NO171994C - Fremgangsmaate for fremstilling av dihydroxylerte 11beta-(4-acetylfenyl)-17beta-hydroxy-17alfa-(1-propynyl)-4,9-estradien-3-oner - Google Patents

Fremgangsmaate for fremstilling av dihydroxylerte 11beta-(4-acetylfenyl)-17beta-hydroxy-17alfa-(1-propynyl)-4,9-estradien-3-oner

Info

Publication number: NO171994C
Authority: NO; Norway
Prior art keywords: 17alfa; estradien; 11beta; oner; 17beta
Prior art date: 1985-02-07

Application number

NO860425A

Other languages

English (en)

Norwegian (no)

Other versions

NO171994B (no

NO860425L (no

Inventor

Guenter Neef

Sybille Beier

Walter Elger

David Henderson

Eckard Ottow

Ralph Rohde

Rudolf Wiechert

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-02-07

Filing date

1986-02-06

Publication date

1993-05-26

1985-02-07 Priority claimed from DE19853504421 external-priority patent/DE3504421A1/de

1985-07-29 Priority claimed from DE19853527517 external-priority patent/DE3527517A1/de

1986-02-06 Application filed by Schering Ag filed Critical Schering Ag

1986-08-08 Publication of NO860425L publication Critical patent/NO860425L/no

1986-10-21 Priority to NO864209A priority Critical patent/NO170285C/no

1993-02-15 Publication of NO171994B publication Critical patent/NO171994B/no

1993-05-26 Publication of NO171994C publication Critical patent/NO171994C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/001—Lactones
- C07J21/003—Lactones at position 17
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO860425A 1985-02-07 1986-02-06 Fremgangsmaate for fremstilling av dihydroxylerte 11beta-(4-acetylfenyl)-17beta-hydroxy-17alfa-(1-propynyl)-4,9-estradien-3-oner NO171994C (no)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
NO864209A NO170285C (no)	1985-02-07	1986-10-21	13-alkyl-llbeta-fenyl-gonaner, og antikonsepsjonsmiddel inneholdende disse

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19853504421 DE3504421A1 (de)	1985-02-07	1985-02-07	Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate
DE19853527517 DE3527517A1 (de)	1985-07-29	1985-07-29	11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate

Publications (3)

Publication Number	Publication Date
NO860425L NO860425L (no)	1986-08-08
NO171994B NO171994B (no)	1993-02-15
NO171994C true NO171994C (no)	1993-05-26

Family

ID=25829248

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO860425A NO171994C (no)	1985-02-07	1986-02-06	Fremgangsmaate for fremstilling av dihydroxylerte 11beta-(4-acetylfenyl)-17beta-hydroxy-17alfa-(1-propynyl)-4,9-estradien-3-oner

Country Status (16)

Country	Link
US (1)	US5089635A (da)
EP (1)	EP0190759B1 (da)
CN (1)	CN1033753C (da)
AU (1)	AU580843B2 (da)
CA (1)	CA1310630C (da)
DE (1)	DE3665307D1 (da)
DK (1)	DK161709C (da)
ES (1)	ES8701778A1 (da)
FI (1)	FI85377C (da)
GR (1)	GR860342B (da)
HU (1)	HU194904B (da)
IE (1)	IE58149B1 (da)
IL (1)	IL77762A (da)
NO (1)	NO171994C (da)
NZ (1)	NZ214998A (da)
PT (1)	PT81969B (da)

Families Citing this family (44)

