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NL1004082A1 - Verbeterde inrichting voor het inkapselen van cellen. - Google Patents

Verbeterde inrichting voor het inkapselen van cellen.

Info

Publication number
NL1004082A1
NL1004082A1 NL1004082A NL1004082A NL1004082A1 NL 1004082 A1 NL1004082 A1 NL 1004082A1 NL 1004082 A NL1004082 A NL 1004082A NL 1004082 A NL1004082 A NL 1004082A NL 1004082 A1 NL1004082 A1 NL 1004082A1
Authority
NL
Netherlands
Prior art keywords
improved device
encapsulating cells
encapsulating
cells
improved
Prior art date
Application number
NL1004082A
Other languages
English (en)
Other versions
NL1004082C2 (nl
Inventor
Mark Damon Butler
Paul Douglas Drumheller
Stanley Lawrence Mish
Original Assignee
Gore Hybrid Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gore Hybrid Technologies Inc filed Critical Gore Hybrid Technologies Inc
Publication of NL1004082A1 publication Critical patent/NL1004082A1/nl
Application granted granted Critical
Publication of NL1004082C2 publication Critical patent/NL1004082C2/nl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/022Artificial gland structures using bioreactors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12GWINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
    • C12G1/00Preparation of wine or sparkling wine
    • C12G1/06Preparation of sparkling wine; Impregnation of wine with carbon dioxide
    • C12G1/064Preparation of sparkling wine; Impregnation of wine with carbon dioxide using enclosed yeast
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/08Flask, bottle or test tube
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/22Transparent or translucent parts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/34Internal compartments or partitions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/38Caps; Covers; Plugs; Pouring means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/16Particles; Beads; Granular material; Encapsulation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/14Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Sustainable Development (AREA)
  • Biotechnology (AREA)
  • Clinical Laboratory Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Telephone Function (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
NL1004082A 1995-09-22 1996-09-20 Verbeterde inrichting voor het inkapselen van cellen. NL1004082C2 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53292595A 1995-09-22 1995-09-22
US53292595 1995-09-22

Publications (2)

Publication Number Publication Date
NL1004082A1 true NL1004082A1 (nl) 1997-03-25
NL1004082C2 NL1004082C2 (nl) 1998-04-10

Family

ID=24123770

Family Applications (1)

Application Number Title Priority Date Filing Date
NL1004082A NL1004082C2 (nl) 1995-09-22 1996-09-20 Verbeterde inrichting voor het inkapselen van cellen.

Country Status (6)

