NL300979I2 - galcanezumab - Google Patents

galcanezumab Download PDF

Info

Publication number: NL300979I2
Authority: NL; Netherlands
Prior art keywords: galcanezumab
Prior art date: 2010-06-10

Application number

NL300979C

Other languages

English (en)

Other versions

NL300979I1 (nl

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-06-10

Filing date

2019-04-11

Publication date

2019-07-11

2019-04-11 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2019-04-17 Publication of NL300979I1 publication Critical patent/NL300979I1/nl

2019-07-11 Publication of NL300979I2 publication Critical patent/NL300979I2/nl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57527—Calcitonin gene related peptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57545—Neuropeptide Y
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Mycology (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Toxicology (AREA)
Orthopedic Medicine & Surgery (AREA)
Zoology (AREA)
Physical Education & Sports Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NL300979C 2010-06-10 2019-04-11 galcanezumab NL300979I2 (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US35332310P	2010-06-10	2010-06-10
PCT/US2011/039381 WO2011156324A1 (en)	2010-06-10	2011-06-07	Cgrp antibodies

Publications (2)

Publication Number	Publication Date
NL300979I1 NL300979I1 (nl)	2019-04-17
NL300979I2 true NL300979I2 (nl)	2019-07-11

Family

ID=45096388

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL300979C NL300979I2 (nl)	2010-06-10	2019-04-11	galcanezumab

Country Status (33)

Country	Link
US (3)	US9073991B2 (nl)
EP (2)	EP3318272B1 (nl)
JP (2)	JP6021806B2 (nl)
KR (1)	KR101489566B1 (nl)
CN (2)	CN104292332B (nl)
AR (1)	AR081434A1 (nl)
AU (1)	AU2011265050B2 (nl)
BR (1)	BR112012031501B1 (nl)
CA (1)	CA2802102C (nl)
CY (2)	CY1119789T1 (nl)
DK (1)	DK2579894T3 (nl)
EA (1)	EA022931B1 (nl)
ES (2)	ES2930321T3 (nl)
HR (1)	HRP20171992T1 (nl)
HU (2)	HUE038135T2 (nl)
IL (2)	IL222885B (nl)
JO (1)	JO3330B1 (nl)
LT (2)	LT2579894T (nl)
LU (1)	LUC00112I2 (nl)
ME (1)	ME02862B (nl)
MX (2)	MX363209B (nl)
NL (1)	NL300979I2 (nl)
NO (2)	NO2579894T3 (nl)
NZ (1)	NZ603607A (nl)
PL (1)	PL2579894T3 (nl)
PT (1)	PT2579894T (nl)
RS (1)	RS56638B1 (nl)
SG (1)	SG185648A1 (nl)
SI (1)	SI2579894T1 (nl)
TW (1)	TWI423818B (nl)
UA (1)	UA109658C2 (nl)
WO (1)	WO2011156324A1 (nl)
ZA (1)	ZA201208996B (nl)

