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NO163867C - Fremgangsmaate for fremstilling av et enzymderivat. - Google Patents

Fremgangsmaate for fremstilling av et enzymderivat.

Info

Publication number
NO163867C
NO163867C NO803304A NO803304A NO163867C NO 163867 C NO163867 C NO 163867C NO 803304 A NO803304 A NO 803304A NO 803304 A NO803304 A NO 803304A NO 163867 C NO163867 C NO 163867C
Authority
NO
Norway
Prior art keywords
procedure
preparation
enzyme derivative
enzyme
derivative
Prior art date
Application number
NO803304A
Other languages
English (en)
Other versions
NO803304L (no
NO163867B (no
Inventor
Richard Anthony Godwin Smith
John Gordon Winchester
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of NO803304L publication Critical patent/NO803304L/no
Publication of NO163867B publication Critical patent/NO163867B/no
Publication of NO163867C publication Critical patent/NO163867C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO803304A 1979-11-05 1980-11-04 Fremgangsmaate for fremstilling av et enzymderivat. NO163867C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7938279 1979-11-05

Publications (3)

Publication Number Publication Date
NO803304L NO803304L (no) 1981-05-06
NO163867B NO163867B (no) 1990-04-23
NO163867C true NO163867C (no) 1990-08-01

Family

ID=10508982

Family Applications (1)

Application Number Title Priority Date Filing Date
NO803304A NO163867C (no) 1979-11-05 1980-11-04 Fremgangsmaate for fremstilling av et enzymderivat.

Country Status (18)

Country Link
US (1) US4808405A (no)
EP (1) EP0028489B1 (no)
JP (1) JPS5678590A (no)
AR (1) AR224786A1 (no)
CA (1) CA1174621A (no)
CS (2) CS391991A3 (no)
DE (1) DE3065190D1 (no)
DK (1) DK158994C (no)
ES (1) ES8204467A1 (no)
GR (1) GR72121B (no)
HK (1) HK65886A (no)
HU (1) HU185223B (no)
IE (1) IE50174B1 (no)
IL (1) IL61408A (no)
NL (1) NL930029I2 (no)
NO (1) NO163867C (no)
NZ (1) NZ195469A (no)
ZA (1) ZA806641B (no)

Families Citing this family (78)