Country Link
US (1) US5902745A (nl)
AU (1) AU6854696A (nl)
FR (1) FR2739028B1 (nl)
IT (1) IT1284549B1 (nl)
NL (1) NL1004082C2 (nl)
WO (1) WO1997010807A1 (nl)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5855613A (en) 1995-10-13 1999-01-05 Islet Sheet Medical, Inc. Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change
DE19631320A1 (de) * 1996-08-02 1998-02-05 Bayer Ag In Hydrogelen eingebettetes biologisches Material, ein Verfahren zu dessen Einbettung sowie dessen Verwendung als künstliches Saatgut
US6303136B1 (en) * 1998-04-13 2001-10-16 Neurotech S.A. Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane
US6391149B1 (en) * 1998-06-04 2002-05-21 Advanced Cardiovascular Systems, Inc. Method and apparatus for concentrating a solute in solution with a solvent
US8012500B2 (en) * 2000-01-01 2011-09-06 Beta-O2 Technologies Ltd. Implantable device
IL134009A (en) * 2000-01-12 2011-07-31 Bo2 Technologies Ltd Transplant device
WO2008065660A2 (en) * 2006-11-28 2008-06-05 Beta O2 Technologies Ltd. Oxygen supply for cell transplant and vascularization
US6617151B1 (en) 2000-02-29 2003-09-09 Gore Enterprise Holdings, Inc. Method of closing a cell containment device with a wet seal
US6810880B1 (en) 2000-04-10 2004-11-02 Gore Enterprise Holdings, Inc. Surgical implant system
FR2820057A1 (fr) * 2001-01-30 2002-08-02 Ct De Transfert De Technologie Membrane pour chambre d'encapsulation de cellules produisant au moins une substance biologiquement active et organe bio-artificiel comprenant une telle membrane
DE10134447B4 (de) * 2001-07-16 2006-04-20 Gkss-Forschungszentrum Geesthacht Gmbh Trägermembran für Biohybridorgane, Verfahren zur Herstellung und Verwendung
JP2005517025A (ja) 2002-02-08 2005-06-09 エクサイト セラピーズ, インコーポレイテッド 免疫学的欠損を有する患者において免疫応答性を回復するための、組成物および方法
US20030225439A1 (en) * 2002-05-31 2003-12-04 Cook Alonzo D. Implantable product with improved aqueous interface characteristics and method for making and using same
EP1539929B1 (en) 2002-06-28 2013-04-10 Life Technologies Corporation Methods for restoring immune repertoire in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
US7025982B2 (en) * 2002-09-19 2006-04-11 Medtronic, Inc. Medical assembly suitable for long-term implantation and method for fabricating the same
ATE481476T1 (de) * 2003-05-08 2010-10-15 Life Technologies Corp Erzeugung und isolierung antigenspezifischer t- zellen
US9861346B2 (en) 2003-07-14 2018-01-09 W. L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure device with linearly elongating petals
US20050015140A1 (en) * 2003-07-14 2005-01-20 Debeer Nicholas Encapsulation device and methods of use
US8257963B2 (en) 2007-06-01 2012-09-04 Depuy Mitek, Inc. Chondrocyte container and method of use
US7927599B2 (en) * 2003-09-08 2011-04-19 Ethicon, Inc. Chondrocyte therapeutic delivery system
US7897384B2 (en) * 2003-09-08 2011-03-01 Ethicon, Inc. Chondrocyte therapeutic delivery system
EP1682438B1 (en) * 2003-10-30 2013-05-08 Cytonome/ST, LLC Multilayer hydrodynamic sheath flow structure
KR20130072261A (ko) 2004-06-01 2013-07-01 크와라타 트레이딩 리미티드 줄기세포를 사용한 시험관내 기술
US7951357B2 (en) * 2004-07-14 2011-05-31 Glusense Ltd. Implantable power sources and sensors
CN102491969B (zh) * 2005-01-07 2015-08-19 辉瑞产品公司 杂芳族喹啉化合物及其作为pde10抑制剂的用途
US7381331B2 (en) * 2005-09-30 2008-06-03 General Electric Company Hydrophilic membrane and associated method
US7631768B2 (en) * 2005-11-04 2009-12-15 General Electric Company Membrane and associated method
US7291696B2 (en) * 2005-11-04 2007-11-06 General Electric Company Composition and associated method
TW200734462A (en) 2006-03-08 2007-09-16 In Motion Invest Ltd Regulating stem cells
US7923054B2 (en) * 2006-04-19 2011-04-12 Gore Enterprise Holdings, Inc. Functional porous substrates for attaching biomolecules
