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NL2035174A - Lactobacillus fermentum and applications of lactobacillus fermentum in preparation for improving hyperlipidemia - Google Patents

Lactobacillus fermentum and applications of lactobacillus fermentum in preparation for improving hyperlipidemia Download PDF

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Publication number
NL2035174A
NL2035174A NL2035174A NL2035174A NL2035174A NL 2035174 A NL2035174 A NL 2035174A NL 2035174 A NL2035174 A NL 2035174A NL 2035174 A NL2035174 A NL 2035174A NL 2035174 A NL2035174 A NL 2035174A
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Netherlands
Prior art keywords
lactobacillus fermentum
preparation
cholesterol
mice
level
Prior art date
Application number
NL2035174A
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English (en)
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NL2035174B1 (en
Inventor
Shu Xi
Peng Lin
Zhang Feng
Jiang Yuanyuan
Wang Qiang
Yin Manni
Jia Cuiqing
Chen Zuguo
Deng Yadan
Wang Jing
Original Assignee
Chongqing Tianyou Dairy Co Ltd
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Publication of NL2035174A publication Critical patent/NL2035174A/en
Application granted granted Critical
Publication of NL2035174B1 publication Critical patent/NL2035174B1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225—Lactobacillus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Claims (10)

CONCLUSIES
1. Lactobacillus fermentum (Lactobacillus fermentum), met het kenmerk, dat het ingediend is met verzamelingsnummer CGMCC Nr. 25738 bij het Algemene Microbiologische Centrum van het Chinese Beheerscomité voor het Verzamelen van Microbiologische Culturen.
2. Lactobacillus fermentum volgens conclusie 1, met het kenmerk, dat een 16SrDNA-sequentie een sequentie weergegeven in SEQ ID Nr.1 bevat.
3. Samenstelling, met het kenmerk, dat de samenstelling één of een combinatie van een veelvoud van de volgende stoffen bevat: (a) de lactobacillus fermentum volgens conclusie 1 of 2; (b) een lysaat van de lactobacillus fermentum volgens conclusie 1 of 2; (c) een cultuur van de lactobacillus fermentum volgens conclusie 1 of 2; en (d) een gistingsbouillon van de lactobacillus fermentum volgens conclusie 1 of 2.
4. Samenstelling volgens conclusie 3, met het kenmerk, dat de samenstelling verder één of een combinatie van probiotica, prebiotica, voedingsvezels en traditionele Chinese geneeskunde bevat.
5. Bereiding, met het kenmerk, dat de bereiding de lactobacillus fermentum volgens conclusie 1 of 2 bevat of/en de samenstelling volgens conclusie 3 of 4, en een drager, waarbij de drager een medicinale drager of een eetbare drager is.
6. Bereiding volgens conclusie 5, met het kenmerk, dat de bereiding tabletten, pillen, capsules, poeders, gels, korrels of vloeistoffen zijn.
7. Toepassingen van lactobacillus fermentum volgens conclusie 1 of 2 of samenstelling volgens conclusie 3 of 4 bij de bereiding van bereidingen voor het verbeteren van hyperlipidemie.
8. Toepassingen volgens conclusie 7, met het kenmerk, dat de toepassing omvat: een toepassing van de lactobacillus fermentum volgens conclusie 1 of 2 of de samenstellingen volgens conclusie 3 of 4 bij de bereiding van bereidingen die het triglycerideniveau en/of het totale cholesterolniveau en/of lage dichtheid lipoproteineniveau in het bloedserum verlagen.
9. Toepassingen volgens conclusie 7 of 8, met het kenmerk, dat de toepassing één of een combinatie van een veelvoud van de volgende combinaties omvat: (a) een toepassing van de lactobacillus fermentum volgens conclusie 1 of 2 of de samenstellingen volgens conclusie 3 of 4 bij de bereiding van bereidingen die het triglycerideniveau en/of het cholesterolniveau in de lever verlagen; (b) een toepassing van de lactobacillus fermentum volgens conclusie 1 of 2 of de samenstelling volgens conclusie 3 of 4 bij de bereiding van de bereidingen die de afscheiding van vetzuren met korte keten in de darm bevorderen.
10. Toepassingen volgens conclusie 9, met het kenmerk, dat het vetzuur met korte keten in de toepassing (c) één of meer van azijnzuur, propionzuur of boterzuur is.
NL2035174A 2022-11-23 2023-06-26 Lactobacillus fermentum and applications of lactobacillus fermentum in preparation for improving hyperlipidemia NL2035174B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202211477777.8A CN116004442B (zh) 2022-11-23 2022-11-23 一种发酵乳杆菌及其在改善高脂血症制剂中的应用

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NL2035174A true NL2035174A (en) 2023-09-21
NL2035174B1 NL2035174B1 (en) 2024-05-06

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117866798B (zh) * 2023-10-08 2025-07-15 卡士酸奶(苏州)有限公司 发酵乳杆菌glf-217及其在溃疡性结肠炎、高脂血症和降低器官损伤中的应用

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KR20180011490A (ko) * 2016-07-25 2018-02-02 명지대학교 산학협력단 프로바이오틱 활성을 갖는 신규 락토바실러스 퍼멘텀 및 이의 용도
WO2020080736A1 (en) * 2018-10-19 2020-04-23 Clinical Nutrition Intl (M) Sdn Bhd Probiotic strain for ageing, muscle and bone, gut, hyperlipidemia, skin and brain
CN114621896A (zh) * 2022-03-23 2022-06-14 广东省科学院微生物研究所(广东省微生物分析检测中心) 一株具有降糖降脂功能的植物乳杆菌84-3及其应用
TWI784621B (zh) * 2021-07-16 2022-11-21 大江生醫股份有限公司 中藥發酵液及其提神、改善疲勞、護肝、提升免疫力、降血脂之用途

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CN108728382B (zh) * 2018-06-07 2021-04-27 四川大学 一株具降胆固醇及促进肠道短链脂肪酸产生能力的植物乳杆菌及其应用
KR102215592B1 (ko) * 2019-12-11 2021-02-15 주식회사 에이치이엠 신규한 락토바실러스 퍼멘텀 hem 1036 균주, 및 상기 균주 또는 이의 배양물을 포함하는 장내 환경 개선용 조성물
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WO2020080736A1 (en) * 2018-10-19 2020-04-23 Clinical Nutrition Intl (M) Sdn Bhd Probiotic strain for ageing, muscle and bone, gut, hyperlipidemia, skin and brain
TWI784621B (zh) * 2021-07-16 2022-11-21 大江生醫股份有限公司 中藥發酵液及其提神、改善疲勞、護肝、提升免疫力、降血脂之用途
CN114621896A (zh) * 2022-03-23 2022-06-14 广东省科学院微生物研究所(广东省微生物分析检测中心) 一株具有降糖降脂功能的植物乳杆菌84-3及其应用

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HUANG WENLI ET AL: "Cholesterol-Lowering Effects of Two Lactobacillus Strains in Hyperlipidemia Mice - CNKI", JOURNAL OF UNIVERSITY OF SHANGHAI FOR SCIENCE AND TECHNOLOGY, 10 April 2019 (2019-04-10), XP093140580, Retrieved from the Internet <URL:10.13255/j.cnki.jusst.2019.06.003> [retrieved on 20240312] *

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CN116004442B (zh) 2024-12-31
NL2035174B1 (en) 2024-05-06
CN116004442A (zh) 2023-04-25

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