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NZ214998A (en) *	1985-02-07	1989-06-28	Schering Ag	13-(methyl or ethyl)-11-beta-phenyl-gonane derivatives; preparatory processes and pharmaceutical compositions
GB8513723D0 (en) *	1985-05-31	1985-07-03	Erba Farmitalia	11-beta substituted steroids
EP0289073B1 (en) *	1987-04-24	1991-11-27	Akzo N.V.	Novel 11-aryloestrane and 11-arylpregnane derivatives
DE3723788A1 (de) *	1987-07-16	1989-01-26	Schering Ag	11(beta)-phenyl-4,9,15-estratriene, deren herstellung und diese enthaltende pharmazeutische praeparate
AU625450B2 (en) *	1987-07-16	1992-07-09	Schering Aktiengesellschaft Berlin Und Bergkamen	11beta-phenyl-4,9,15-estratrienes, their manufacture, and pharmaceutical preparations containing them
ES2053714T3 (es) *	1987-12-12	1994-08-01	Akzo Nv	Proceso para la preparacion de 11-arilesteroides.
DE3822770A1 (de) *	1988-07-01	1990-01-04	Schering Ag	13-alkyl-11ss-phenylgonane
FR2665901B2 (fr) *	1989-02-24	1994-07-29	Roussel Uclaf	Nouveaux 19-nor sterouides ayant en position 11beta une chaine carbonee comportant une fonction amide, leur preparation, leur application comme medicaments.
FR2643638B1 (fr) *	1989-02-24	1991-06-14	Roussel Uclaf	Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
US5364847A (en) *	1989-03-10	1994-11-15	Endorecherche	Inhibitors of sex steroid biosynthesis and methods for their production and use
US5372996A (en) *	1989-03-10	1994-12-13	Endorecherche, Inc.	Method of treatment of androgen-related diseases
JP3350048B2 (ja) *	1989-07-07	2002-11-25	アンドルシェルシュ・インコーポレイテッド	アンドロゲン関連疾患の治療方法
DE69032648T2 (de) *	1989-07-07	1999-04-08	Endorecherche Inc., Ste-Foy, Quebec	Androgenderivate zur Hemming der Aktivität der Sexualsteroide
ES2127181T3 (es) *	1989-08-04	1999-04-16	Schering Ag	11-beta-aril-gona-4,9-dien-3-onas.
DE4042007A1 (de) *	1990-12-22	1992-06-25	Schering Ag	6,7-modifizierte-11(beta)-aryl-4-estrene
DK0471612T3 (da) *	1990-08-14	1999-02-22	Hoechst Marion Roussel Inc	Nye 19-nor steroider med carbonkæde omfattende en amidgruppe i 11-beta-stillingen, fremgangsmåde til deres fremstilling, de
US5407928A (en) *	1990-08-15	1995-04-18	Schering Aktiengesellschaft	11β-aryl-gona-4,9-dien-3-ones
FR2688004A1 (fr) *	1992-02-27	1993-09-03	Roussel Uclaf	Nouveaux sterouides comportant en position 17 un radical methylene lactone, leur procede et des intermediaires de preparation, leur application comme medicaments.
TW239145B (da) *	1992-05-21	1995-01-21	Endorech Inc
DE4332283A1 (de) *	1993-09-20	1995-04-13	Jenapharm Gmbh	Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE4332284C2 (de) *	1993-09-20	1997-05-28	Jenapharm Gmbh	11-Benzaldoxim-17beta-methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5639598A (en) *	1994-05-19	1997-06-17	The Trustees Of The University Of Pennsylvania	Method and kit for identification of antiviral agents capable of abrogating HIV Vpr-Rip-1 binding interactions
US5780220A (en) *	1994-05-19	1998-07-14	Trustees Of The University Of Pennsylvania	Methods and compositions for inhibiting HIV replication
US5576310A (en) *	1994-09-20	1996-11-19	Jenapharm Gmbh	11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds
US5521166A (en) *	1994-12-19	1996-05-28	Ortho Pharmaceitical Corporation	Antiprogestin cyclophasic hormonal regimen
ZA9510926B (en)	1994-12-23	1996-07-03	Schering Ag	Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
ATE194358T1 (de)	1996-05-01	2000-07-15	Us Gov Health & Human Serv	21-substituierte progesteron derivate als antigestagene
US6900193B1 (en) *	1996-05-01	2005-05-31	The United States Of America As Represented By The Department Of Health And Human Services	Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
IL122740A (en) *	1997-01-15	2003-09-17	Akzo Nobel Nv	16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them
US6090798A (en) *	1997-12-19	2000-07-18	Alcon Laboratories, Inc.	Treatment of GLC1A glaucoma with glucocorticoid antagonists
US6020328A (en) *	1998-03-06	2000-02-01	Research Triangle Institute	20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US5962444A (en) *	1998-05-29	1999-10-05	Research Triangle Institute	17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6262042B1 (en)	1998-05-29	2001-07-17	Research Triangle Institute	17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
EP1285927A3 (de) *	2001-08-16	2005-06-29	Schering Aktiengesellschaft	Verwendung von Glucocorticoid-Rezeptorantagonisten zur Vorbeugung und Behandlung von Erkrankungen des männlichen Reproduktionssystems
DE10236405A1 (de) *	2002-08-02	2004-02-19	Schering Ag	Progesteronrezeptormodulatoren mit erhöhter antigonadotroper Aktivität für die weibliche Fertilitätskontrolle und Hormonersatztherapie
DE102009034367A1 (de) *	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
US11103514B2 (en)	2010-05-26	2021-08-31	Corcept Therapeutics, Inc.	Treatment of muscular dystrophy
CN107530435A (zh)	2015-03-02	2018-01-02	科赛普特治疗学股份有限公司	使用糖皮质激素受体拮抗剂和生长抑素治疗acth分泌型肿瘤
WO2016160969A1 (en)	2015-03-30	2016-10-06	Corcept Therapeutics, Inc.	Use of glucocorticoid receptor antagonists in combination with glucocorticoids to treat adrenal insufficiency
KR20180052120A (ko)	2015-08-13	2018-05-17	코어셉트 쎄라퓨틱스, 잉크.	Acth-의존성 쿠싱 증후군을 감별 진단하는 방법
KR102197526B1 (ko)	2016-01-19	2020-12-31	코어셉트 쎄라퓨틱스 인코포레이티드	이소성 쿠싱 증후군의 감별 진단
CA3055076C (en)	2017-03-31	2022-02-22	Corcept Therapeutics, Inc.	Glucocorticoid receptor modulators to treat cervical cancer
JP7670462B2 (ja)	2017-06-20	2025-04-30	コーセプトセラピューティクス，インコーポレイテッド	選択的グルココルチコイドレセプターモジュレーターを使用して神経上皮腫瘍を処置する方法
AU2021400069A1 (en)	2020-12-18	2023-07-06	Instil Bio (Uk) Limited	Processing of tumor infiltrating lymphocytes