US20100047311A1 (en) * 2006-11-22 2010-02-25 Beta O2 Technologies Ltd. Protecting algae from body fluids
EP1927652A1 (en) * 2006-11-29 2008-06-04 Koninklijke Philips Electronics N.V. Cell array or matrix assembly and electroporation
WO2008100559A2 (en) * 2007-02-14 2008-08-21 Bioengine, Inc. Medical devices having a micro-fluidic channeled vasculature
US9005242B2 (en) 2007-04-05 2015-04-14 W.L. Gore & Associates, Inc. Septal closure device with centering mechanism
AU2008289461A1 (en) 2007-08-23 2009-02-26 Intrexon Corporation Methods and compositions for diagnosing disease
WO2009031154A2 (en) 2007-09-07 2009-03-12 Beta O2 Technologies Ltd. Air gap for supporting cells
RU2499599C2 (ru) 2007-09-28 2013-11-27 Интрексон Корпорейшн Конструкции терапевтического переключения генов и биореакторы для экспрессии биотерапевтических молекул и их применение
US20130165967A1 (en) 2008-03-07 2013-06-27 W.L. Gore & Associates, Inc. Heart occlusion devices
US20100080784A1 (en) * 2008-09-12 2010-04-01 Torrey Pines Institute For Molecular Studies Methods for treating cachexia and lymphopenia
US9540630B2 (en) * 2008-09-17 2017-01-10 Beta O2 Technologies Ltd. Optimization of alginate encapsulation of islets for transplantation
US9446168B2 (en) 2010-06-07 2016-09-20 Beta-O2 Technologies Ltd. Multiple-layer immune barrier for donor cells
JP2012508584A (ja) 2008-11-14 2012-04-12 ヴィアサイト,インコーポレイテッド ヒト多能性幹細胞由来膵臓細胞のカプセル化
US8043271B2 (en) * 2008-11-26 2011-10-25 Beta 02 Technologies Ltd. Apparatus for transportation of oxygen to implanted cells
US20100160749A1 (en) * 2008-12-24 2010-06-24 Glusense Ltd. Implantable optical glucose sensing
US20120029556A1 (en) 2009-06-22 2012-02-02 Masters Steven J Sealing device and delivery system
US8956389B2 (en) 2009-06-22 2015-02-17 W. L. Gore & Associates, Inc. Sealing device and delivery system
US20120208255A1 (en) * 2011-02-14 2012-08-16 Geosynfuels, Llc Apparatus and process for production of an encapsulated cell product
US9415193B2 (en) 2011-03-04 2016-08-16 W. L. Gore & Associates, Inc. Eluting medical devices
US9037205B2 (en) 2011-06-30 2015-05-19 Glusense, Ltd Implantable optical glucose sensing
US9770232B2 (en) 2011-08-12 2017-09-26 W. L. Gore & Associates, Inc. Heart occlusion devices
US9644179B2 (en) 2011-11-23 2017-05-09 The Trustees Of The University Of Pennsylvania Use of PDL1 expressing cells to convert T cells into regulatory T cells
USD726307S1 (en) * 2011-12-12 2015-04-07 Viacyte Inc. Cell encapsulation device
USD728095S1 (en) * 2011-12-12 2015-04-28 Viacyte, Inc. Cell encapsulation device
USD726306S1 (en) 2011-12-12 2015-04-07 Viacyte, Inc. Cell encapsulation device
USD734847S1 (en) 2012-05-31 2015-07-21 Viacyte, Inc. Cell encapsulation device
US10173038B2 (en) 2012-09-05 2019-01-08 W. L. Gore & Associates, Inc. Retractable sheath devices, systems, and methods
US10828019B2 (en) 2013-01-18 2020-11-10 W.L. Gore & Associates, Inc. Sealing device and delivery system
EP3398559B1 (en) 2013-03-07 2024-05-01 ViaCyte, Inc. 3-dimensional large capacity cell encapsulation device assembly
DK2971039T3 (da) 2013-03-14 2020-04-06 Immusoft Corp Fremgangsmåder til in vitro-differentiering af hukommelses-b-celler og transduktion med vsv-g-pseudotypeomdannede virusvektorer
CN105283753B (zh) 2013-03-14 2020-07-10 塞通诺米/St有限责任公司 流体动力聚焦设备和方法
EP3049020B1 (en) 2013-09-24 2022-06-15 Giner Life Sciences, Inc. System for gas treatment of a cell implant
US9808230B2 (en) 2014-06-06 2017-11-07 W. L. Gore & Associates, Inc. Sealing device and delivery system
EP3206567A1 (en) 2014-10-13 2017-08-23 Glusense, Ltd. Analyte-sensing device
CA2966035A1 (en) 2014-10-31 2016-05-06 The Trustees Of The University Of Pennsylvania Compositions and methods of stimulating and expanding t cells
US20170258835A1 (en) 2014-10-31 2017-09-14 The Trustees Of The University Of Pennsylvania Methods and compositions for modified t cells
