NL8004486A - Depotpreparaat met een verlengde afgifte van de werkzame verbinding. - Google Patents

Depotpreparaat met een verlengde afgifte van de werkzame verbinding. Download PDF

Info

Publication number: NL8004486A
Authority: NL; Netherlands
Prior art keywords: depot preparation; active compound; veterinary medicinal; preparation according; depot
Prior art date: 1979-08-16

Application number

NL8004486A

Other languages

English (en)

Dutch (nl)

Original Assignee

Ciba Geigy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-08-16

Filing date

1980-08-06

Publication date

1981-02-18

1980-08-06 Application filed by Ciba Geigy filed Critical Ciba Geigy

1981-02-18 Publication of NL8004486A publication Critical patent/NL8004486A/nl

Links

150000001875 compounds Chemical class 0.000 title claims description 53
239000003405 delayed action preparation Substances 0.000 title claims description 51
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
239000000203 mixture Substances 0.000 claims description 23
238000000034 method Methods 0.000 claims description 15
238000003756 stirring Methods 0.000 claims description 13
229920000896 Ethulose Polymers 0.000 claims description 12
239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 claims description 12
235000019326 ethyl hydroxyethyl cellulose Nutrition 0.000 claims description 12
235000014113 dietary fatty acids Nutrition 0.000 claims description 11
239000000194 fatty acid Substances 0.000 claims description 11
229930195729 fatty acid Natural products 0.000 claims description 11
150000004665 fatty acids Chemical class 0.000 claims description 11
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 11
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 10
235000021355 Stearic acid Nutrition 0.000 claims description 10
239000011575 calcium Substances 0.000 claims description 10
229910052791 calcium Inorganic materials 0.000 claims description 10
159000000003 magnesium salts Chemical class 0.000 claims description 10
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 10
238000002360 preparation method Methods 0.000 claims description 10
239000008117 stearic acid Substances 0.000 claims description 10
239000008187 granular material Substances 0.000 claims description 9
241000255925 Diptera Species 0.000 claims description 8
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 8
241001414987 Strepsiptera Species 0.000 claims description 8
LVQDKIWDGQRHTE-UHFFFAOYSA-N cyromazine Chemical compound NC1=NC(N)=NC(NC2CC2)=N1 LVQDKIWDGQRHTE-UHFFFAOYSA-N 0.000 claims description 8
230000003179 granulation Effects 0.000 claims description 8
238000005469 granulation Methods 0.000 claims description 8
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 8
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
150000003839 salts Chemical class 0.000 claims description 8
241000238631 Hexapoda Species 0.000 claims description 7
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 6
125000004432 carbon atom Chemical group C* 0.000 claims description 6
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 6
239000000945 filler Substances 0.000 claims description 6
239000007788 liquid Substances 0.000 claims description 6
241000282849 Ruminantia Species 0.000 claims description 5
239000002253 acid Substances 0.000 claims description 5
125000000217 alkyl group Chemical group 0.000 claims description 5
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 5
239000004033 plastic Substances 0.000 claims description 5
230000008569 process Effects 0.000 claims description 5
TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims description 4
IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 4
229920002678 cellulose Polymers 0.000 claims description 3
239000001913 cellulose Substances 0.000 claims description 3
238000013265 extended release Methods 0.000 claims description 3
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 3
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 3
230000008961 swelling Effects 0.000 claims description 3
VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 claims description 3
HWSISDHAHRVNMT-UHFFFAOYSA-N Bismuth subnitrate Chemical compound O[NH+]([O-])O[Bi](O[N+]([O-])=O)O[N+]([O-])=O HWSISDHAHRVNMT-UHFFFAOYSA-N 0.000 claims description 2
CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical class [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 claims description 2
241000257191 Oestridae Species 0.000 claims description 2
235000021314 Palmitic acid Nutrition 0.000 claims description 2
241000257185 Sarcophagidae Species 0.000 claims description 2
229960001482 bismuth subnitrate Drugs 0.000 claims description 2
WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 2
