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NO173237C - CHEMILUMINIZING ACRIDINE DERIVATIVES - Google Patents

CHEMILUMINIZING ACRIDINE DERIVATIVES

Info

Publication number
NO173237C
NO173237C NO890689A NO890689A NO173237C NO 173237 C NO173237 C NO 173237C NO 890689 A NO890689 A NO 890689A NO 890689 A NO890689 A NO 890689A NO 173237 C NO173237 C NO 173237C
Authority
NO
Norway
Prior art keywords
chemiluminizing
acridine derivatives
formula
image
derivatives
Prior art date
Application number
NO890689A
Other languages
Norwegian (no)
Other versions
NO890689D0 (en
NO890689L (en
NO173237B (en
Inventor
Tonio Kinkel
Peter Molz
Erwin Schmidt
Gerd Schnorr
Heinz Juergen Skrzipczyk
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19883805318 external-priority patent/DE3805318C2/en
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO890689D0 publication Critical patent/NO890689D0/en
Publication of NO890689L publication Critical patent/NO890689L/en
Priority to NO923800A priority Critical patent/NO303657B1/en
Publication of NO173237B publication Critical patent/NO173237B/en
Publication of NO173237C publication Critical patent/NO173237C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B15/00—Acridine dyes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Luminescent Compositions (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Paints Or Removers (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Chemiluminescent acridinium derivatives of the formula I <IMAGE> in which R<4> is a radical of the formula II or III <IMAGE> and A<(-)>, X-, R<1>-R<3>, R<5> and R<6> have the specified meanings, and processes for the preparation of the compounds of the formula (I) and the use thereof in chemiluminescence immunoassays.
NO890689A 1988-02-20 1989-02-17 CHEMILUMINIZING ACRIDINE DERIVATIVES NO173237C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO923800A NO303657B1 (en) 1988-02-20 1992-09-30 Method for Preparing a Luminescent Compound and Using the Compound Made in a Luminescence Immunoassay to Determine an Antigenic Substance in a Liquid Specimen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19883805318 DE3805318C2 (en) 1988-02-20 1988-02-20 Special chemiluminescent acridine derivatives and their use in luminescent immunoassays

Publications (4)

Publication Number Publication Date
NO890689D0 NO890689D0 (en) 1989-02-17
NO890689L NO890689L (en) 1989-08-21
NO173237B NO173237B (en) 1993-08-09
NO173237C true NO173237C (en) 1993-11-17

Family

ID=6347802

Family Applications (1)

Application Number Title Priority Date Filing Date
NO890689A NO173237C (en) 1988-02-20 1989-02-17 CHEMILUMINIZING ACRIDINE DERIVATIVES

Country Status (11)

Country Link
EP (1) EP0330050B1 (en)
JP (1) JP2602315B2 (en)
AT (1) ATE195757T1 (en)
CA (1) CA1339390C (en)
DE (2) DE3844954C2 (en)
DK (1) DK175493B1 (en)
ES (1) ES2151474T3 (en)
FI (1) FI90537C (en)
GR (1) GR3034888T3 (en)
NO (1) NO173237C (en)
PT (1) PT89759B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110932A (en) * 1986-10-06 1992-05-05 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
EP0273115B1 (en) * 1986-10-22 1994-09-07 Abbott Laboratories Chemiluminescent acridinium and phenanthridinium salts
US5281712A (en) * 1987-12-31 1994-01-25 London Diagnostics, Inc. Ammonium substituted chemiluminescent labels and their conjugates, and assays therefrom
US5321136A (en) * 1987-12-31 1994-06-14 London Diagnostics, Inc. Peri substituted fused ring chemiluminescent labels and their conjugates, and assays therefrom
US5338847A (en) * 1987-12-31 1994-08-16 London Diagnostics, Inc. Hydrolytically stable chemiluminescent labels and their conjugates, and assays therefrom by adduct formation
US5227489A (en) * 1988-08-01 1993-07-13 Ciba Corning Diagnostics Corp. Stable hydrophilic acridinium esters suitable for liposome encapsulation
US5663074A (en) * 1988-09-26 1997-09-02 Chiron Diagnostics Corporation Nucleophilic polysubstituted aryl acridinium ester conjugates and syntheses thereof
US5241070A (en) * 1988-09-26 1993-08-31 Ciba Corning Diagnostics Corp. Nucleophilic polysubstituted aryl acridinium esters and uses thereof
WO1992009580A1 (en) * 1990-11-21 1992-06-11 Beckman Instruments, Inc. Chemiluminescent compounds
DE4041080A1 (en) 1990-12-21 1992-06-25 Behringwerke Ag METHOD FOR DETERMINING AN ANALYT
DE69215983T2 (en) * 1991-07-10 1997-05-22 Tdk Corp Method for measuring the concentration of an immunoreactant using electrochemiluminescence
DE4228839A1 (en) 1992-08-29 1994-03-03 Behringwerke Ag Methods for the detection and determination of mediators
JP3207933B2 (en) * 1992-09-09 2001-09-10 株式会社ヤトロン Light emission method of acridinium derivative and method of detecting target substance using the same
BE1008216A4 (en) * 1994-01-25 1996-02-20 Biocode Sa HETEROCYCLIC CHEMOLUMINESCENT DERIVATIVES.
CA2193082C (en) * 1994-06-24 2007-08-28 Stephan Neuenhofer A method for stabilizing hydrolysis-sensitive molecules or molecular moieties
US5731148A (en) * 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
EP0761652A1 (en) * 1995-08-01 1997-03-12 Mochida Pharmaceutical Co., Ltd. Acridinium compound having a plurality of luminescent groups and binding groups, and conjugate thereof
AU9110698A (en) * 1997-08-21 1999-03-08 Capricorn Products, Inc. Peroxide-based chemiluminescent assays and chemiluminescent compounds used ther ein

