NL181906C - METHOD FOR PREPARING OR MANUFACTURING A PREPARATION WITH ANTIMICROBIAL ACTIVITY, AND PROCESS FOR PREPARING 1- (2-ARYL-1,3-DIOXOLAN-2-YLMETHYL) IMIDAZOLE DERIVATIVES SUITABLE FOR USE - Google Patents

METHOD FOR PREPARING OR MANUFACTURING A PREPARATION WITH ANTIMICROBIAL ACTIVITY, AND PROCESS FOR PREPARING 1- (2-ARYL-1,3-DIOXOLAN-2-YLMETHYL) IMIDAZOLE DERIVATIVES SUITABLE FOR USE

Info

Publication number: NL181906C
Authority: NL; Netherlands
Prior art keywords: preparing; dioxolan; ylmethyl; aryl; preparation
Prior art date: 1975-01-27

Application number

NLAANVRAGE7514381,A

Other languages

Dutch (nl)

Other versions

NL7514381A (en

NL181906B (en

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-01-27

Filing date

1975-12-10

Publication date

1987-12-01

1975-01-27 Priority claimed from US05/544,157 external-priority patent/US3936470A/en

1975-12-10 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1976-07-29 Publication of NL7514381A publication Critical patent/NL7514381A/en

1976-10-15 Priority claimed from US05/732,828 external-priority patent/US4101664A/en

1987-07-01 Publication of NL181906B publication Critical patent/NL181906B/en

1987-12-01 Application granted granted Critical

1987-12-01 Publication of NL181906C publication Critical patent/NL181906C/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
- C07C29/10—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes
- C07C29/103—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes of cyclic ethers
- C07C29/106—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes of cyclic ethers of oxiranes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/16—Radicals substituted by halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Agronomy & Crop Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pest Control & Pesticides (AREA)
Plant Pathology (AREA)
Engineering & Computer Science (AREA)
Dentistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NLAANVRAGE7514381,A 1975-01-27 1975-12-10 METHOD FOR PREPARING OR MANUFACTURING A PREPARATION WITH ANTIMICROBIAL ACTIVITY, AND PROCESS FOR PREPARING 1- (2-ARYL-1,3-DIOXOLAN-2-YLMETHYL) IMIDAZOLE DERIVATIVES SUITABLE FOR USE NL181906C (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US05/544,157 US3936470A (en)	1975-01-27	1975-01-27	1,3-Dioxolan-2-ylmethylimidazoles
US61986375A	1975-10-06	1975-10-06
US71099476A	1976-08-02	1976-08-02
US05/732,828 US4101664A (en)	1975-10-06	1976-10-15	1-(2-Ar-4-aryloxymethyl-1,3-dioxolan-2-ylmethyl)-imidazoles
US05/732,826 US4101666A (en)	1975-10-06	1976-10-15	1-(2-Ar-4-R-1,3-dioxolan-2-ylmethyl)imidazoles

Publications (3)

Publication Number	Publication Date
NL7514381A NL7514381A (en)	1976-07-29
NL181906B NL181906B (en)	1987-07-01
NL181906C true NL181906C (en)	1987-12-01

Family

ID=27541875

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NLAANVRAGE7514381,A NL181906C (en)	1975-01-27	1975-12-10	METHOD FOR PREPARING OR MANUFACTURING A PREPARATION WITH ANTIMICROBIAL ACTIVITY, AND PROCESS FOR PREPARING 1- (2-ARYL-1,3-DIOXOLAN-2-YLMETHYL) IMIDAZOLE DERIVATIVES SUITABLE FOR USE

Country Status (8)

