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NL1044585B1 - PZF system for personalized treatment via the peripheral nervous system - Google Patents

PZF system for personalized treatment via the peripheral nervous system Download PDF

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NL1044585B1
NL1044585B1 NL1044585A NL1044585A NL1044585B1 NL 1044585 B1 NL1044585 B1 NL 1044585B1 NL 1044585 A NL1044585 A NL 1044585A NL 1044585 A NL1044585 A NL 1044585A NL 1044585 B1 NL1044585 B1 NL 1044585B1
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nerve
peripheral
brain
artificial
pathways
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Omidvar Mehrdad
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Omidvar Mehrdad
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A61N1/0556—Cuff electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/294—Bioelectric electrodes therefor specially adapted for particular uses for nerve conduction study [NCS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/388—Nerve conduction study, e.g. detecting action potential of peripheral nerves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4082—Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36067—Movement disorders, e.g. tremor or Parkinson disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36071—Pain

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  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
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Abstract

PZF systeem heeft betrekking op een elektronisch besturingssysteem waarmee PZF systeem met behulp van PFZ Dual Nerve Cuffs en de PZF elektroden via de perifere zenuwbanen de ongewenste signalen van en naar de hersenen detecteert, classificeert, registreert, vervormd, filtert en/of blokkeert. Bovendien kan het besturingssysteem via dezelfde Dual Nerve Cuffs en de PZF elektroden de gewenste signalen van en naar de hersenen herkennen, registreren en zonder wijzigen doorlaten. Dit systeem is ook in staat om via de perifere zenuwbanen de ongewenste pijnsignalen, die vanuit de spieren en zenuwbanen naar de hersenen en vanuit de hersenen naar de zenuwbanen verstuurd worden, te herkennen, vervormen, isoleren, blokkeren en/of filteren. PZF systeem omvat innovatieve Dual Nerve Cuffs en PZF elektroden die de signalen, van en naar de hersenen, via het perifere zenuwstelsel naar het besturingssysteem geleid.PZF system refers to an electronic control system with which PZF system detects, classifies, registers, distorts, filters and/or blocks the unwanted signals to and from the brain via the peripheral nerve pathways using PFZ Dual Nerve Cuffs and PZF electrodes. In addition, the control system can recognize, register and allow the desired signals to and from the brain without modification via the same Dual Nerve Cuffs and PZF electrodes. This system is also able to recognize, distort, isolate, block and/or filter the unwanted pain signals that are sent from the muscles and nerve pathways to the brain and from the brain to the nerve pathways via the peripheral nerve pathways. PZF system includes innovative Dual Nerve Cuffs and PZF electrodes that conduct the signals to and from the brain via the peripheral nervous system to the control system.

Description

ii

Korte aanduiding: PZP systeem voor een gepersonalisserde behan: deling via het perifere zenuwstelselShort name: PZP system for personalized treatment: delivery via the peripheral nervous system

BESCHRIJVINGDESCRIPTION

In dit patent iz een technologie en systeem beschreven dat toe- gepast wordt bij een gepersonaliseerde behandeling van tremors en ongewenste hersensimalern. Het PEF systeem detecteert, ver vormd, filtert en/of blokkesrt de ongewenste signalen en impul-This patent describes a technology and system that is applied to a personalized treatment of tremors and unwanted brain signals. The PEF system detects, distorts, filters and/or blocks the unwanted signals and impulses.

LO sen, van an naar de hersenen, via het perifere zenuwstelsel,LO sen, from an to the brain, via the peripheral nervous system,

Deze uitvinsging beoogt te voorzien in de beschrijving van eenThe purpose of this invention is to provide the description of a

Perifenr Zenuwstelsel Filter systeem met Dual Nerve Cuffs en PAF slektroden die aangesloten worden aan het perifere zenuwstelsel,Peripheral Nervous System Filter system with Dual Nerve Cuffs and PAF electrodes that connect to the peripheral nervous system,

Mat het acroniem PEF wordt deze aitvinding kortheidshalve aange- duid,This invention is referred to for brevity by the acronym PEF,

