NL300247I1 - 2-Halogeen-9-(2-desoxy-2-fluor-bêta-D-arabinofuranosyl)-adeninenucleosiderivaten. - Google Patents

2-Halogeen-9-(2-desoxy-2-fluor-bêta-D-arabinofuranosyl)-adeninenucleosiderivaten.

Info

Publication number: NL300247I1
Authority: NL; Netherlands
Prior art keywords: arabinofuranosyl; deoxy; fluoro; beta; halogen
Prior art date: 1989-05-23

Application number

NL300247C

Other languages

English (en)

Other versions

NL300247I2 (nl

Original Assignee

Southern Res Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-23

Filing date

2006-11-24

Publication date

2007-02-01

2006-11-24 Application filed by Southern Res Inst filed Critical Southern Res Inst

2007-02-01 Publication of NL300247I2 publication Critical patent/NL300247I2/nl

2007-02-01 Publication of NL300247I1 publication Critical patent/NL300247I1/nl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NL300247C 1989-05-23 2006-11-24 2-Halogeen-9-(2-desoxy-2-fluor-bêta-D-arabinofuranosyl)-adeninenucleosiderivaten. NL300247I1 (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/355,358 US5034518A (en)	1989-05-23	1989-05-23	2-fluoro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine nucleosides
PCT/US1990/002927 WO1990014352A1 (en)	1989-05-23	1990-05-23	2-halo-9-(2-deoxy-2-fluoro-b-d-arabinofuranosyl) adenine nucleoside derivatives

Publications (2)

Publication Number	Publication Date
NL300247I2 NL300247I2 (nl)	2007-02-01
NL300247I1 true NL300247I1 (nl)	2007-02-01

Family

ID=23397161

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL300247C NL300247I1 (nl)	1989-05-23	2006-11-24	2-Halogeen-9-(2-desoxy-2-fluor-bêta-D-arabinofuranosyl)-adeninenucleosiderivaten.

Country Status (9)

Country	Link
US (1)	US5034518A (nl)
EP (1)	EP0473708B1 (nl)
JP (1)	JP3160288B2 (nl)
AT (1)	ATE147751T1 (nl)
AU (1)	AU5831590A (nl)
DE (2)	DE69029733T2 (nl)
ES (1)	ES2098266T3 (nl)
NL (1)	NL300247I1 (nl)
WO (1)	WO1990014352A1 (nl)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5384310A (en) *	1989-05-23	1995-01-24	Southern Research Institute	2'-fluoro-2-haloarabinoadinosines and their pharmaceutical compositions
AU1254892A (en) *	1990-12-18	1992-07-22	Sloan-Kettering Institute For Cancer Research	Novel synthesis of 2'-"up" fluorinated 2''-deoxy-arabinofuranosylpurines
DE4141454A1 (de) *	1991-11-25	1993-05-27	Schering Ag	Neues verfahren zur herstellung von 2-fluorpurin-derivaten
AU678557B2 (en) *	1992-05-19	1997-06-05	Scripps Research Institute, The	Use of 2-halo adenine derivatives as therapeutic agents against chronic myelogenous leukemia
WO1996003134A1 (en) *	1994-07-21	1996-02-08	Thomas Jefferson University	Treatment of diarrhea with 2-substituted adenosine derivatives
BR9908270A (pt) *	1998-02-25	2004-06-29	Univ Emory	2-fluoro-nucleosìdeos, composições farmacêuticas e seus usos
EP2251015B1 (en)	2000-10-18	2013-02-20	Gilead Pharmasset LLC	Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation
CA2381367A1 (en) *	2001-04-12	2002-10-12	Hironori Komatsu	Method for purifying 5'-protected 2'-deoxypurine nucleosides
EP1478322A4 (en)	2001-06-22	2007-08-08	Pharmasset Ltd	Beta 2'-OR 3'-HALONUCLEOSIDE
WO2004029025A2 (en) *	2002-09-27	2004-04-08	Bioenvision, Inc.	Methods and compositions for the treatment of autoimmune disorders using clofarabine
US20060135463A1 (en) *	2002-09-27	2006-06-22	Wood Christopher B	Methods and compositions for the treatment of lupus using clofarabine
AU2003287081A1 (en) *	2002-10-16	2004-05-04	Ilex Products, Inc.	Clofarabine and taxane chemotherapy combination
EP1794172B1 (en) *	2004-08-23	2009-07-15	F.Hoffmann-La Roche Ag	Antiviral 4'-azido-nucleosides
US8895531B2 (en) *	2006-03-23	2014-11-25	Rfs Pharma Llc	2′-fluoronucleoside phosphonates as antiviral agents
ATE493428T1 (de) *	2006-10-10	2011-01-15	Medivir Ab	Hcv-nukleosidinhibitor
US20090274686A1 (en) *	2008-05-02	2009-11-05	Yat Sun Or	Nucleoside phosphonate derivatives
CN102311472B (zh)	2010-07-09	2014-09-03	神隆(昆山)生化科技有限公司	2-氯-9-(2’-脱氧-2’-氟-β-D-阿拉伯呋喃糖基)-腺嘌呤的制备
CN103665075A (zh) *	2013-12-26	2014-03-26	南通康鑫药业有限公司	一种氯法拉滨的合成方法
EP2937420A1 (en)	2014-04-23	2015-10-28	Synbias Pharma AG	Method for the synthesis of clofarabine
CN110325542A (zh) *	2016-11-03	2019-10-11	劳伦斯·I·吴	克罗拉滨的前体药物
JP7378764B2 (ja) *	2018-10-04	2023-11-14	国立大学法人鹿児島大学	抗ｂ型肝炎ウイルス剤
US20220008450A1 (en) *	2018-10-04	2022-01-13	Daikin Industries, Ltd.	Anti-hepatitis b virus agent
GB201816825D0 (en)	2018-10-16	2018-11-28	Phoremost Ltd	Target for anti-cancer therapy
JP2020176082A (ja) *	2019-04-17	2020-10-29	ダイキン工業株式会社	核酸アナログ及び抗ｂ型肝炎ウイルス剤
KR20220034780A (ko) *	2019-06-14	2022-03-18	써던 리서취 인스티튜트	2,4,7-치환된-7-데아자-2'-데옥시-2'-플루오로아라비노실 뉴클레오사이드 및 뉴클레오타이드 전구약물 및 이의 용도

