MY138409A - Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the same - Google Patents
Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the sameInfo
- Publication number
- MY138409A MY138409A MYPI20034436A MY138409A MY 138409 A MY138409 A MY 138409A MY PI20034436 A MYPI20034436 A MY PI20034436A MY 138409 A MY138409 A MY 138409A
- Authority
- MY
- Malaysia
- Prior art keywords
- pharmaceutically acceptable
- acceptable salts
- local anesthetic
- pain
- nsaid
- Prior art date
Links
- 239000003589 local anesthetic agent Substances 0.000 title abstract 4
- 150000003839 salts Chemical class 0.000 title abstract 3
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract 5
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 5
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 abstract 3
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical group OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 abstract 3
- 229960004194 lidocaine Drugs 0.000 abstract 3
- 208000002193 Pain Diseases 0.000 abstract 2
- 229960001259 diclofenac Drugs 0.000 abstract 2
- 238000002411 thermogravimetry Methods 0.000 abstract 2
- 208000006820 Arthralgia Diseases 0.000 abstract 1
- 206010019973 Herpes virus infection Diseases 0.000 abstract 1
- 238000004566 IR spectroscopy Methods 0.000 abstract 1
- 208000000112 Myalgia Diseases 0.000 abstract 1
- 208000002847 Surgical Wound Diseases 0.000 abstract 1
- 206010053692 Wound complication Diseases 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000113 differential scanning calorimetry Methods 0.000 abstract 1
- 238000004128 high performance liquid chromatography Methods 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 208000013465 muscle pain Diseases 0.000 abstract 1
- 229940052264 other local anesthetics in atc Drugs 0.000 abstract 1
- 229940058287 salicylic acid derivative anticestodals Drugs 0.000 abstract 1
- 150000003872 salicylic acid derivatives Chemical class 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
THE PRESENT INVENTION PROVIDES PHARMACEUTICALIY ACCEPTABLE SALTS HAVING LOCAL ANESTHETIC AND ANTI-INFLAMMATORY ACTIVITIES. THE PREFERRED PHARMACEUTICALLY ACCEPTABLE SALT IS A DICLOFENAC SALT OF LIDOCAINE. DICLOFENAC IS A NON-STEROIDAL ANTI-INFLAMMATORY DRUG ("NSAID"). LIDOCAINE IS A LOCAL ANESTHETIC. OTHER NSAID (EXCEPT THE SALICYLIC ACID DERIVATIVES OF NSAID) CAN BE USED TO REPLACE DICLOFENAC AND/OR OTHER LOCAL ANESTHETICS CAN BE USED TO REPLACE LIDOCAINE. THE PHARMACEUTICALLY ACCEPTABLE SALTS ARE CRYSTALLINE COMPOUNDS, WHICH ARE DISTINCTIVELY DIFFERENT FROM EITHER THE NSAID ALONE OR THE LOCAL ANESTHETIC ALONE, AS INDICATED BY DIFFERENTIAL SCANNING CALORIMETRY (DSC), THERMOGRAVIMETRIC ANALYSIS (TGA), HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) AND FOURIER-TRANSFORMED INFRARED SPECTROSCOPY (FTIR) ANALYSES. THESE PHARMACEUTICALLY ACCEPTABLE SALTS ARE SUITABLE FOR USE IN TOPICAL TREATMENT OR PARENTERAL INJECTION TO TREAT PATIENTS WITH LOCALIZED PAIN, INCLUDING MUSCLE PAIN, JOINT PAIN, PAIN ASSOCIATED WITH HERPES INFECTION, AND WOUND PAIN (SUCH AS SURGICAL WOUND, BUM WOUND ETC.).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MYPI20034436 MY138409A (en) | 2003-11-19 | 2003-11-19 | Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MYPI20034436 MY138409A (en) | 2003-11-19 | 2003-11-19 | Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY138409A true MY138409A (en) | 2009-05-29 |
Family
ID=45756751
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI20034436 MY138409A (en) | 2003-11-19 | 2003-11-19 | Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the same |
Country Status (1)
| Country | Link |
|---|---|
| MY (1) | MY138409A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2055853A1 (en) * | 1970-11-13 | 1972-05-25 | Phenylbutazone procaine salt - with anti-inflammatory and analgesic activity | |
| WO1998052540A1 (en) * | 1997-05-22 | 1998-11-26 | The Boots Company Plc | Pharmaceutical compositions |
| US5900249A (en) * | 1998-02-09 | 1999-05-04 | Smith; David J. | Multicomponent pain relief topical medication |
| WO2003068159A2 (en) * | 2002-02-11 | 2003-08-21 | Wake Forest University | Compositions and methods for treating pain using cyclooxygenase-1 inhibitors |
-
2003
- 2003-11-19 MY MYPI20034436 patent/MY138409A/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2055853A1 (en) * | 1970-11-13 | 1972-05-25 | Phenylbutazone procaine salt - with anti-inflammatory and analgesic activity | |
| WO1998052540A1 (en) * | 1997-05-22 | 1998-11-26 | The Boots Company Plc | Pharmaceutical compositions |
| US5900249A (en) * | 1998-02-09 | 1999-05-04 | Smith; David J. | Multicomponent pain relief topical medication |
| WO2003068159A2 (en) * | 2002-02-11 | 2003-08-21 | Wake Forest University | Compositions and methods for treating pain using cyclooxygenase-1 inhibitors |
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