[go: up one dir, main page]

MXPA05011498A - Derivados de 9-azabiciclo[3.3.1]non-6-eno con un heteroatomo en la posicion 3 como inhibidores de renina. - Google Patents

Derivados de 9-azabiciclo[3.3.1]non-6-eno con un heteroatomo en la posicion 3 como inhibidores de renina.

Info

Publication number
MXPA05011498A
MXPA05011498A MXPA05011498A MXPA05011498A MXPA05011498A MX PA05011498 A MXPA05011498 A MX PA05011498A MX PA05011498 A MXPA05011498 A MX PA05011498A MX PA05011498 A MXPA05011498 A MX PA05011498A MX PA05011498 A MXPA05011498 A MX PA05011498A
Authority
MX
Mexico
Prior art keywords
derivatives
heteroatom
renin inhibitors
compounds
preparation
Prior art date
Application number
MXPA05011498A
Other languages
English (en)
Inventor
Lubos Remen
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MXPA05011498A publication Critical patent/MXPA05011498A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invencion se refiere a los nuevos derivados del 9-azabiciclo[3.3.1]noneno y a los compuestos relacionados y a su uso como ingredientes activos en la preparacion de composiciones farmaceuticas. La invencion tambien se refiere a los aspectos relacionados que incluyen los procesos para la preparacion de los compuestos, las composiciones farmaceuticas que contienen uno o mas de estos compuestos y especialmente su uso como inhibidores de la renina.
MXPA05011498A 2003-04-30 2004-04-26 Derivados de 9-azabiciclo[3.3.1]non-6-eno con un heteroatomo en la posicion 3 como inhibidores de renina. MXPA05011498A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP0304492 2003-04-30
PCT/EP2004/004371 WO2004096366A1 (en) 2003-04-30 2004-04-26 9-azabicyclo’3.3.1!non-6-ee derivatives with a heteroatom at the 3-position as renin inhibitors

Publications (1)

Publication Number Publication Date
MXPA05011498A true MXPA05011498A (es) 2005-12-15

Family

ID=33395690

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05011498A MXPA05011498A (es) 2003-04-30 2004-04-26 Derivados de 9-azabiciclo[3.3.1]non-6-eno con un heteroatomo en la posicion 3 como inhibidores de renina.

Country Status (13)

Country Link
US (1) US20060258648A1 (es)
EP (1) EP1622685A1 (es)
JP (1) JP2006524655A (es)
KR (1) KR20060008937A (es)
CN (1) CN1780663A (es)
AU (1) AU2004233575A1 (es)
BR (1) BRPI0409884A (es)
CA (1) CA2521938A1 (es)
MX (1) MXPA05011498A (es)
NO (1) NO20054974L (es)
RU (1) RU2005137155A (es)
WO (1) WO2004096366A1 (es)
ZA (1) ZA200509661B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007509099A (ja) * 2003-10-23 2007-04-12 アクテリオン　ファマシューティカルズ　リミテッド 新規ジアザビシクロノネンおよび新規極性側鎖を有するテトラヒドロピリジン誘導体
CN1890239A (zh) * 2003-12-05 2007-01-03 埃科特莱茵药品有限公司 二氮杂二环壬烯及带有新的侧链的四氢吡啶衍生物
WO2006021403A1 (en) * 2004-08-25 2006-03-02 Actelion Pharmaceuticals Ltd Bicyclononene derivatives
US8138340B2 (en) 2004-08-25 2012-03-20 Actelion Pharmaceuticals Ltd. Bicyclononene derivatives
WO2006058546A1 (en) * 2004-12-01 2006-06-08 Actelion Pharmaceuticals Ltd Novel lactame derivatives as renin inhibitors
WO2006063610A1 (en) * 2004-12-17 2006-06-22 Actelion Pharmaceuticals Ltd Heteroaryl substituted diazabicyclononene derivatives
GB0428526D0 (en) 2004-12-30 2005-02-09 Novartis Ag Organic compounds
GB0514203D0 (en) 2005-07-11 2005-08-17 Novartis Ag Organic compounds
PT2420491E (pt) 2005-12-30 2013-10-14 Novartis Ag Compostos de piperidina 3,5-substituída como inibidores de renina
JP2009526767A (ja) 2006-02-02 2009-07-23 アクテリオン ファーマシューティカルズ リミテッド 新規二級アミン
EP2007725A2 (en) * 2006-03-16 2008-12-31 Nicox S.A. Non-peptidic renin inhibitors nitroderivatives
WO2008141462A1 (en) 2007-05-24 2008-11-27 Merck Frosst Canada Ltd. Novel case of renin inhibitors
CA2689109A1 (en) 2007-06-25 2008-12-31 Novartis Ag N5-(2-ethoxyethyl)-n3-(2-pyridinyl) -3,5-piperidinedicarboxamide derivatives for use as renin inhibitors
US8334308B2 (en) 2007-08-20 2012-12-18 Merck Sharp & Dohme Corp. Renin inhibitors
CN101888999B (zh) 2007-12-05 2013-12-11 巴斯夫欧洲公司 吡啶基甲基磺酰胺化合物
ES2548134T3 (es) 2008-05-05 2015-10-14 Actelion Pharmaceuticals Ltd. Derivados de piperidina 3,4-sustituida como inhibidores de renina
EP2189462B9 (en) * 2008-11-25 2012-06-13 Universita' Degli Studi di Firenze Bicyclic peptidomimetic inhibitors of aspartyl-proteases for the treatment of infectious diseases
CN102093389B (zh) * 2009-12-09 2014-11-19 华东理工大学 双联和氧桥杂环新烟碱化合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3509161A (en) * 1967-07-10 1970-04-28 Boehringer & Soehne Gmbh 3-phenyl-granatene-(2)-derivatives
US5380758A (en) * 1991-03-29 1995-01-10 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
PL193686B1 (pl) * 1995-09-07 2007-03-30 Hoffmann La Roche Pochodne piperydyny, środki lecznicze zawierającepochodne piperydyny, sposoby wytwarzania tych pochodnych oraz zastosowanie pochodnych
AU2003233963B2 (en) * 2002-04-29 2008-09-11 Actelion Pharmaceuticals Ltd 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases
MXPA04012136A (es) * 2002-06-27 2005-04-19 Actelion Pharmaceuticals Ltd Nuevos derivados de tetrahidropiridina como inhibidores de renina.