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WO1984001960A1 (en) * 1982-11-11 1984-05-24 Beecham Group Plc Pharmaceutically active compounds
GB8400653D0 (en) * 1984-01-11 1984-02-15 Beecham Group Plc Conjugates
GB8430253D0 (en) * 1984-11-30 1985-01-09 Beecham Group Plc Compounds
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AU647391B2 (en) * 1989-05-01 1994-03-24 University Of Notre Dame Du Lac, The Methods and materials for expression of human plasminogen in a eukaryotic cell system
EP0397366A1 (en) * 1989-05-09 1990-11-14 The Board Of Regents Of The University Of Oklahoma Hybrid streptokinases with fibrin binding domains and methods for the synthesis of same
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US5190756A (en) * 1989-12-01 1993-03-02 Genentech, Inc. Methods and materials for expression of human plasminogen variant
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US6458360B1 (en) 1990-04-25 2002-10-01 The Johns Hopkins University Soluble complement regulatory molecules
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AU1873092A (en) * 1991-04-09 1992-11-17 Brigham And Women's Hospital Chimeric molecule with plasminogen activator activity and affinity for atherosclerotic plaques
US5520912A (en) * 1993-07-02 1996-05-28 Immuno Aktiengesellschaft Prevention and treatment of ischemic events and reperfusion injury resulting therefrom using lys-plasminogen
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EP1899299B1 (en) 2005-06-27 2010-10-20 Bristol-Myers Squibb Company C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
WO2007146719A2 (en) 2006-06-08 2007-12-21 Bristol-Myers Squibb Company 2-aminocarbonylphenylamino-2-phenylacetamides as factor viia inhibitors useful as anticoagulants
US7960569B2 (en) 2006-10-17 2011-06-14 Bristol-Myers Squibb Company Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
US7910597B2 (en) * 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
EP2102189B1 (en) 2006-12-15 2015-07-29 Bristol-Myers Squibb Company Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors
PE20081775A1 (es) 2006-12-20 2008-12-18 Bristol Myers Squibb Co Compuestos macrociclicos como inhibidores del factor viia
MX2009012847A (es) 2007-06-13 2009-12-08 Bristol Myers Squibb Co Analogos dipeptidicos como inhibidores de factores de coagulacion.
US20090130017A1 (en) * 2007-11-19 2009-05-21 Searete Llc Targeted short-lived drug delivery
US8148363B2 (en) 2008-05-19 2012-04-03 Schering Corporation Heterocyclic compounds as factor IXA inhibitors
SMT202000093T1 (it) 2009-06-16 2020-03-13 Pfizer Forme di dosaggio di apixaban
TWI393716B (zh) 2009-08-04 2013-04-21 Merck Sharp & Dohme 作為ｉｘａ因子抑制劑之雜環化合物
EP2534154B1 (en) 2010-02-11 2020-08-05 Bristol-Myers Squibb Company Macrocycles as factor xia inhibitors
TW201311689A (zh) 2011-08-05 2013-03-16 必治妥美雅史谷比公司 作為因子ｘｉａ抑制劑之新穎巨環化合物
TW201319068A (zh) 2011-08-05 2013-05-16 必治妥美雅史谷比公司 作為ｘｉａ因子抑制劑之環狀ｐ１接合劑
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CN103987696B (zh) 2011-10-14 2016-12-21 百时美施贵宝公司 作为因子xia抑制剂的取代的四氢异喹啉化合物
WO2013055984A1 (en) 2011-10-14 2013-04-18 Bristol-Myers Squibb Company Substituted tetrahydroisoquinoline compounds as factor xia inhibitors
PE20161219A1 (es) 2011-11-11 2016-11-17 Pfizer 2-tiopirimidinonas
CN104334557A (zh) 2012-04-06 2015-02-04 辉瑞公司 二酰基甘油酰基转移酶2抑制剂
SMT201700240T1 (it) 2012-08-03 2017-07-18 Bristol Myers Squibb Co Diidropiridone-p1 come inibitore del fattore xia
PL2882734T3 (pl) 2012-08-03 2017-05-31 Bristol-Myers Squibb Company Dihydropirydon jako inhibitory czynnika XIA
ES2712699T3 (es) 2013-03-25 2019-05-14 Bristol Myers Squibb Co Tetrahidroisoquinolinas que contienen azoles sustituidos como inhibidores del factor XIa
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SI3099687T1 (en) 2014-01-31 2018-08-31 Bristol-Myers Squibb Company Macrocycles with hetrocyclic p2' groups as factor xia inhibitors
NO2760821T3 (no) 2014-01-31 2018-03-10
AU2015233094B2 (en) 2014-03-17 2017-04-27 Pfizer Inc. Diacylglycerol acyltransferase 2 inhibitors for use in the treatment of metabolic and related disorders
PT3126330T (pt) 2014-04-04 2019-04-29 Pfizer Compostos bicíclicos de heteroarilo ou arilo fusionados e a sua utilização como inibidores de irak4
WO2015160636A1 (en) 2014-04-16 2015-10-22 Merck Sharp & Dohme Corp. Factor ixa inhibitors
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US4178368A (en) * 1971-09-30 1979-12-11 Behringwerke Aktiengesellschaft Method for the treatment of thromboembolism
JPS5325775A (en) * 1976-08-24 1978-03-09 Miller Fluid Power Corp Module type fluid flow control element
US4082612A (en) * 1976-09-24 1978-04-04 Michael Reese Research Foundation Plasminogen activator complex
NZ191320A (en) * 1978-09-07 1982-09-14 Beecham Group Ltd In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions

Also Published As

Publication number Publication date
CS391191A3 (en) 1992-08-12
DE3065190D1 (en) 1983-11-10
IE50174B1 (en) 1986-02-19
EP0028489B1 (en) 1983-10-05
DK158994B (da) 1990-08-13
ES496586A0 (es) 1982-05-01
AR224786A1 (es) 1982-01-15
IL61408A (en) 1983-10-31
AU534017B2 (en) 1983-12-22
CS391991A3 (en) 1992-06-17
IL61408A0 (en) 1980-12-31
NO803304L (no) 1981-05-06
ZA806641B (en) 1981-10-28
US4808405A (en) 1989-02-28
NL930029I1 (nl) 1993-06-01
DK158994C (da) 1991-01-07
AU6401180A (en) 1981-05-14
NZ195469A (en) 1984-05-31
NO163867B (no) 1990-04-23
GR72121B (no) 1983-09-16
IE802277L (en) 1981-05-05
JPS5678590A (en) 1981-06-27
EP0028489A1 (en) 1981-05-13
DK468880A (da) 1981-05-06
HU185223B (en) 1984-12-28
ES8204467A1 (es) 1982-05-01
CA1174621A (en) 1984-09-18
NL930029I2 (nl) 1993-12-01
HK65886A (en) 1986-09-12
JPH0316114B2 (no) 1991-03-04

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