NO165922C - Analogifremgangsmaate for fremstilling av terapeutisk aktive estere av hexahydro-8-hydroxy-2,6-methano-2h-kinolizin-3-(4h)-on og beslektede forbindelser. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive estere av hexahydro-8-hydroxy-2,6-methano-2h-kinolizin-3-(4h)-on og beslektede forbindelser.

Info

Publication number: NO165922C
Authority: NO; Norway
Prior art keywords: quinolizin; methano; hexahydro; hydroxy; preparation
Prior art date: 1986-11-03

Application number

NO874550A

Other languages

English (en)

Other versions

NO874550L (no

NO874550D0 (no

NO165922B (no

Inventor

Maurice Ward Gittos

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-11-03

Filing date

1987-11-02

Publication date

1991-05-02

1987-11-02 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

1987-11-02 Publication of NO874550D0 publication Critical patent/NO874550D0/no

1988-05-04 Publication of NO874550L publication Critical patent/NO874550L/no

1991-01-21 Publication of NO165922B publication Critical patent/NO165922B/no

1991-05-02 Publication of NO165922C publication Critical patent/NO165922C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO874550A 1986-11-03 1987-11-02 Analogifremgangsmaate for fremstilling av terapeutisk aktive estere av hexahydro-8-hydroxy-2,6-methano-2h-kinolizin-3-(4h)-on og beslektede forbindelser. NO165922C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US92661986A	1986-11-03	1986-11-03

Publications (4)

Publication Number	Publication Date
NO874550D0 NO874550D0 (no)	1987-11-02
NO874550L NO874550L (no)	1988-05-04
NO165922B NO165922B (no)	1991-01-21
NO165922C true NO165922C (no)	1991-05-02

Family

ID=25453460

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO874550A NO165922C (no)	1986-11-03	1987-11-02	Analogifremgangsmaate for fremstilling av terapeutisk aktive estere av hexahydro-8-hydroxy-2,6-methano-2h-kinolizin-3-(4h)-on og beslektede forbindelser.
NO1999020C NO1999020I1 (no)	1986-11-03	1999-08-26	Dolasetron

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO1999020C NO1999020I1 (no)	1986-11-03	1999-08-26	Dolasetron

Country Status (21)

Country	Link
EP (1)	EP0266730B1 (no)
JP (2)	JP2542225B2 (no)
KR (1)	KR950011737B1 (no)
CN (1)	CN1021654C (no)
AR (1)	AR246264A1 (no)
AT (1)	ATE109779T1 (no)
AU (1)	AU600318B2 (no)
CA (1)	CA1329203C (no)
DE (2)	DE19775092I2 (no)
DK (1)	DK171116B1 (no)
ES (1)	ES2061469T3 (no)
FI (1)	FI87786C (no)
HU (1)	HU197008B (no)
IE (1)	IE63670B1 (no)
IL (1)	IL84309A (no)
NL (1)	NL970043I2 (no)
NO (2)	NO165922C (no)
NZ (1)	NZ222349A (no)
PH (2)	PH24664A (no)
PT (1)	PT86060B (no)
ZA (1)	ZA878096B (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0329932B1 (en) *	1988-02-23	1995-10-18	Merrell Pharmaceuticals Inc.	Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments
EP0329905A1 (en) *	1988-02-23	1989-08-30	Merrell Dow Pharmaceuticals Inc.	Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments for increasing gastric motility
EP0329903A1 (en) *	1988-02-23	1989-08-30	Merrell Dow Pharmaceuticals Inc.	Use of quinolizinone and quinolizine derivatives in the manufacture of medicaments for the treatment of glaucoma
EP0329902A1 (en) *	1988-02-23	1989-08-30	Merrell Dow Pharmaceuticals Inc.	Use of quinolizinone and quinolizine derivatives in the manufacture of medicaments for the treatment of psychosis
US5011846A (en) *	1988-02-23	1991-04-30	Merrell Dow Pharmaceuticals Inc.	Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof
EP0329904A1 (en) *	1988-02-23	1989-08-30	Merrell Dow Pharmaceuticals Inc.	Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments for the treatment of anxiety
EP0330788A1 (en) *	1988-03-01	1989-09-06	Merrell Dow Pharmaceuticals Inc.	Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments for the treatment of cardiac arrhythmia
ZA893008B (en) *	1988-04-29	1989-12-27	Merrell Dow Pharma	Process for preparing indole-3-carboxylic acid esters of transhexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one
GB8928837D0 (en) *	1989-12-21	1990-02-28	Beecham Group Plc	Pharmaceuticals
EP0492020A1 (en) *	1990-12-21	1992-07-01	Merrell Dow Pharmaceuticals Inc.	Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds for treating cognitive disorders
DK1040094T3 (da) *	1997-12-17	2009-06-02	Biocryst Pharm Inc	Substitueret cyklopentan og cyklopenten-forbindelser anvendelige som neuraminidase-inhibitorer
CN100390172C (zh) *	2004-09-10	2008-05-28	成都欣捷高新技术开发有限公司	一种甲磺酸多拉司琼晶型及其制备方法
US20070299260A1 (en) *	2004-11-25	2007-12-27	Cilag Ltd.	Method for Preparing Hexahydro-8-Hydroxy-2, 6-Methano-2H-Chinolizin-3 (4H) -One Esters
DE602006003227D1 (de) *	2005-07-06	2008-11-27	Inke Sa	Verfahren zur gewinnung der pharmazeutisch aktivendavon und verfahren zu deren gewinnung
ES2264901B1 (es)	2005-07-06	2007-12-01	Inke, S.A.	Procedimiento para la obtencion de un compuesto farmaceuticamente activo, sus intermedios de sintesis y procedimiento para la obtencion de los mismos.
US20070203177A1 (en) *	2006-01-05	2007-08-30	Janos Hajko	Forms of dolasetron mesylate and processes for their preparation
EP2060557B1 (en)	2007-11-13	2012-06-06	Inke, S.A.	Intermediate compounds useful to prepare dolasetron
CN102458400B (zh)	2009-05-20	2014-10-08	国立健康与医学研究所	用于治疗病灶性前庭功能障碍的血清素5-ht3受体拮抗剂
EP2253316B1 (en)	2009-05-20	2013-08-14	INSERM (Institut National de la Santé et de la Recherche Médicale)	Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
EP3347011A4 (en)	2015-09-11	2019-06-19	Chase Pharmaceuticals Corporation	MUSCARIN COMBINATION AND ITS USE FOR COMBATING HYPOCHOLINERGEN DISORDERS OF THE CENTRAL NERVOUS SYSTEM
CN108976230A (zh) *	2018-06-18	2018-12-11	东莞市联洲知识产权运营管理有限公司	一种基于石墨烯活化制备甲磺酸多拉司琼关键中间体的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI74707C (fi) *	1982-06-29	1988-03-10	Sandoz Ag	Foerfarande foer framstaellning av terapeutiskt anvaendbara alkylenoeverbryggade piperidylestrar eller -amider av bicykliska karboxylsyror.
WO1985001048A1 (en) *	1983-08-26	1985-03-14	Sandoz Ag	Aromatic esters or amides of carboxylic acid and sulfonic acid
EP0189002B1 (en) *	1984-12-20	1993-03-03	Sandoz Ag	Treatment of gastrointestinal disorders using 5-ht3 antagonists