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CN101309704B (zh)	2005-11-14	2012-10-10	礼纳特神经系统科学公司	针对降钙素基因相关肽的拮抗剂抗体及其使用方法
US8293239B2 (en)	2008-03-04	2012-10-23	Pfizer Limited	Methods of treating chronic pain
AU2010288194B2 (en)	2009-08-28	2013-08-29	Teva Pharmaceuticals International Gmbh	Methods for treating visceral pain by administering antagonist antibodies directed against calcitonin gene-related peptide
JO3330B1 (ar) *	2010-06-10	2019-03-13	Lilly Co Eli	الأجسام المضادة cgrp
KR101965461B1 (ko)	2011-05-20	2019-04-04	앨더바이오 홀딩스 엘엘씨	필요한 대상체, 특히 편두통 환자의 광선공포증 또는 광선 혐오증을 예방 또는 억제하기 위한 항-cgrp 항체 및 항체 단편의 용도
CN103748111B (zh)	2011-05-20	2018-04-27	奥尔德生物控股有限责任公司	抗cgrp组合物及其用途
EP2709662B1 (en)	2011-05-20	2019-07-31	AlderBio Holdings LLC	Use of anti-cgrp or anti-cgrp-r antibodies or antibody fragments to treat or prevent chronic and acute forms of diarrhea
MX362456B (es)	2012-08-24	2019-01-18	Univ California	Anticuerpos y vacunas para utilizarse en el tratamiento de canceres por ror1 y para inhibir la metastasis.
US20170114122A1 (en)	2015-10-23	2017-04-27	Alderbio Holdings Llc	Regulation of glucose metabolism using anti-cgrp antibodies
MX378344B (es)	2014-03-21	2025-03-10	Teva Pharmaceuticals Int Gmbh	Anticuerpos antagonistas dirigidos contra el peptido relacionado con el gen de calcitonina y metodos que usan los mismos.
US10556945B2 (en)	2014-03-21	2020-02-11	Teva Pharmaceuticals International Gmbh	Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
EP3209682B1 (en)	2014-10-24	2020-12-30	Merck Sharp & Dohme Corp.	Co-agonists of the glucagon and glp-1 receptors
TWI595006B (zh) *	2014-12-09	2017-08-11	禮納特神經系統科學公司	抗ｐｄ－１抗體類和使用彼等之方法
JOP20200116A1 (ar)	2015-04-24	2017-06-16	Amgen Inc	طرق لعلاج أو الوقاية من الصداع النصفي
AR104847A1 (es) *	2015-06-17	2017-08-16	Lilly Co Eli	Formulación de anticuerpo anti-cgrp
CN108135983A (zh) *	2015-10-30	2018-06-08	伊莱利利公司	抗cgrp /抗il-23双特异性抗体及其用途
CN105483091A (zh) *	2015-12-29	2016-04-13	天津三箭生物技术股份有限公司	小鼠抗人Calcitonin单克隆抗体及分泌该单克隆抗体的杂交瘤细胞株
US20190031748A1 (en) *	2016-01-28	2019-01-31	Eli Lilly And Company	Cgrp antibodies and uses thereof
JP6815407B2 (ja)	2016-02-01	2021-01-20	イーライリリーアンドカンパニー	副甲状腺ホルモン−抗ｒａｎｋｌ抗体融合化合物
KR20230047507A (ko)	2016-06-27	2023-04-07	더 리젠츠 오브 더 유니버시티 오브 캘리포니아	암 치료 조합
WO2018055573A1 (en)	2016-09-23	2018-03-29	Teva Pharmaceuticals International Gmbh	Treating cluster headache
PE20191148A1 (es) *	2016-09-23	2019-09-02	Teva Pharmaceuticals Int Gmbh	Tratamiento de la migrana refractaria
RU2770066C2 (ru)	2017-03-02	2022-04-14	Бет Изрейэл Диконисс Медикал Сентер, Инк.	Отбор пациентов с головной болью, восприимчивых к антителам, направленным против кальцитонин ген-родственного пептида
AR111845A1 (es)	2017-05-03	2019-08-28	Lilly Co Eli	Anticuerpos biespecíficos anti-cgrp / anti-il-23 y usos de los mismos
EP3642218A4 (en) *	2017-06-21	2021-04-07	Cephalon, Inc.	WASH BUFFER FOR CATION EXCHANGE CHROMATOGRAPHY
TWI754772B (zh) *	2017-09-06	2022-02-11	美商美國禮來大藥廠	用於治療偏頭痛之拉米迪坦(lasmiditan)與cgrp拮抗劑之組合療法
AU2019207915B2 (en)	2018-01-12	2025-09-04	Amgen Inc.	PAC1 antibodies and uses thereof
WO2019231800A1 (en)	2018-05-31	2019-12-05	Eli Lilly And Company	Anti-cgrp antibodies for treating menstrual-related migraines
WO2020041468A1 (en)	2018-08-22	2020-02-27	Eli Lilly And Company	Anti-cgrp antibodies for treatment-resistant patients
BR112020018192A2 (pt)	2019-01-08	2021-08-24	H. Lundbeck A/S	Tratamento agudo e tratamento rápido de dor de cabeça com o uso de anticorpos anti-cgrp
EP3744400A1 (en) *	2019-05-28	2020-12-02	Etablissement Français du Sang	Car-t cells targeting il-1rap and their use in acute myeloid leukemia (aml)
CN114127110B (zh) *	2019-05-30	2022-07-01	山东博安生物技术股份有限公司	抗cgrp抗体及其应用
AU2020368369A1 (en)	2019-10-15	2022-05-12	Eli Lilly And Company	Recombinantly engineered, lipase/esterase-deficient mammalian cell lines
AU2020202454A1 (en)	2020-04-06	2021-10-21	H. Lundbeck A/S	Treatment of most bothersome symptom (MBS) associated with migraine using anti-CGRP antibodies
JP2024509165A (ja)	2021-03-02	2024-02-29	シージーアールピーダイアグノスティクスゲーエムベーハー	片頭痛の治療及び／又は発生の低減
KR20240153599A (ko)	2022-02-28	2024-10-23	트리뎀 바이오사이언스 게엠베하 & 씨오 케이지	적어도 β-글루칸 또는 만난으로 구성되거나 또는 이를 포함하는 접합체
CN117586390A (zh) *	2022-08-11	2024-02-23	上海君实生物医药科技股份有限公司	抗cgrp抗体及用途
CN118271438B (zh) *	2024-05-27	2024-08-30	上海宏成药业有限公司	抗cgrp抗体或其抗原结合片段及其用途
CN119320450B (zh) *	2024-12-13	2025-07-25	中国人民解放军军事科学院军事医学研究院	针对降钙素基因相关肽的抗体