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Publication number	Priority date	Publication date	Assignee	Title
FR2377418A1 (fr) *	1977-01-13	1978-08-11	Roussel Uclaf	Nouveaux derives steroides 4,9-dieniques 11b-substitues, leur procede de preparation et leur application comme medicaments
ZA8231B (en) *	1981-01-09	1982-11-24	Roussel Uclaf	New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2522328B1 (fr) *	1982-03-01	1986-02-14	Roussel Uclaf	Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
DE3231827A1 (de) *	1982-08-24	1984-03-01	Schering AG, 1000 Berlin und 4709 Bergkamen	11ss-aryl-17(alpha)-alkinyl-17ss-hydroxy-4,9(10)- estradien-3-on-derivate, deren herstellung und diese enthaltende pharmazeutische praeparate
FR2573657B1 (fr) *	1984-11-29	1989-05-12	Roussel Uclaf	Produit comprenant une substance antiprogestomimetique et une substance uterotonique
NZ214998A (en) *	1985-02-07	1989-06-28	Schering Ag	13-(methyl or ethyl)-11-beta-phenyl-gonane derivatives; preparatory processes and pharmaceutical compositions

1986
- 1986-01-31 NZ NZ214998A patent/NZ214998A/xx unknown
- 1986-01-31 AU AU52913/86A patent/AU580843B2/en not_active Ceased
- 1986-02-02 IL IL77762A patent/IL77762A/xx not_active IP Right Cessation
- 1986-02-03 CN CN86100994A patent/CN1033753C/zh not_active Expired - Lifetime
- 1986-02-04 ES ES551625A patent/ES8701778A1/es not_active Expired
- 1986-02-05 DK DK056086A patent/DK161709C/da not_active IP Right Cessation
- 1986-02-05 PT PT81969A patent/PT81969B/pt not_active IP Right Cessation
- 1986-02-05 GR GR860342A patent/GR860342B/el unknown
- 1986-02-06 CA CA000501252A patent/CA1310630C/en not_active Expired - Lifetime
- 1986-02-06 NO NO860425A patent/NO171994C/no not_active IP Right Cessation
- 1986-02-06 IE IE33486A patent/IE58149B1/en not_active IP Right Cessation
- 1986-02-06 DE DE8686101548T patent/DE3665307D1/de not_active Expired
- 1986-02-06 EP EP86101548A patent/EP0190759B1/de not_active Expired
- 1986-02-06 HU HU86499A patent/HU194904B/hu not_active IP Right Cessation
- 1986-02-07 FI FI860559A patent/FI85377C/fi not_active IP Right Cessation
- 1986-02-07 US US06/827,050 patent/US5089635A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0190759B1 (de)	1989-08-30
HU194904B (en)	1988-03-28
US5089635A (en)	1992-02-18
NO171994B (no)	1993-02-15
DK161709B (da)	1991-08-05
IE860334L (en)	1986-08-07
ES8701778A1 (es)	1986-12-16
NZ214998A (en)	1989-06-28
PT81969A (de)	1986-03-01
GR860342B (en)	1986-06-03
EP0190759A2 (de)	1986-08-13
NO860425L (no)	1986-08-08
HUT40453A (en)	1986-12-28
DK161709C (da)	1992-01-13
FI860559A0 (fi)	1986-02-07
FI860559L (fi)	1986-08-08
DK56086D0 (da)	1986-02-05
CN86100994A (zh)	1986-10-08
DE3665307D1 (en)	1989-10-05
EP0190759A3 (en)	1986-11-20
IL77762A (en)	1992-08-18
FI85377B (fi)	1991-12-31
ES551625A0 (es)	1986-12-16
PT81969B (pt)	1988-03-03
CA1310630C (en)	1992-11-24
IE58149B1 (en)	1993-07-14
CN1033753C (zh)	1997-01-08
AU5291386A (en)	1986-08-14
AU580843B2 (en)	1989-02-02
FI85377C (fi)	1992-04-10
DK56086A (da)	1986-08-08