239000007787 solid Substances 0.000 claims description 2
231100000331 toxic Toxicity 0.000 claims description 2
230000002588 toxic effect Effects 0.000 claims description 2
241000257161 Calliphoridae Species 0.000 claims 1
241000531134 Cuterebrinae Species 0.000 claims 1
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical group CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
238000007580 dry-mixing Methods 0.000 claims 1
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 12
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 12
238000012360 testing method Methods 0.000 description 11
241001465754 Metazoa Species 0.000 description 10
235000013601 eggs Nutrition 0.000 description 9
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 8
206010061217 Infestation Diseases 0.000 description 8
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 8
238000005259 measurement Methods 0.000 description 7
244000045947 parasite Species 0.000 description 7
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 6
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
229910021529 ammonia Inorganic materials 0.000 description 6
241001494479 Pecora Species 0.000 description 5
-1 for example Substances 0.000 description 5
230000000694 effects Effects 0.000 description 4
125000005843 halogen group Chemical group 0.000 description 4
150000003335 secondary amines Chemical class 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
208000006123 Myiasis Diseases 0.000 description 3
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
239000008280 blood Substances 0.000 description 3
210000004369 blood Anatomy 0.000 description 3
229910052801 chlorine Inorganic materials 0.000 description 3
125000001309 chloro group Chemical group Cl* 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
239000013078 crystal Substances 0.000 description 3
230000008021 deposition Effects 0.000 description 3
230000008029 eradication Effects 0.000 description 3
229920013821 hydroxy alkyl cellulose Polymers 0.000 description 3
238000007654 immersion Methods 0.000 description 3
238000001727 in vivo Methods 0.000 description 3
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
230000003071 parasitic effect Effects 0.000 description 3
239000007909 solid dosage form Substances 0.000 description 3
JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 description 2
KCZIUKYAJJEIQG-UHFFFAOYSA-N 1,3,5-triazin-2-amine Chemical compound NC1=NC=NC=N1 KCZIUKYAJJEIQG-UHFFFAOYSA-N 0.000 description 2
241000283690 Bos taurus Species 0.000 description 2
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
206010011469 Crying Diseases 0.000 description 2
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
230000002411 adverse Effects 0.000 description 2
239000011248 coating agent Substances 0.000 description 2
238000000576 coating method Methods 0.000 description 2
238000001816 cooling Methods 0.000 description 2
238000007598 dipping method Methods 0.000 description 2
238000001035 drying Methods 0.000 description 2
239000012530 fluid Substances 0.000 description 2
230000005484 gravity Effects 0.000 description 2
238000000338 in vitro Methods 0.000 description 2
229910052742 iron Inorganic materials 0.000 description 2
230000001418 larval effect Effects 0.000 description 2
230000007774 longterm Effects 0.000 description 2
238000002844 melting Methods 0.000 description 2
230000008018 melting Effects 0.000 description 2
231100000252 nontoxic Toxicity 0.000 description 2
230000003000 nontoxic effect Effects 0.000 description 2
210000001331 nose Anatomy 0.000 description 2
239000002245 particle Substances 0.000 description 2
238000009304 pastoral farming Methods 0.000 description 2
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
239000012256 powdered iron Substances 0.000 description 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
239000000047 product Substances 0.000 description 2
239000011541 reaction mixture Substances 0.000 description 2
229920006395 saturated elastomer Polymers 0.000 description 2
229910052938 sodium sulfate Inorganic materials 0.000 description 2
235000011152 sodium sulphate Nutrition 0.000 description 2
239000002904 solvent Substances 0.000 description 2
239000007858 starting material Substances 0.000 description 2
238000005303 weighing Methods 0.000 description 2
HUWSZNZAROKDRZ-RRLWZMAJSA-N (3r,4r)-3-azaniumyl-5-[[(2s,3r)-1-[(2s)-2,3-dicarboxypyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]amino]-5-oxo-4-sulfanylpentane-1-sulfonate Chemical compound OS(=O)(=O)CC[C@@H](N)[C@@H](S)C(=O)N[C@@H]([C@H](C)CC)C(=O)N1CCC(C(O)=O)[C@H]1C(O)=O HUWSZNZAROKDRZ-RRLWZMAJSA-N 0.000 description 1
