MY161034A - Modulation of growth of bifidobacteria using a combination of oligosaccharides found in human milk - Google Patents
Modulation of growth of bifidobacteria using a combination of oligosaccharides found in human milkInfo
- Publication number
- MY161034A MY161034A MYPI2013701285A MYPI2013701285A MY161034A MY 161034 A MY161034 A MY 161034A MY PI2013701285 A MYPI2013701285 A MY PI2013701285A MY PI2013701285 A MYPI2013701285 A MY PI2013701285A MY 161034 A MY161034 A MY 161034A
- Authority
- MY
- Malaysia
- Prior art keywords
- bifidobacteria
- growth
- modulation
- combination
- human milk
- Prior art date
Links
- 241000186000 Bifidobacterium Species 0.000 title abstract 2
- 210000004251 human milk Anatomy 0.000 title 1
- 235000020256 human milk Nutrition 0.000 title 1
- 229920001542 oligosaccharide Polymers 0.000 title 1
- 150000002482 oligosaccharides Chemical class 0.000 title 1
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- TYALNJQZQRNQNQ-UHFFFAOYSA-N #alpha;2,6-sialyllactose Natural products O1C(C(O)C(O)CO)C(NC(=O)C)C(O)CC1(C(O)=O)OCC1C(O)C(O)C(O)C(OC2C(C(O)C(O)OC2CO)O)O1 TYALNJQZQRNQNQ-UHFFFAOYSA-N 0.000 abstract 1
- CILYIEBUXJIHCO-UHFFFAOYSA-N 102778-91-6 Natural products O1C(C(O)C(O)CO)C(NC(=O)C)C(O)CC1(C(O)=O)OC1C(O)C(OC2C(C(O)C(O)OC2CO)O)OC(CO)C1O CILYIEBUXJIHCO-UHFFFAOYSA-N 0.000 abstract 1
- 229940062827 2'-fucosyllactose Drugs 0.000 abstract 1
- HWHQUWQCBPAQQH-UHFFFAOYSA-N 2-O-alpha-L-Fucosyl-lactose Natural products OC1C(O)C(O)C(C)OC1OC1C(O)C(O)C(CO)OC1OC(C(O)CO)C(O)C(O)C=O HWHQUWQCBPAQQH-UHFFFAOYSA-N 0.000 abstract 1
- HWHQUWQCBPAQQH-BWRPKUOHSA-N 2-fucosyllactose Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O HWHQUWQCBPAQQH-BWRPKUOHSA-N 0.000 abstract 1
- DVGKRPYUFRZAQW-UHFFFAOYSA-N 3 prime Natural products CC(=O)NC1OC(CC(O)C1C(O)C(O)CO)(OC2C(O)C(CO)OC(OC3C(O)C(O)C(O)OC3CO)C2O)C(=O)O DVGKRPYUFRZAQW-UHFFFAOYSA-N 0.000 abstract 1
- CILYIEBUXJIHCO-UITFWXMXSA-N N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose Chemical compound O1[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(=O)C)[C@@H](O)C[C@@]1(C(O)=O)O[C@@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)O[C@@H]2CO)O)O[C@H](CO)[C@@H]1O CILYIEBUXJIHCO-UITFWXMXSA-N 0.000 abstract 1
- OIZGSVFYNBZVIK-UHFFFAOYSA-N N-acetylneuraminosyl-D-lactose Natural products O1C(C(O)C(O)CO)C(NC(=O)C)C(O)CC1(C(O)=O)OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1O OIZGSVFYNBZVIK-UHFFFAOYSA-N 0.000 abstract 1
- SNFSYLYCDAVZGP-UHFFFAOYSA-N UNPD26986 Natural products OC1C(O)C(O)C(C)OC1OC1C(OC2C(OC(O)C(O)C2O)CO)OC(CO)C(O)C1O SNFSYLYCDAVZGP-UHFFFAOYSA-N 0.000 abstract 1
- TYALNJQZQRNQNQ-JLYOMPFMSA-N alpha-Neup5Ac-(2->6)-beta-D-Galp-(1->4)-beta-D-Glcp Chemical compound O1[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(=O)C)[C@@H](O)C[C@@]1(C(O)=O)OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)O[C@@H]2CO)O)O1 TYALNJQZQRNQNQ-JLYOMPFMSA-N 0.000 abstract 1
- 235000013350 formula milk Nutrition 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000013406 prebiotics Nutrition 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
- A23C9/1307—Milk products or derivatives; Fruit or vegetable juices; Sugars, sugar alcohols, sweeteners; Oligosaccharides; Organic acids or salts thereof or acidifying agents; Flavours, dyes or pigments; Inert or aerosol gases; Carbonation methods