KR102781429B1 (ko) 2014-10-31 2025-03-18 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 변형된 t 세포에서 유전자 발현의 변경 및 그의 용도
EP3234107B1 (en) 2014-12-19 2022-09-14 Immusoft Corporation B cells for in vivo delivery of therapeutic agents
EP4223873A3 (en) 2015-01-31 2023-09-06 The Trustees of the University of Pennsylvania Compositions and methods for t cell delivery of therapeutic molecules
AU2016220324B2 (en) 2015-02-16 2020-07-02 The Trustees Of The University Of Pennsylvania A fully-human T cell receptor specific for the 369-377 epitope derived from the HER2/Neu (ERBB2) receptor protein
TW201642820A (zh) * 2015-02-19 2016-12-16 健生生物科技公司 細胞封裝加載裝置
US10871487B2 (en) 2016-04-20 2020-12-22 Glusense Ltd. FRET-based glucose-detection molecules
US10039882B2 (en) * 2016-09-01 2018-08-07 Arthrex, Inc. Binding syringe
US11338068B2 (en) * 2016-11-08 2022-05-24 W. L. Gore & Associates, Inc. Two-part implantable therapy delivery device
JP7088564B2 (ja) 2016-11-10 2022-06-21 ヴィアサイト,インコーポレイテッド 細胞送達装置におけるpdx1膵臓内胚葉細胞及びその方法
USD824042S1 (en) * 2016-11-10 2018-07-24 Viacyte, Inc. Perforated cell encapsulation device
CN110167613B (zh) 2016-11-15 2022-01-11 吉纳生命科学公司 适合用于皮下植入物的经皮气体扩散装置
US10863737B2 (en) 2017-05-22 2020-12-15 Drobot Biotechnology Limited Company Culture container, and system and method of transferring a cultured organism between culture containers
WO2019139987A1 (en) 2018-01-09 2019-07-18 Elstar Therapeutics, Inc. Calreticulin binding constructs and engineered t cells for the treatment of diseases
WO2019178362A1 (en) 2018-03-14 2019-09-19 Elstar Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
JP2021515576A (ja) 2018-03-16 2021-06-24 イミュソフト コーポレーション フォリスタチンを分泌するように遺伝子操作されたb細胞ならびにフォリスタチン関連疾患、状態、障害を処置するために、ならびに筋肉の成長および強度を増強するためにこれを使用する方法
CN108379663B (zh) * 2018-04-24 2023-05-26 中国人民解放军第四军医大学 一种多孔规则体支架材料中截留及富集细胞的装置和方法
WO2019241700A1 (en) 2018-06-14 2019-12-19 W. L. Gore & Associates, Inc. Epitheliazing microporous biomaterial for use in avascular environments and in corneal implants
DE202019005887U1 (de) 2018-07-03 2023-06-14 Marengo Therapeutics, Inc. Anti-TCR-Antikörpermoleküle und Verwendungen davon
WO2020068366A1 (en) * 2018-09-26 2020-04-02 W. L. Gore & Associates, Inc. Cell encapsulation devices with controlled cell bed thickness
WO2020150134A1 (en) * 2019-01-16 2020-07-23 Boston Scientific Scimed Inc Cryotherapeutic delivery device
AU2020224681A1 (en) 2019-02-21 2021-09-16 Marengo Therapeutics, Inc. Antibody molecules that bind to NKp30 and uses thereof
AU2020226893B2 (en) 2019-02-21 2025-02-27 Marengo Therapeutics, Inc. Multifunctional molecules that bind to T cell related cancer cells and uses thereof
EP3976236A1 (en) 2019-05-31 2022-04-06 W.L. Gore & Associates Inc. A biocompatible membrane composite
CN114173837A (zh) 2019-05-31 2022-03-11 W.L.戈尔及同仁股份有限公司 生物相容性膜复合材料
CA3257300A1 (en) 2019-05-31 2025-06-12 W. L. Gore & Associates, Inc. Cell encapsulation devices with controlled oxygen diffusion distances
JP2023506207A (ja) * 2019-12-13 2023-02-15 ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド 強化バイオポリマー
CA3166629A1 (en) 2020-01-03 2021-07-08 Marengo Therapeutics, Inc. Anti-tcr antibody molecules and uses thereof
US20250295832A1 (en) 2022-09-30 2025-09-25 W. L. Gore & Associates, Inc. Implantable membrane construct and encapsulation devices incorporating the same
WO2025096730A1 (en) 2023-11-01 2025-05-08 University Of Virginia Patent Foundation Novel autoregulated car t cells and uses thereof
WO2025106856A1 (en) 2023-11-15 2025-05-22 Immusoft Corporation Migratory modified differentiated b cells for cancer therapy
WO2025147573A2 (en) 2024-01-05 2025-07-10 Immusoft Corporation Glp-1 expressing modified b cells for the treatment of metabolic disease

