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NO177055C - Analogous Process for the Preparation of Therapeutically Active 2-Oxetanones - Google Patents

Analogous Process for the Preparation of Therapeutically Active 2-Oxetanones

Info

Publication number
NO177055C
NO177055C NO910729A NO910729A NO177055C NO 177055 C NO177055 C NO 177055C NO 910729 A NO910729 A NO 910729A NO 910729 A NO910729 A NO 910729A NO 177055 C NO177055 C NO 177055C
Authority
NO
Norway
Prior art keywords
oxetanones
preparation
therapeutically active
analogous process
novel
Prior art date
Application number
NO910729A
Other languages
Norwegian (no)
Other versions
NO177055B (en
NO910729L (en
NO910729D0 (en
Inventor
Romano Derungs
Hans Peter Marki
Henri Stalder
Andre Szente
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO910729D0 publication Critical patent/NO910729D0/en
Publication of NO910729L publication Critical patent/NO910729L/en
Publication of NO177055B publication Critical patent/NO177055B/en
Publication of NO177055C publication Critical patent/NO177055C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

Novel oxetanones inhibiting pancreatic lipase, of the formula <IMAGE> in which Q, R<1> and R<2> have the meaning given in the description, are disclosed, which are prepared starting from the corresponding beta -hydroxycarboxylic acids.
NO910729A 1990-02-26 1991-02-25 Analogous Process for the Preparation of Therapeutically Active 2-Oxetanones NO177055C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH60490 1990-02-26
CH400590 1990-12-17

Publications (4)

Publication Number Publication Date
NO910729D0 NO910729D0 (en) 1991-02-25
NO910729L NO910729L (en) 1991-08-27
NO177055B NO177055B (en) 1995-04-03
NO177055C true NO177055C (en) 1995-07-12

Family

ID=25685091

Family Applications (1)

Application Number Title Priority Date Filing Date
NO910729A NO177055C (en) 1990-02-26 1991-02-25 Analogous Process for the Preparation of Therapeutically Active 2-Oxetanones

Country Status (18)

Country Link
EP (1) EP0444482B1 (en)
JP (1) JP2753403B2 (en)
KR (1) KR0183036B1 (en)
AT (1) ATE133167T1 (en)
AU (1) AU645291B2 (en)
CA (1) CA2035967C (en)
DE (1) DE59107262D1 (en)
DK (1) DK0444482T3 (en)
ES (1) ES2082869T3 (en)
FI (1) FI115054B (en)
GR (1) GR3019618T3 (en)
HU (1) HU218272B (en)
IE (1) IE72196B1 (en)
IL (1) IL97148A (en)
MC (1) MC2226A1 (en)
NO (1) NO177055C (en)
NZ (1) NZ237170A (en)
PT (1) PT96887B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2035972C (en) * 1990-02-23 2006-07-11 Martin Karpf Process for the preparation of oxetanones
CA2098167C (en) * 1992-06-24 2006-12-19 Dorothea Isler Foodstuffs and feedstuffs containing a lipase inhibitor
NL1004559C2 (en) * 1996-11-18 1998-05-19 Unilife Butter.
US6348492B1 (en) * 1999-10-29 2002-02-19 2Pro Chemical Oxetanone derivatives
US6342519B2 (en) * 1999-10-29 2002-01-29 2 Pro Chemical Oxetanone derivatives
CA2358921A1 (en) * 1999-10-29 2001-05-10 John Jason Gentry Mullins Oxetanone derivatives
US7074822B2 (en) 2004-02-23 2006-07-11 Solvay Pharmaceuticals Gmbh Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them
DE102004009076A1 (en) * 2004-02-23 2005-10-27 Solvay Pharmaceuticals Gmbh Alkylcarbamate-substituted β-lactones, processes and intermediates for their preparation, and medicaments containing these compounds
JP2011502167A (en) 2007-10-31 2011-01-20 バーンハム インスティテュート フォー メディカル リサーチ β-lactone compounds
SG11202000239XA (en) * 2017-07-12 2020-02-27 Mayo Found Medical Education & Res Compounds for the reducing lipotoxic damage

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS608117B2 (en) * 1977-02-08 1985-02-28 財団法人微生物化学研究会 New physiologically active substance esterastin and its production method
GB2023604B (en) * 1978-05-25 1982-07-28 Microbial Chem Res Found Physiologically active derivatives of esterastin and production thereof
JPH0669130B2 (en) * 1984-08-09 1994-08-31 三菱電機株式会社 Delay line

Also Published As

Publication number Publication date
ATE133167T1 (en) 1996-02-15
GR3019618T3 (en) 1996-07-31
JP2753403B2 (en) 1998-05-20
IL97148A0 (en) 1992-05-25
ES2082869T3 (en) 1996-04-01
IL97148A (en) 1996-11-14
KR0183036B1 (en) 1999-05-01
NZ237170A (en) 1993-12-23
NO177055B (en) 1995-04-03
IE910631A1 (en) 1991-08-28
EP0444482A2 (en) 1991-09-04
IE72196B1 (en) 1997-03-26
PT96887B (en) 1998-09-30
AU7122891A (en) 1991-08-29
FI910925L (en) 1991-08-27
HUT56557A (en) 1991-09-30
EP0444482B1 (en) 1996-01-17
FI115054B (en) 2005-02-28
CA2035967A1 (en) 1991-08-27
HU218272B (en) 2000-07-28
NO910729L (en) 1991-08-27
DK0444482T3 (en) 1996-05-06
PT96887A (en) 1991-10-31
NO910729D0 (en) 1991-02-25
MC2226A1 (en) 1993-02-02
KR910021391A (en) 1991-12-20
FI910925A0 (en) 1991-02-26
CA2035967C (en) 2001-10-16
AU645291B2 (en) 1994-01-13
JPH0770099A (en) 1995-03-14
EP0444482A3 (en) 1991-12-04
DE59107262D1 (en) 1996-02-29

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