SZTNFYPHSWHKLS-UHFFFAOYSA-N 1,3,5-triazin-2-amine;dihydrochloride Chemical compound Cl.Cl.NC1=NC=NC=N1 SZTNFYPHSWHKLS-UHFFFAOYSA-N 0.000 description 1
VZXTWGWHSMCWGA-UHFFFAOYSA-N 1,3,5-triazine-2,4-diamine Chemical compound NC1=NC=NC(N)=N1 VZXTWGWHSMCWGA-UHFFFAOYSA-N 0.000 description 1
KKVNELLMUOYULB-UHFFFAOYSA-N 1,3,5-triazine;dihydrochloride Chemical compound Cl.Cl.C1=NC=NC=N1 KKVNELLMUOYULB-UHFFFAOYSA-N 0.000 description 1
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 1
SRDNQMPCQFDOJE-UHFFFAOYSA-N 2-n,4-n-dicyclopropyl-1,3,5-triazine-2,4,6-triamine Chemical compound N=1C(NC2CC2)=NC(N)=NC=1NC1CC1 SRDNQMPCQFDOJE-UHFFFAOYSA-N 0.000 description 1
YBXAUCWDTLINED-UHFFFAOYSA-N 2-n-cyclopropyl-4-n-methyl-1,3,5-triazine-2,4,6-triamine Chemical compound CNC1=NC(N)=NC(NC2CC2)=N1 YBXAUCWDTLINED-UHFFFAOYSA-N 0.000 description 1
CTRPRMNBTVRDFH-UHFFFAOYSA-N 2-n-methyl-1,3,5-triazine-2,4,6-triamine Chemical compound CNC1=NC(N)=NC(N)=N1 CTRPRMNBTVRDFH-UHFFFAOYSA-N 0.000 description 1
YNQOIUWYAFEDSZ-UHFFFAOYSA-N 6-chloro-2-n-cyclopropyl-4-n-methyl-1,3,5-triazine-2,4-diamine Chemical compound CNC1=NC(Cl)=NC(NC2CC2)=N1 YNQOIUWYAFEDSZ-UHFFFAOYSA-N 0.000 description 1
241000282472 Canis lupus familiaris Species 0.000 description 1
HTJDQJBWANPRPF-UHFFFAOYSA-N Cyclopropylamine Chemical compound NC1CC1 HTJDQJBWANPRPF-UHFFFAOYSA-N 0.000 description 1
241000202828 Dermatobia hominis Species 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
241000283086 Equidae Species 0.000 description 1
241000283074 Equus asinus Species 0.000 description 1
241001331845 Equus asinus x caballus Species 0.000 description 1
241000282326 Felis catus Species 0.000 description 1
241000257176 Hypoderma <fly> Species 0.000 description 1
241000543830 Hypoderma bovis Species 0.000 description 1
241001194722 Hypoderma tarandi Species 0.000 description 1
241000257162 Lucilia <blowfly> Species 0.000 description 1
241000543819 Oestrus ovis Species 0.000 description 1
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
241000282941 Rangifer tarandus Species 0.000 description 1
241001194723 Rhinoestrus Species 0.000 description 1
244000007853 Sarothamnus scoparius Species 0.000 description 1
241000282887 Suidae Species 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
241000609107 Wohlfahrtia vigil Species 0.000 description 1
230000009471 action Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000037396 body weight Effects 0.000 description 1
235000010980 cellulose Nutrition 0.000 description 1
230000008859 change Effects 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000000470 constituent Substances 0.000 description 1
239000012043 crude product Substances 0.000 description 1
125000006317 cyclopropyl amino group Chemical group 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
238000010586 diagram Methods 0.000 description 1
230000001079 digestive effect Effects 0.000 description 1
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
239000000428 dust Substances 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
235000013305 food Nutrition 0.000 description 1
210000001061 forehead Anatomy 0.000 description 1
235000011389 fruit/vegetable juice Nutrition 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
244000144980 herd Species 0.000 description 1
239000012442 inert solvent Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
244000144972 livestock Species 0.000 description 1
230000005923 long-lasting effect Effects 0.000 description 1
235000013336 milk Nutrition 0.000 description 1
239000008267 milk Substances 0.000 description 1
210000004080 milk Anatomy 0.000 description 1
239000011707 mineral Substances 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
230000024241 parasitism Effects 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
210000003800 pharynx Anatomy 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
238000003825 pressing Methods 0.000 description 1
150000003141 primary amines Chemical class 0.000 description 1
230000019617 pupation Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000028327 secretion Effects 0.000 description 1
238000004062 sedimentation Methods 0.000 description 1
238000005507 spraying Methods 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
230000007704 transition Effects 0.000 description 1
210000002268 wool Anatomy 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0068—Rumen, e.g. rumen bolus
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/66—1,3,5-Triazines, not hydrogenated and not substituted at the ring nitrogen atoms
- A01N43/68—1,3,5-Triazines, not hydrogenated and not substituted at the ring nitrogen atoms with two or three nitrogen atoms directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/54—Three nitrogen atoms
- C07D251/70—Other substituted melamines