De uitviding omvat een elekironisch besturingssystsem waarmee ongewenste signalen worden herkend, gelokaliseerd, geregi streerd, vervormd, geblokkeerd en/ of gefilterd: kabels waarmee de PAY elektroden en de Dual Nerve Cuifs aan het besturingssys- teem aangesloten worden; accu en De Dual Nerve Cuffs en PAY eipktroden, waarmee het bescuringssysteen vanuit de perifere zer nuwbanen de ongewenste signalen en frequenties detecteert, vlas- sificeart, registreert, filtert en/of blokkeert. Bovendien kan het besturingssysteem met behulp van dezelfde Dual Nerve Cuffs on de PAF elektroden de gewenste signalen van en naar de herss- nen herkennen, registyeren en ongewijzigd doorlaten,The invention comprises an electronic control system with which unwanted signals are recognized, located, registered, distorted, blocked and/or filtered: cables with which the PAY electrodes and the Dual Nerve Cuffs are connected to the control system; battery and the Dual Nerve Cuffs and PAY electrodes, with which the control system detects, simplifies, registers, filters and/or blocks unwanted signals and frequencies from the peripheral nerve pathways. In addition, the control system can recognize, register and allow the desired signals to and from the brain to pass through unchanged using the same Dual Nerve Cuffs on the PAF electrodes.

DEEL 1 — Probleemstelling, samenvatting en het verschil met de huidige bestaande technolcgiePART 1 — Problem statement, summary and difference with current existing technology

De huidige bestaande technologieën en systemen zijn gebaseerd opCurrent existing technologies and systems are based on

Diepe Hersenstimalatie {DBS} en Neuromcdulatie, Om Diepe Hersens stimulatie {DES} te kunnen Toepassen moet de patiënt sen hersen-Deep Brain Stimulation {DBS} and Neuromodulation, In order to apply Deep Brain Stimulation {DES} the patient must have a brain-

operatie ondergaan. Tijdens de hersenoperatie worden de elekiror den van DBS ia de hersenen geïmplanteerd. Deze hersenoperatie is heel complex en kan veel complicaties met zich meebrengen.undergo surgery. During brain surgery, the DBS electrodes are implanted in the brain. This brain surgery is very complex and can have many complications.

PEF (deze uitvinding) heeft betrekking op de ontwikkeling. ger bruik en de toepassing van helt totale PZF systeem, dat ervoor zorgt dat medisch specialisten via het perifere zenuwstelsel {ze- nowbanen} de ongewenste signalen bij patiënten kunnen traceren, lokaliseren, registreren, vervormen, filteren en/of blokkeren. 1D Dit gebeurt zonder een operatie in de hersenen van de patiënt,PEF (this invention) relates to the development, use and application of the complete PZF system, which enables medical specialists to trace, localize, register, distort, filter and/or block unwanted signals in patients via the peripheral nervous system {ze- nowbanen}. 1D This is done without surgery in the patient's brain,

Ben ander groo verschii tussen de huidige bestaande systemen {DBS} en deze uitvinding {PEF} is dat de huidige bestaande sys- temen (DBI) gebruik maken van een soort Neuromodulatie en het verzenden van signalen naar de hersengebieden. PAY maakt echteet ib geen gebruik van esn Neuromodulatie techniek en de slesktraden van PIF sturen ook geen signalen naar de hersenen vm de hersen- gebieden te hunnen stimuleren of beïnvloeden. De PZF elektroden en de Dual Nerve Cuffs van PEF traceren, lokaliseren en regi“ streren via het perifere zenuwstelsel zenuwbanen), de ongewenste signalen die van en naar de hersenen gestuurd worden. Vila het verifere zenuwstelsel {zenuwbanen} worden vervolgens deze signa- len, met hehulp van de Dual Nerve Cuffs en de PIF elektroden, naat het filtersvetsem van PLP geleidt: en door het filtersystesem gefilterd en/of geblokkeerd, Tegelijkertijd laat het PAF systeem de gewenste signalen, die van en naar de hersenen gestuurd wor-r den, via het perifere zenuwsteisel{zenuwbanen) ongewijzigd door, zonder deze te blokkeren of beïnvloeden,Another big difference between the current existing systems {DBS} and this invention {PEF} is that the current existing systems (DBI) use a kind of Neuromodulation and sending signals to the brain areas. PAY however does not use a Neuromodulation technique and the PIF electrodes do not send signals to the brain to stimulate or influence the brain areas. The PZF electrodes and the Dual Nerve Cuffs of PEF trace, locate and register via the peripheral nervous system (nerve pathways), the unwanted signals that are sent to and from the brain. The peripheral nervous system then conducts these signals, with the help of the Dual Nerve Cuffs and the PIF electrodes, to the PLP filter system and filters and/or blocks them. At the same time, the PAF system allows the desired signals sent to and from the brain to pass through the peripheral nervous system unchanged, without blocking or influencing them.

