[go: up one dir, main page]

NO154803C - Fremgangsmaate ved fremstilling av et faktor-xa-preparat for bruk ved bestemmelse av prothrombin i biologisk materiale. - Google Patents

Fremgangsmaate ved fremstilling av et faktor-xa-preparat for bruk ved bestemmelse av prothrombin i biologisk materiale.

Info

Publication number
NO154803C
NO154803C NO83833884A NO833884A NO154803C NO 154803 C NO154803 C NO 154803C NO 83833884 A NO83833884 A NO 83833884A NO 833884 A NO833884 A NO 833884A NO 154803 C NO154803 C NO 154803C
Authority
NO
Norway
Prior art keywords
preparation
prothrombine
factor
procedure
determining
Prior art date
Application number
NO83833884A
Other languages
English (en)
Other versions
NO154803B (no
NO833884L (no
Inventor
Bruno Kirchhof
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO833884L publication Critical patent/NO833884L/no
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of NO154803B publication Critical patent/NO154803B/no
Publication of NO154803C publication Critical patent/NO154803C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0804Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0812Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10Anilides
    • C12Q2337/12Para-Nitroanilides p-NA
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/4609Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates from reptiles
    • G01N2333/4613Snake venom
    • G01N2333/4616Snake venom from Russell's viper
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/4609Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates from reptiles
    • G01N2333/4613Snake venom
    • G01N2333/4633Snake venom from Echis carinatus; Ecarin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433Serine endopeptidases (3.4.21)
    • G01N2333/96441Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96444Factor X (3.4.21.6)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974Thrombin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/04Phospholipids, i.e. phosphoglycerides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Analytical Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
NO83833884A 1977-12-24 1983-10-25 Fremgangsmaate ved fremstilling av et faktor-xa-preparat for bruk ved bestemmelse av prothrombin i biologisk materiale. NO154803C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772757992 DE2757992A1 (de) 1977-12-24 1977-12-24 Verfahren zur prothrombin-bestimmung

Publications (3)

Publication Number Publication Date
NO833884L NO833884L (no) 1979-06-26
NO154803B NO154803B (no) 1986-09-15
NO154803C true NO154803C (no) 1986-12-29

Family

ID=6027271

Family Applications (2)

Application Number Title Priority Date Filing Date
NO784318A NO151792C (no) 1977-12-24 1978-12-21 Fremgangsmaate ved bestemmelse av prothrombin i biologisk materiale og reagens for anvendelse ved fremgangsmaaten
NO83833884A NO154803C (no) 1977-12-24 1983-10-25 Fremgangsmaate ved fremstilling av et faktor-xa-preparat for bruk ved bestemmelse av prothrombin i biologisk materiale.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO784318A NO151792C (no) 1977-12-24 1978-12-21 Fremgangsmaate ved bestemmelse av prothrombin i biologisk materiale og reagens for anvendelse ved fremgangsmaaten

Country Status (9)

Country Link
US (1) US4334018A (no)
EP (1) EP0003474B1 (no)
JP (2) JPS588840B2 (no)
AT (1) AT360661B (no)
CA (1) CA1127942A (no)
DE (2) DE2757992A1 (no)
DK (1) DK150719C (no)
FI (1) FI64466C (no)
NO (2) NO151792C (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289498A (en) * 1979-01-08 1981-09-15 Ortho Diagnostics, Inc. One-stage prothrombin assay and compositions useful therein
US4463090A (en) * 1981-09-30 1984-07-31 Harris Curtis C Cascade amplification enzyme immunoassay
DE3413311A1 (de) * 1984-04-09 1985-10-17 Behringwerke Ag, 3550 Marburg Reagenz zur bestimmung der thromboplastinzeit
GB2178533B (en) * 1985-07-22 1989-07-19 Asahi Chemical Ind Analytical method of enzyme precursors and device therefor
DE3607559A1 (de) * 1986-03-07 1987-09-10 Boehringer Mannheim Gmbh Verfahren zur photometrischen bestimmung der protein c- und/oder protein s-aktivitaet
US5190864A (en) * 1986-04-15 1993-03-02 Northeastern University Enzyme amplification by using free enzyme to release enzyme from an immobilized enzyme material
US4937188A (en) * 1986-04-15 1990-06-26 Northeastern University Enzyme activity amplification method for increasing assay sensitivity
US5312745A (en) * 1987-06-18 1994-05-17 Chromogenix Ab Determination of components active in proteolysis
DE3727610A1 (de) * 1987-08-19 1989-03-02 Behringwerke Ag Synthetische peptide, gegen diese gerichtete antikoerper und deren verwendung
US6541275B1 (en) * 1988-02-03 2003-04-01 Dade Behring Inc. Immunoassay for F1.2 prothrombin fragment
DE4203980A1 (de) * 1992-02-11 1993-08-12 Max Planck Gesellschaft Verfahren zur bestimmung von hirudin und synthetischen thrombininhibitoren
AT396937B (de) * 1992-04-06 1993-12-27 Immuno Ag Verfahren zur aktivierung von blutgerinnungsfaktoren
US5780255A (en) * 1995-06-09 1998-07-14 Instrumentation Laboratory, S.P.A. Protein C pathway screening test
DE102010025972A1 (de) * 2010-07-02 2012-01-05 Papst Licensing Gmbh & Co. Kg Verfahren zur Bestimmung von Proteasen und ihren Proformen
KR102317930B1 (ko) * 2015-02-06 2021-10-29 광저우 바이오실 바이오테크 캄파니 리미티드 트롬빈의 제조 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3486981A (en) * 1965-03-15 1969-12-30 Roy E Speck Substances relating to testing of blood-coagulation
SE380257B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser
ES431736A1 (es) * 1973-11-13 1977-05-16 Behringwerke Ag Procedimiento para la preparacion de un agente para diagnos-tico para el proposito de efectuar el control de la capaci- dad de coagulacion de la sangre.
CH622286A5 (no) * 1975-06-23 1981-03-31 Pentapharm Ag
US4061625A (en) * 1975-07-11 1977-12-06 Ab Kabi Novel chromogenic thrombin substrates
SE407405B (sv) * 1975-07-11 1979-03-26 Kabi Ab Nya kromogena trombinsubstrat
SE419871B (sv) * 1975-12-01 1981-08-31 Pharmacia Ab Sett att bestemma aktiviteten hos faktor xa-inhibitor i blod