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Dentistry (AREA)
Physiology (AREA)
Plant Pathology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Pest Control & Pesticides (AREA)
Agronomy & Crop Science (AREA)
Nutrition Science (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicinal Preparation (AREA)

NL8004486A 1979-08-16 1980-08-06 Depotpreparaat met een verlengde afgifte van de werkzame verbinding. NL8004486A (nl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
CH751679		1979-08-16
CH751679		1979-08-16
CH372980		1980-05-13
CH372980		1980-05-13

Publications (1)

Publication Number	Publication Date
NL8004486A true NL8004486A (nl)	1981-02-18

Family

ID=25693719

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8004486A NL8004486A (nl)	1979-08-16	1980-08-06	Depotpreparaat met een verlengde afgifte van de werkzame verbinding.

Country Status (14)

Country	Link
AR (1)	AR225641A1 (sv)
AT (1)	AT367294B (sv)
AU (1)	AU6147980A (sv)
DE (1)	DE3030646A1 (sv)
DK (1)	DK354480A (sv)
FI (1)	FI802543A7 (sv)
FR (1)	FR2462910A1 (sv)
GB (1)	GB2057262A (sv)
IT (1)	IT8024166A0 (sv)
NL (1)	NL8004486A (sv)
NO (1)	NO802452L (sv)
NZ (1)	NZ194682A (sv)
SE (1)	SE8005760L (sv)
ZW (1)	ZW18980A1 (sv)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8603964D0 (en) *	1986-02-18	1986-03-26	Cooper Animal Health Ltd	Compositions
NZ221262A (en) *	1986-08-06	1990-08-28	Ciba Geigy Ag	Preventing the reinfestation of dogs and cats by fleas by administering to the host a flea growth inhibiting substance orally, parenterally or by implant
RU2119335C1 (ru) *	1997-12-25	1998-09-27	Пастушенков Леонид Васильевич	Средство для лечения острой и внезапной сенсоневральной тугоухости и глухоты
LT4037666T (lt)	2020-12-08	2024-06-10	Ruminant Biotech Corp Limited	Medžiagų pristatymo gyvūnams prietaisų ir būdų patobulinimai

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3507952A (en) *	1968-12-20	1970-04-21	Smithkline Corp	Sustained release bolus for animal husbandry

1980
- 1980-06-25 AT AT0332580A patent/AT367294B/de not_active IP Right Cessation
- 1980-08-06 NL NL8004486A patent/NL8004486A/nl not_active Application Discontinuation
- 1980-08-12 GB GB8026239A patent/GB2057262A/en not_active Withdrawn
- 1980-08-13 FI FI802543A patent/FI802543A7/sv not_active Application Discontinuation
- 1980-08-13 FR FR8017859A patent/FR2462910A1/fr active Pending
- 1980-08-13 DE DE19803030646 patent/DE3030646A1/de not_active Withdrawn
- 1980-08-14 IT IT8024166A patent/IT8024166A0/it unknown
- 1980-08-14 ZW ZW189/80A patent/ZW18980A1/xx unknown
- 1980-08-14 AR AR282169A patent/AR225641A1/es active
- 1980-08-15 NZ NZ194682A patent/NZ194682A/xx unknown
- 1980-08-15 SE SE8005760A patent/SE8005760L/sv not_active Application Discontinuation
- 1980-08-15 NO NO802452A patent/NO802452L/no unknown
- 1980-08-15 DK DK354480A patent/DK354480A/da not_active Application Discontinuation
- 1980-08-15 AU AU61479/80A patent/AU6147980A/en not_active Abandoned