Het PZF zysteen heeft tevens de mogelijkheid om vanuit het peris fere zenuwstelsel (zenuwbanen), de pijnsignalen bij patiénten met neurvopalhie te herkennen, registreren, filteren en/of te blokkeren,The PZF system also has the ability to recognize, register, filter and/or block pain signals from the peripheral nervous system (nerve pathways) in patients with neurological disorders.

DEEL 2 ~ Inleiding tot de uitvindingPART 2 ~ Introduction to the Invention

PIF richt zich op verschillende ziektebeelden waar symptomen, zoals onder andere trillen {tremors}, bewegingsarmoede {(akine-~ > alie}, essentié&ls tremor, cngswensitie bewegingen {onwillekeurigs bewegingen/oncontroleschare spierbewegingen), stijfheid {rigidi- teithypokinesie}, tic, ataxie en houdingsafwijkingen voorkomen,PIF focuses on various disease patterns where symptoms such as tremors, lack of movement (akine-~ > alie), essential tremor, involuntary movements (uncontrolled muscle movements), rigidity (hypokinesia), tic, ataxia and postural deviations occur.

PLE wordt door middel van de Dual Nerve Cuffs en de FEF elekiro- den aan het perifere zenuwstelsel (zenuwbanen) van de patiënt ger 9 koppeld. Dit vindt plaats buiten de hersengebieden en zonder enige hersencperatie. Zodoende kan de PIF de ongewenste signalen vanuit het perifere zenuwstelsel classificeren, lokaliseren, re- gistreren, vervormen, filteren en/of blokkeren, Gok kan BEF via het perifere zenuwstelsel (zenuwbanen) de ongewenste signalen, if die ten gevolge van beschadiging van het centrale of perifere zenuwstelsel veroorzaakt zijn (zoais bijvoorbeeld bij diabeti- sche neuropathie} herkennen, registeren, filteren en/of blokker cen,PLE is coupled to the peripheral nervous system (nerve pathways) of the patient by means of the Dual Nerve Cuffs and the FEF electrodes. This takes place outside the brain areas and without any brain operation. In this way, the PIF can classify, localize, register, distort, filter and/or block the unwanted signals from the peripheral nervous system. Also, BEF can recognize, register, filter and/or block the unwanted signals via the peripheral nervous system (nerve pathways) if they are caused by damage to the central or peripheral nervous system (such as in diabetic neuropathy).

Hos werkt de PAF technologies en sysLeenHos operates the PAF technologies and systems

De Dual Nerve Cuffs en de PIF elekiroeden van PAE worden respear tievelijk om en in het perifere zenuwstelsel {zenuwbanen)} aange" bracht. Via speciale kabels zijn deze aangeslioten aan het bestu- 23 ringssysteoem van PEF. De Dual Nerve Cuffs sn de PAF elektroden herkennen en Lraceren de signalen van en naar de hersenen, Ver- volgens zal het basturingssysteem de signalen classificeren. Dit betekent: dat PEF de signaien in meerdere klassementen onderver- deelt.The Dual Nerve Cuffs and the PIF electrodes of PAE are placed around and in the peripheral nervous system (nerve pathways) respectively. They are connected to the control system of PEF via special cables. The Dual Nerve Cuffs and the PAF electrodes recognize and trace the signals to and from the brain. The control system will then classify the signals. This means that PEF divides the signals into several classifications.