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993072A (en) * 1974-08-28 1976-11-23 Alza Corporation Microporous drug delivery device
GB1538810A (en) * 1976-08-10 1979-01-24 Sumitomo Electric Industries Hydrophilic porous fluorocarbon structures and process for their production
GB1537448A (en) * 1976-08-20 1978-12-29 Sumitomo Electric Industries Vascular prostheses and process for production thereof
US4743545A (en) * 1984-08-09 1988-05-10 Torobin Leonard B Hollow porous microspheres containing biocatalyst
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
US4409331A (en) * 1979-03-28 1983-10-11 Damon Corporation Preparation of substances with encapsulated cells
US4353457A (en) * 1979-04-24 1982-10-12 Lerco Corporation Airlift
US4298002A (en) * 1979-09-10 1981-11-03 National Patent Development Corporation Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation
US4420589A (en) * 1980-07-07 1983-12-13 Stoy Vladimir A Polymer composition including polyacrylonitrile polymers and process for preparing same
US4353888A (en) * 1980-12-23 1982-10-12 Sefton Michael V Encapsulation of live animal cells
US4495288A (en) * 1981-03-13 1985-01-22 Damon Biotech, Inc. Method of culturing anchorage dependent cells
US4378016A (en) * 1981-07-15 1983-03-29 Biotek, Inc. Artificial endocrine gland containing hormone-producing cells
US4505266A (en) * 1981-10-26 1985-03-19 Massachusetts Institute Of Technology Method of using a fibrous lattice
WO1984001287A1 (en) * 1982-09-29 1984-04-12 Theodore E Spielberg Encapsulated genetically programmed living organisms producing therapeutic substances
CA1196862A (en) * 1983-06-01 1985-11-19 Anthony M.F. Sun Microencapsulation of living tissue and cells
US4806355A (en) * 1983-06-06 1989-02-21 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4631188A (en) * 1983-08-31 1986-12-23 S.K.Y. Polymers, Ltd. (Kingston Technologies) Injectable physiologically-acceptable polymeric composition
US4803168A (en) * 1983-09-01 1989-02-07 Damon Biotech, Inc. Microencapsulation with polymers
AU3542684A (en) * 1983-11-15 1985-05-23 Johnson & Johnson Corporation Glycemia regulating implant
US4663286A (en) * 1984-02-13 1987-05-05 Damon Biotech, Inc. Encapsulation of materials
US4686098A (en) * 1984-05-14 1987-08-11 Merck & Co., Inc. Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo
CA1215922A (en) * 1984-05-25 1986-12-30 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4722898A (en) * 1985-04-29 1988-02-02 Minnesota Mining And Manufacturing Company Immobilization of biological cells in polytetrafluoroethylene matrix
US4997443A (en) * 1985-08-26 1991-03-05 Hana Biologics, Inc. Transplantable artificial tissue and process
AU589438B2 (en) * 1985-08-26 1989-10-12 Hana Biologics, Inc. Transplantable artificial tissue and process
US4902295A (en) * 1985-08-26 1990-02-20 Hana Biologics, Inc. Transplantable artificial tissue
US5218039A (en) * 1987-04-28 1993-06-08 Kingston Technologies, Inc. Pan emulsion
US4911717A (en) * 1987-06-18 1990-03-27 Gaskill Iii Harold V Intravasular artificial organ
US4942129A (en) * 1987-07-28 1990-07-17 Queen's University At Kingston Multiple membrane microencapsulation
US5418154A (en) * 1987-11-17 1995-05-23 Brown University Research Foundation Method of preparing elongated seamless capsules containing biological material
US5182111A (en) * 1987-11-17 1993-01-26 Boston University Research Foundation In vivo delivery of active factors by co-cultured cell implants
US4892538A (en) * 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5773286A (en) * 1987-11-17 1998-06-30 Cytotherapeutics, Inc. Inner supported biocompatible cell capsules
US5786216A (en) * 1987-11-17 1998-07-28 Cytotherapeutics, Inc. Inner-supported, biocompatible cell capsules
US5106627A (en) * 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
US5158881A (en) * 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US5283187A (en) * 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
EP0331521A3 (en) * 1988-03-04 1991-01-23 Kingston Technologies, Inc. Novel polyacrylonitrile compositions and method for producing same
US5081035A (en) * 1988-04-18 1992-01-14 The University Of Michigan Bioreactor system
US4941812A (en) * 1988-05-10 1990-07-17 E. I. Du Pont De Nemours And Company Spinneret for production of a hollow filament within a hollow filament composite fiber having spacing means
FR2634382B1 (fr) * 1988-07-21 1990-10-26 Applic Techn Photoniques Pancreas artificiel
AU4071789A (en) * 1988-08-12 1990-03-05 Cell Biotech, Inc. Process for purification of islet cells; monoclonal antibodies directed to islet and acinar cells; and process for making and using same