Country	Link
JP (1)	JPS6135196B2 (en)
AU (1)	AU503981B2 (en)
CA (1)	CA1065873A (en)
CH (1)	CH626361A5 (en)
DE (1)	DE2602770A1 (en)
FR (1)	FR2298328A1 (en)
GB (1)	GB1528639A (en)
NL (1)	NL181906C (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4144346A (en) *	1977-01-31	1979-03-13	Janssen Pharmaceutica N.V.	Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
US4160841A (en) *	1977-01-31	1979-07-10	Janssen Pharmaceutica, N.V.	Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
CH637392A5 (en) *	1978-07-24	1983-07-29	Janssen Pharmaceutica Nv	2-Phenyl-2-azolylmethyl-cyclohexa(d)-1,3-dioxolane derivatives, processes for their preparation, compositions containing these active substances as microbicides, and their use
CH634842A5 (en) *	1978-07-25	1983-02-28	Janssen Pharmaceutica Nv	2-Phenyl-2-(1(H)-imidazolylmethyl)-1,3-dioxane derivatives, processes for their preparation, microbicides containing these active substances, and their use
US4277486A (en) *	1979-03-09	1981-07-07	Syntex (U.S.A.) Inc.	1-[(Substituted-naphthyl)ethyl]-imidazole derivatives
US4321272A (en) *	1980-08-25	1982-03-23	Syntex (U.S.A.) Inc.	Derivatives of substituted N-alkylimidazoles
DE3039087A1 (en)	1980-10-16	1982-05-19	Hoechst Ag, 6000 Frankfurt	1- (1,3-DIOXOLAN-2-YLMETHYL) -AZOLES, THEIR SALTS, METHOD FOR THE PRODUCTION AND THEIR USE
EP0052905B1 (en) *	1980-11-24	1984-10-03	Janssen Pharmaceutica N.V.	Novel (2-aryl-4-phenylthioalkyl-1,3-dioxolan-2-yl-methyl)azole derivatives
DE3144318A1 (en) *	1981-11-07	1983-05-19	Bayer Ag, 5090 Leverkusen	2-IMIDAZOLYLMETHYL-2-PHENYL-1, 3-DIOXOLANE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS FUNGICIDES
JPS58134089A (en) *	1982-02-02	1983-08-10	Yoshiki Hamada	1,3-dioxolane benzoate derivative and preparation thereof
DK354185A (en) *	1984-08-31	1986-03-01	Hoffmann La Roche	1,3-dioxolane derivatives
US4940799A (en) *	1987-07-20	1990-07-10	Ciba-Geigy Corporation	Preparation of the diastereomeric mixture 2R,4S-1-[2-(2,4-dichlorophenyl)-4-n-propyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole
WO2020166710A1 (en) *	2019-02-15	2020-08-20	国立大学法人東北大学	1, 3-dioxolan derivative

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3575999A (en) *	1968-08-19	1971-04-20	Janssen Pharmaceutica Nv	Ketal derivatives of imidazole
SU557755A3 (en) *	1968-08-19	1977-05-05	Янссен Фармасьютика Н.В. (Фирма)	Method for preparing imidazole derivatives
US3658813A (en) *	1970-01-13	1972-04-25	Janssen Pharmaceutica Nv	1-(beta-aryl-beta-(r-oxy)-ethyl)-imidazoles
DE2037610A1 (en) *	1970-07-29	1972-02-03	Bayer Ag	New alpha-substituted benzyl-azoles, processes for their production and their use as pharmaceuticals
DE2041771C3 (en) *	1970-08-22	1979-07-26	Bayer Ag, 5090 Leverkusen	derivatives

1975
- 1975-11-26 CA CA240,561A patent/CA1065873A/en not_active Expired
- 1975-12-10 NL NLAANVRAGE7514381,A patent/NL181906C/en not_active IP Right Cessation
1976
- 1976-01-09 GB GB846/76A patent/GB1528639A/en not_active Expired
- 1976-01-12 FR FR7600614A patent/FR2298328A1/en active Granted
- 1976-01-22 AU AU10496/76A patent/AU503981B2/en not_active Expired
- 1976-01-23 JP JP51006041A patent/JPS6135196B2/ja not_active Expired
- 1976-01-26 DE DE19762602770 patent/DE2602770A1/en active Granted
- 1976-01-26 CH CH94276A patent/CH626361A5/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
FR2298328A1 (en)	1976-08-20
NL7514381A (en)	1976-07-29
JPS6135196B2 (en)	1986-08-12
CH626361A5 (en)	1981-11-13
DE2602770A1 (en)	1976-07-29
CA1065873A (en)	1979-11-06
FR2298328B1 (en)	1978-08-18
GB1528639A (en)	1978-10-18
AU1049676A (en)	1977-07-28
NL181906B (en)	1987-07-01
AU503981B2 (en)	1979-09-27
JPS51100073A (en)	1976-09-03

