769A1/es unknown
- 1998-10-22 TR TR2000/01050T patent/TR200001050T2/xx unknown
- 1998-10-22 HR HR20000236A patent/HRP20000236A2/hr not_active Application Discontinuation
- 1998-10-22 PE PE1998000996A patent/PE123799A1/es not_active Application Discontinuation
- 1998-10-22 CA CA002306877A patent/CA2306877A1/en not_active Abandoned
- 1998-10-22 AR ARP980105267A patent/AR020047A1/es unknown
- 1998-10-22 WO PCT/US1998/022313 patent/WO1999021573A1/en not_active Ceased
- 1998-10-22 AU AU11166/99A patent/AU747926B2/en not_active Ceased
- 1998-10-22 EA EA200000453A patent/EA200000453A1/ru unknown
- 1998-10-22 JP JP2000517731A patent/JP2001521004A/ja not_active Withdrawn
- 1998-10-22 CN CN98810334A patent/CN1276731A/zh active Pending
- 1998-10-22 ID IDW20000748A patent/ID24890A/id unknown
- 1998-10-22 JP JP2000517736A patent/JP2001521006A/ja not_active Withdrawn
- 1998-10-22 US US09/177,685 patent/US6268335B1/en not_active Expired - Lifetime
- 1998-10-22 CA CA002306905A patent/CA2306905A1/en not_active Abandoned
- 1998-10-22 WO PCT/US1998/022434 patent/WO1999021578A1/en not_active Ceased
- 1998-10-22 EP EP98953852A patent/EP1039920A4/en not_active Withdrawn
- 1998-10-22 HU HU0004169A patent/HUP0004169A3/hu unknown
- 1998-10-22 BR BR9813111-7A patent/BR9813111A/pt not_active IP Right Cessation
- 1998-10-22 SV SV1998000125A patent/SV1998000125A/es unknown
- 1998-10-22 PL PL98340255A patent/PL340255A1/xx not_active Application Discontinuation
-
2000
- 2000-04-18 NO NO20002038A patent/NO20002038L/no not_active Application Discontinuation
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2001
- 2001-01-17 US US09/761,903 patent/US6465426B2/en not_active Expired - Fee Related
- 2001-12-06 US US10/010,038 patent/US20020082199A1/en not_active Abandoned
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|---|---|
| EP1039920A1 (en) | 2000-10-04 |
| AU747926B2 (en) | 2002-05-30 |
| AU1111799A (en) | 1999-05-17 |
| IL134901A0 (en) | 2001-05-20 |
| SV1998000125A (es) | 1999-05-24 |
| TR200001050T2 (tr) | 2000-08-21 |
| US6465426B2 (en) | 2002-10-15 |
| KR20010024556A (ko) | 2001-03-26 |
| HUP0004169A3 (en) | 2001-06-28 |
| PL340255A1 (en) | 2001-01-29 |
| AR020047A1 (es) | 2002-04-10 |
| US6268335B1 (en) | 2001-07-31 |
| CN1276731A (zh) | 2000-12-13 |
| CA2306905A1 (en) | 1999-05-06 |
| NO20002038L (no) | 2000-06-26 |
| WO1999021573A1 (en) | 1999-05-06 |
| HUP0004169A2 (hu) | 2001-05-28 |
| AU1116699A (en) | 1999-05-17 |
| JP2001521006A (ja) | 2001-11-06 |
| JP2001521004A (ja) | 2001-11-06 |
| ID24890A (id) | 2000-08-31 |
| CO4970769A1 (es) | 2000-11-07 |
| BR9813111A (pt) | 2000-08-15 |
| WO1999021578A1 (en) | 1999-05-06 |
| HRP20000236A2 (en) | 2001-02-28 |
| CA2306877A1 (en) | 1999-05-06 |
| EA200000453A1 (ru) | 2000-10-30 |
| US20020082199A1 (en) | 2002-06-27 |
| US20010036916A1 (en) | 2001-11-01 |
| PE123799A1 (es) | 1999-12-13 |
| EP1039920A4 (en) | 2003-05-28 |
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