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS542993A (en) *	1977-06-10	1979-01-10	Agency Of Ind Science & Technol	Thermochemical production of hydrogen using wate as raw material
US4210745A (en) *	1978-01-04	1980-07-01	The United States Of America As Represented By The Department Of Health, Education And Welfare	Procedure for the preparation of 9-β-D-arabinofuranosyl-2-fluoroadenine
US4188378A (en) *	1978-01-04	1980-02-12	The United States Of America As Represented By The Department Of Health, Education And Welfare	Anticancer and antiviral activity of 9-β-D-arabinofuranosyl-2-fluoroadenine
US4357324A (en) *	1981-02-24	1982-11-02	The United States Of America As Represented By The Department Of Health And Human Services	Prodrug derivatives of 9β-D-arabinofuranosyl-2-fluoroadenine
US4751221A (en) *	1985-10-18	1988-06-14	Sloan-Kettering Institute For Cancer Research	2-fluoro-arabinofuranosyl purine nucleosides
EP0314011A3 (de) *	1987-10-30	1990-04-11	F. Hoffmann-La Roche Ag	Purinderivate
DE68924319T2 (de) *	1988-03-16	1996-05-15	Scripps Research Inst	Als therapeutische mittel verwendbare substituierte adeninderivate.

1989
- 1989-05-23 US US07/355,358 patent/US5034518A/en not_active Expired - Lifetime
1990
- 1990-05-23 EP EP90909080A patent/EP0473708B1/en not_active Expired - Lifetime
- 1990-05-23 AU AU58315/90A patent/AU5831590A/en not_active Abandoned
- 1990-05-23 JP JP50878990A patent/JP3160288B2/ja not_active Expired - Lifetime
- 1990-05-23 DE DE69029733T patent/DE69029733T2/de not_active Expired - Lifetime
- 1990-05-23 DE DE122006000060C patent/DE122006000060I2/de active Active
- 1990-05-23 AT AT90909080T patent/ATE147751T1/de not_active IP Right Cessation
- 1990-05-23 WO PCT/US1990/002927 patent/WO1990014352A1/en not_active Ceased
- 1990-05-23 ES ES90909080T patent/ES2098266T3/es not_active Expired - Lifetime
2006
- 2006-11-24 NL NL300247C patent/NL300247I1/nl unknown