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pediatric Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dairy Products (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
A PREBIOTIC FORMULATION FOR ORAL ADMINISTRATION TO A HUMAN COMPRISING 2'-FUCOSYLLACTOSE, 3'-SIALYLLACTOSE AND 6'-SIALYLLACTOSE, AND A METHOD FOR MODULATING OR STIMULATING THE GROWTH OF BIFIDOBACTERIA IN THE GUT. THE FORMULATION MAY BE AN INFANT FORMULA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161441451P | 2011-02-10 | 2011-02-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY161034A true MY161034A (en) | 2017-04-14 |
Family
ID=45809349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI2013701285A MY161034A (en) | 2011-02-10 | 2012-02-03 | Modulation of growth of bifidobacteria using a combination of oligosaccharides found in human milk |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20140371173A1 (en) |
| EP (2) | EP2672844B2 (en) |
| CN (2) | CN104126749A (en) |
| AU (1) | AU2012215042B2 (en) |
| BR (1) | BR112013020108A2 (en) |
| CA (1) | CA2825697A1 (en) |
| CL (1) | CL2013002210A1 (en) |
| ES (2) | ES2527200T5 (en) |
| IL (1) | IL227487A (en) |
| MX (2) | MX362129B (en) |
| MY (1) | MY161034A (en) |
| PH (1) | PH12013501501A1 (en) |
| PL (1) | PL2672844T3 (en) |
| PT (1) | PT2672844E (en) |
| RU (1) | RU2586928C2 (en) |
| SG (1) | SG192095A1 (en) |
| TW (1) | TW201244640A (en) |
| WO (1) | WO2012107865A2 (en) |
| ZA (1) | ZA201306751B (en) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104126749A (en) | 2011-02-10 | 2014-11-05 | 雀巢产品技术援助有限公司 | Modulation of growth of bifidobacteria using a combination of oligosaccharides found in human milk |
| WO2012177556A2 (en) | 2011-06-20 | 2012-12-27 | H.J. Heinz Company | Probiotic compositions and methods |
| WO2013154725A1 (en) * | 2012-04-13 | 2013-10-17 | Trustees Of Boston College | Prebiotic compositions and methods of use |
| EP2708145B1 (en) | 2012-09-14 | 2016-05-04 | Abbott Laboratories | Nutritional compositions for use in methods for modulating corticosterone levels in psychologically stressed individuals |
| SG11201608248YA (en) | 2014-04-08 | 2016-10-28 | Abbott Lab | Methods for enhancing mucosal innate immune responses to and/or detection of pathogens using human milk oligosaccharides |
| DK3209308T3 (en) * | 2014-10-24 | 2022-10-03 | Evolve Biosystems Inc | ACTIVATED BIFIDOBACTERIA AND METHODS OF USING THEREOF |
| MX2017006701A (en) * | 2014-11-26 | 2018-02-13 | Abbott Lab | Infant formula with rrr-alpha-tocopherol, 2'-fucosyllactose, and a probiotic. |
| RU2706963C2 (en) * | 2014-11-26 | 2019-11-21 | Абботт Лаборэтриз | Milk mixture containing breast milk oligosaccharides, polyunsaturated fatty acids, nucleotides and lutein |
| US10881674B2 (en) | 2014-12-08 | 2021-01-05 | Glycom A/S | Synthetic composition for treating metabolic disorders |
| CN107106584A (en) | 2014-12-08 | 2017-08-29 | 格礼卡姆股份公司 | Synthetic compositions for treating metabolic disorders |
| US10835544B2 (en) | 2014-12-08 | 2020-11-17 | Glycom A/S | Synthetic composition for regulating satiety |
| US10987368B2 (en) | 2014-12-08 | 2021-04-27 | Glycom A/S | Synthetic composition for preventing or treating CVD |
| PH12017550039B1 (en) * | 2015-03-05 | 2022-07-20 | SociaTa Des Produits Nestla S A | Compositions for use in improving stool consistency or frequency in infants or young children |
