NI201400104A - Esketamina para el tratamiento de la depresión refractaria al tratamiento o resistente al tratamiento - Google Patents
Esketamina para el tratamiento de la depresión refractaria al tratamiento o resistente al tratamientoInfo
- Publication number
- NI201400104A NI201400104A NI201400104A NI201400104A NI201400104A NI 201400104 A NI201400104 A NI 201400104A NI 201400104 A NI201400104 A NI 201400104A NI 201400104 A NI201400104 A NI 201400104A NI 201400104 A NI201400104 A NI 201400104A
- Authority
- NI
- Nicaragua
- Prior art keywords
- treatment
- esketamine
- resistant
- depression
- refractory
- Prior art date
Links
- YQEZLKZALYSWHR-ZDUSSCGKSA-N (S)-ketamine Chemical compound C=1C=CC=C(Cl)C=1[C@@]1(NC)CCCCC1=O YQEZLKZALYSWHR-ZDUSSCGKSA-N 0.000 title abstract 2
- 229960000450 esketamine Drugs 0.000 title abstract 2
- 208000020401 Depressive disease Diseases 0.000 title 1
- 208000028552 Treatment-Resistant Depressive disease Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 238000002648 combination therapy Methods 0.000 abstract 1
- 238000009097 single-agent therapy Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se dirige a métodos para el tratamiento de la depresión refractaria al tratamiento o depresión resistente al tratamiento; los métodos comprenden administrar a un paciente que lo necesita una cantidad terapéuticamente eficaz de esketamina como monoterapia o como terapia de combinación con al menos un antidepresivo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261609641P | 2012-03-12 | 2012-03-12 | |
| US201261610058P | 2012-03-13 | 2012-03-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NI201400104A true NI201400104A (es) | 2016-11-30 |
Family
ID=47913632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NI201400104A NI201400104A (es) | 2012-03-12 | 2014-09-10 | Esketamina para el tratamiento de la depresión refractaria al tratamiento o resistente al tratamiento |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20130236573A1 (es) |
| KR (1) | KR20140136982A (es) |
| CN (1) | CN104519878A (es) |
| CL (1) | CL2014002406A1 (es) |
| CO (1) | CO7071129A2 (es) |
| CR (1) | CR20140410A (es) |
| GT (1) | GT201400191A (es) |
| HK (1) | HK1209323A1 (es) |
| MX (1) | MX2014010939A (es) |
| NI (1) | NI201400104A (es) |
| PE (1) | PE20141906A1 (es) |
| PH (1) | PH12014501997A1 (es) |
| SG (1) | SG11201405530SA (es) |
| WO (1) | WO2013138322A1 (es) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10583138B2 (en) | 2012-07-12 | 2020-03-10 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| US9737531B2 (en) | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| BR112015022972B1 (pt) | 2013-03-15 | 2023-02-14 | Janssen Pharmaceutica Nv | Composição farmacêutica de cloridrato de s-cetamina e formas de dosagem da mesma |
| MX370506B (es) | 2013-04-12 | 2019-12-16 | Icahn School Med Mount Sinai | Método para tratar trastorno de estrés post-traumático. |
| WO2015037248A1 (en) | 2013-09-13 | 2015-03-19 | National University Corporation Chiba University | Application of r-ketamine and salt thereof as pharmaceuticals |
| CA2936809A1 (en) * | 2014-01-14 | 2015-07-23 | Children's Hospital Medical Center | Compositions comprising ketamine for treating an autism spectrum disorder |
| HUE051264T2 (hu) | 2014-04-17 | 2021-03-01 | Develco Pharma Schweiz Ag | Ketamin orális dózisformája |
| KR20170013890A (ko) * | 2014-05-06 | 2017-02-07 | 노쓰웨스턴유니버시티 | Nmdar 조절 화합물의 조합물 |
| JP6545788B2 (ja) * | 2014-08-13 | 2019-07-17 | ヤンセン ファーマシューティカ エヌ.ベー. | うつ病の治療方法 |
| CN107208133A (zh) | 2014-09-15 | 2017-09-26 | 詹森药业有限公司 | 用于治疗抑郁症的Val66Met (SNPrs6265)基因型特异性给药方案和方法 |
| WO2016094358A1 (en) | 2014-12-08 | 2016-06-16 | Cima Labs Inc. | Immediate release abuse-deterrent granulated dosage forms |
