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NI201100133A - DERIVATIVES OF 2-PYRIDIN - 2 - IL - PIRAZOL - 3 (2H) -ONA, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS AS HIF ACTIVATORS - Google Patents

DERIVATIVES OF 2-PYRIDIN - 2 - IL - PIRAZOL - 3 (2H) -ONA, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS AS HIF ACTIVATORS

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Publication number
NI201100133A
NI201100133A NI201100133A NI201100133A NI201100133A NI 201100133 A NI201100133 A NI 201100133A NI 201100133 A NI201100133 A NI 201100133A NI 201100133 A NI201100133 A NI 201100133A NI 201100133 A NI201100133 A NI 201100133A
Authority
NI
Nicaragua
Prior art keywords
group
alkyl
heterocycloalkyl
hydrogen atom
aryl
Prior art date
Application number
NI201100133A
Other languages
Spanish (es)
Inventor
Altenburger Jean-Michel
Fossey Valérie
Illiano Stéphane
Manette Géraldine
Original Assignee
Aplicaciones Terapeuticas En El Dominio Cardiovascular De Derivados
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0807474A external-priority patent/FR2940651B1/en
Application filed by Aplicaciones Terapeuticas En El Dominio Cardiovascular De Derivados filed Critical Aplicaciones Terapeuticas En El Dominio Cardiovascular De Derivados
Publication of NI201100133A publication Critical patent/NI201100133A/en

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Abstract

La invención se refiere a los compuestos que responden a la fórmula (I): R representa un grupo -S02-NR3R4, un átomo de hidrógeno, un átomo de halógeno, un grupo -halógenoalquilo(C1-C5), un grupo -CO2R5 o un grupo SO2-R4 ; R1 representa un grupo heterocicloalquilo que no contiene átomo de nitrógeno, un grupo-W-cicloalquilo(C3-C6), un grupo -W-arilo, un grupo-W-heteroarilo, un grupo -W - heterocicloalquilo, un grupo -W-COOR5, un grupo -W-CONR5R6.; R2 representa un átomo de hidrógeno, un grupo -alquilo(C1-C5), un grupo -alquileno(C1-C5)-O- alquilo(C1-C5), un grupo -halógenoalquilo(C1-C5), un grupo -W-COOR5, un grupo -W-C(O)NHR5 o un grupo -W-C(O)-NR5R6; n representa 0, 1 ó 2 ; W es un grupo - alquileno(C1-C5)- o un grupo -cicloalquileno(C3-C6)- ; R3 y R4, idénticos o diferentes, representan, independientemente el uno del otro, un átomo de hidrógeno, un grupo - alquilo(C1 -C5), un grupo -cicloalquilo(C3-C6), un grupo -alquileno(C1 -C5) - O - alquilo(C1-C5), un arilo, un grupo -CH2-arilo, un heteroarilo, un heterocicloalquilo, un grupo -W-OH, un grupo -W-CHOH-CH2OH, un grupo -W-CO2R5, un grupo -W-NR5R6 o un grupo -W-O-(CH2)n-arilo; o bien R3 y R4 forman junto con el átomo de nitrógeno al que están unidos un grupo heterocicloalquilo ; R5 y R6, idénticos o diferentes, representan, independientemente el uno del otro, un átomo de hidrógeno, un grupo - alquilo (C1-C5) o un grupo halógenoalquilo(C1 -C5), así como su procedimiento de preparación y sus aplicaciones en terapéutica.The invention relates to the compounds that respond to formula (I): R represents a group -S02-NR3R4, a hydrogen atom, a halogen atom, a -halogenoalkyl group (C1-C5), a group -CO2R5 or a SO2-R4 group; R1 represents a heterocycloalkyl group containing no nitrogen atom, a -W-cycloalkyl group (C3-C6), a -W-aryl group, a -W-heteroaryl group, a -W-heterocycloalkyl group, a -W- group COOR5, a -W-CONR5R6 group; R2 represents a hydrogen atom, a -alkyl (C1-C5) group, a -alkylene (C1-C5) -O-alkyl (C1-C5) group, a -haloalkyl (C1-C5) group, a -W group -COOR5, a -WC (O) NHR5 group or a -WC (O) -NR5R6 group; n represents 0, 1 or 2; W is a group - (C1-C5) alkylene - or a -cycloalkylene (C3-C6) group -; R3 and R4, identical or different, represent, independently of each other, a hydrogen atom, a group - alkyl (C1-C5), a group -cycloalkyl (C3-C6), a group -alkylene (C1 -C5) - O-(C1-C5) alkyl, an aryl, a -CH2-aryl group, a heteroaryl, a heterocycloalkyl, a -W-OH group, a -W-CHOH-CH2OH group, a -W-CO2R5 group, a -W-NR5R6 group or -WO- (CH2) n-aryl group; or R3 and R4 together with the nitrogen atom to which they are attached form a heterocycloalkyl group; R5 and R6, identical or different, represent, independently of each other, a hydrogen atom, a group - alkyl (C1-C5) or a halogenoalkyl group (C1-C5), as well as their preparation process and their applications in therapy.

NI201100133A 2008-12-29 2011-06-28 DERIVATIVES OF 2-PYRIDIN - 2 - IL - PIRAZOL - 3 (2H) -ONA, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS AS HIF ACTIVATORS NI201100133A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0807474A FR2940651B1 (en) 2008-12-29 2008-12-29 2-PYRIDIN-2-YL-PYRAZOL-3 (2H) -ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE AS HIF ACTIVATORS
FR0984092 2009-08-28

Publications (1)

Publication Number Publication Date
NI201100133A true NI201100133A (en) 2011-11-02

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ID=70471669

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201100133A NI201100133A (en) 2008-12-29 2011-06-28 DERIVATIVES OF 2-PYRIDIN - 2 - IL - PIRAZOL - 3 (2H) -ONA, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS AS HIF ACTIVATORS

Country Status (1)

Country Link
NI (1) NI201100133A (en)

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