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3352791A (en) * 1965-01-22 1967-11-14 American Cyanamid Co Generation of light by the reaction of peroxide with heterocyclic derivatives
FR2043486B1 (en) * 1969-05-28 1973-07-13 Roussel Uclaf
GB1461877A (en) * 1974-02-12 1977-01-19 Wellcome Found Assay method utilizing chemiluminescence
IN142734B (en) * 1975-04-28 1977-08-20 Miles Lab
GB2008247B (en) * 1977-11-17 1982-12-15 Welsh Nat School Med Detecting or quantifying substances using labelling techniques
US4334069A (en) * 1978-07-24 1982-06-08 Miles Laboratories, Inc. Chemiluminescent phthalhydrazide-labeled hapten conjugates
GB2112779B (en) * 1981-12-11 1986-10-15 Welsh Nat School Med Aryl acridinium esters as luminescent labelling materials
EP0134307B1 (en) * 1983-07-29 1989-04-19 Henning Berlin GmbH Chemie und Pharmawerk Preactivated surfaces of synthetic materials for immobilizing organochemical and biological substances, process for preparing them and their use
US4687747A (en) * 1984-07-02 1987-08-18 Mallinckrodt, Inc. Phenanthridinium ester as a labelling compound in luminometric immunoassay
JPS6261969A (en) * 1985-09-06 1987-03-18 アモコ・コーポレーション Synthesis of acridinium ester
DE3645292C2 (en) * 1986-08-22 1997-12-11 Hoechst Ag New chemiluminescent 9-carboxy-acridinium cpds.
EP0273115B1 (en) * 1986-10-22 1994-09-07 Abbott Laboratories Chemiluminescent acridinium and phenanthridinium salts
JPH0699401A (en) * 1992-09-18 1994-04-12 I N R Kenkyusho:Kk Woodworking machine

Also Published As

Publication number Publication date
FI90537B (en) 1993-11-15
EP0330050B1 (en) 2000-08-23
EP0330050A2 (en) 1989-08-30
GR3034888T3 (en) 2001-02-28
DK74289A (en) 1989-08-21
NO890689D0 (en) 1989-02-17
FI90537C (en) 1994-02-25
FI890754A0 (en) 1989-02-16
DK175493B1 (en) 2004-11-08
DE58909877D1 (en) 2000-09-28
PT89759B (en) 1994-03-31
ATE195757T1 (en) 2000-09-15
DK74289D0 (en) 1989-02-17
NO890689L (en) 1989-08-21
EP0330050A3 (en) 1991-11-06
DE3844954C2 (en) 1998-07-16
FI890754L (en) 1989-08-21
PT89759A (en) 1989-10-04
CA1339390C (en) 1997-08-26
JP2602315B2 (en) 1997-04-23
NO173237B (en) 1993-08-09
JPH01261461A (en) 1989-10-18
ES2151474T3 (en) 2001-01-01

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