NL8420264A - METHOD FOR PREPARING MEDICINAL COSMETIC PREPARATIONS. - Google Patents

Description

'B 4 2 O 2 6 4' V.0.7231

Process for the preparation of medicinal cosmetic preparations.

The invention relates to the preparation of the health-protecting and regenerating preparations, in which human blood, characteristic of the species and type of the given living organism, for example belonging to the blood types A, B, AB, 0, Rh positive, Rh negative and / or proteins and / or tissues derived therefrom derived from an animal organism of the given species or type and / or elements thereof and / or proteins obtained therefrom, processed on their own and / or by reaction thereof with inorganic substances, for example elements with a trace element function in the organism, whether or not together with known additives, auxiliary substances, and / or fillers, which can be incorporated in the preparation with health, body and skin protective properties and / or in the form of internally preparations to be served.

The greatest importance of the present invention lies in the use of the elements and plasma proteins of human blood, in a reaction thereof with inorganic ions and in the administration of the products obtained for body-protecting purposes, namely externally and / or internally, for example per oral.

Mineral substances, especially the trace elements, are known to play an important role in the functioning of a living organism 20 also in very small concentrations, primarily because they form components of various enzymes, enzyme activators or inhibitors as components of large molecules, or interact with these molecules and thus play a regulatory role in the functioning of the organism.

The trace elements are known to exert a specific activity in the living organism despite the fact that they are inactive in vitro. The trace elements develop their specific and desired effect by binding to so-called carrier molecules and thereby ending up in biologically active transport. These kinds of large molecules are the plasma proteins. The coupling between the trace elements and the proteins 30 can be established in the organism, if the conditions are fulfilled. However, this coupling is not always appropriate or does not occur to the desired extent, as a result of which the effect of the trace elements does not occur, enzymes with the appropriate activity are not formed, and skin diseases and deficiency diseases are therefore caused. According to the literature, the lack of trace elements can cause cancerous changes in the organism, in which cases the administration of appropriate protein / trace element products to the organism may be beneficial. If the trace elements do not reach the required places of the organism, they do not occur in a biologically active form without a transmitter, so that they do not participate in the vital processes, which has an adverse effect on health. This occurs, for example, with zinc deficiency in the form of an external change of the skin.

Zinc is a constituent of at least 30 enzymes and plays an important role in the protein synthesis of the skin. For example, a lack of copper degrades the quality of sheep's wool as it leads to inadequate protein synthesis. The zinc metalloenzymes participate in the synthesis of DNA and RNA, a lack of which inhibits the transfer of genetic information necessary for the formation of proteins, causes dwarfism, inhibits the regeneration of the skin. In a copper deficiency, the collagen structure of the skin is damaged.

Experience has shown that the above drawbacks cannot be avoided by applying the minerals on their own, which is evidenced by the fact that a simple addition of iron salts cannot cure the ailments caused by iron deficiency. The details about the activation processes of the trace elements are not yet known, but it has already been proven that they need a carrier molecule to play their biologically important role.

The object of the invention is to eliminate the above-mentioned drawbacks. The main point of the invention lies in the fact that by using proteins and trace elements, which are species or type-specific, an adduct is obtained, from which an active absorption of trace elements is ensured, so that health-protecting and skin-regenerating preparations can be prepared therefrom .

The use of the components shown above eliminates the undesired antigenic effect, does not cause allergic reactions and guarantees a rapid regeneration of the damaged cells of the skin as well as an adequate functioning of the metalloenzymes. It has been found that a skin regenerating cream prepared according to the invention has, for example, healed a wound on the nose of pebble size, which had been there for 35 years and was considered incurable by applying the preparation twice a day for 8 days, leaving the 8420264 4-3 skin of the nose fully regenerated and the wound left no traces. In other cases, a cream according to the invention regenerated the rat's lead skin in 6 days to such an extent that even the animal's hair regrowthed on the lead skin and while a control piece of skin was still completely was injured. The present cream can advantageously be applied, for example, to a skin suffering from psoriasis.

The health-protecting regenerating compositions of the invention can also be administered internally. The adduct of trace elements and the species or type-specific protein guarantees that the trace elements are also absorbed for the enzyme systems, which are necessary for the functioning of the entire organism. This allows optimal functioning of the organism in view of the specific condition of this organism.

The invention therefore relates to a species and type specific health-protecting composition, which can be administered both externally and internally, and which is characterized in that for its preparation trace elements and proteins, protein-containing substances are typically used for the given species or type, and the preparation obtained is used for the health preservation of the living organism of the same species or type.

The preparation of the health-protecting and regenerating preparations according to the invention is illustrated by the following non-limitative examples.

