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NL192326B - A method of preparing a medicament in which a purified, detoxified endotoxin is brought into a form suitable for therapeutic administration together with a carrier and optionally other additives. - Google Patents

A method of preparing a medicament in which a purified, detoxified endotoxin is brought into a form suitable for therapeutic administration together with a carrier and optionally other additives.

Info

Publication number
NL192326B
NL192326B NL8402515A NL8402515A NL192326B NL 192326 B NL192326 B NL 192326B NL 8402515 A NL8402515 A NL 8402515A NL 8402515 A NL8402515 A NL 8402515A NL 192326 B NL192326 B NL 192326B
Authority
NL
Netherlands
Prior art keywords
medicament
additives
purified
brought
carrier
Prior art date
Application number
NL8402515A
Other languages
Dutch (nl)
Other versions
NL8402515A (en
NL192326C (en
Original Assignee
Ribi Immunochem Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribi Immunochem Research Inc filed Critical Ribi Immunochem Research Inc
Publication of NL8402515A publication Critical patent/NL8402515A/en
Publication of NL192326B publication Critical patent/NL192326B/en
Application granted granted Critical
Publication of NL192326C publication Critical patent/NL192326C/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/05—Immunological preparations stimulating the reticulo-endothelial system, e.g. against cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

A composition which is capable of producing an effective adjuvant response or stimulating the immune response of a warm blooded animal which comprises an effective amount of a refined detoxified endotoxin material, in combination with a pharmaceutically acceptable carrier.
NL8402515A 1983-08-26 1984-08-16 A method of preparing a medicament in which a purified, detoxified endotoxin is brought into a form suitable for therapeutic administration together with a carrier and optionally other additives. NL192326C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52696783A 1983-08-26 1983-08-26
US52696783 1983-08-26

Publications (3)

Publication Number Publication Date
NL8402515A NL8402515A (en) 1985-03-18
NL192326B true NL192326B (en) 1997-02-03
NL192326C NL192326C (en) 1997-06-04

Family

ID=24099553

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8402515A NL192326C (en) 1983-08-26 1984-08-16 A method of preparing a medicament in which a purified, detoxified endotoxin is brought into a form suitable for therapeutic administration together with a carrier and optionally other additives.

Country Status (22)

Country Link
JP (1) JPS6072825A (en)
KR (1) KR880002223B1 (en)
AT (1) AT389228B (en)
AU (1) AU554039B2 (en)
BE (1) BE900377A (en)
CA (1) CA1225592A (en)
CH (1) CH660125A5 (en)
DE (2) DE3448164C2 (en)
DK (1) DK389384A (en)
ES (1) ES8606883A1 (en)
FI (1) FI843204L (en)
FR (1) FR2550945B1 (en)
GB (1) GB2147806B (en)
HU (1) HU191713B (en)
IL (1) IL72675A (en)
IN (1) IN157910B (en)
IT (1) IT1177974B (en)
NL (1) NL192326C (en)
NO (1) NO843243L (en)
NZ (1) NZ209233A (en)
SE (1) SE8404090L (en)
ZA (1) ZA846309B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4629722A (en) * 1984-07-12 1986-12-16 Ribi Immunochem Research, Inc. Method of inhibiting the onset of acute radiation syndrome
US4806352A (en) * 1986-04-15 1989-02-21 Ribi Immunochem Research Inc. Immunological lipid emulsion adjuvant
US4803070A (en) * 1986-04-15 1989-02-07 Ribi Immunochem Research Inc. Immunological emulsion adjuvants for polysaccharide vaccines
DE10115310A1 (en) * 2001-03-28 2002-10-10 Nodar A Daniela Bacteriophage preparation
KR100868443B1 (en) * 2002-05-27 2008-11-11 주식회사 포스코 Launch box manufacturing device with variable width and length

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2160326B1 (en) * 1971-11-19 1975-02-07 Anvar
BE793260A (en) * 1971-12-24 1973-06-22 Pasteur Institut IMMUNOSTIMULANT AGENT, MEDICINES CONTAINING IT AND METHOD FOR MANUFACTURING SUCH IMMUNOSTIMULANT AGENT
FR2275224A1 (en) * 1974-06-20 1976-01-16 Anvar MYCOBACTERIAL FRACTIONS FOR USE AS ANTI-INFECTIOUS AGENT, AND PROCESS FOR THEIR PREPARATION
FR2393065A1 (en) * 1977-05-31 1978-12-29 Merieux Inst PROCESS FOR SEPARATION OF LIPIDS FROM BACTERIAL ENDOTOXINS AND IN PARTICULAR FROM BORDETELLA PERTUSSIS ENDOTOXIN
US4436728A (en) * 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4436727A (en) * 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4435386A (en) * 1982-05-26 1984-03-06 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product

Also Published As

Publication number Publication date
BE900377A (en) 1985-02-18
DE3431058C2 (en) 1987-06-11
ATA273384A (en) 1989-04-15
DE3448164C2 (en) 1987-06-25
SE8404090D0 (en) 1984-08-14
SE8404090L (en) 1985-02-27
FR2550945B1 (en) 1988-09-16
AU3221584A (en) 1985-02-28
IL72675A0 (en) 1984-11-30
HU191713B (en) 1987-03-30
ES535124A0 (en) 1986-05-01
DE3431058A1 (en) 1985-03-07
NL8402515A (en) 1985-03-18
IL72675A (en) 1988-04-29
ZA846309B (en) 1985-03-27
NZ209233A (en) 1987-11-27
DK389384D0 (en) 1984-08-13
IT8448757A0 (en) 1984-08-24
HUT34887A (en) 1985-05-28
NO843243L (en) 1985-02-27
ES8606883A1 (en) 1986-05-01
CH660125A5 (en) 1987-03-31
DK389384A (en) 1985-02-27
IT8448757A1 (en) 1986-02-24
JPH0556326B2 (en) 1993-08-19
FI843204A7 (en) 1985-02-27
CA1225592A (en) 1987-08-18
FI843204A0 (en) 1984-08-14
KR850001696A (en) 1985-04-01
AT389228B (en) 1989-11-10
GB2147806B (en) 1986-10-22
KR880002223B1 (en) 1988-10-20
FR2550945A1 (en) 1985-03-01
IN157910B (en) 1986-07-19
GB8420612D0 (en) 1984-09-19
GB2147806A (en) 1985-05-22
JPS6072825A (en) 1985-04-24
NL192326C (en) 1997-06-04
FI843204L (en) 1985-02-27
IT1177974B (en) 1987-09-03
AU554039B2 (en) 1986-08-07

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Legal Events

Date Code Title Description
BA A request for search or an international-type search has been filed
BT A notification was added to the application dossier and made available to the public
BB A search report has been drawn up
BC A request for examination has been filed
V4 Discontinued because of reaching the maximum lifetime of a patent

Effective date: 20040816