Doze verdeling anvat onder andere: Gewenste signalen, ongewenste signalen, signalen van de hersenen naar de spieren of signalen van de spieren naar de hersenen.This division includes: Desired signals, unwanted signals, signals from the brain to the muscles or signals from the muscles to the brain.

Hierna zal PZE het proces van de verzwakking van de ongewenste signalen uitvoeren en daarna de ongewenste signalen zo nodig vervormen en volledig blokkeren. Dit proces gebeurt door een filter technologie dat in het besturingssysteem is ingebouwd.After this, PZE will perform the process of attenuating the unwanted signals and then distort the unwanted signals if necessary and block them completely. This process is done by a filter technology that is built into the control system.

Dit stappenplan en het proces geldt voor alle signalen die van- uit de hersenen naar de spieren en zenuwbanen verzonden worden en ook voor alle signalen die vanuit de spieren en zenuwbanen maat de hersenen verzonden worden,This step-by-step plan and process applies to all signals sent from the brain to the muscles and nerve pathways and also to all signals sent from the muscles and nerve pathways to the brain,

De instellingen en data verzameling van het besruringssyzteem van PZE worden draadloos vanuit een externe compurer aange- stuurd,The settings and data collection of the PZE control system are controlled wirelessly from an external computer,

PEF systeem heeft diverse programma grcepen die op basis van oe id behandeling en klachten gekozen worden. Onder andere, PIF sys- teem activeren bij: e Svecijieke activiteit ° Bepaalde lichasmsdelen © Bepaald Lype stoomis ° Repaald pijnniveau @ Bepaalde periodePEF system has several program groups that are chosen based on the treatment and complaints. Among other things, PEF system activates at: e Svecijic activity ° Certain body parts ° Certain lymphatic system ° Certain pain level @ Certain period

Onderdelen van PAF systeem: 1} Besturingssysteenm 2} Dual Nerve Cuffs 3} PEF electroden 4) Kabels 5) AccuParts of PAF system: 1} Control system 2} Dual Nerve Cuffs 3} PEF electrodes 4) Cables 5) Battery

Claims (15)

