NL7016630A - Sweet aspartylaminoacid esters prepn - Google Patents
Sweet aspartylaminoacid esters prepnInfo
- Publication number
- NL7016630A NL7016630A NL7016630A NL7016630A NL7016630A NL 7016630 A NL7016630 A NL 7016630A NL 7016630 A NL7016630 A NL 7016630A NL 7016630 A NL7016630 A NL 7016630A NL 7016630 A NL7016630 A NL 7016630A
- Authority
- NL
- Netherlands
- Prior art keywords
- aspartylaminoacid
- esters
- prepn
- sweet
- ester
- Prior art date
Links
- 150000002148 esters Chemical class 0.000 title abstract 4
- 235000009508 confectionery Nutrition 0.000 title 1
- -1 amino-acid ester salt Chemical class 0.000 abstract 1
- OZPYEGOBGWQOSZ-VIFPVBQESA-N benzyl n-[(3s)-2,5-dioxooxolan-3-yl]carbamate Chemical compound C=1C=CC=CC=1COC(=O)N[C@H]1CC(=O)OC1=O OZPYEGOBGWQOSZ-VIFPVBQESA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/31—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives
- A23L27/32—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives containing dipeptides or derivatives
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Peptides Or Proteins (AREA)
Abstract
Aspartylaminoacid esters are prepd. by reacting N-carbobenzoxyaspartic acid anhydride with an amino-acid ester salt in an inert polar solvent while adding an amount of base at least equivalent to the ester, isolating the N-carbobenzoxy-alpha- and/or beta-aspartylaminoacid ester and removing the protecting gp. Compared with the known method, this gives higher yields, suppresses the formation of diketopiperzines and gives products of high optical purity. The products are useful as sweeteners in foods, drinks and pharmaceuticals.
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7016630A NL7016630A (en) | 1970-11-13 | 1970-11-13 | Sweet aspartylaminoacid esters prepn |
| CH713671A CH553751A (en) | 1970-05-19 | 1971-05-13 | METHOD FOR PRODUCING ASPARTYLAMINO ACID ESTERS. |
| FR7117531A FR2091628A5 (en) | 1970-05-19 | 1971-05-14 | |
| IT50379/71A IT989588B (en) | 1970-05-19 | 1971-05-17 | PROCEDURE FOR THE PRODUCTION OF ASPARAGIL AMINO ACID ESTERS AND PRODUCT OBTAINED |
| BE767299A BE767299A (en) | 1970-05-19 | 1971-05-18 | PROCESS FOR THE PREPARATION OF ASPARTYL-AMINO-ACID ESTERS |
| US00144639A US3808190A (en) | 1970-05-19 | 1971-05-18 | Process for the preparation of aspartyl dipeptide esters involving little racemization |
| GB1582971*[A GB1336650A (en) | 1970-05-19 | 1971-05-19 | Process for the preparation of aspartyl aminoacid esters involving little racemization |
| DE19712125065 DE2125065A1 (en) | 1970-05-19 | 1971-05-19 | Process for the preparation of aspartic amino acid esters |
| JP3397271A JPS5336446B1 (en) | 1970-05-19 | 1971-05-19 | |
| SE7106515A SE393602B (en) | 1970-05-19 | 1971-05-19 | PROCEDURE FOR THE PREPARATION OF ALFA ASPARTYL-AMINO ACID ESTERS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7016630A NL7016630A (en) | 1970-11-13 | 1970-11-13 | Sweet aspartylaminoacid esters prepn |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL7016630A true NL7016630A (en) | 1972-05-16 |
Family
ID=19811549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL7016630A NL7016630A (en) | 1970-05-19 | 1970-11-13 | Sweet aspartylaminoacid esters prepn |
Country Status (1)
| Country | Link |
|---|---|
| NL (1) | NL7016630A (en) |
-
1970
- 1970-11-13 NL NL7016630A patent/NL7016630A/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BI | The patent application has been withdrawn |