Publication	Publication Date	Title
NO171994C (no)	1993-05-26	Fremgangsmaate for fremstilling av dihydroxylerte 11beta-(4-acetylfenyl)-17beta-hydroxy-17alfa-(1-propynyl)-4,9-estradien-3-oner
DK162371C (da)	1992-03-23	Loefteindretning til handikappede
NO903920L (no)	1986-09-15	Fremgangsmaate for fremstilling av en isomerblanding.
NO865013D0 (no)	1986-12-11	Fremgangsmaate for fremstilling av antibaktercelle kinolon-derivater.
NO864879L (no)	1987-06-09	Fremgangsmaate for fremstilling av terapeutisk aktive tiazolforbindelser.
NO165143C (no)	1991-01-09	Fremgangsmaate til fremstilling av hydrokloridet av fenyl-1-dietylaminokarbonyl-1-aminometyl-2-cyklopropan (z).
NO861486L (no)	1986-10-20	Fremgangsmaate til fremstilling av fluorerte benzyltriazolforbindelser.
NO864108D0 (no)	1986-10-15	Fremgangsmaate for fremstilling av nye flavon-derivater.
NO863251L (no)	1987-02-16	Fremgangsmaate for fremstilling av sphingosinderivater.
NO862942D0 (no)	1986-07-22	Fremgangsmaate for fremstilling av kalsiumfluorsilikat.
NO864515D0 (no)	1986-11-12	Fremgangsmaate for fremstilling av heterocyliske oxazoloner
NO860429L (no)	1986-08-11	Fremgangsmaate for fremstilling av imidazolyl-indol-derivater.
NO863389D0 (no)	1986-08-22	Fremgangsmaate til fremstilling av substituerte toluidiner.
NO863616L (no)	1987-03-12	Fremgangsmaate for fremstilling av n-sulfamyl-3-(2-guanidinothiazolo-4-yl-methylthio)-propionamid.
NO864446D0 (no)	1986-11-07	Fremgangsmaate til fremstilling av en oksydisk katalysatorforloeper.
NO862270D0 (no)	1986-06-06	Fremgangsmaate for fremstilling av nye isatinforbindelser.
NO863343L (no)	1987-02-23	Fremgangsmaate for fremstilling av gem-dihalo-1,8-diamino-4-aza-octaner.
NO164543C (no)	1990-10-17	Fremgangsmaate til fremstilling av n7-amidino substituerte mitomycin c-derivater.
NO864121D0 (no)	1986-10-16	Fremgangsmaate til fremstilling av polyvinylklorid.
NO863769D0 (no)	1986-09-22	Fremgangsmaate for fremstilling av 4-hydroksy-2-oksopyrrolin-1-yl-acetamid.
FI863883A0 (fi)	1986-09-25	Anordning foer tillslutning av flaskhals.
NO864087D0 (no)	1986-10-14	Fremgangsmaate for fremstilling av aroylthiazoloner.
NO862493L (no)	1986-12-22	Fremgangsmaate for fremstilling av 2-halonicergolinderivater.
NO863045D0 (no)	1986-07-28	Fremgangsmaate for fremstilling av alkyl-2-karboalkoksy-3,4-dialkoksybenzenkarbamater.
FI864790A0 (fi)	1986-11-25	Foerfarande foer framstaellning av 5-klor- och 5-brom-2-hydroxinikotinsyror.

Legal Events

Date	Code	Title	Description
2004-12-20	MM1K	Lapsed by not paying the annual fees