| WO2017071716A1 (en) | 2015-10-28 | 2017-05-04 | Glycom A/S | Synthetic composition and method for modulating emotion and mood disorders |
| US10835545B2 (en) | 2015-10-28 | 2020-11-17 | Glycom A/S | Synthetic composition and method for modulating brain function and behaviour |
| CN108541221B (en) * | 2015-12-15 | 2023-02-28 | 格礼卡姆股份公司 | Mixtures of HMOs |
| CN109561724A (en) | 2016-06-21 | 2019-04-02 | 阿拉食品公司 | The product for producing the method for the improvement nutrition product containing lactoprotein and lactose class and being obtained by this method |
| EP3490567A4 (en) * | 2016-07-28 | 2020-03-18 | Fonterra Co-Operative Group Limited | Dairy product and process |
| RU2740156C1 (en) * | 2017-06-21 | 2021-01-12 | Эбботт Лабораториз | Methods for improving growth of useful bacteria in gastrointestinal tract |
| CN111683665A (en) * | 2017-11-30 | 2020-09-18 | 格礼卡姆股份公司 | Human milk oligosaccharides for microbiota modulation and their synthetic compositions |
| CN113950247A (en) * | 2019-06-05 | 2022-01-18 | 森永乳业株式会社 | Composition comprising a metal oxide and a metal oxide |
| JP7474596B2 (en) * | 2020-01-20 | 2024-04-25 | 森永乳業株式会社 | Novel Bifidobacterium bacteria, compositions containing said bacteria, and compositions for promoting the growth of said bacteria |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260280A (en) | 1989-02-07 | 1993-11-09 | Snow Brand Milk Products Co., Ltd. | Bacterial toxin neutralizer |
| JP2003522784A (en) * | 2000-02-17 | 2003-07-29 | ワイス | Nutritional formulations containing prebiotic substances |
| WO2001060246A2 (en) * | 2000-02-18 | 2001-08-23 | Argose, Inc. | Multivariate analysis of green to ultraviolet spectra of cell and tissue samples |
| US6913778B2 (en) | 2001-12-21 | 2005-07-05 | Wyeth | Infant formula compositions comprising increased amounts of alpha-lactalbumin |
| US7867541B2 (en) * | 2003-04-14 | 2011-01-11 | Mead Johnson Nutrition Company | Compositions and methods of formulation for enteral formulas containing sialic acid |
| WO2004112509A2 (en) | 2003-06-23 | 2004-12-29 | Nestec S.A. | Nutritional formula for optimal gut barrier function |
| MXPA06006392A (en) † | 2003-12-05 | 2007-03-15 | Childrens Hosp Medical Center | Oligosaccharide compositions and use thereof in the treatment of infection. |
| EP1951060B1 (en) | 2005-11-04 | 2017-11-01 | Arla Foods Amba | A concentrate derived from a milk product enriched in naturally occurring sialyllactose and a process for preparation thereof |
| WO2007114683A1 (en) * | 2006-03-30 | 2007-10-11 | N.V. Nutricia | Milk oligosaccharides for stimulating the immune system |
| EP2060257A1 (en) | 2007-11-08 | 2009-05-20 | Nestec S.A. | Prevention and treatment of secondary infections following viral infection |
| EP2072052A1 (en) † | 2007-12-17 | 2009-06-24 | Nestec S.A. | Prevention of opportunistic infections in immune-compromised subjects |
| NL2001377C2 (en) | 2008-03-14 | 2009-09-15 | Friesland Brands Bv | Process for isolating sialic acid-containing oligosaccharides, as well as the compositions containing sialic acid-containing oligosaccharides. |
| IN2012DN00282A (en) * | 2009-07-31 | 2015-05-08 | Nestec Sa | |
| NL2004200C2 (en) * | 2010-02-05 | 2011-08-08 | Friesland Brands Bv | Use of sialyl oligosaccharides in weight management. |