Also Published As

Publication number	Publication date
JP3160288B2 (ja)	2001-04-25
NL300247I2 (nl)	2007-02-01
WO1990014352A1 (en)	1990-11-29
DE122006000060I1 (de)	2007-04-05
US5034518A (en)	1991-07-23
DE69029733T2 (de)	1997-07-17
DE69029733D1 (de)	1997-02-27
JPH05502014A (ja)	1993-04-15
HK1007561A1 (en)	1999-04-16
EP0473708B1 (en)	1997-01-15
DE122006000060I2 (de)	2010-10-21
ATE147751T1 (de)	1997-02-15
ES2098266T3 (es)	1997-05-01
EP0473708A1 (en)	1992-03-11
AU5831590A (en)	1990-12-18
EP0473708A4 (en)	1992-04-22

Similar Documents

Publication	Publication Date	Title
NL300247I2 (nl)	2007-02-01	2-Halogeen-9-(2-desoxy-2-fluor-bêta-D-arabinofuranosyl)-adeninenucleosiderivaten.
DZ1270A1 (fr)	2004-09-13	Dérivés de fluorocytidine.
PT526253E (pt)	2003-03-31	Analogos do nucleosido 1,3-oxatiolano
NL960002I1 (nl)	1996-05-01	Nieuwe taxolderivaten,werkwijzen ter bereiding daarvan en farmaceutische preparaten,die deze bevatten.
DE3773245D1 (de)	1991-10-31	Nukleosid-derivate und ihre verwendung in der oligonukleosid-synthese.
DK0545966T3 (da)	1995-05-08	Phospholipidderivater af nucleosider, deres fremstilling samt deres anvendelse som anti-virale lægemidler
KR950700298A (ko)	1995-01-16	뉴클레오시드 치료제(Therapeutic Nucleosides)
DK696988A (da)	1989-01-31	Nucleosider og nucleosidanaloge, farmaceutiske praeparater indeholdende disse forbindelser og fremgangsmaade til fremstilling af forbindelserne
SE8900192L (sv)	1989-07-21	Dideoxididehydrokarbocykliska nukleosider
FI880405A7 (fi)	1988-08-05	Adenosin-5'-karboxamidderivat.
ES515081A0 (es)	1983-05-01	"procedimiento para la preparacion de derivados de 6-metilprednisolona".
OA07647A (fr)	1985-05-23	Sels de dérivés organophosphorés fongicides.
DE3173954D1 (en)	1986-04-10	Use of adenosin derivatives for the manufacture of psychopharmacons
IT8719107A0 (it)	1987-01-19	Procedimento di decomposizione dicomposti organici alogenati.
DK454086A (da)	1987-03-25	Quinolinderivater og deres anvendelse
ES2052897T3 (es)	1994-07-16	Nucleosidos didesoxidideshidrocarbociclicos.
FI922014A7 (fi)	1992-05-05	Nukleosidijohdannaiset
FR2696745B1 (fr)	1995-05-12	Procédé de préparation de dérivés de phényltétrazole.
OA06527A (fr)	1981-07-31	Préparation de derivés hydroxylés de l'isopropylamine pyrimidine (séquence base minéral).
ES2058196T3 (es)	1994-11-01	Derivados de azacromano.
OA07701A (fr)	1985-08-30	Perfectionnements relatifs à des dérivés de benzothiénylglycyl-céphalosporines.
OA08742A (fr)	1989-03-31	Dérivés de pyrimidine.
NO913659D0 (no)	1991-09-17	Hemming av hiv ved anvendelse av synergistiske kombinasjoner av nukleosidderivater.
KR930701470A (ko)	1993-06-11	누클레오시드의 인지질 유도체, 이것의 제조방법 및 항바이러스제로서의 사용
ES551865A0 (es)	1987-04-16	Procedimiento para la preparacion de derivados de 5'-o-(glicosilureidosulfonil) uridina.