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NL300123I2 - Een gejodeerde neuroprobe voor het vastleggen van monoamine-heropnameplaatsen. - Google Patents

Een gejodeerde neuroprobe voor het vastleggen van monoamine-heropnameplaatsen.

Info

Publication number
NL300123I2
NL300123I2 NL300123C NL300123C NL300123I2 NL 300123 I2 NL300123 I2 NL 300123I2 NL 300123 C NL300123 C NL 300123C NL 300123 C NL300123 C NL 300123C NL 300123 I2 NL300123 I2 NL 300123I2
Authority
NL
Netherlands
Prior art keywords
group
isotope
cnh2n
neuroprobe
iodinated
Prior art date
Application number
NL300123C
Other languages
English (en)
Other versions
NL300123I1 (nl
Original Assignee
Amersham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Plc filed Critical Amersham Plc
Publication of NL300123I1 publication Critical patent/NL300123I1/nl
Publication of NL300123I2 publication Critical patent/NL300123I2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Valve-Gear Or Valve Arrangements (AREA)
  • Testing Or Measuring Of Semiconductors Or The Like (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Window Of Vehicle (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measuring Leads Or Probes (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NL300123C 1992-02-25 2003-04-09 Een gejodeerde neuroprobe voor het vastleggen van monoamine-heropnameplaatsen. NL300123I2 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/841,617 US5310912A (en) 1992-02-25 1992-02-25 Iodinated neuroprobe for mapping monoamine reuptake sites
PCT/US1993/006170 WO1995001184A1 (en) 1992-02-25 1993-06-29 An iodinated neuroprobe for mapping monoamine reuptake sites

Publications (2)

Publication Number Publication Date
NL300123I1 NL300123I1 (nl) 2003-06-02
NL300123I2 true NL300123I2 (nl) 2003-08-01

Family

ID=25285315

Family Applications (1)

Application Number Title Priority Date Filing Date
NL300123C NL300123I2 (nl) 1992-02-25 2003-04-09 Een gejodeerde neuroprobe voor het vastleggen van monoamine-heropnameplaatsen.

Country Status (12)

Country Link
US (2) US5310912A (nl)
EP (1) EP0703791B1 (nl)
JP (1) JP3228422B2 (nl)
AT (1) ATE228858T1 (nl)
AU (1) AU674331B2 (nl)
DE (2) DE69332544T2 (nl)
DK (1) DK0703791T3 (nl)
ES (1) ES2189792T3 (nl)
FI (1) FI120183B (nl)
NL (1) NL300123I2 (nl)
PT (1) PT703791E (nl)
WO (1) WO1995001184A1 (nl)