| EP2563165A1 (en) * | 2010-04-27 | 2013-03-06 | N.V. Nutricia | Use of 6'-sialyl lactose in infant and toddler nutrition |
| NZ612386A (en) * | 2010-12-31 | 2015-02-27 | Abbott Lab | Synbiotic combination of probiotic and human milk oligosaccharides to promote growth of beneficial microbiota |
| CN104126749A (en) | 2011-02-10 | 2014-11-05 | 雀巢产品技术援助有限公司 | Modulation of growth of bifidobacteria using a combination of oligosaccharides found in human milk |
-
2012
- 2012-02-03 CN CN201410384571.XA patent/CN104126749A/en active Pending
- 2012-02-03 ES ES12707135T patent/ES2527200T5/en active Active
- 2012-02-03 MY MYPI2013701285A patent/MY161034A/en unknown
- 2012-02-03 SG SG2013056064A patent/SG192095A1/en unknown
- 2012-02-03 CN CN2012800083041A patent/CN103347405A/en active Pending
- 2012-02-03 PH PH1/2013/501501A patent/PH12013501501A1/en unknown
- 2012-02-03 US US13/984,362 patent/US20140371173A1/en not_active Abandoned
- 2012-02-03 BR BR112013020108A patent/BR112013020108A2/en not_active Application Discontinuation
- 2012-02-03 MX MX2014008513A patent/MX362129B/en unknown
- 2012-02-03 AU AU2012215042A patent/AU2012215042B2/en active Active
- 2012-02-03 PT PT127071355T patent/PT2672844E/en unknown
- 2012-02-03 EP EP12707135.5A patent/EP2672844B2/en active Active
- 2012-02-03 ES ES14177597.3T patent/ES2692533T3/en active Active
- 2012-02-03 EP EP14177597.3A patent/EP2792252B1/en active Active
- 2012-02-03 PL PL12707135T patent/PL2672844T3/en unknown
- 2012-02-03 MX MX2013009087A patent/MX345413B/en active IP Right Grant
- 2012-02-03 RU RU2013141449/13A patent/RU2586928C2/en active
- 2012-02-03 CA CA2825697A patent/CA2825697A1/en not_active Abandoned
- 2012-02-03 WO PCT/IB2012/050511 patent/WO2012107865A2/en not_active Ceased
- 2012-02-08 TW TW101104099A patent/TW201244640A/en unknown
- 2012-02-09 US US13/369,619 patent/US20120208782A1/en not_active Abandoned
-
2013
- 2013-07-15 IL IL227487A patent/IL227487A/en not_active IP Right Cessation
- 2013-08-01 CL CL2013002210A patent/CL2013002210A1/en unknown
- 2013-09-09 ZA ZA2013/06751A patent/ZA201306751B/en unknown
-
2015
- 2015-01-26 US US14/604,951 patent/US20150141367A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX345413B (en) | 2017-01-27 |
| MX2013009087A (en) | 2013-09-13 |
| WO2012107865A2 (en) | 2012-08-16 |
| IL227487A0 (en) | 2013-09-30 |
| EP2792252A3 (en) | 2015-03-25 |
| CL2013002210A1 (en) | 2014-01-10 |
| ES2527200T3 (en) | 2015-01-21 |
| EP2672844A2 (en) | 2013-12-18 |
| WO2012107865A3 (en) | 2012-11-01 |
| RU2013141449A (en) | 2015-03-20 |
| ZA201306751B (en) | 2015-05-27 |
| PT2672844E (en) | 2015-02-04 |
| CA2825697A1 (en) | 2012-08-16 |
| BR112013020108A2 (en) | 2017-06-13 |
| US20140371173A1 (en) | 2014-12-18 |
| PL2672844T3 (en) | 2015-04-30 |
| RU2586928C2 (en) | 2016-06-10 |
| IL227487A (en) | 2015-10-29 |
| EP2792252A2 (en) | 2014-10-22 |
| TW201244640A (en) | 2012-11-16 |
| ES2527200T5 (en) | 2022-12-29 |
| ES2692533T3 (en) | 2018-12-04 |
| MX362129B (en) | 2019-01-07 |
| EP2672844B1 (en) | 2014-11-19 |
| PH12013501501A1 (en) | 2019-10-07 |
| US20120208782A1 (en) | 2012-08-16 |
| SG192095A1 (en) | 2013-08-30 |
| EP2672844B2 (en) | 2022-10-05 |
| CN104126749A (en) | 2014-11-05 |
| AU2012215042B2 (en) | 2016-01-14 |
| CN103347405A (en) | 2013-10-09 |
| US20150141367A1 (en) | 2015-05-21 |
| EP2792252B1 (en) | 2018-09-12 |
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