1987
- 1987-10-28 ZA ZA878096A patent/ZA878096B/xx unknown
- 1987-10-29 FI FI874768A patent/FI87786C/fi not_active IP Right Cessation
- 1987-10-29 NZ NZ222349A patent/NZ222349A/xx unknown
- 1987-10-29 IL IL84309A patent/IL84309A/xx not_active IP Right Cessation
- 1987-10-29 CA CA000550612A patent/CA1329203C/en not_active Expired - Lifetime
- 1987-10-30 AR AR87309166A patent/AR246264A1/es active
- 1987-10-30 PH PH36006A patent/PH24664A/en unknown
- 1987-11-02 AT AT87116119T patent/ATE109779T1/de not_active IP Right Cessation
- 1987-11-02 DK DK572887A patent/DK171116B1/da not_active IP Right Cessation
- 1987-11-02 HU HU874918A patent/HU197008B/hu unknown
- 1987-11-02 NO NO874550A patent/NO165922C/no not_active IP Right Cessation
- 1987-11-02 EP EP87116119A patent/EP0266730B1/en not_active Expired - Lifetime
- 1987-11-02 PT PT86060A patent/PT86060B/pt unknown
- 1987-11-02 DE DE1997175092 patent/DE19775092I2/de active Active
- 1987-11-02 DE DE3750359T patent/DE3750359T2/de not_active Expired - Lifetime
- 1987-11-02 CN CN87107629A patent/CN1021654C/zh not_active Expired - Lifetime
- 1987-11-02 AU AU80596/87A patent/AU600318B2/en not_active Expired
- 1987-11-02 JP JP62275894A patent/JP2542225B2/ja not_active Expired - Lifetime
- 1987-11-02 ES ES87116119T patent/ES2061469T3/es not_active Expired - Lifetime
- 1987-11-02 IE IE295587A patent/IE63670B1/en not_active IP Right Cessation
- 1987-11-03 KR KR1019870012286A patent/KR950011737B1/ko not_active Expired - Lifetime
1990
- 1990-01-02 PH PH39830A patent/PH26261A/en unknown
1996
- 1996-02-27 JP JP8065408A patent/JP2657267B2/ja not_active Expired - Lifetime
1997
- 1997-12-17 NL NL970043C patent/NL970043I2/nl unknown
1999
- 1999-08-26 NO NO1999020C patent/NO1999020I1/no unknown