CONCLUSIESCONCLUSIONS 1. PEF systeem, met het kenmerk dat PZP via het perifere zenuw-~ stelsel (zenuwbanen), of via een kunstmatige perifere zenuwbaan, 5 de ongewenste en gewenste signalen die vanuit de hersenen naar de zenuwbanen, kunstmatige zenuwbanen en/ of spieren verstuurd warden tracesrt, lokaliseert en registreert. 1. PEF system, characterized in that PEF traces, localizes and records the unwanted and desired signals sent from the brain to the nerve pathways, artificial nerve pathways and/or muscles via the peripheral nervous system (nerve pathways) or via an artificial peripheral nerve pathway. AN PZE systeem volgens vonclusie 1, met het kenmerk dat PAF via het peritere zenuwstelsel {zenuwbanen) of via een kunstmatige pe- rifere zenuwhaan de ongewenste signalen die vanuit de hersenen naax de zenuwbanen, kunstmatige zenuwbanen en/ of spieren ver- stuurd worden vervormd, isoleert, blokkeert en filtart.AN PZE system according to claim 1, characterized in that PAF distorts, isolates, blocks and filters the unwanted signals sent from the brain to the nerve pathways, artificial nerve pathways and/or muscles via the peripheral nervous system (nerve tracts) or via an artificial peripheral nerve. 3. PEF systeem volgens concinsie 1, met het kenmerk dat PAY via het perifere zenuwstelsei (zenuwbanen) of via een kunstmatige per rifere zenuwbaan de gewenste signalen die vanuit de hersenen naar de zenuwbanen, kunstmatige zenuwbanen en/ of spisren ver stuurd worden niet blokkeert en ongewijzigd doorlaat.3. PEF system according to claim 1, characterized in that PAY does not block the desired signals sent from the brain to the nerve pathways, artificial nerve pathways and/or spleens via the peripheral nervous system (nerve pathways) or via an artificial peripheral nerve pathway and allows them to pass through unchanged. 4. FRE gysteem, met het kenmerk dat FF via het perifere zenuw- stelsel (zenuwbanen)of via een kunstmatige perifere zenuwbaan de ongewenste signalen en gewenste signalen die vanuit de spieren, zenuwbanen en/ of een kunstmatige perifere zenuwbaan naar de hersenen verstuurd worden traceert, lokaliseert en registreert.4. FRE system, characterized in that FF traces, localizes and registers the unwanted signals and desired signals that are sent from the muscles, nerve pathways and/or an artificial peripheral nerve pathway to the brain via the peripheral nervous system (nerve pathways) or via an artificial peripheral nerve pathway. 5. PZE systeem vaigens conclusie 4, met het kenmerk dat PEP via het perifere zenuwstelsel (zenuwbanen)}of via een kunstmatige per rifers zenuwbaan de ongewenste signalen die vanuit de spieren, zenuwbanen en/ of een kunstmatige perifere zenuwbaan naar de hersenen verstuurd worden vervormd, isoleert, blokkeert en f£il- tart.5. PZE system according to claim 4, characterised in that PEP distorts, isolates, blocks and filters the unwanted signals sent from the muscles, nerve pathways and/or an artificial peripheral nerve pathway to the brain via the peripheral nervous system (nerve pathways) or via an artificial peripheral nerve pathway. 6. PZF systeem volgens vonclusie 4, met het kenmerk dat BEF via het perifere zenuwstelsel (zenuwbanen) of via een kunstmatige per rifere zenuwbaan de gewenste signalen die vanuilt de spieren, zer nuwbanen en/ of een kunstmatige perifere zenuwbaan naar de her gzenen verstuurd worden niet blokkeert en cagewijzigd door laat,6. PZF system according to claim 4, characterized in that BEF does not block the desired signals sent from the muscles, nerve pathways and/or an artificial peripheral nerve pathway to the brain via the peripheral nervous system (nerve pathways) or via an artificial peripheral nerve pathway and does not allow them to be modified, 7. PZE systeem volgens conclusie 1, 2, 3, 4, &, 6, 9, 19 en 11 met het kenmerk dat PIF systeem wordt toegepast bij patiénten met bewegingsstoornissen die veroorzaakt worden door de ziekte LO van Parkinson.7. PZE system according to claim 1, 2, 3, 4, &, 6, 9, 19 and 11, characterized in that the PIF system is used in patients with movement disorders caused by Parkinson's disease. dg. PLE systeen volgens conclusie 1, 2, 3, 4, 5, &, 9, 10, en 11 mat het kenmerk dat PZY systeem wordt toegepast bid patiënten met Restless Legs Syndroom (HLS) en Periodic Limb Movement: Syne droom (PLMS},dg. PLE system according to claim 1, 2, 3, 4, 5, &, 9, 10, and 11 with the feature