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NL189354C (en)	1993-03-16	PROCESS FOR PREPARING AN ANTIMICROBIAL PREPARATION, AND PROCESS FOR PREPARING A DERIVATIVE OF A 7- (2- (2-IMINO-4-THIAZOLIN-4-YL) ACETAMIDO) -3-CEPHEM-4-CARBONIC ACID.
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NL182400C (en)	1988-03-01	PROCESS FOR THE PREPARATION OF A PHARMACOLOGICAL PREPARATION CONTAINING AT LEAST A PROSTANIC ACID DERIVATIVE AND METHOD FOR PREPARING PROSTANIC ACID DERIVATIVES FOR USE IN THIS PROCESS
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NL169591C (en)	1982-08-02	PROCEDURE FOR THE PREPARATION OF 2-Ÿ4-(2-FUROYL)-PIPERAZINE-1-YLŸ-4-AMINO-6,7-DIMETHOXYCHINAZOLINE.HYDROCHLORIDE WITH BLOOD PRESSURE-LOWERING ACTIVITY AND A BLOOD PRESSURE-LOWERING MEDICINAL PRODUCT CONTAINING THIS SALT.
NL7509257A (en)	1976-02-09	PROCEDURE FOR PREPARING DERIVATIVES OF 1-THIADIAZOLYLIMIDAZOLIDINONE, PROCEDURE FOR PREPARING A HERBICIDE PREPARATION INCLUDING THIS COMPOUND AND PROCEDURE FOR TREATING WEEDS WITH IT.
NL7709010A (en)	1978-02-21	METHOD OF PREPARING 1- (2-DEOXY- (BETA) -D- -PENTOFURANOSYL) -5,6-DIHYDRO-S-TRIAZINES.
NL7709246A (en)	1978-02-27	METHOD FOR PREPARING CYCLICAL COMPOUNDS AND THEIR USE AS A PHARMACEUTICAL AGENT.
NL7703011A (en)	1977-09-21	PROCESS FOR PREPARING 1-AZACARBOCYCLICAL 2-YLIDEEN DERIVATIVES OF GUANIDINE, PROCEDURE FOR PREPARING A PHARMACEUTICAL PREPARATION USING IT AND SUCH PREPARATION.
NL159598B (en)	1979-03-15	PROCESS FOR PREPARING A RODIUM-CONTAINING CATALYST AND USE THEREOF IN THE PREPARATION OF 6-DESOXY-5-OXYTETRACYCLINE.
NL7613253A (en)	1977-06-03	METHOD OF PREPARING AN ANTI-TRICHOPHYTIA ACTIVE AGENT.
NL166010B (en)	1981-01-15	PROCESS FOR THE PREPARATION OF A MEDICINAL PRODUCT WITH ANTI-ARTERIOSCLEROTIC EFFICIENCY, MEDICINAL PRODUCT AND METHOD FOR THE PREPARATION OF ANTI-ARTERIOSCLEROTICALLY ACTIVE ABETAMIDE DERIVATIVES
NL152246B (en)	1977-02-15	PROCEDURE FOR PREPARING A PREPARATION WITH ANTI-ARHYTHMIC ACTIVITY, PREPARATION FORMED, AND PROCEDURE FOR PREPARING A SUITABLE COMPOUND.
NL7610834A (en)	1977-04-01	METHOD FOR PREPARING 1,3-BENZODITHIOPHEN-2-ON AND 1,3-BENZODITHIOPHEN-2-THION COMPOUNDS WITH BIOCIDE ACTIVITY.
NL168229B (en)	1981-10-16	METHOD FOR PREPARING OR MANUFACTURING A PHARMACEUTICAL OR VETERINARY PREPARATION WITH ANTHELMINTIC EFFECT AND METHOD FOR PREPARING AN ANTHELMINTIC COMPOUND SUITABLE FOR USE AT THE SAME TIME.
NL187809C (en)	1992-01-16	METHOD FOR PREPARING A FUNGICIDE PREPARATION, SO AVAILABLE, PREPARATION OF FUNGI AND METHOD FOR PREPARING MORPHOLINE DERIVATIVES.
NL161154C (en)	1980-01-15	METHOD FOR PREPARING A PHARMACEUTICAL PREPARATION CONTAINING A 4-OXAZOLINE-2-ON DERIVATIVE, FORMED PREPARATION AND METHOD FOR PREPARING A COMPOUND SUITABLE FOR USE IN THE FOREGOING PROCESS
NL7704085A (en)	1977-10-18	PROCESS FOR PREPARING BIS-PENICILLANOYLOXYALKENES WITH MEDICINAL ACTIVITY.
NL7512173A (en)	1976-04-21	PROCESS FOR THE PREPARATION OF MALONIC ACID DERIVATIVES AND OF A FUNGICIDE PREPARATION.
NL169479B (en)	1982-02-16	METHOD FOR MANUFACTURING A PHARMACEUTICAL OR VETERINARY PREPARATION WITH ANTHELMINTIC ACTION AND METHOD FOR PREPARING A COMPOUND WITH ANTHELMINTIC ACTION SUITABLE FOR USE IN THE FOREGOING METHOD

Legal Events

Date	Code	Title
1982-08-02	BA	A request for search or an international-type search has been filed
1982-08-02	BB	A search report has been drawn up
1982-09-01	BC	A request for examination has been filed
1985-01-01	A85	Still pending on 85-01-01
1994-08-16	V1	Lapsed because of non-payment of the annual fee