NL300055I2 - Rapamycinepreparaten voor orale toediening. - Google Patents
Rapamycinepreparaten voor orale toediening.Info
- Publication number
- NL300055I2 NL300055I2 NL300055C NL300055C NL300055I2 NL 300055 I2 NL300055 I2 NL 300055I2 NL 300055 C NL300055 C NL 300055C NL 300055 C NL300055 C NL 300055C NL 300055 I2 NL300055 I2 NL 300055I2
- Authority
- NL
- Netherlands
- Prior art keywords
- oral administration
- rapamycin
- volume
- preparations
- rapamycin preparations
- Prior art date
Links
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title abstract 3
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title abstract 3
- 229960002930 sirolimus Drugs 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title 1
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 229940067606 lecithin Drugs 0.000 abstract 1
- 235000010445 lecithin Nutrition 0.000 abstract 1
- 239000000787 lecithin Substances 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12952993A | 1993-09-30 | 1993-09-30 | |
| US12952393A | 1993-09-30 | 1993-09-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NL300055I1 NL300055I1 (nl) | 2001-12-01 |
| NL300055I2 true NL300055I2 (nl) | 2002-04-02 |
Family
ID=26827648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL300055C NL300055I2 (nl) | 1993-09-30 | 2001-09-10 | Rapamycinepreparaten voor orale toediening. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0648494B1 (nl) |
| AT (1) | ATE173628T1 (nl) |
| AU (1) | AU688782B2 (nl) |
| DE (2) | DE69414810T2 (nl) |
| DK (1) | DK0648494T3 (nl) |
| ES (1) | ES2124852T3 (nl) |
| FI (1) | FI115033B (nl) |
| GR (1) | GR3029439T3 (nl) |
| HU (1) | HU220870B1 (nl) |
| LU (1) | LU90832I2 (nl) |
| NL (1) | NL300055I2 (nl) |
| SG (1) | SG47803A1 (nl) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH686761A5 (de) | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
| DE4336434A1 (de) * | 1993-10-26 | 1995-04-27 | Hoechst Ag | Pharmazeutische Zubereitung für die parenterale, enterale und dermale Verabreichung von praktisch unlöslichen Arzneistoffen und Verfahren zu ihrer Herstellung |
| MY129435A (en) * | 1994-10-26 | 2007-04-30 | Novartis Ag | Pharmaceutical microemulsion preconcentrates |
| FR2736550B1 (fr) | 1995-07-14 | 1998-07-24 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule |
| GB9601120D0 (en) * | 1996-01-19 | 1996-03-20 | Sandoz Ltd | Organic compounds |
| GB2331924A (en) * | 1997-12-08 | 1999-06-09 | Phares Pharm Res Nv | Lipid compositions and their use |
| US6682758B1 (en) | 1998-12-22 | 2004-01-27 | The United States Of America As Represented By The Department Of Health And Human Services | Water-insoluble drug delivery system |
| CA2356959C (en) * | 1998-12-22 | 2009-03-31 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Water-insoluble drug delivery system |
| PL216224B1 (pl) | 2002-02-01 | 2014-03-31 | Ariad Pharmaceuticals | Pochodne rapamycyny zawierające fosfor, kompozycja je zawierająca oraz ich zastosowanie |
| WO2005110360A2 (en) * | 2004-05-18 | 2005-11-24 | Phares Pharmaceutical Research N.V. | Compositions for injection |
| JP5528708B2 (ja) * | 2006-02-09 | 2014-06-25 | 参天製薬株式会社 | 安定な製剤ならびにそれらを調製および使用する方法 |
| EP3738592B1 (en) | 2013-10-08 | 2022-01-26 | AI Therapeutics, Inc. | Rapamycin for the treatment of lymphangioleiomyomatosis |
| JP2017505789A (ja) * | 2014-02-11 | 2017-02-23 | ラム・セラピューティクス，インコーポレーテッド | リンパ脈管筋腫症の治療のためのラパマイシン |
| BR112016022598A8 (pt) | 2014-04-04 | 2021-06-29 | Ai Therapeutics Inc | composição aerossol farmacêutica na forma de um pó seco para liberação pulmonar, forma de dosagem unitária, pacote farmacêutico, kit e uso |
| CA2963085C (en) | 2014-10-07 | 2023-02-21 | Lam Therapeutics, Inc. | An inhalable rapamycin formulation for the treatment of pulmonary hypertension |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU543727B2 (en) * | 1980-06-02 | 1985-05-02 | Ayerst Mckenna & Harrison Inc. | Injectable composition of rapamycin |
| US5100899A (en) * | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
| GB9103430D0 (en) * | 1991-02-19 | 1991-04-03 | Smithkline Beecham Plc | Novel compound |
| IL111003A0 (en) * | 1993-09-30 | 1994-11-28 | American Home Prod | Multi-component oral rapamycin formulation |
-
1994
- 1994-09-26 AU AU74205/94A patent/AU688782B2/en not_active Ceased
- 1994-09-28 HU HU9402786A patent/HU220870B1/hu not_active IP Right Cessation
- 1994-09-29 ES ES94307117T patent/ES2124852T3/es not_active Expired - Lifetime
- 1994-09-29 DE DE69414810T patent/DE69414810T2/de not_active Expired - Lifetime
- 1994-09-29 EP EP94307117A patent/EP0648494B1/en not_active Expired - Lifetime
- 1994-09-29 DE DE2001199046 patent/DE10199046I1/de active Pending
- 1994-09-29 AT AT94307117T patent/ATE173628T1/de active
- 1994-09-29 SG SG1996004442A patent/SG47803A1/en unknown
- 1994-09-29 FI FI944535A patent/FI115033B/fi not_active IP Right Cessation
- 1994-09-29 DK DK94307117T patent/DK0648494T3/da active
-
1999
- 1999-02-17 GR GR990400522T patent/GR3029439T3/el unknown
-
2001
- 2001-09-10 NL NL300055C patent/NL300055I2/nl unknown
- 2001-09-11 LU LU90832C patent/LU90832I2/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL300055I1 (nl) | 2001-12-01 |
| ES2124852T3 (es) | 1999-02-16 |
| ATE173628T1 (de) | 1998-12-15 |
| LU90832I2 (fr) | 2001-11-12 |
| HU9402786D0 (en) | 1994-12-28 |
| HK1010342A1 (en) | 1999-06-17 |
| AU688782B2 (en) | 1998-03-19 |
| EP0648494B1 (en) | 1998-11-25 |
| FI944535A0 (fi) | 1994-09-29 |
| DE10199046I1 (de) | 2002-01-10 |
| DE69414810D1 (de) | 1999-01-07 |
| DE69414810T2 (de) | 1999-04-22 |
| AU7420594A (en) | 1995-04-13 |
| DK0648494T3 (da) | 1999-08-09 |
| FI115033B (fi) | 2005-02-28 |
| GR3029439T3 (en) | 1999-05-28 |
| HU220870B1 (en) | 2002-06-29 |
| HUT71115A (en) | 1995-11-28 |
| EP0648494A1 (en) | 1995-04-19 |
| SG47803A1 (en) | 1998-04-17 |
| FI944535L (fi) | 1995-03-31 |
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