MY106232A - Lactam derivatives - Google Patents
Lactam derivativesInfo
- Publication number
- MY106232A MY106232A MYPI90000144A MYPI19900144A MY106232A MY 106232 A MY106232 A MY 106232A MY PI90000144 A MYPI90000144 A MY PI90000144A MY PI19900144 A MYPI19900144 A MY PI19900144A MY 106232 A MY106232 A MY 106232A
- Authority
- MY
- Malaysia
- Prior art keywords
- group
- alkyl
- phenyl
- hydrogen atom
- alkoxy
- Prior art date
Links
- 150000003951 lactams Chemical class 0.000 title abstract 2
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical group [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 7
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 7
- -1 IMIDAZOLYL GROUP Chemical group 0.000 abstract 6
- 150000002367 halogens Chemical group 0.000 abstract 3
- 102000035037 5-HT3 receptors Human genes 0.000 abstract 1
- 108091005477 5-HT3 receptors Proteins 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical group [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
THE INVENTION RELATES TO TRICYCLIC LACTAMS OF THE GENERAL FORMULA1 WHEREIN IM REPRESENTS AN IMIDAZOLYL GROUP OF THE FORMULA:(FORMULA 2)AND R1 REPRESENTS A HYDROGEN ATOM OR A GROUP SELECTED FROM C1- 6 ALKYL, C3- 6 ALKENYL, C3- 10 ALKYNYL, C3- 7 CYCLOALKYL, C3- 7 CYCLOALKYL C1- 4 ALKYL, PHENYL, PHENYL C1- 3 ALKYL, - CO2R5, -COR5,-CONR5R6 OR - SO2R5 (WHEREIN R5 AND R6, WHICH MAY BE THE SAME OR DIFFERENT, EACH REPRESENTS A HYDROGEN ATOM, A C1- 6 ALKYL OR C3- 7 CYCLOALKYL GROUP, OR A PHENYL OR PHENYL C1- 4 ALKYL - GROUP, IN WHICH THE PHENYL GROUP IS OPTIONALLY SUBSTITUTED BY ONE OR MORE C1- 4 ALKYL, C1- 4 ALKOXY OR HYDROXY GROUPS OR HALOGEN ATOMS, WITH THE PROVISO THAT R5 DOES NOT REPRESENT A HYDROGEN ATOM WHEN R1 REPRESENTS A GROUP -CO2R5 OR- SO2R5); ONE OF THE GROUPS REPRESENTS BY R2, R3 AND R4 IS HYDROGEN ATOM OR A C1-6 ALKYL, C3- 7 CYCLOALKYL, C3- 6 ALKENYL, PHENYL OR PHENYL C1-3 ALKYL,- GROUP, AND EACH OF THE OTHER TWO GROUPS, WHICH MAY BE THE SAME OR DIFFERENT, REPRESENTS A HYDROGEN ATOM OR A C1-6 ALKYL GROUP; Y REPRESENTS THE GROUP CH=CH OR (CH2)N, WHEREIN N REPRESENTS 2 OR 3; Q REPRESENTS A HALOGEN ATOM, OR A GROUP SELECTED FROM HYDROXY, C1-4 ALKOXY, PHENYL C1-3 ALKOXY, C1- 6ALKYL, CYANO, PHENYL WHICH MAY BE UNSUBTITUTED OR SUBSTITUTED BY ONE OR MORE C1- 4 ALKYL, C1-4 ALKOXY OR HYDROXY GROUPS OR HALOGEN ATOMS, -NR7R8, - CONR7R8 OR -(CH2)P CONR7R8 (WHEREIN R7 AND R8, WHICH MAY BE THE SAME OF DIFFERENT, EACH REPRESENTS A HYDROGEN ATOM OR A C1- 4 ALKYL OR C3- 4 ALKENYL GROUP, OR TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED FORM A SATURATED 5 TO 7 MEMBERED RING; AND P REPRESENTS 1, 2 OR 3 ), -(CH2)QNR9R10 (WHEREIN R9 REPRESENTS A HYDROGEN ATOM OR A C1-4 ALKYL GROUP, AND R10 REPRESENTS A GROUP -COR11 OR -SO2R11 WHEREIN R11 REPRESENTS A C1-4ALKYL GROUP; AND Q REPRESENTS 0, 1, 2 OR 3 ), OR -(CH2)2CO2R11 (R11 BEING AS DEFINED PREVIOUSLY); Q' REPRESENTS A HYDROGEN OR A FLUORINE ATOM; AND PHYSIOLOGICALLY ACCEPTABLE SALTS AND SOLVATES THEREOF.THE COMPOUNDS ARE POTENT AND SELECTIVE ANTAGONISTS OF THE EFFECT OF 5-HT AT 5-HT3 RECEPTORS AND ARE USEFUL,FOR EXAMPLE, IN THE TREATMENT OF PSYCHOCTIC DISORDERS,ANXIETY,NAUSEA AND VOMITING.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MYPI90000144A MY106232A (en) | 1990-01-30 | 1990-01-30 | Lactam derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MYPI90000144A MY106232A (en) | 1990-01-30 | 1990-01-30 | Lactam derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY106232A true MY106232A (en) | 1995-04-29 |
Family
ID=79554156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI90000144A MY106232A (en) | 1990-01-30 | 1990-01-30 | Lactam derivatives |
Country Status (1)
| Country | Link |
|---|---|
| MY (1) | MY106232A (en) |
-
1990
- 1990-01-30 MY MYPI90000144A patent/MY106232A/en unknown
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