Also Published As

Publication number	Publication date
AU6147980A (en)	1981-02-19
ZW18980A1 (en)	1981-03-11
FR2462910A1 (fr)	1981-02-20
NO802452L (no)	1981-02-17
GB2057262A (en)	1981-04-01
DK354480A (da)	1981-02-17
IT8024166A0 (it)	1980-08-14
ATA332580A (de)	1981-11-15
FI802543A7 (sv)	1981-01-01
AR225641A1 (es)	1982-04-15
DE3030646A1 (de)	1981-03-26
SE8005760L (sv)	1981-02-17
NZ194682A (en)	1983-05-31
AT367294B (de)	1982-06-25

Publication	Publication Date	Title
RU2080789C1 (ru)	1997-06-10	Артропоцидная или растительно-нематоцидная композиция
AU606349B2 (en)	1991-02-07	Method of preventing the reinfestation of dogs and cats by fleas
ES2201775T3 (es)	2004-03-16	Combinacion oral de lufenuron y nitenpyram contra pulgas.
JPS62501418A (ja)	1987-06-11	温血動物の体内寄生虫及び体外寄生虫を防除するためのアシル尿素化合物の使用
JPH0269464A (ja)	1990-03-08	Ｎ‐フェニルピラゾール誘導体
AT405514B (de)	1999-09-27	Giftige köder zur schädlingsbekämpfung
JPH03118369A (ja)	1991-05-20	殺虫剤としてのｎ―フェニルピラゾール誘導体
JP2001506616A (ja)	2001-05-22	定温動物の寄生体の系統的なコントロールのための組成物
JPS63316770A (ja)	1988-12-26	Ｎ−フェニルピラゾール誘導体
US4066776A (en)	1978-01-03	Anti-bacterial compositions containing certain 3-nitropyrazoles
CZ20021898A3 (cs)	2003-04-16	Způsob likvidace členovců u zvířat
JPS58150559A (ja)	1983-09-07	オキシムエ−テル誘導体、その製造法およびそれを有効成分として含有する殺虫剤
NL8004486A (nl)	1981-02-18	Depotpreparaat met een verlengde afgifte van de werkzame verbinding.
JPS6011907B2 (ja)	1985-03-28	チアゾリルケイ皮酸ニトリル、その化合物の製造方法及びその化合物を含有する農業用殺虫剤
PL205344B1 (pl)	2010-04-30	Kompozycja fipronilu wzbogaconego w enancjomer (S) i jej zastosowanie
TWI264288B (en)	2006-10-21	New combinations
DK202370419A1 (en)	2023-08-25	Cyclopropylamide compounds against parasites in fish
JPH0267270A (ja)	1990-03-07	Ｎ‐フェニルピラゾール‐４‐イルエーテル誘導体
PT1450767E (pt)	2007-09-05	Microesférulas contendo um derivado de pleuromutilina.
US5416102A (en)	1995-05-16	Method of preventing the reinfestation of dogs and cats by fleas
EP4656047A2 (en)	2025-12-03	Cyclopropylamide compounds against parasites in fish
JPH04120007A (ja)	1992-04-21	殺虫組成物
DE2757111A1 (de)	1978-07-06	Phthalamid- und nikotinsaeuren und ihre verwendung in pflanzenwuchsregulierenden mitteln
JPS6018643B2 (ja)	1985-05-11	動物薬組成物
US4187305A (en)	1980-02-05	Procedure for treating mammals to control parasitic diptera larvae

Legal Events

Date	Code	Title	Description
1984-04-02	BV	The patent application has lapsed