| US20180015054A1 (en) * | 2014-12-31 | 2018-01-18 | Icahn School Of Medicine At Mount Sinai | Method of Maintaining the Anti-Depressant Effect of Ketamine With Lithium |
| US9844551B2 (en) | 2015-01-14 | 2017-12-19 | Children's Hospital Medical Center | Compositions and methods for treatment of fragile X syndrome |
| WO2016172672A1 (en) * | 2015-04-24 | 2016-10-27 | Icahn School Of Medicine At Mount Sinai | Method for treating suicidal ideation |
| US20160332962A1 (en) | 2015-05-13 | 2016-11-17 | Janssen Pharmaceutica Nv | (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine |
| US20160338977A1 (en) * | 2015-05-20 | 2016-11-24 | Janssen Pharmaceutica Nv | Methods and kits for treating depression |
| HK1248578A1 (zh) | 2015-06-27 | 2018-10-19 | Shenox Pharmaceuticals, Llc | 氯胺酮透皮递送系统 |
| CN106562952B (zh) * | 2015-10-09 | 2020-06-09 | 江阴安博生物医药有限公司 | 氯胺酮在治疗重性抑郁障碍中的应用 |
| US11110070B2 (en) | 2015-11-17 | 2021-09-07 | The Trustees Of Columbia University In The City Of New York | Pharmacological prophylactics against stress-induced affective disorders and their associated symptoms |
| JPWO2018079693A1 (ja) * | 2016-10-27 | 2019-10-31 | 国立大学法人千葉大学 | (s)−ノルケタミンおよびその塩の医薬品としての応用 |
| EP3641742A2 (en) * | 2017-06-23 | 2020-04-29 | Develco Pharma Schweiz AG | Hydroxynorketamine for the use in the treatment of depression |
| US20200009081A1 (en) | 2017-09-13 | 2020-01-09 | Janssen Pharmaceutica N.V. | Delivery Of Esketamine For The Treatment Of Depression |
| WO2019094757A1 (en) | 2017-11-09 | 2019-05-16 | The Trustees Of Columbia University In The City Of New York | Pharmacological prophylactics against stress-induced affective disorders in females |
| WO2019094596A1 (en) | 2017-11-09 | 2019-05-16 | The Trustees Of Columbia University In The City Of New York | Biomarkers for efficacy of prophylactic treatments against stress-induced affective disorders |
| CN107823195A (zh) * | 2017-11-24 | 2018-03-23 | 无锡市精神卫生中心 | R‑氯胺酮在抑郁症急性期治疗中的应用 |
| CN112423789A (zh) * | 2017-12-22 | 2021-02-26 | 詹森药业有限公司 | 用于治疗抑郁症的艾司氯胺酮 |
| EP3505157B1 (en) * | 2017-12-29 | 2021-12-08 | Celon Pharma S.A. | Dry powder ketamine composition for pulmonary administration in treatment-resistant depression |
| CN111936127A (zh) | 2018-02-15 | 2020-11-13 | 国立大学法人千叶大学 | 炎症性疾病或骨病的预防或治疗剂及医药组合物 |
| US11426367B2 (en) | 2018-05-04 | 2022-08-30 | Perception Neuroscience, Inc. | Methods of treating substance abuse |
| EP3813807A1 (en) | 2018-06-27 | 2021-05-05 | Clexio Biosciences Ltd. | Method of treating major depressive disorder |
| WO2020027344A1 (en) * | 2018-08-03 | 2020-02-06 | Takeda Pharmaceutical Company Limited | Ch24h inhibitors for mdd use |
| PL3628313T3 (pl) | 2018-09-28 | 2025-06-23 | Novohale Therapeutics, Llc | Kompozycja ketaminy do zastosowania w sposobie leczenia depresji przez podawanie dopłucne |
| CA3113198A1 (en) | 2018-10-05 | 2020-04-09 | Clexio Biosciences Ltd. | Dosage regime of esketamine for treating major depressive disorder |
| US12364672B2 (en) | 2018-10-11 | 2025-07-22 | Clexio Biosciences Ltd. | Esketamine for use in treating major depressive disorder |
| WO2020168337A1 (en) * | 2019-02-17 | 2020-08-20 | Magid Abraham | Compositions and methods for treatment of depression and other disorders |
| JP2022524008A (ja) | 2019-03-05 | 2022-04-27 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | うつ病の治療のためのエスケタミン |
| US20220062200A1 (en) * | 2019-05-07 | 2022-03-03 | Clexio Biosciences Ltd. | Abuse-deterrent dosage forms containing esketamine |
| CN113905777B (zh) | 2019-05-31 | 2025-06-20 | 赛隆制药股份公司 | 用于电子监督胃肠外施用药物组合物的吸入器 |
| KR20220012922A (ko) | 2019-05-31 | 2022-02-04 | 셀론 파르마 에스.에이. | 약학적 조성물의 전자적으로 관리된 투여 |
| EP4021432A4 (en) * | 2019-08-28 | 2023-08-16 | Janssen Pharmaceuticals, Inc. | ESKETAMIN FOR THE TREATMENT OF PATIENTS WITH MAJOR DEPRESSIVE DISORDER, INCLUDING SUICIDALITY |
| CA3153856A1 (en) * | 2019-09-13 | 2021-03-18 | Janssen Pharmaceuticals, Inc. | Intranasal administration of esketamine |
