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NO1994015I1 - Iodixanol/ 1,3-bis(acetylamino-N,N<O>1</O>-bis[3,5-bis(2,3-dihydroksypropylaminokrabonyl)-2,4,6-trijod-fenyl]-2-hydroksypropan - Google Patents

Iodixanol/ 1,3-bis(acetylamino-N,N<O>1</O>-bis[3,5-bis(2,3-dihydroksypropylaminokrabonyl)-2,4,6-trijod-fenyl]-2-hydroksypropan

Info

Publication number
NO1994015I1
NO1994015I1 NO1994015C NO1994015C NO1994015I1 NO 1994015 I1 NO1994015 I1 NO 1994015I1 NO 1994015 C NO1994015 C NO 1994015C NO 1994015 C NO1994015 C NO 1994015C NO 1994015 I1 NO1994015 I1 NO 1994015I1
Authority
NO
Norway
Prior art keywords
bis
acetylamino
ch2ch
dihydroxypropylaminocarbonyl
iodixanol
Prior art date
Application number
NO1994015C
Other languages
English (en)
Original Assignee
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As
Publication of NO1994015I1 publication Critical patent/NO1994015I1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Medicinal Preparation (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Polyesters Or Polycarbonates (AREA)
NO1994015C 1982-11-08 1994-09-05 Iodixanol/ 1,3-bis(acetylamino-N,N<O>1</O>-bis[3,5-bis(2,3-dihydroksypropylaminokrabonyl)-2,4,6-trijod-fenyl]-2-hydroksypropan NO1994015I1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8231796 1982-11-08
EP83306766A EP0108638B1 (en) 1982-11-08 1983-11-07 X-ray contrast agents

Publications (1)

Publication Number Publication Date
NO1994015I1 true NO1994015I1 (no) 1994-09-05

Family

ID=10534110

Family Applications (2)

Application Number Title Priority Date Filing Date
NO834056A NO161368C (no) 1982-11-08 1983-11-07 Roentgenkontrastmidler samt radiologiske preparater derav.
NO1994015C NO1994015I1 (no) 1982-11-08 1994-09-05 Iodixanol/ 1,3-bis(acetylamino-N,N<O>1</O>-bis[3,5-bis(2,3-dihydroksypropylaminokrabonyl)-2,4,6-trijod-fenyl]-2-hydroksypropan

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO834056A NO161368C (no) 1982-11-08 1983-11-07 Roentgenkontrastmidler samt radiologiske preparater derav.

Country Status (10)

Country Link
US (1) US5349085A (no)
EP (1) EP0108638B1 (no)
JP (1) JPS59104352A (no)
AT (1) ATE20733T1 (no)
DE (1) DE3364536D1 (no)
DK (1) DK160868C (no)
HK (1) HK46791A (no)
LU (1) LU88639I2 (no)
NL (1) NL950010I1 (no)
NO (2) NO161368C (no)