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AU2003271174A1 (en) *	2003-10-10	2005-04-27	Chugai Seiyaku Kabushiki Kaisha	Double specific antibodies substituting for functional protein
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CN101309704B (zh) *	2005-11-14	2012-10-10	礼纳特神经系统科学公司	针对降钙素基因相关肽的拮抗剂抗体及其使用方法
WO2007076336A1 (en) *	2005-12-22	2007-07-05	Eli Lilly And Company	Treatment of migraine with anti-cgrp antibodies
CA2716799C (en) *	2008-03-04	2018-05-22	Pfizer Limited	Methods of treating inflammatory pain
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JO3330B1 (ar) *	2010-06-10	2019-03-13	Lilly Co Eli	الأجسام المضادة cgrp

2011
- 2011-05-31 JO JOP/2011/0177A patent/JO3330B1/ar active
- 2011-05-31 AR ARP110101867A patent/AR081434A1/es active IP Right Grant
- 2011-06-03 TW TW100119683A patent/TWI423818B/zh active
- 2011-06-07 SG SG2012084885A patent/SG185648A1/en unknown
- 2011-06-07 RS RS20171265A patent/RS56638B1/sr unknown
- 2011-06-07 NZ NZ603607A patent/NZ603607A/en unknown
- 2011-06-07 CN CN201410474677.9A patent/CN104292332B/zh active Active
- 2011-06-07 WO PCT/US2011/039381 patent/WO2011156324A1/en not_active Ceased
- 2011-06-07 ES ES17201603T patent/ES2930321T3/es active Active
- 2011-06-07 EP EP17201603.2A patent/EP3318272B1/en active Active
- 2011-06-07 ES ES11792989.3T patent/ES2656000T3/es active Active
- 2011-06-07 JP JP2013514281A patent/JP6021806B2/ja active Active
- 2011-06-07 NO NO11792989A patent/NO2579894T3/no unknown
- 2011-06-07 CA CA2802102A patent/CA2802102C/en active Active
- 2011-06-07 HR HRP20171992TT patent/HRP20171992T1/hr unknown
- 2011-06-07 ME MEP-2017-280A patent/ME02862B/me unknown
- 2011-06-07 BR BR112012031501-3A patent/BR112012031501B1/pt active IP Right Grant
- 2011-06-07 HU HUE11792989A patent/HUE038135T2/hu unknown
- 2011-06-07 DK DK11792989.3T patent/DK2579894T3/en active
- 2011-06-07 KR KR1020127032068A patent/KR101489566B1/ko active Active
- 2011-06-07 LT LTEP11792989.3T patent/LT2579894T/lt unknown
- 2011-06-07 CN CN201180028611.1A patent/CN102946905B/zh active Active
- 2011-06-07 EA EA201270769A patent/EA022931B1/ru not_active IP Right Cessation
- 2011-06-07 PL PL11792989T patent/PL2579894T3/pl unknown
- 2011-06-07 MX MX2016005150A patent/MX363209B/es unknown
- 2011-06-07 PT PT117929893T patent/PT2579894T/pt unknown
- 2011-06-07 EP EP11792989.3A patent/EP2579894B1/en active Active
- 2011-06-07 US US13/154,538 patent/US9073991B2/en active Active
- 2011-06-07 MX MX2012014480A patent/MX340999B/es active IP Right Grant
- 2011-06-07 SI SI201131359T patent/SI2579894T1/en unknown
- 2011-06-07 AU AU2011265050A patent/AU2011265050B2/en active Active
- 2011-07-06 UA UAA201212663A patent/UA109658C2/ru unknown
2012
- 2012-11-05 IL IL222885A patent/IL222885B/en active Protection Beyond IP Right Term
- 2012-11-28 ZA ZA2012/08996A patent/ZA201208996B/en unknown
2015
- 2015-06-04 US US14/730,270 patent/US9505838B2/en active Active
- 2015-11-02 IL IL242409A patent/IL242409B/en active IP Right Grant
2016
- 2016-06-28 JP JP2016127666A patent/JP6466883B2/ja active Active
- 2016-11-02 US US15/341,166 patent/US20170073403A1/en not_active Abandoned
2018
- 2018-01-18 CY CY20181100064T patent/CY1119789T1/el unknown
2019
- 2019-04-02 CY CY2019017C patent/CY2019017I1/el unknown
- 2019-04-02 HU HUS1900020C patent/HUS1900020I1/hu unknown
- 2019-04-05 NO NO2019017C patent/NO2019017I1/no unknown
- 2019-04-09 LU LU00112C patent/LUC00112I2/fr unknown
- 2019-04-11 NL NL300979C patent/NL300979I2/nl unknown
- 2019-04-12 LT LTPA2019011C patent/LTC2579894I2/lt unknown