Also Published As

Publication number	Publication date
DK572887D0 (da)	1987-11-02
KR880006240A (ko)	1988-07-22
JP2657267B2 (ja)	1997-09-24
IL84309A (en)	1991-09-16
FI874768A7 (fi)	1988-05-04
CA1329203C (en)	1994-05-03
JP2542225B2 (ja)	1996-10-09
HU197008B (en)	1989-02-28
FI87786B (fi)	1992-11-13
AU8059687A (en)	1988-05-05
JPS63258476A (ja)	1988-10-25
AU600318B2 (en)	1990-08-09
PH24664A (en)	1990-09-07
DK171116B1 (da)	1996-06-17
AR246264A1 (es)	1994-07-29
HUT45055A (en)	1988-05-30
DE3750359T2 (de)	1994-12-08
FI874768A0 (fi)	1987-10-29
NO874550L (no)	1988-05-04
ES2061469T3 (es)	1994-12-16
ZA878096B (en)	1988-04-26
CN1021654C (zh)	1993-07-21
NO874550D0 (no)	1987-11-02
DE19775092I2 (de)	2001-11-22
CN87107629A (zh)	1988-06-15
IE63670B1 (en)	1995-05-31
NO1999020I1 (no)	1999-08-26
NO165922B (no)	1991-01-21
EP0266730A1 (en)	1988-05-11
PT86060B (pt)	1990-07-31
KR950011737B1 (ko)	1995-10-09
IE872955L (en)	1988-05-03
NL970043I1 (nl)	1998-03-02
NZ222349A (en)	1990-05-28
ATE109779T1 (de)	1994-08-15
EP0266730B1 (en)	1994-08-10
JPH0977769A (ja)	1997-03-25
DE3750359D1 (de)	1994-09-15
NL970043I2 (nl)	1998-10-01
DK572887A (da)	1988-05-04
PT86060A (en)	1987-12-01
FI87786C (fi)	1993-02-25
PH26261A (en)	1992-04-01

Publication	Publication Date	Title
NO165922C (no)	1991-05-02	Analogifremgangsmaate for fremstilling av terapeutisk aktive estere av hexahydro-8-hydroxy-2,6-methano-2h-kinolizin-3-(4h)-on og beslektede forbindelser.
NO165344C (no)	1991-01-30	Analogifremgangsmaate for fremstilling av teraputisk aktive indolizin-derivater.
NO166639C (no)	1991-08-21	Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte, basiske 2-aminotetraliner.
NO871277D0 (no)	1987-03-26	Fremgangsmaate for fremstilling av terapeutisk aktive oxadiazoler.
NO871266D0 (no)	1987-03-26	Fremgangsmaate for fremstilling av terapeutisk aktive kinazolin-derivater.
NO874869D0 (no)	1987-11-23	Fremgangsmaate for fremstilling av terapeutisk aktive forbindelser.
NO870526D0 (no)	1987-02-11	Fremgangsmaate for fremstilling av terapeutisk aktive dikloranilin-derivater.
NO902411D0 (no)	1990-05-31	Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-hydroksy-n-propylaminer.
NO874032D0 (no)	1987-09-25	Fremgangsmaate for fremstilling av terapeutisk aktive catecholderivater.
NO871588L (no)	1987-10-16	Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske karboksamider.
NO166080C (no)	1991-05-29	Analogifremgangsmaate for fremstilling av terapeutisk aktive 5,6,8-trifluorkinoliner.
NO171412C (no)	1993-03-10	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,3-oksatiolan- eller 1,3-ditiolanderivater
NO883485D0 (no)	1988-08-05	Fremgangsmaate for fremstilling av terapeutisk aktive piperidinyl-isokinolinforbindelser.
NO875488D0 (no)	1987-12-30	Fremgangsmaate for fremstilling av terapeutisk aktive alkansulfonanilid-derivater.
NO880667L (no)	1988-08-18	Fremgangsmaate for fremstilling av terapeutisk aktive arylpiperazinyl-alkylen-fenyl-heterocykliske forbindelser.
NO165069C (no)	1990-12-19	Analogifremgangsmaate for fremstilling av terapeutisk aktive cyklopentyletere.
NO167802C (no)	1991-12-11	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzotiazepinderivater.
NO168247C (no)	1992-01-29	Analogifremgangsmaate for fremstilling av terapeutisk aktive 5-metoksy-alkyl-ammonium-tetrahydrofuraner.
NO882281D0 (no)	1988-05-25	Fremgangsmaate for fremstilling av terapeutisk aktive pyrazinamider.
NO892871D0 (no)	1989-07-11	Fremgangsmaate for fremstilling av terapeutisk aktive forbindelser.
NO871907D0 (no)	1987-05-07	Fremgangsmaate for fremstilling av terapeutisk aktive alkenamid-derivater.
NO882282L (no)	1988-11-28	Fremgangsmaate for fremstilling av terapeutisk aktive pyrazinamider.
NO883959D0 (no)	1988-09-06	Fremgangsmaate for fremstilling av terapeutisk aktive fenolestere.
NO166715C (no)	1991-08-28	Analogifremgangsmaate for fremstilling av terapeutisk aktive cytorodin s derivater.
NO170545C (no)	1992-10-28	Analogifremgangsmaate for fremstilling av terapeutisk virksomme 6,21-dimethyl-19-nor-pregna-diener

Legal Events

Date	Code	Title	Description
2007-12-03	MK1K	Patent expired
2011-10-10	MK1K	Patent expired