Also Published As

Publication number Publication date
JPS5718626A (en) 1982-01-30
JPS5812257B2 (ja) 1983-03-07
FI64466C (fi) 1983-11-10
DE2861386D1 (en) 1982-01-28
FI64466B (fi) 1983-07-29
NO151792B (no) 1985-02-25
DK150719B (da) 1987-06-01
DK150719C (da) 1988-06-06
CA1127942A (en) 1982-07-20
DE2757992A1 (de) 1979-06-28
NO154803B (no) 1986-09-15
US4334018A (en) 1982-06-08
NO833884L (no) 1979-06-26
ATA924378A (de) 1980-06-15
EP0003474B1 (de) 1981-11-25
AT360661B (de) 1981-01-26
FI783880A7 (fi) 1979-06-25
NO151792C (no) 1985-06-05
JPS588840B2 (ja) 1983-02-17
JPS5492393A (en) 1979-07-21
EP0003474A1 (de) 1979-08-22
DK571978A (da) 1979-06-25
NO784318L (no) 1979-06-26

Similar Documents

Publication Publication Date Title
IT1100470B (it) Materiale alimentare contenente proteine
DK152890C (da) Underlag til brug ved inkontinens
FI781830A7 (fi) Vaermeenergi lagrande material
SE7811460L (sv) Syntetisk dna och forfarande for dess framstellning
IT7927394A0 (it) Procedimento per la fabbricazione di sovrascarpe in materiale nontessuto.
AT368190B (de) Pruefmittel zur bestimmung von glucose
NO154803C (no) Fremgangsmaate ved fremstilling av et faktor-xa-preparat for bruk ved bestemmelse av prothrombin i biologisk materiale.
BE850505A (fr) Materiaux-supports de fermentation biologique
DK230779A (da) Analyseenhed
NO152955C (no) Reagens for bestemmelse av et immunologisk aktivt materiale
DK156667C (da) Middel og testmateriale til paavisning af tilstedevaerelsen af glucose i en forsoegsproeve
IT1107881B (it) Glicerol ossidasi e procedimento biochimico per la sua preparazione
IT1108596B (it) Tessuto e procedimento e macchina per la sua fabbricazione
DK485680A (da) Automatiseret blodtryksmaaling
DK484278A (da) Enzym-analyse
FI783442A7 (fi) Stroemmatare foer smaelt material
IT1093109B (it) Fotocellula e procedimento per la sua fabbricazione
SE7900456L (sv) Bensodiazeptinkoncentrationsbestemning
IT1094300B (it) Materiale flastico con migliorata compatielita' per il sangue
IT1112572B (it) Procedimento per la suddivisione di materiale in lastra rivestito,nonche' dispositivo per la sua esecuzione
SE7703939L (sv) Temperaturkensligt material
BE872837A (fr) Bac gerbable-emboitable
NL7808059A (nl) Bloedplaatjesreferentiemonsters.
TR20800A (tr) Reaktif bovar maddeler
DK117678A (da) Testmateriale