Also Published As

Publication number	Publication date
CN102946905A (zh)	2013-02-27
ES2930321T3 (es)	2022-12-09
HUE038135T2 (hu)	2018-09-28
KR20130034024A (ko)	2013-04-04
JP6466883B2 (ja)	2019-02-06
US20150259415A1 (en)	2015-09-17
KR101489566B1 (ko)	2015-02-03
AR081434A1 (es)	2012-08-29
EP3318272A1 (en)	2018-05-09
EA022931B1 (ru)	2016-03-31
US20170073403A1 (en)	2017-03-16
NO2579894T3 (nl)	2018-04-21
IL242409B (en)	2020-07-30
ES2656000T3 (es)	2018-02-22
HK1203211A1 (en)	2015-10-23
LUC00112I2 (nl)	2019-12-27
AU2011265050A1 (en)	2012-11-08
JP6021806B2 (ja)	2016-11-09
LTPA2019011I1 (lt)	2019-05-10
EP3318272B1 (en)	2022-08-10
IL222885A0 (en)	2012-12-31
SG185648A1 (en)	2012-12-28
CN104292332A (zh)	2015-01-21
CN102946905B (zh)	2014-10-15
NL300979I1 (nl)	2019-04-17
JO3330B1 (ar)	2019-03-13
ZA201208996B (en)	2014-05-28
DK2579894T3 (en)	2018-01-15
MX2012014480A (es)	2013-02-07
CY2019017I2 (el)	2020-05-29
LUC00112I1 (nl)	2019-04-10
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JP2013532143A (ja)	2013-08-15
JP2017014203A (ja)	2017-01-19
BR112012031501A2 (pt)	2016-10-25
EP2579894B1 (en)	2017-11-22
PT2579894T (pt)	2018-02-06
NO2019017I1 (no)	2019-04-05
EP2579894A1 (en)	2013-04-17
TW201210618A (en)	2012-03-16
LT2579894T (lt)	2018-02-26
SI2579894T1 (en)	2018-01-31
AU2011265050B2 (en)	2013-06-27
HRP20171992T1 (hr)	2018-02-09
NZ603607A (en)	2014-09-26
LTC2579894I2 (lt)	2020-03-25
CY2019017I1 (el)	2020-05-29
CA2802102C (en)	2016-07-26
IL222885B (en)	2019-09-26
EP2579894A4 (en)	2013-12-04
TWI423818B (zh)	2014-01-21
MX363209B (es)	2019-03-14
CN104292332B (zh)	2019-11-01
MX340999B (es)	2016-08-03
HUS1900020I1 (hu)	2019-05-28
EA201270769A1 (ru)	2013-04-30
CA2802102A1 (en)	2011-12-15
RS56638B1 (sr)	2018-03-30
ME02862B (me)	2018-04-20
US9073991B2 (en)	2015-07-07
BR112012031501B1 (pt)	2020-02-11
PL2579894T3 (pl)	2018-04-30
UA109658C2 (xx)	2015-09-25
WO2011156324A1 (en)	2011-12-15
CY1119789T1 (el)	2018-06-27

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