GB8820493D0 (en) * 1988-08-30 1988-09-28 Secretary Trade Ind Brit Membrane bioreactor
US5345587A (en) * 1988-09-14 1994-09-06 Digital Equipment Corporation Extensible entity management system including a dispatching kernel and modules which independently interpret and execute commands
CA1323959C (en) * 1988-09-16 1993-11-09 Andreas F. Von Recum Soft tissue implant with micron-scale surface texture to optimize anchorage
US5068195A (en) * 1988-11-02 1991-11-26 Du Pont Merck Pharmaceutical Company Dot matrix membrane cell expansion and maintenance vessel
US5011486A (en) * 1988-11-18 1991-04-30 Brown University Research Foundation Composite nerve guidance channels
US5017490A (en) * 1989-03-10 1991-05-21 Baxter International Inc. Method for in vitro reproduction and growth of cells in culture medium
ES2072434T3 (es) * 1989-04-25 1995-07-16 Childrens Medical Center Implantes para grandes volumenes de celulas sobre matrices polimeras.
WO1990015637A2 (en) * 1989-06-21 1990-12-27 Brown University Research Foundation Neurological therapy system
US5030255A (en) * 1989-06-29 1991-07-09 Texaco Inc. Fluid separator
WO1991000119A1 (en) * 1989-06-30 1991-01-10 Baxter International Inc. Implantable device
US5116494A (en) * 1989-08-25 1992-05-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device with temperature sensitive matrix
US5002661A (en) * 1989-08-25 1991-03-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device
US5116493A (en) * 1989-08-25 1992-05-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device with reseedable matrix
US5100392A (en) * 1989-12-08 1992-03-31 Biosynthesis, Inc. Implantable device for administration of drugs or other liquid solutions
WO1991010470A1 (en) * 1990-01-08 1991-07-25 Brown University Research Foundation Devices and methods for enhanced delivery of active factors
US4969705A (en) * 1990-01-19 1990-11-13 Kingston Technologies, L.P. Memory polymer multiple cavity fiber splicer
US5084350A (en) * 1990-02-16 1992-01-28 The Royal Institution For The Advance Of Learning (Mcgill University) Method for encapsulating biologically active material including cells
US5256418A (en) * 1990-04-06 1993-10-26 Organogenesis, Inc. Collagen constructs
US5344454A (en) * 1991-07-24 1994-09-06 Baxter International Inc. Closed porous chambers for implanting tissue in a host
US5314471A (en) * 1991-07-24 1994-05-24 Baxter International Inc. Tissue inplant systems and methods for sustaining viable high cell densities within a host
AU645155B2 (en) * 1990-10-31 1994-01-06 Baxter International Inc. Close vascularization implant material
DE4108772A1 (de) * 1991-03-18 1992-09-24 Inst Textil & Faserforschung Implantierbares biohybrides organ
EP0585368B1 (en) * 1991-04-25 1997-08-06 Brown University Research Foundation Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
US5453278A (en) * 1991-07-24 1995-09-26 Baxter International Inc. Laminated barriers for tissue implants
US5116753A (en) * 1991-07-30 1992-05-26 The Salk Institute For Biological Studies Maintenance of pancreatic islets
CA2121040A1 (en) * 1991-10-30 1993-05-13 James E. Stein Prevascularized polymeric implants for organ transplantation
WO1993019701A1 (en) * 1992-04-01 1993-10-14 Baxter International Inc. Angiogenic tissue implant systems and methods
WO1993021902A1 (en) * 1992-04-24 1993-11-11 Somatix Therapy Corporation Biocompatible, therapeutic, implantable device
WO1993022427A1 (en) * 1992-04-24 1993-11-11 Somatix Therapy Corporation Method of culturing viable cells and method of regulating the level of a compound in a body fluid
US5209850A (en) * 1992-06-19 1993-05-11 W. L. Gore & Associates, Inc. Hydrophilic membranes
EP0663951B1 (en) * 1992-09-28 2002-06-05 Brown University Research Foundation Chitosan matrices for encapsulated cells
CN1129402A (zh) * 1993-06-23 1996-08-21 布朗大学研究基金会 密封可植入的薄膜封装件的方法和装置
ATE274340T1 (de) * 1993-08-10 2004-09-15 Gore & Ass Zelleinkapselungsvorrichtung
US5352511A (en) * 1993-11-15 1994-10-04 W. L. Gore & Associates, Onc. Hydrophilic compositions with increased thermal resistance
WO1995018583A1 (en) * 1994-01-11 1995-07-13 Baxter International Inc. Ported tissue implant systems and methods of using same

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AU6854696A (en) 1997-04-09
US5902745A (en) 1999-05-11
FR2739028B1 (fr) 1998-06-26
WO1997010807A1 (en) 1997-03-27
FR2739028A1 (fr) 1997-03-28
ITMI961913A1 (it) 1998-03-18
IT1284549B1 (it) 1998-05-21

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