| IL293506A (en) | 2019-12-30 | 2022-08-01 | Clexio Biosciences Ltd | Dosage regime with esketamine for treating major depressive disorder |
| JP2023507926A (ja) | 2019-12-30 | 2023-02-28 | クレキシオ バイオサイエンシーズ エルティーディー. | 神経精神状態または神経学的状態を治療するためのエスケタミンを用いた投与計画 |
| CN115768519A (zh) * | 2020-05-28 | 2023-03-07 | 詹森药业有限公司 | 治疗抑郁症的方法 |
| JP2023538901A (ja) | 2020-08-18 | 2023-09-12 | オークウッド ラボラトリーズ,エル.エル.シー. | ケタミンを含むマイクロスフェア製剤ならびにその製造及び使用方法 |
| CN114681407A (zh) * | 2020-12-30 | 2022-07-01 | 北京万全德众医药生物技术有限公司 | 一种盐酸艾司氯胺酮颗粒剂 |
| JP2025087929A (ja) * | 2022-02-22 | 2025-06-11 | 国立大学法人京都大学 | うつ病および/またはうつ状態の治療および/または予防用医薬 |
| WO2025057111A1 (en) * | 2023-09-12 | 2025-03-20 | Clexio Biosciences Ltd. | Esketamine or a pharmaceutical salt thereof for use in a method of treating major depressive disorder |
| CN120919140A (zh) * | 2025-09-09 | 2025-11-11 | 徐州百瑞麻醉科技研究院有限公司 | 一种艾司氯胺酮与米氮平协同的抗抑郁药物组合物及应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6176242B1 (en) * | 1999-04-30 | 2001-01-23 | Medtronic Inc | Method of treating manic depression by brain infusion |
| EP1103256A1 (de) * | 1999-11-26 | 2001-05-30 | Claudius Dr. med. Böck | Verwendung von Ketamin zur Behandlung von neuroendokriner Immundysfunktion und algogenem Psychosyndrom |
| MXPA05000294A (es) * | 2002-07-30 | 2005-08-19 | Peter Migaly | Terapia combinada para la depresion, prevencion de suicidios y varias condiciones medicas y psiquiatricas. |
| US7273889B2 (en) * | 2002-09-25 | 2007-09-25 | Innovative Drug Delivery Systems, Inc. | NMDA receptor antagonist formulation with reduced neurotoxicity |
| CN101466364A (zh) * | 2006-03-22 | 2009-06-24 | 纽约大学西奈山医学院 | 鼻内施用氯胺酮治疗抑郁症 |
| BRPI0711872A2 (pt) * | 2006-05-22 | 2011-12-06 | Vanda Pharmaceuticals Inc | tratamento para distúrbios depressivos |
| DE102007009888A1 (de) * | 2007-02-28 | 2008-09-04 | Hermann, Holger Lars, Dr. | Verwendung von S-(+)-Ketamin zur Behandlung von Depressionen |
| US20110038807A1 (en) * | 2009-08-14 | 2011-02-17 | Demitri Papolos | Compositions and methods for treating bipolar disorder |
| ES2560676T3 (es) * | 2010-06-15 | 2016-02-22 | Grünenthal GmbH | Combinación farmacéutica para el tratamiento del dolor |
-
2013
- 2013-03-12 KR KR1020147028246A patent/KR20140136982A/ko not_active Ceased
- 2013-03-12 CN CN201380013908.XA patent/CN104519878A/zh active Pending
- 2013-03-12 MX MX2014010939A patent/MX2014010939A/es unknown
- 2013-03-12 HK HK15110013.5A patent/HK1209323A1/xx unknown
- 2013-03-12 WO PCT/US2013/030476 patent/WO2013138322A1/en not_active Ceased
- 2013-03-12 US US13/795,454 patent/US20130236573A1/en not_active Abandoned
- 2013-03-12 SG SG11201405530SA patent/SG11201405530SA/en unknown
- 2013-03-12 PE PE2014001406A patent/PE20141906A1/es not_active Application Discontinuation
- 2013-12-05 US US14/098,498 patent/US20140093592A1/en not_active Abandoned
-
2014
- 2014-09-04 CR CR20140410A patent/CR20140410A/es unknown
- 2014-09-08 PH PH12014501997A patent/PH12014501997A1/en unknown
- 2014-09-10 CO CO14200330A patent/CO7071129A2/es unknown
- 2014-09-10 NI NI201400104A patent/NI201400104A/es unknown
- 2014-09-11 CL CL2014002406A patent/CL2014002406A1/es unknown
- 2014-09-11 GT GT201400191A patent/GT201400191A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140136982A (ko) | 2014-12-01 |
| MX2014010939A (es) | 2014-11-13 |
| HK1209323A1 (en) | 2016-04-01 |
| CR20140410A (es) | 2014-11-17 |
| US20130236573A1 (en) | 2013-09-12 |
| PH12014501997A1 (en) | 2014-11-24 |
| CO7071129A2 (es) | 2014-09-30 |
| CL2014002406A1 (es) | 2015-01-09 |
| CN104519878A (zh) | 2015-04-15 |
| WO2013138322A1 (en) | 2013-09-19 |
| SG11201405530SA (en) | 2014-11-27 |
| PE20141906A1 (es) | 2014-12-05 |
| GT201400191A (es) | 2017-07-03 |
| US20140093592A1 (en) | 2014-04-03 |
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