Also Published As

Publication number Publication date
EP1622685A1 (en) 2006-02-08
CN1780663A (zh) 2006-05-31
RU2005137155A (ru) 2006-03-27
NO20054974L (no) 2005-11-28
CA2521938A1 (en) 2004-11-11
NO20054974D0 (no) 2005-10-26
US20060258648A1 (en) 2006-11-16
WO2004096366A1 (en) 2004-11-11
ZA200509661B (en) 2006-11-29
JP2006524655A (ja) 2006-11-02
KR20060008937A (ko) 2006-01-27
AU2004233575A1 (en) 2004-11-11
BRPI0409884A (pt) 2006-05-23

Similar Documents

Publication Publication Date Title
TW200514786A (en) Novel diazabicyclononene derivatives
TW200514772A (en) Novel tetrahydropyridine derivatives
MXPA05011498A (es) Derivados de 9-azabiciclo[3.3.1]non-6-eno con un heteroatomo en la posicion 3 como inhibidores de renina.
MXPA05010137A (es) Derivados de tetrahidroisoquinolil acetamida para usarse como antagonistas del receptor de orexina.
IL150986A0 (en) 1,2,3,4,- tetrahydroisoquinoline derivatives
IL155806A0 (en) Novel benzazepines and related heterocyclic derivatives which are useful as orexin receptor antagonists
MY144992A (en) Substituted 1,2,3,4-tetrahydroisoquinoline derivatives.
WO2000055124A3 (en) Novel compounds and compositions as protease inhibitors
WO2004026836A3 (en) 1-pyridin-4-yl-urea derivatives
MXPA05011711A (es) Derivados de diazabiciclononeno.
YU87202A (sh) Derivati arilmetilamina koji se koriste kao inhibitori triptaze
MXPA05011496A (es) Derivados de azabiciclononeno.
WO2002048148A3 (en) Pyrazolopyridine derivatives
TNSN07435A1 (en) Novel piperidine carboxylic acid amide derivatives
MXPA05011497A (es) Derivados de tropano y su uso como inhibidores de la enzima de conversion de angiotensina (ace).
WO2005030209A8 (en) Pyridine derivatives and use thereof as urotensin ii antagonists
WO2002070464A3 (en) Hydrazones and their therapeutic use
WO2005054244A3 (en) Azabicyclooctene and other tetrahydropyridine derivatives with a new side-chain
AU2001289714A1 (en) Benzofuran derivatives and their use as antibacterial agents
MXPA04001773A (es) Derivados de 6,7-dihidroxitetrahidroisquinolinas 3-sustituidas parta uso como agentes antibacterianos.
TW200637861A (en) Novel diazabicyclononene derivative
TW200621773A (en) Bicyclononene derivatives
TW200628468A (en) Bicyclononene derivatives
CA2299036A1 (en) 4-phenyl-4-heteroarylpiperidine derivatives
TW200621774A (en) Bicyclononene derivatives