that PLE system is used in patients with Restless Legs Syndrome (HLS) and Periodic Limb Movement: Syndrome (PLMS), 3. PSF systeem volgens conclusie 1, 2, 3, 4, 5: 6 en 10 met het kenmerk dat PIP systeem word: gebruikt: voor het behandelen van afwijkingen in bet centrale zenuwstelsel (hersenen en ruggen- 2 merg} en patholegis of afwijkingen die betrekking hebben op het gehele perifere zenuwstelsel.3. PSF system according to claim 1, 2, 3, 4, 5: 6 and 10, characterized in that the PIP system is: used: for the treatment of disorders in the central nervous system (brain and spinal cord) and pathologies or disorders relating to the entire peripheral nervous system. 10. P2¥ systeem volgens conclusie 1, 2, 3, 4, 5, en 6 met het kenmerk dat PZY systeem met bshulp van de Dual Nerve Cuffs en de PEF elektroden ook aangesloten kunnen worden aan een zenuwbrans-— plantaat.10. The P2¥ system according to claim 1, 2, 3, 4, 5, and 6, characterized in that the PZY system can also be connected to a nerve source implant with the aid of the Dual Nerve Cuffs and the PEF electrodes. 11. PEF systesn voigens conciusie i, 2, 3, 4, B, 6, 7, 8, 3 en 12 met het kenmerk dat FAF systeem wordt gebruikt bij patiënten met de symptomen van neurodegeneratleve aandcenigen en neurepa- tische pijn.11. PEF systems according to claims i, 2, 3, 4, B, 6, 7, 8, 3 and 12 with the characteristic that FAF system is used in patients with symptoms of neurodegenerate conditions and neuropathic pain. is. PAF systesn volgens conclusie 1, 2, 3, 4, 5, 6, 7, B, 9 en 11 met het kenmerk dat BZF via het perifere zenuwstelsel {zenuw- Dana of via een kunstmatige perifere zenuwbaan de ongewenste pijn signalen die vanuit de spieren, zenuwbanen en/ of een kunstmatige perifere zenuwbaan naar de hersens verstuurd worden vervormd, isoleert, blokkeert en/of filvert,is. PAF systems according to claim 1, 2, 3, 4, 5, 6, 7, B, 9 and 11, characterized in that BZF distorts, isolates, blocks and/or filters the unwanted pain signals sent from the muscles, nerve pathways and/or an artificial peripheral nerve pathway to the brain via the peripheral nervous system (nerve pathway) or via an artificial peripheral nerve pathway, 13. PZF systeen volgens conclusie 1, 2. 3, 4, 5, & en 10 met het kenmerk dat de Dual Nerve Cuffs en de PEF elektroden van PIF systeem geplaatst kunnen worden op, om, in, Of tussen het peri- fere zenuwstelsel (zenuwbanen).13. PZF system according to claim 1, 2, 3, 4, 5, & and 10, characterized in that the Dual Nerve Cuffs and the PEF electrodes of the PIF system can be placed on, around, in, or between the peripheral nervous system (nerve pathways). 14. BEF svsrteen volgens conclusie 1, 2, 3, 4, 5, 5 en 13 met het iQ kenmerk dat de Dual Nerve Cuffs en de PZF elektroden van FEF systeem asngesiloten kunnen worden aan een kunstmatige perifere zenuwpaan.14. BEF system according to claims 1, 2, 3, 4, 5, 5 and 13, characterized in that the Dual Nerve Cuffs and the PZF electrodes of the FEF system can be connected to an artificial peripheral nerve path. 15. PEP systeem volgens conclusie 1, 2, 3, 4, S en & met het kenmerk dat het PEF registratis onderdeel van hel besturingssys- teem via een draadloze technologie met de databank van een ({aca- gdemisch} ziekenhuis communiceert om de cersgistreerde tremoisge- vevens in het dossier en/ of de centrale databank te vegistre-15. PEP system according to claim 1, 2, 3, 4, S and & characterized in that the PEF registration part of the control system communicates via a wireless technology with the database of an (academic) hospital in order to register the registered tremois data in the file and/or the central database. ten.at. it. PZF systeem volgens conclusie 1, 2, 3, 4, 5, 6, 7, 8, &, 11 en 12 met het kenmerk dat PIF via het perifere zenuwstelsel {(ze~ nuwbanen) of via een hunstmatige perifere zenuwbaan de ongewenste pijn signalen die vanuit de hersenen naar de spieren, zenuwbanen en/ DE een kmnstmarige perifere zenuwbaan verstuurd worden ver- vormd, isoleert, blokkeert en/of filtert,it. PZF system according to claim 1, 2, 3, 4, 5, 6, 7, 8, &, 11 and 12 characterized in that PIF distorts, isolates, blocks and/or filters the unwanted pain signals sent from the brain to the muscles, nerve pathways and/or a regular peripheral nerve pathway via the peripheral nervous system (nerve tracts) or via a regular peripheral nerve tract,
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