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DE3739098A1 (de) * 1987-11-16 1989-05-24 Schering Ag Neue substituierte dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6- trijod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel
GB8919929D0 (en) 1989-09-04 1989-10-18 Nycomed As Compositions
IT1252180B (it) * 1991-12-10 1995-06-05 Bracco Ind Chimica Spa 5,5'-(1,3-propandiil) bis (imino (2-osso-2,1-etandiil)acetilimino)-bis(2,4,6-triiodo-1,3-benzendicarbossiamidi),loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono
WO1994022810A1 (es) * 1993-04-01 1994-10-13 Centro Investigacion Justesa Imagen, S.A. Nuevos dimeros iodados no ionicos como agentes de contraste a los rayos x, metodo para su preparacion y composiciones galenicas que los contienen
US5840967A (en) * 1996-08-29 1998-11-24 Nycomed Imaging As Process for the preparation of contrast agents
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
GB9720969D0 (en) * 1997-10-02 1997-12-03 Nycomed Imaging As Process
GB9903109D0 (en) * 1999-02-11 1999-04-07 Nycomed Imaging As Process
AU2002245169A1 (en) 2000-11-10 2002-07-08 Wm. Marsh Rice University Fullerene (c60)-based x-ray contrast agent for diagnostic imaging
CA2477088A1 (en) 2002-02-22 2003-10-02 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
KR100574087B1 (ko) 2004-09-09 2006-04-27 주식회사태준제약 아이오디사놀의 제조방법
DE602005010747D1 (de) 2005-01-13 2008-12-11 Cinv Ag Kohlenstoffnanopartikel enthaltende verbundwerkstoffe
US7968745B2 (en) 2005-12-19 2011-06-28 Ge Healthcare As Purification process of iodixanol
ES2357861T3 (es) 2006-02-15 2011-05-03 Ge Healthcare As Agentes de contraste.
FR2899581B1 (fr) * 2006-04-07 2008-06-27 Guerbet Sa Procede d'atomisation du ioxilan
US7662859B2 (en) 2007-02-16 2010-02-16 Ge Healthcare As Contrast agents
DK2178568T3 (da) 2007-07-12 2014-07-21 Ge Healthcare As Kontrastmidler
EP2200656B1 (en) 2007-10-12 2012-12-05 GE Healthcare AS Contrast agents
ES2413160T3 (es) 2007-10-12 2013-07-15 Ge Healthcare As Agentes de contraste
US20100221192A1 (en) 2007-10-12 2010-09-02 Duncan George Wynn Contrast agents
CN101820924A (zh) 2007-10-12 2010-09-01 通用电气医疗集团股份有限公司 造影剂
EP2245003A2 (en) 2008-02-27 2010-11-03 GE Healthcare AS Contrast agents
EP2245004A2 (en) * 2008-02-27 2010-11-03 GE Healthcare AS Contrast agents
WO2010060941A2 (en) * 2008-11-27 2010-06-03 Ge Healthcare As Contrast agents
WO2010079201A1 (en) 2009-01-09 2010-07-15 Ge Healthcare As Contrast media compositions
US20110021822A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
US8962886B2 (en) 2009-07-21 2015-02-24 Ge Healthcare As Synthesis of iodixanol in methanol
US7696381B1 (en) * 2009-07-21 2010-04-13 Ge Healthcare As Alternative dimerisation reagents for synthesis of iodixanol
US20110021832A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Synthesis of iodixanol in water
US7999135B2 (en) 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using ultrasound
US7754920B1 (en) * 2009-07-21 2010-07-13 Ge Healthcare As Solvent reduction in crystallisation of intermediate for non-ionic X-ray contrast agents
US7999134B2 (en) 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using milling
US8969619B2 (en) * 2009-07-21 2015-03-03 Ge Healthcare As Synthesis of iodixanol in propyleneglycol
US8962887B2 (en) * 2009-07-21 2015-02-24 Ge Healthcare As Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol
US20110021821A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
KR101545045B1 (ko) * 2009-10-29 2015-08-17 지이 헬스케어 에이에스 탁월한 안전성 프로파일을 갖는 혈장 양이온을 포함하는 진단학적 조성물
WO2011063551A1 (en) 2009-11-26 2011-06-03 Hovione China Holding Limited Preparation and purification of iodixanol
JP2013531685A (ja) 2010-07-12 2013-08-08 ジーイー・ヘルスケア・アクスイェ・セルスカプ 低造影剤濃度及び／又は低放射線量でのｘ線イメージング
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
CN102816125B (zh) * 2011-06-08 2014-03-26 浙江司太立制药股份有限公司 一种造影剂
KR102020080B1 (ko) 2012-01-11 2019-11-04 지이 헬스케어 에이에스 저농도의 요오드를 포함하는 ｘ선 영상화 조영 매질 및 ｘ선 영상화 방법
RU2654461C2 (ru) 2012-09-27 2018-05-18 ДжиИ Хелткер АС Получение промежуточного соединения синтеза иоформинола
JP6248119B2 (ja) 2012-11-12 2017-12-13 ジーイー・ヘルスケア・アクスイェ・セルスカプ Ｘ線造影剤の中間体の製造
EP3220887A1 (en) 2014-11-21 2017-09-27 Technical University of Denmark Gel formulations for local drug release
PT108524B (pt) 2015-06-02 2017-12-15 Hovione Farmaciência S A Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos
EP3458029A1 (en) 2016-05-20 2019-03-27 Technical University of Denmark Palpable marker composition
CN111440084B (zh) * 2019-01-16 2023-01-06 苏州纳微科技股份有限公司 一种碘克沙醇的纯化方法
US20220339285A1 (en) 2019-06-12 2022-10-27 Technical University Of Denmark Dissacharide formulations for controlled drug release
CN113121377A (zh) * 2019-12-31 2021-07-16 江苏汉邦科技有限公司 碘克沙醇的纯化方法

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SE344166B (no) * 1966-12-13 1972-04-04 Pharmacia Ab
SE315974B (no) * 1967-12-28 1969-10-13 Pharmacia Ab
SE315975B (no) * 1967-12-28 1969-10-13 Pharmacia Ab
US3804892A (en) * 1967-12-28 1974-04-16 Pharmacia Ab Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof
US3763227A (en) * 1967-12-28 1973-10-02 Pharmacia Ab Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof
DE2031724C3 (de) * 1969-06-27 1979-06-28 Nyegaard & Co. A/S., Oslo N-substituierte Trijodbenz- bzw. Jodmethansulfon-am'ide, Verfahren zu deren Herstellung und radiologische Zusammensetzungen
NL7102816A (no) * 1970-03-12 1971-09-14
DD104193A5 (no) * 1972-12-22 1974-03-05
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
DE2628517C2 (de) * 1976-06-23 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
DE3038853A1 (de) * 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
FR2511871A1 (fr) * 1981-08-28 1983-03-04 Guerbet Sa Procede pour augmenter la tolerance des produits opacifiants et produits opacifiants ainsi obtenus

Also Published As

Publication number Publication date
DK508283A (da) 1984-05-09
EP0108638B1 (en) 1986-07-16
JPS59104352A (ja) 1984-06-16
JPS6355509B2 (no) 1988-11-02
NO161368C (no) 1989-08-09
DK508283D0 (da) 1983-11-07
US5349085A (en) 1994-09-20
DE3364536D1 (en) 1986-08-21
NO834056L (no) 1984-05-09
LU88639I2 (fr) 1996-02-01
NL950010I2 (nl) 1997-02-03
EP0108638A1 (en) 1984-05-16
ATE20733T1 (de) 1986-08-15
DK160868B (da) 1991-04-29
NO161368B (no) 1989-05-02
NL950010I1 (nl) 1997-02-03
HK46791A (en) 1991-06-21
DK160868C (da) 1991-10-14

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