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US5496953A (en) * 1990-08-09 1996-03-05 Research Triangle Institute Cocaine receptor binding ligands
US5736123A (en) * 1990-08-09 1998-04-07 Research Triangle Institute Cocaine receptor binding ligands
US5128118A (en) * 1990-08-09 1992-07-07 Research Triangle Institute Cocaine receptor binding ligands
US7189737B2 (en) * 1991-08-09 2007-03-13 Research Triangle Institute Cocaine receptor binding ligands
US5750089A (en) * 1996-01-11 1998-05-12 Neuro Imaging Technologies, Llc Halogenated neuroprobe for mapping monoamine reuptake sites
US5770180A (en) * 1992-08-24 1998-06-23 Organix, Inc. Bridge-substituted tropanes for methods of imaging and therapy
US5493026A (en) * 1993-10-25 1996-02-20 Organix, Inc. Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
EP0831941B1 (en) * 1995-06-06 2012-04-04 GE Healthcare Limited Iodinated neuroprobes for mapping monoamine reuptake sites
US5864038A (en) * 1995-08-17 1999-01-26 Emory University Labeled cocaine analogs
US7105678B2 (en) 1995-11-03 2006-09-12 Organix, Inc. Boat tropanes
US6171576B1 (en) * 1995-11-03 2001-01-09 Organix Inc. Dopamine transporter imaging agent
US5948933A (en) 1997-07-11 1999-09-07 Organix, Inc. Tropane analogs and methods for inhibition of monoamine transport
FR2748475B1 (fr) * 1996-05-10 1999-04-16 Cis Bio Int Derives du tropane utilisables en particulier pour la detection in vivo des transporteurs de la dopamine
CA2270242A1 (en) * 1996-10-29 1998-05-07 Guilford Pharmaceuticals Inc. Process for the preparation of radiopharmaceuticals
FI104048B (fi) * 1997-06-16 1999-11-15 Map Medical Technologies Oy Prosessi tuottaa radiojodattuja reseptoriaineita in vivo käyttöön
US6358492B1 (en) * 1997-10-07 2002-03-19 Research Triangle Institute Dopamine transporter imaging ligand
US6013242A (en) * 1998-01-13 2000-01-11 Wake Forest University Tropane derivatives with selective binding to the serotonin reuptake transporters for treatment of mental illness and as intermediates in the formation of imaging diagnostic agents for depression
US6843979B2 (en) 1999-04-26 2005-01-18 Emory University 4-haloethenylphenyl tropane:serotonin transporter imaging agents
US6399042B1 (en) * 1999-04-26 2002-06-04 Emory University 4-fluoroalkyl-3-halophenyl nortropanes
CA2721484A1 (en) 1999-05-12 2000-11-12 President And Fellows Of Harvard College Dopamine transporter imaging agents
KR20040100835A (ko) * 2001-02-15 2004-12-02 킹 파머슈티칼스 리서치 앤드 디벨로프먼트 아이엔씨 안정된 제약및 갑상선 내분비 호르몬 구성물 및 그제조방법
US20030032675A1 (en) * 2001-02-15 2003-02-13 Franz G. Andrew Manufacture of thyroid hormone tablets having consistent active moiety amounts
US6555581B1 (en) 2001-02-15 2003-04-29 Jones Pharma, Inc. Levothyroxine compositions and methods
US20030224047A1 (en) * 2001-02-15 2003-12-04 Franz G. Andrew Levothyroxine compositions and methods
JP4497815B2 (ja) * 2001-02-16 2010-07-07 アベンティス・ファーマスーティカルズ・インコーポレイテツド 新規な複素環式アミド誘導体およびドーパミンｄ３受容体リガンドとしてのその使用
US20030198667A1 (en) * 2001-08-10 2003-10-23 Franz Andrew G. Methods of producing dispersible pharmaceutical compositions
US20030190349A1 (en) * 2001-08-10 2003-10-09 Franz G. Andrew Methods of stabilizing pharmaceutical compositions
US20030180353A1 (en) * 2001-08-10 2003-09-25 Franz G. Andrew Stabilized pharmaceutical compositions
US20030199586A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Unique levothyroxine aqueous materials
US7101569B2 (en) 2001-08-14 2006-09-05 Franz G Andrew Methods of administering levothyroxine pharmaceutical compositions
US20030198672A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique triidothyronine plasma AUC properties
US20030199587A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique Cmax properties
US20030203967A1 (en) * 2001-08-14 2003-10-30 Franz G. Andrew Levothyroxine compositions having unique Tmax properties
US20030195253A1 (en) * 2001-08-14 2003-10-16 Franz G. Andrew Unadsorbed levothyroxine pharmaceutical compositions, methods of making and methods of administration
DE20120708U1 (de) 2001-10-09 2002-08-01 Blundell, Paul, Sommerville, Mass. Tropan-Analoga zur Inhibierung des Monoamin-Transports
US20030191185A1 (en) * 2001-10-29 2003-10-09 Franz G. Andrew Levothyroxine compositions having unique triiodothyronine Tmax properties
CN1313436C (zh) * 2002-04-30 2007-05-02 埃默里大学 肿瘤成像化合物
JP2005154374A (ja) * 2003-11-27 2005-06-16 Hamamatsu Photonics Kk 放射性トロパンアルカロイド誘導体、トロパンアルカロイド誘導体、及びそれらの製造方法。
EP1893244A4 (en) 2005-06-23 2009-06-24 Univ Emory AGENTS FOR IMAGING
US20060292073A1 (en) * 2005-06-23 2006-12-28 Emory University Stereoselective Synthesis of Amino Acid Analogs for Tumor Imaging
EP2212319B1 (en) 2007-10-31 2018-07-18 Alseres Pharmaceuticals, Inc. Labeled iodinated tropane formulation
US8246752B2 (en) 2008-01-25 2012-08-21 Clear Catheter Systems, Inc. Methods and devices to clear obstructions from medical tubes
JP7241013B2 (ja) * 2017-03-17 2023-03-16 日本メジフィジックス株式会社 イオフルパンの製造方法
HUE069514T2 (hu) 2020-01-24 2025-03-28 Rotop Radiopharmacy Gmbh N-monofluor-alkil-tropánok elõállítására szolgáló eljárás és azok felhasználása

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3813404A (en) * 1972-11-15 1974-05-28 Sterling Drug Inc Tropane-2-carboxylates and derivatives
US4942231A (en) * 1984-05-24 1990-07-17 Mallinckrodt, Inc. Method of preparing a chlorinated, brominated, radio-brominated, iodinated and/or radioiodinated aromatic or heteroaromatic compound
US5098996A (en) * 1984-10-26 1992-03-24 The United States Of America As Represented By The Department Of Health And Human Services Process for introducing fluorine into biologically active materials
US5200169A (en) * 1987-04-16 1993-04-06 Neorx Corporation Vinyl substituted radiohalogen conjugates for protein labeling
US5186921A (en) * 1989-04-17 1993-02-16 Trustees Of The University Of Pennsylvania Dopamine receptor ligands and image agents
US5128118A (en) * 1990-08-09 1992-07-07 Research Triangle Institute Cocaine receptor binding ligands
US5104638A (en) * 1990-10-29 1992-04-14 Mallinckrodt Medical, Inc. Method of making a radiopharmaceutical complex from a kit

Also Published As

Publication number Publication date
DE10399020I2 (de) 2005-05-04
DK0703791T3 (da) 2003-03-24
DE10399020I1 (de) 2003-09-18
NL300123I1 (nl) 2003-06-02
ES2189792T3 (es) 2003-07-16
FI956261L (fi) 1995-12-27
FI956261A0 (fi) 1995-12-27
US5439666A (en) 1995-08-08
DE69332544T2 (de) 2003-08-14
US5310912A (en) 1994-05-10
EP0703791B1 (en) 2002-12-04
EP0703791A1 (en) 1996-04-03
JPH09503745A (ja) 1997-04-15
EP0703791A4 (en) 1996-05-22
FI120183B (fi) 2009-07-31
AU4655493A (en) 1995-01-24
JP3228422B2 (ja) 2001-11-12
DE69332544D1 (de) 2003-01-16
AU674331B2 (en) 1996-12-19
ATE228858T1 (de) 2002-12-15
PT703791E (pt) 2003-04-30
WO1995001184A1 (en) 1995-01-12

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