MY188058A - Inhibitors of kras g12c - Google Patents
Inhibitors of kras g12cInfo
- Publication number
- MY188058A MY188058A MYPI2016701035A MYPI2016701035A MY188058A MY 188058 A MY188058 A MY 188058A MY PI2016701035 A MYPI2016701035 A MY PI2016701035A MY PI2016701035 A MYPI2016701035 A MY PI2016701035A MY 188058 A MY188058 A MY 188058A
- Authority
- MY
- Malaysia
- Prior art keywords
- compounds
- inhibitors
- kras
- activity
- mutant kras
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 102100030708 GTPase KRas Human genes 0.000 abstract 2
- 101000584612 Homo sapiens GTPase KRas Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102200006538 rs121913530 Human genes 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): (I) or a pharmaceutically acceptable salt, tautomer, prodrug or stereoisomer thereof, wherein R1, R2a, R3a, R3b, R4a, R4b, G1, G2, L1, L2, m1, m2, A, B, W, X, Y, Z and E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided. (Figure 3)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361889460P | 2013-10-10 | 2013-10-10 | |
| US201462034619P | 2014-08-07 | 2014-08-07 | |
| US201461052366P | 2014-09-18 | 2014-09-18 | |
| JOP/2014/0289A JO3805B1 (en) | 2013-10-10 | 2014-10-09 | Inhibitors of kras g12c |
| TW103135318A TWI659021B (en) | 2013-10-10 | 2014-10-09 | Inhibitors of kras g12c |
| PCT/US2014/060036 WO2015054572A1 (en) | 2013-10-10 | 2014-10-10 | Inhibitors of kras g12c |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY188058A true MY188058A (en) | 2021-11-15 |
Family
ID=81329896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI2016701035A MY188058A (en) | 2013-10-10 | 2014-10-10 | Inhibitors of kras g12c |
Country Status (1)
| Country | Link |
|---|---|
| MY (1) | MY188058A (en) |
-
2014
- 2014-10-10 MY MYPI2016701035A patent/MY188058A/en unknown
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