Example I

100 cm3 of human blood belonging to group A was separated into plasma and blood elements. 1 g of sodium hydrogen carbonate was added to the resulting plasma liquid and this reaction mixture was heated to 80 ° C. The precipitated protein was separated and after drying or still slightly wet on this plasma protein with a dry matter content of 3.5 g: 3 70 cm of an aqueous solution containing 35 µg iron (II), 35 µg zinc ( II), 10 µg copper (II), 10 µg silver (I), 1 µg chromium (III), 2 µg manganese (II), 1 µg gold (III) ions, as well as 1 µq boron and 1 µg molybdenum ions added. The reaction mixture was treated for 60 minutes in a 100 ° C vessel and, after cooling, 100 g of a cream prepared from this material, in a manner known from the cosmetic industry.

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The product obtained was an excellent agent, which was particularly suitable for treating damaged skin surfaces. Example II

Example I was repeated but the plasma proteins and the inorganic materials were heated at 121 ° C for 35 minutes.

Example III-

The procedure of Example I or II was repeated but pig blood was used and the obtained product after heat treatment used to supply trace elements to pigs by applying an ointment to the skin or by oral administration.

Example IV

The procedure of Example I was followed, but Group B human blood was used.

Example V

The procedure of Example 1 was followed, but 70 cm 2 of Hevis medicated water was used instead of the aqueous solution containing the inorganic substances.

Example VI

The procedure of Examples 1 to 4 was repeated, but the egg white was reacted this time with medicinal water from Czaszarbath in Budapest.

Example VII

The procedure of Examples 1 to 4 was followed, but this time using mineral water, for example Paradi, instead of the aqueous solution obtained in Example I.

Example VIII

To 10 l of bovine blood plasma was added 25 l of water, 100 mg of copper sulphate and 100 mg of zinc sulphate, after which the reaction mixture was kept at 121 ° C for 60 minutes. The product obtained was sprayed onto the skin or hair of animals or into animal wash water upon failure caused by a lack of trace elements.

Example IX

To a dry plasma powder obtained from human blood belonging to group 3, according to example I, 400 cm of water and 0.5 cm of the commercial product "Béres-csepp" containing various trace elements were added 8420264-5 *.

added. This reaction mixture was heated at 121 ° C for 35 minutes and then processed into a cream in a manner known per se. This cream was applicable for regenerating heat damaged skin. Example X.

The procedure of Examples I to IX was followed but the protein-containing substance was heated in a medium free of oxygen or in the presence of an inert gas.

Example XI

The procedure of Examples I to IX was repeated, but this time the preparation was prepared from the tissue of the subject's organism.

Example XII 3 100 cm Human blood was separated into plasma liquid and blood particles. 80 µg ferrous sulfate, 8 µg manganol chloride, 40 µg zinc chloride, 40 µg curpisulfate, 80 µg potassium chloride and 4 µg boric acid, silver nitrate and gold (III) chloride each were added, after which the reaction mixture was heated at 36 ° C for 30 minutes. was stirred. The resulting solution was administered parenterally.

Example XIII

3 To 400 g of dry, hydrophilic human blood plasma, 400 cm of physiological sodium chloride solution was added, in which previously 160 yxq ferrous sulphate, 16 yxq manganol chloride, 80 yq zinc chloride, 80 iq copper sulphate, 160 g potassium chloride and 8 g silver nitrate, boric acid and gold each. (III) chloride were dissolved. The reaction mixture was sterilized in a sealed container at 121 ° C for 30 minutes. The solution thus obtained was administered parenterally.

8420264

Claims (7)

A method for the preparation of medicinal cosmetic preparations using for their preparation: human blood, characteristic of the species or type of the given living organism, for example belonging to the blood groups A, B, AB, O, Rh positive, 2. Method according to claim 1, characterized in that the blood and / or the elements thereof derived from the relevant animal species are incorporated in preparations intended for animals. Method according to claims 1 or 2, characterized in that the protein-containing material is reacted with natural water and / or mineral water, medicinal water and / or the original substances contained therein. Process according to claims 1, 2 and 3, characterized in that the protein-containing material is converted into a medium which is free of oxygen and / or in an atmosphere of an inert gas. Method according to claims 1, 3 and 4, characterized in that the preparation is prepared for a given person by using the blood or tissue of the person concerned. Rh negative or elements thereof and / or proteins therefrom, by themselves and / or by reacting them with trace elements, whether or not together with known substances, which are commonly used in the preparation of cosmetic preparations. 6. Method for converting human blood plasma with trace elements, inorganic materials for using the obtained product, characterized in that the blush plasma is reacted with inorganic salts below 70 ° C and the resulting solution is used parenterally. Method for converting a protein obtained from human blood plasma with inorganic materials for use of the obtained product, characterized in that the protein obtained from the blood plasma is reacted with inorganic materials in an aqueous medium at 90-140 ° C, then sterilizes the resulting solution and administers to regenerate internal wounds of an organism, eg intravenously. 8420264